Cited by 508Mitochondrial Function and PathologyNitric Oxide and Endothelin EffectsAutophagy in Disease and Therapy

The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.

Mitochondria and Endothelial Function

Open access

Kluge, Matthew A., Fetterman, Jessica L., Vita, Joseph A.·2013·Circulation Research

DOI 10.1161/circresaha.111.300233PMC PMC3700369

Open this paper in CoChat — free account Open PDF

Abstract

In contrast to their role in cell types with higher energy demands, mitochondria in endothelial cells primarily function in signaling cellular responses to environmental cues. This article provides an overview of key aspects of mitochondrial biology in endothelial cells, including subcellular location, biogenesis, dynamics, autophagy, reactive oxygen species production and signaling, calcium homeostasis, regulated cell death, and heme biosynthesis. In each section, we introduce key concepts and then review studies showing the importance of that mechanism to endothelial control of vasomotor tone, angiogenesis, and/or inflammatory activation. We particularly highlight the small number of clinical and translational studies that have investigated each mechanism in human subjects. Finally, we review interventions that target different aspects of mitochondrial function and their effects on endothelial function. The ultimate goal of such research is the identification of new approaches for therapy. The reviewed studies make it clear that mitochondria are important in endothelial physiology and pathophysiology. A great deal of work will be needed, however, before mitochondria-directed therapies are available for the prevention and treatment of cardiovascular disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/circresaha.111.300233

Cites

213 of 213 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Apoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
The BCL-2 protein family: opposing activities that mediate cell death
Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,806
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
Mechanisms of mitophagy
Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

