The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Cardiac Tissue Engineering: State of the Art
Abstract
The engineering of 3-dimensional (3D) heart muscles has undergone exciting progress for the past decade. Profound advances in human stem cell biology and technology, tissue engineering and material sciences, as well as prevascularization and in vitro assay technologies make the first clinical application of engineered cardiac tissues a realistic option and predict that cardiac tissue engineering techniques will find widespread use in the preclinical research and drug development in the near future. Tasks that need to be solved for this purpose include standardization of human myocyte production protocols, establishment of simple methods for the in vitro vascularization of 3D constructs and better maturation of myocytes, and, finally, thorough definition of the predictive value of these methods for preclinical safety pharmacology. The present article gives an overview of the present state of the art, bottlenecks, and perspectives of cardiac tissue engineering for cardiac repair and in vitro testing.
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Cites
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
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Growth of engineered human myocardium with mechanical loading and vascular coculture
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Self-citationDevelopment of a drug screening platform based on engineered heart tissue
Hansen, A., Eder, A., Bönstrup, M., Flato, M., Mewe, M., Schaaf, S., Aksehirlioglu, B., Schwörer, A., Uebeler, J., & Eschenhagen, T. (2010) · Circulation Research · doi:10.1161/circresaha.109.211458 · Cited by 510
Self-citationGuha, P., Morgan, J. W., Mostoslavsky, G., Rodrigues, N. P., & Boyd, A. S. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.01.006 · Cited by 368
Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology
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Self-citationPerfusable branching microvessel bed for vascularization of engineered tissues
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Cited by
3D printing of functional biomaterials for tissue engineering
Zhu, W., Ma, X., Gou, M., Mei, D., Zhang, K., & Chen, S. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.03.014 · Cited by 822
Limitations of Animal Studies for Predicting Toxicity in Clinical Trials
Van Norman, G. A. (2019) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.10.008 · Cited by 732
One million haemopoietic stem-cell transplants: a retrospective observational study
Gratwohl, A., Pasquini, M. C., Aljurf, M., Atsuta, Y., Baldomero, H., Foeken, L., Gratwohl, M., Bouzas, L. F., Confer, D., Frauendorfer, K., et al. (2015) · The Lancet Haematology · doi:10.1016/s2352-3026(15)00028-9 · Cited by 441
Flexible shape-memory scaffold for minimally invasive delivery of functional tissues
Montgomery, M., Ahadian, S., Davenport Huyer, L., Lo Rito, M., Civitarese, R. A., Vanderlaan, R. D., Wu, J., Reis, L. A., Momen, A., Akbari, S., et al. (2017) · Nature Materials · doi:10.1038/nmat4956 · Cited by 409
Human Engineered Heart Tissue: Analysis of Contractile Force
Mannhardt, I., Breckwoldt, K., Letuffe-Brenière, D., Schaaf, S., Schulz, H., Neuber, C., Benzin, A., Werner, T., Eder, A., Schulze, T., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.04.011 · Cited by 398
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Metadata
- Authors
- Hirt, M. N., Hansen, A., & Eschenhagen, T.
- Venue
- Circulation Research
- Published
- 2014-01-17
- Volume
- 114
- Issue
- 2
- Pages
- 354-367
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2120473106
- Cited by
- 425
- References
- 12
- FWCI
- 52.57
- Type
- journal article
- Language
- en
- Open access
- closed
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