Cited by 508Mitochondrial Function and PathologyNitric Oxide and Endothelin EffectsAutophagy in Disease and Therapy

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Mitochondria and Endothelial Function

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Kluge, Matthew A., Fetterman, Jessica L., Vita, Joseph A.·2013·Circulation Research

DOI 10.1161/circresaha.111.300233PMC PMC3700369

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Abstract

In contrast to their role in cell types with higher energy demands, mitochondria in endothelial cells primarily function in signaling cellular responses to environmental cues. This article provides an overview of key aspects of mitochondrial biology in endothelial cells, including subcellular location, biogenesis, dynamics, autophagy, reactive oxygen species production and signaling, calcium homeostasis, regulated cell death, and heme biosynthesis. In each section, we introduce key concepts and then review studies showing the importance of that mechanism to endothelial control of vasomotor tone, angiogenesis, and/or inflammatory activation. We particularly highlight the small number of clinical and translational studies that have investigated each mechanism in human subjects. Finally, we review interventions that target different aspects of mitochondrial function and their effects on endothelial function. The ultimate goal of such research is the identification of new approaches for therapy. The reviewed studies make it clear that mitochondria are important in endothelial physiology and pathophysiology. A great deal of work will be needed, however, before mitochondria-directed therapies are available for the prevention and treatment of cardiovascular disease.

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Authors: Kluge, M. A., Fetterman, J. L., & Vita, J. A.
Affiliations: Boston University (US)
ORCID: Fetterman, Jessica L.
Vita, Joseph A.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-04-12
Volume: 112
Issue: 8
Pages: 1171-1188
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.111.300233
PMC: PMC3700369
OpenAlex: W2171435588
Cited by: 508
References: 213
Citations by year: 2026: 25 · 2025: 44 · 2024: 49 · 2023: 34 · 2022: 60 · 2021: 52 · 2020: 49 · 2019: 33 · 2018: 37 · 2017: 37 · 2016: 25 · 2015: 25 · 2014: 34 · 2013: 4
FWCI: 2.76
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL060886, R01HL102299, HL081587, P50HL083801, K12HL083781, P01HL081587, R01HL075795, T32HL007224, HL083781, R01HL083269, HL083801, HL102299, R01HL115391)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondria, endothelial cells, endothelial function, mitochondrial biogenesis, mitochondrial dynamics, mitophagy, reactive oxygen species, calcium homeostasis, regulated cell death, heme biosynthesis, vascular tone, angiogenesis, inflammation, mitochondrial-targeted therapy, cardiovascular disease
MeSH terms: Animals, Autophagy, Endothelium, Vascular, Homeostasis, Humans, Mitochondria, Signal Transduction, Reactive Oxygen Species, Endothelial Cells

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