Show all 213 references

Research works printed but not linked: 1

10.1161/circ.126.suppl_21.A16000 · DOI

Sorted by citations

Items 301–400 of 508

Twist1 signaling in age-dependent decline in angiogenesis and lung regeneration
Hendee, K., Hunyenyiwa, T., Matus, K., Toledo, M., Mammoto, A., & Mammoto, T. (2021) · Aging · doi:10.18632/aging.202875 · Cited by 14
Mitochondrial-derived peptides: New markers for cardiometabolic dysfunction
Rochette, L., Rigal, E., Dogon, G., Malka, G., Zeller, M., Vergely, C., & Cottin, Y. (2021) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2021.10.013 · Cited by 16
Hypoxia-Induced Changes in Endothelial Cell Phenotype and Function
Tóth, A., & Jeney, V. (2025) · Antioxidants and Redox Signaling · doi:10.1089/ars.2025.1022 · Cited by 14
Deep-Red and Near-Infrared Compact Cyanine Dyes for Sensitive NAD(P)H Sensing in Live Cells and Kidney Disease Tissues
Norouzi, M., Amoli, A., Zhang, Y., Zhang, Y., Beatty, A. C., Jarvi, A., Ata, A., Werner, T., & Liu, H. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01345 · Cited by 13
Chronic nitric oxide deprivation induces an adaptive antioxidant status in human endothelial cells
Cattaneo, M. G., Cappellini, E., Ragni, M., Tacchini, L., Scaccabarozzi, D., Nisoli, E., & Vicentini, L. M. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.026 · Cited by 13
Neonatal Intermittent Hypoxia, Reactive Oxygen Species, and Oxygen-Induced Retinopathy
Beharry, K. D. A., Cai, C. L., Valencia, G., Valencia, A. M., Lazzaro, D. R., Bany-Mohammed, F., & Aranda, J. V. (2017) · doi:10.20455/ros.2017.805 · Cited by 13
The Multifaceted Role of Mitochondria in Angiogenesis
Cannito, S., Giardino, I., D’Apolito, M., Pettoello‐Mantovani, M., Scaltrito, F., Mangieri, D., & Piscazzi, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167960 · Cited by 15
Mitochondrial Permeability Transition Pore: The Cardiovascular Disease’s Molecular Achilles Heel
Nesci, S., & Rubattu, S. D. (2025) · Biomedicines · doi:10.3390/biomedicines13123014 · Cited by 12
Mitochondrial Changes in Rat Brain Endothelial Cells Associated with Hepatic Encephalopathy: Relation to the Blood–Brain Barrier Dysfunction
Milewski, K., Orzeł-Gajowik, K., & Zielińska, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03698-7 · Cited by 12
Mitochondrial dynamics in vascular remodeling and target-organ damage
Zhu, T., Hu, Q., Yuan, Y., Yao, H., Zhang, J., & Qi, J. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1067732 · Cited by 12
New Highly Sensitive and Specific Raman Probe for Live Cell Imaging of Mitochondrial Function
Pieczara, A., Reyes, R. A. A., Keyes, T. E., Dawiec, P., & Barańśka, M. (2024) · ACS Sensors · doi:10.1021/acssensors.3c02576 · Cited by 14
miR‐210 as a therapeutic target in diabetes‐associated endothelial dysfunction
Collado, A., Jiao, T., Kontidou, E., Carvalho, L. R. R. A., Chernogubova, E., Yang, J., Zaccagnini, G., Zhao, A. Z., Tengbom, J., Zheng, X., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17329 · Cited by 12
A redox-sensitive signaling pathway mediates pro-angiogenic effect of chlordecone via estrogen receptor activation
Alibrahim, E. A., Andriantsitohaina, R., Hardonnière, K., Soleti, R., Faure, S., & Simard, G. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.02.008 · Cited by 12
Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling
Zhang, B., Alruwaili, N., Kandhi, S., Deng, W., Huang, A., Wolin, M. S., & Sun, D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200307 · Cited by 12
Changes in the mitochondrial membrane potential in endothelial cells can be detected by Raman microscopy
Pieczara, A., Matuszyk, E., Szcześniak, P., Młynarski, J., & Barańśka, M. (2022) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2022.121978 · Cited by 12
Molecular characterization, immune and xenobiotic responses of glutathione S-transferase omega 1 from the big-belly seahorse: Novel insights into antiviral defense
Udayantha, H. M. V., Liyanage, D. S., Nadarajapillai, K., Omeka, W. K. M., Yang, H., Jeong, T., & Lee, J. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.12.010 · Cited by 12
VLDL Induced Modulation of Nitric Oxide Signalling and Cell Redox Homeostasis in HUVEC
Magnifico, M. C., Oberkersch, R. E., Mollo, A., Giambelli, L., Grooten, Y., Sarti, P., Calabrese, G. C., & Arese, M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2697364 · Cited by 12
Therapeutic ultrasound protects HUVECs from ischemia/hypoxia-induced apoptosis via the PI3K-Akt pathway.
Huang, J., Shi, Y., Li, R., Hu, A., Lu, Z., Weng, L., Han, Y., Wang, S.-Q., Zhang, L., Hao, C., et al. (2017) · PubMed Central · Cited by 12
Mitochondria at the crossroads of aging and cardiovascular disease
Lateef, O. M., Fakorede, S., Harris, C., Lateef, A. M., & Ajayi, A. F. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124127 · Cited by 11
Endothelial cells differentially sense laminar and disturbed flows by altering the lipid order of their plasma and mitochondrial membranes
Yamamoto, K., Maeno, R., Kawabe, K., Shimogonya, Y., & Ando, J. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00393.2023 · Cited by 12
Repurposing Metformin for the Treatment of Atrial Fibrillation: Current Insights
Sarkar, A., Fanous, K., Marei, I., Ding, H., Ladjimi, M. M., MacDonald, R. S., Hollenberg, M. D., Anderson, T. J., Hill, M. A., & Triggle, C. R. (2024) · Vascular Health and Risk Management · doi:10.2147/vhrm.s391808 · Cited by 11
Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report
Hough, R. F., Alvira, C. M., Bastarache, J. A., ERZURUM, S. C., Kuebler, W. M., Schmidt, E. P., Shimoda, L. A., Abman, S. H., Alvarez, D. F., Belvitch, P. G., et al. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2024-0330st · Cited by 13
Hypoxia-Induced Mitochondrial ROS and Function in Pulmonary Arterial Endothelial Cells
Wang, H., Song, T., Reyes-García, J., & Wang, Y.-X. (2024) · Cells · doi:10.3390/cells13211807 · Cited by 11
Lung endothelial cell heterogeneity in health and pulmonary vascular disease
Massad, K. M., Dai, Z., Petrache, I., Ventetuolo, C. E., & Lahm, T. (2025) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00296.2024 · Cited by 11
Mitochondrial Dysfunction and Atherosclerosis: The Problem and the Search for Its Solution
Невойт, Г. В., Jaruševičius, G., Potyazhenko, M., Mintser, O. P., Bumblytė, I. A., & Vainoras, A. (2025) · Biomedicines · doi:10.3390/biomedicines13040963 · Cited by 14
Oxidative Stress in the Pathophysiology of Chronic Venous Disease: An Overview
Raţiu, S., Mariș, M. I., Furdui-Lința, A. V., Sima, L., Bratu, T. I., Sturza, A., Muntean, D. M., & Cretu, O. M. (2025) · Antioxidants · doi:10.3390/antiox14080989 · Cited by 12
High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells
Hansen, C. C., Olsen, K., Pilegaard, H., Bangsbo, J., Gliemann, L., & Hellsten, Y. (2021) · Physiological Reports · doi:10.14814/phy2.14855 · Cited by 11
Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease
Li, K., Dai, M., Sacirovic, M., Zemmrich, C., Pagonas, N., Ritter, O., Grisk, O., Lubomirov, L. T., Lauxmann, M. A., Bramlage, P., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1157571 · Cited by 12
Blood–Brain Barrier Breakdown in Stress and Neurodegeneration: Biochemical Mechanisms and New Models for Translational Research
Salmina, A. B., Komleva, Y. K., Malinovskaya, N. A., Morgun, A. V., Тепляшина, Е. А., Lopatina, O. L., Gorina, Y. V., Kharitonova, E. V., Хилажева, Е. Д., & Shuvaev, А. N. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921060122 · Cited by 12
Paraoxonase 2 protects against the CML mediated mitochondrial dysfunction through modulating JNK pathway in human retinal cells
Ravi, R., & Rajesh, B. S. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130043 · Cited by 11
Aldosterone Suppresses Endothelial Mitochondria through Mineralocorticoid Receptor/Mitochondrial Reactive Oxygen Species Pathway
Peng, S., Tsai, C., Wu, X.-M., Huang, H.-H., Chen, Z., Lee, B., Chang, Y., Pan, C., Wu, V., Chou, C., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10051119 · Cited by 11
Relationship of Mitochondrial DNA Haplogroups with Complex Diseases
Urzúa-Traslaviña, C. G. (2014) · Journal of Genetics and Genome Research · doi:10.23937/2378-3648/1410011 · Cited by 11
Mitochondria-targeted Uncouplers Decrease Inflammatory Reactions in Endothelial Cells by Enhancing Methylation of the ICAM1 Gene Promoter
Zinovkina, L. A., Makievskaya, C. I., Galkin, I. I., & Zinovkin, R. A. (2023) · Current Molecular Pharmacology · doi:10.2174/1874467217666230815142556 · Cited by 10
Roles of Protein S-Nitrosylation in Endothelial Homeostasis and Dysfunction
Luo, S., Ye, D., Wang, Y., Liu, X., Wang, X., Xie, L., & Ji, Y. H. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0406 · Cited by 10
Nanoparticle‐based therapeutic strategies for mitochondrial dysfunction in cardiovascular disease
Suzuki, I., Xing, H., Giblin, J., Ashraf, A., & Chung, E. J. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37668 · Cited by 12
Mitochondrial regulation of diabetic endothelial dysfunction: Pathophysiological links
Fang, X., Zhang, Y., Wu, H., Wang, H., Miao, R., Wei, J., Zhang, Y., Tian, J., & Tong, X. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106569 · Cited by 10
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
Zhang, H., Muhetarijiang, M., Chen, R. J., Hu, X., Han, J., Zheng, L., & Chen, T. (2024) · Aging and Disease · doi:10.14336/ad.2024.0058 · Cited by 12
Pathological roles of mitochondrial dysfunction in endothelial cells during the cerebral no-reflow phenomenon: A review
Luo, X., Zhang, S., Wang, L., & Li, J. (2024) · Medicine · doi:10.1097/md.0000000000040951 · Cited by 12
From DNA Repair to Redox Signaling: The Multifaceted Role of APEX1 (Apurinic/Apyrimidinic Endonuclease 1) in Cardiovascular Health and Disease
Yuan, H.-H., Yin, H. R., Marincas, M., Xie, L., Bu, L.-L., Guo, M.-H., & Zheng, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073034 · Cited by 10
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury
Luo, A., Wang, R., Gong, J., Wang, S., Yun, C., Chen, Z., Jiang, Y., Liu, X., Dai, H., Liu, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202414960 · Cited by 10
Endothelotropic activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in the conditions of experimental cerebral ischemia
Voronkov, A. V., & Pozdnyakov, D. I. (2018) · Research Results in Pharmacology · doi:10.3897/rrpharmacology.4.26519 · Cited by 10
Computational simulations of the 4D micro-circulatory network in zebrafish tail amputation and regeneration
Roustaei, M., Baek, K. I., Wang, Z., Cavallero, S., Satta, S., Lai, A. C., O’Donnell, R., Vedula, V., Ding, Y., Marsden, A. L., et al. (2022) · Journal of The Royal Society Interface · doi:10.1098/rsif.2021.0898 · Cited by 10
Multifunctions of CRIF1 in cancers and mitochondrial dysfunction
Jiang, Y., Xiang, Y., Lin, C., Zhang, W., Yang, Z., Xiang, L., Xiao, Y., Chen, L., Ran, Q., & Li, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1009948 · Cited by 10
Mitochondrial Dynamics during Development
Maheshwari, A., He, L., & Tronstad, K. J. (2023) · Newborn · doi:10.5005/jp-journals-11002-0053 · Cited by 10
Dipeptidyl peptidase‐4 inhibitors and aerobic exercise synergistically protect against liver injury in ovariectomized rats
Younan, N., Elattar, S., Youssef, M. F., Rashed, L. A., & Estaphan, S. (2019) · Physiological Reports · doi:10.14814/phy2.14191 · Cited by 10
Metabolic profiling reveals the heterogeneity of vascular endothelial function phenotypes in individuals at extreme cardiovascular risk
Mao, B., Yi, Y., Mo, Q., Yang, C., & Zhong, Q. (2019) · RSC Advances · doi:10.1039/c9ra05526f · Cited by 10
Chronic imaging of mitochondria in the murine cerebral vasculature using in vivo two-photon microscopy
Rutkai, I., Evans, W. R., Bess, N., Salter‐Cid, T., Čikić, S., Chandra, P. K., Katakam, P. V. G., Mostany, R., & Busija, D. W. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00751.2019 · Cited by 10
Renal Revascularization Attenuates Myocardial Mitochondrial Damage and Improves Diastolic Function in Pigs with Metabolic Syndrome and Renovascular Hypertension
Farahani, R. A., Yu, S., Ferguson, C. M., Zhu, X., Tang, H. J., Jordan, K. L., Saadiq, I. M., Herrmann, S. M., Chade, A., Lerman, A., et al. (2021) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-021-10155-3 · Cited by 10
Wall shear stress modulates metabolic pathways in endothelial cells
Simões-Faria, R., Daems, M., Peacock, H. M., Declercq, M., Willems, A., Jones, E. A. V., & Ghesquière, B. (2025) · Metabolomics · doi:10.1007/s11306-024-02214-y · Cited by 9
Endothelial cell senescence and mitochondrial dysfunction in vascular ageing
Walczak, I., Tarnawska, M., Stawarska, K., Braczko, A., Paterek, A., Rolski, F., Leszek, P., Smolarek, D., Kapusta, M., Narajczyk, M., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103119 · Cited by 13
Inhibition of IP3R3 attenuates endothelial to mesenchymal transition induced by TGF-β1 through restoring mitochondrial function
Xu, Y., Guo, X., Ning, S., He, Q., Meng, B., FuShan, X., & Yin, Y. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.06.033 · Cited by 9
Amyloid $$\upbeta$$ (1–42) peptide impairs mitochondrial respiration in primary human brain microvascular endothelial cells: impact of dysglycemia and pre-senescence
Sakamuri, S. S. V. P., Sure, V. N. L. R., Wang, X., Bix, G. J., Fonseca, V. A., Mostany, R., & Katakam, P. V. G. (2022) · GeroScience · doi:10.1007/s11357-022-00644-x · Cited by 9
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
Garcia‐Vilas, J. A., Martı́nez-Poveda, B., Quesada, A. R., & Medina, M. Á. (2018) · Marine Drugs · doi:10.3390/md16090316 · Cited by 9
Microarray Based Functional Analysis of Myricetin and Proteomic Study on Its Anti-Inflammatory Property
Li, T., Zhu, J., Deng, F., Wu, W., Zheng, Z., Lv, C., Li, Y., Xiang, W., Lu, X., & Qin, S. (2019) · BioMed Research International · doi:10.1155/2019/3746326 · Cited by 9
MTHFR variant links homocysteine metabolism and endothelial cell dysfunction by targeting mitophagy in human thoracic aortic dissection patient induced pluripotent stem cell (iPSC) models
You, Y., Shao, L., Zhang, M., Guo, X., Chen, Y., Shen, H., Teng, X., Zhu, J., Yu, M., Hu, S., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.02.032 · Cited by 8
Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis
Dalal, K. K., Katari, V., Kondapalli, N. B., Paruchuri, S. M., & Thodeti, C. K. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00352.2025 · Cited by 9
Mitophagy: a novel avenue for herbal medicines alleviating myocardial ischemia/reperfusion injury
Liao, M., Men, L., Gong, M., Li, Y., Wang, Y., De-sheng, X., Luan, J., Zhou, H., Liu, M., & Chen, M. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02178-x · Cited by 8
Tributyltin Alters Calcium Levels, Mitochondrial Dynamics, and Activates Calpains Within Dorsal Root Ganglion Neurons
Fross, S., Mansel, C. O., McCormick, M., & Vohra, B. P. S. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa193 · Cited by 8
MiR-34a and endothelial biology
Li, Q., & Zhang, Q. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121976 · Cited by 8
Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dysfunction: a Systematic Review
Li, T., Han, X., Chen, S., Wang, B., Teng, Y., Cheng, W., Lu, Z., Li, Y., Wu, X., Jiang, Y., et al. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10282-5 · Cited by 9
Why is Qi-Invigorating Therapy in Chinese Medicine Suitable for Mitochondrial Diseases? A Bioenergetic Perspective
Li, X.-T., Kuang, H., & Zhao, J. (2015) · InTech eBooks · doi:10.5772/60675 · Cited by 8
Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells
Joo, H. K., Lee, Y. R., Choi, S., Park, M. S., Kang, G., Kim, C., & Jeon, B. H. (2017) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2017.21.4.377 · Cited by 8
Protective effects of a new glutamic acid derivative against stress after nNOS blockade
Tyurenkov, I. N., Popova, T. A., Perfilova, V. N., Prokofiev, I. I., Borisov, A. V., Kustova, M. V., Zaypullaev, G. I., & Ostrovskij, O. V. (2017) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20176301047 · Cited by 8
Oxidized Cell‐Free Hemoglobin Induces Mitochondrial Dysfunction by Activation of the Mitochondrial Permeability Transition Pore in the Pulmonary Microvasculature
Riedmann, K. J., Meegan, J. E., Afzal, A., Cervantes‐Cruz, Y., Obeidalla, S. N., Bogart, A. M., Ware, L. B., Shaver, C. M., & Bastarache, J. A. (2025) · Microcirculation · doi:10.1111/micc.70012 · Cited by 8
Experimental Renovascular Disease Induces Endothelial Cell Mitochondrial Damage and Impairs Endothelium-Dependent Relaxation of Renal Artery Segments
Nargesi, A. A., Zhu, X.-Y., Saadiq, I. M., Jordan, K. L., Lerman, A., Lerman, L. O., & Eirin, A. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa047 · Cited by 7
Sepiapterin Improves Vascular Reactivity and Insulin‐Stimulated Glucose in Wistar Rats
Keller, A. C., Knaub, L. A., Scalzo, R. L., Hull, S., Johnston, A., Walker, L. A., & Reusch, J. E. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7363485 · Cited by 7
Endothelial mechanotransduction in cardiovascular development and regeneration: emerging approaches and animal models
Cavallero, S., Blázquez‐Medela, A. M., Satta, S., & Hsiai, T. K. (2021) · Current topics in membranes · doi:10.1016/bs.ctm.2021.07.002 · Cited by 7
Effect of high-fat diet on rat myometrium during pregnancy—isolated myometrial mitochondria are not affected
Gam, C. M. B. F., Mortensen, O. H., Qvortrup, K., Damm, P., & Quistorff, B. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1599-7 · Cited by 7
Extracellular Vesicles as an Index for Endothelial Injury and Cardiac Dysfunction in a Rodent Model of GDM
Kereliuk, S. M., Xiao, F., Burger, D. E., & Dolinsky, V. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094970 · Cited by 7
Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes
Zaharia, O., Schön, M., Löffler, L., Straßburger, K., Möser, C., Yurchenko, I., Bódis, K. B., Antoniou, S., Karusheva, Y., Szendroedi, J., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac480 · Cited by 6
Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases
Deshpande, D., Janero, D. R., Segura-Ibarra, V., Blanco, E., & Amiji, M. M. (2016) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-12-3-134 · Cited by 7
Metabolic Regulation of Endothelial Cells: A New Era for Treating Wet Age-Related Macular Degeneration
Chen, X., Xu, Y., Ju, Y., & Gu, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115926 · Cited by 7
Holotomographic microscopy reveals label-free quantitative dynamics of endothelial cells during endothelialization
Leineweber, W. D., Munares, G. A., Leycam, C., Michael, R., Noyer, J., & Jurney, P. (2025) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2025.151492 · Cited by 6
Urolithin A supplementation to improve endothelial and cerebrovascular function in middle-aged adults with obesity: Study protocol for a double-blind placebo-controlled randomized study
Pinaffi‐Langley, A. C. D. C., Pinto, C. B., Szarvas, Z., Péterfi, A., Kaposzta, Z., Mukli, P., Muranyi, M., Owens, C. D., Adams, C., Shahriari, A., et al. (2025) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2025.04.004 · Cited by 6
Exosome-derived mtDNA disrupts endothelial barrier integrity and accelerates sepsis progression by inducing mitochondrial dysfunction through the PKCδ gene
Peng, Z., Cao, X., Gao, H., Li, C., Zhang, J., & Liu, Y. (2025) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2025.130871 · Cited by 6
Role of Mitochondria in Cerebral Vascular Function: Energy Production, Cellular Protection, and Regulation of Vascular Tone
Busija, D. W., Rutkai, I., Dutta, S., & Katakam, P. V. G. (2016) · Comprehensive physiology · doi:10.1002/j.2040-4603.2016.tb00718.x · Cited by 6
Sodium and potassium regulate endothelial phospholipase C-γ and Bmx
Ying, W., Aaron, K. J., & Sanders, P. W. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00615.2013 · Cited by 6
Elevating the significance of legume intake: A novel strategy to counter aging‐related mitochondrial dysfunction and physical decline
Zheng, Q., Wang, F., Nie, C., Zhang, K., Sun, Y., AL‐Ansi, W., Wu, Q., Wang, L., Du, J., & Li, Y. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13342 · Cited by 6
Effects of resveratrol on laminar shear stress-induced mitochondrial biogenesis in human vascular endothelial cells
Kim, J., & Park, J. (2019) · Physical Activity and Nutrition · doi:10.20463/jenb.2019.0002 · Cited by 6
Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells.
Zhang, S., Gao, Y., & Wang, J. (2017) · PubMed Central · Cited by 6
Vascular Endothelial Function
Widlansky, M. E., & Malik, M. A. (2015) · Springer eBooks · doi:10.1007/978-3-642-37078-6_8 · Cited by 6
Complementary Therapies for the Body, Mind and Soul
Saad, M. (2015) · InTech eBooks · doi:10.5772/59418 · Cited by 5
Mitochondrial Transfer to Endothelial Cells: Mechanisms, Evidence, and Therapeutic Potential
Im, G., & Melero‐Martin, J. M. (2026) · Circulation Research · doi:10.1161/circresaha.125.326982 · Cited by 5
Energy metabolism dysregulation, cerebrovascular aging, and time-restricted eating: Current evidence and proof-of-concept findings
Pinaffi‐Langley, A. C. D. C., Pinto, C. B., Mukli, P., Péterfi, A., Kaposzta, Z., Owens, C. D., Szarvas, Z., Muranyi, M., Adams, C., Shahriari, A., et al. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae505 · Cited by 6
Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells
Moiz, B., Walls, M., Vargas, V. A., Addepall, A., Weber, C. M., Li, A., Sriram, G., & Clyne, A. M. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106769 · Cited by 5
Blocking cholesterol formation and turnover improves cellular and mitochondria function in murine heart microvascular endothelial cells and cardiomyocytes
Braczko, A., Harasim, G., Kawecka, A., Walczak, I., Kapusta, M., Narajczyk, M., Stawarska, K., Smolenski, R. T., & Kutryb-Zając, B. A. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1216267 · Cited by 5
Porównanie dożylnego i podskórnego podawania insulin na intensywność bólu neuropatycznego u chorych na cukrzycę
Rokicka, D., Wróbel, M. P., Szymborska‐Kajanek, A., Adamczyk-Sowa, M. H., Bożek, A., Pierzchała, K., & Strojek, K. (2015) · Endokrynologia Polska · doi:10.5603/ep.2015.0031 · Cited by 5
Nitrate and Nitrite in Aging and Age-Related Disease
Johnson, L. C., DeVan, A. E., Justice, J. N., & Seals, D. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_18 · Cited by 5
Intrinsic Exercise Capacity and Mitochondrial DNA Lead to Opposing Vascular-Associated Risks
Roy, S., Edwards, J. M., Tomcho, J. C., Schreckenberger, Z. J., Bearss, N. R., Zhang, Y., Morgan, E. E., Cheng, X., Spegele, A. C., Vijay–Kumar, M., et al. (2020) · Function · doi:10.1093/function/zqaa029 · Cited by 5
The Effect of Ubiquinol on Cerebral Endothelial Cells in Different Regions of Rat Brain
Shapoval, N. S., Malinovskaya, N. A., Morgun, A. V., Salmina, A. B., Оболенская, О. Н., Na, M., & Os, M. (2021) · Cell and Tissue Biology · doi:10.1134/s1990519x21030111 · Cited by 5
Polymer-coated nanoparticles and their effects on mitochondrial function in brain endothelial cells
Bittner, A., Ducray, A., Stoffel, M. H., Felser, A., & Mevissen, M. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114800 · Cited by 5
Endothelial Drp1 Couples VEGF-induced Redox Signaling with Glycolysis Through Cysteine Oxidation to Drive AngiogenesisPreprint
Nagarkoti, S., Kim, Y.-M., Das, A., Ash, D., Vitriol, E. A., Read, T., Varadarajan, S., Hossain, M. S., Yadav, S., McMenamin, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.15.599174 · Cited by 5
MSCs ameliorates hyperglycemia-induced endothelial injury through modulation of mitochondrial dynamics
Wei, J., Mao, R., Chen, Y., Si, K., Yao, L., Li, J., & Zhu, W. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08175-x · Cited by 4
FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology
Zou, W., Lv, Y., Li, L., Zhang, S., Liang, J., Wu, C., Huang, E., Jiao, J., & Zhang, J. (2025) · Advanced Science · doi:10.1002/advs.202503082 · Cited by 4
Adipose stromal vascular fraction reverses mitochondrial dysfunction and hyperfission in aging-induced coronary microvascular disease
Tracy, E. P., Nair, R., Rowe, G., Beare, J. E., Beyer, A., & LeBlanc, A. J. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00311.2022 · Cited by 4
Hydrogen sulfide ameliorated endothelial dysfunction in hyperhomocysteinemia rats: Mechanism of IRE1α/JNK pathway-mediated autophagy
Gao, Y., Xu, J., He, K., Guo, Q., Xiao, L., Jin, S., Tian, D., Teng, X., An, C., Xue, H., et al. (2024) · Nitric Oxide · doi:10.1016/j.niox.2024.10.008 · Cited by 4
Endothelium at a Glance
Lenasi, H. (2018) · InTech eBooks · doi:10.5772/intechopen.81286 · Cited by 4
Narrative review of endothelial cell metabolism and aberrations in atherosclerosis and peripheral artery disease
Carr, S. M., Scrivner, O., & Hekman, K. E. (2025) · JVS Vascular Science · doi:10.1016/j.jvssci.2025.100285 · Cited by 3
Metformin limits cerebral cavernous malformation development by targeting KLF4-mediated mitochondrial damage
Yan, C., Ye, Y., Liu, N., Zhang, D., Du, W., Li, Y., Li, G., Li, C., Li, J., Ma, S., et al. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152241 · Cited by 3
Potential health benefits of cold‐water immersion: the central role of PGC‐1α
Hohenauer, E., Douzi, W., & Burtscher, J. (2025) · The Journal of Physiology · doi:10.1113/jp289536 · Cited by 4

Authors: Kluge, M. A., Fetterman, J. L., & Vita, J. A.
Affiliations: Boston University (US)
ORCID: Fetterman, Jessica L.
Vita, Joseph A.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-04-12
Volume: 112
Issue: 8
Pages: 1171-1188
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.111.300233
PMC: PMC3700369
OpenAlex: W2171435588
Cited by: 508
References: 213
Citations by year: 2026: 25 · 2025: 44 · 2024: 49 · 2023: 34 · 2022: 60 · 2021: 52 · 2020: 49 · 2019: 33 · 2018: 37 · 2017: 37 · 2016: 25 · 2015: 25 · 2014: 34 · 2013: 4
FWCI: 2.76
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL060886, R01HL102299, HL081587, P50HL083801, K12HL083781, P01HL081587, R01HL075795, T32HL007224, HL083781, R01HL083269, HL083801, HL102299, R01HL115391)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondria, endothelial cells, endothelial function, mitochondrial biogenesis, mitochondrial dynamics, mitophagy, reactive oxygen species, calcium homeostasis, regulated cell death, heme biosynthesis, vascular tone, angiogenesis, inflammation, mitochondrial-targeted therapy, cardiovascular disease
MeSH terms: Animals, Autophagy, Endothelium, Vascular, Homeostasis, Humans, Mitochondria, Signal Transduction, Reactive Oxygen Species, Endothelial Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondria and Endothelial Function

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks