Growth of engineered human myocardium with mechanical loading and vascular coculture
Open accessAbstract
Rationale: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood. Objective: We seek to elucidate the responses of immature human myocardium to mechanical load and vascularization using tissue engineering approaches. Methods and Results: Using human embryonic stem cell and human induced pluripotent stem cell–derived cardiomyocytes in a 3-dimensional collagen matrix, we show that uniaxial mechanical stress conditioning promotes 2-fold increases in cardiomyocyte and matrix fiber alignment and enhances myofibrillogenesis and sarcomeric banding. Furthermore, cyclic stress conditioning markedly increases cardiomyocyte hypertrophy (2.2-fold) and proliferation rates (21%) versus unconditioned constructs. Addition of endothelial cells enhances cardiomyocyte proliferation under all stress conditions (14% to 19%), and addition of stromal supporting cells enhances formation of vessel-like structures by ≈10-fold. Furthermore, these optimized human cardiac tissue constructs generate Starling curves, increasing their active force in response to increased resting length. When transplanted onto hearts of athymic rats, the human myocardium survives and forms grafts closely apposed to host myocardium. The grafts contain human microvessels that are perfused by the host coronary circulation. Conclusions: Our results indicate that both mechanical load and vascular cell coculture control cardiomyocyte proliferation, and that mechanical load further controls the hypertrophy and architecture of engineered human myocardium. Such constructs may be useful for studying human cardiac development as well as for regenerative therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Those constructs do not permit pressure- and volume-based measures that directly reflect pump performance.
“but not pressure- and volume-based metrics directly representing pump performance of the heart”
From Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells (2018) · cites this paper as [9]
Experimental — accuracy not yet measuredEngineered cardiac thin films, micro-tissues, and strips permit measurement of twitch force.
“engineered cardiac thin films, micro-tissues and strips allow the assessment of twitch force [9,12–19]”
From Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells (2018) · cites this paper as [9]
Experimental — accuracy not yet measuredPrior studies have arranged hPSC-derived ventricular cardiomyocytes as monolayers and patches for electrophysiology and for surgical implantation.
“Although hPSC-vCMs have been organized as monolayers and patches for electrophysiological assessment [6–8] and even surgical engraftment [9–11]”
From Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells (2018) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947 · see citing works
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310 · see citing works
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130 · see citing works
Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., Reinecke, H., Xu, C., Hassanipour, M., Police, S., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1327 · Cited by 2,207 · see citing works
Self-citationStrauer, B. E., Brehm, M. U., Zeus, T., Köstering, M., Hernandez, A., Sorg, R. V., Kögler, G., & Wernet, P. (2002) · Circulation · doi:10.1161/01.cir.0000034046.87607.1c · Cited by 2,065 · see citing works
Kehat, I., Kenyagin‐Karsenti, D., Snir, M., Segev, H., Amit, M., Gepstein, A., Livne, E., Binah, O., Itskovitz‐Eldor, J., & Gepstein, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12131 · Cited by 1,814 · see citing works
Murry, C., & Keller, G. (2008) · Cell · doi:10.1016/j.cell.2008.02.008 · Cited by 1,805 · see citing works
Self-citationKehat, I., Kenyagin‐Karsenti, D., Snir, M., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112131 · Cited by 1,536 · see citing works
Functional Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
Zhang, J.-H., Wilson, G. F., Soerens, A., Koonce, C. H., Yu, J.-Y., Palecek, S., Thomson, J., & Kamp, T. (2009) · Circulation Research · doi:10.1161/circresaha.108.192237 · Cited by 1,463 · see citing works
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., et al. (2008) · Nature · doi:10.1038/nature06894 · Cited by 1,389 · see citing works
Engineering vascularized skeletal muscle tissue
Levenberg, S., Rouwkema, J., Macdonald, M. L., Garfein, E. S., Kohane, D. S., Darland, D. C., Marini, R. P., van Blitterswijk, C., Mulligan, R. C., D'Amore, P. A., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1109 · Cited by 1,293 · see citing works
Multiple essential functions of neuregulin in development
Meyer, D., & Birchmeier, C. (1995) · Nature · doi:10.1038/378386a0 · Cited by 1,265 · see citing works
Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241 · see citing works
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
Gassmann, M., Casagranda, F., Orioli, D., Simon, H. H., Lai, C., Klein, R., & Lemke, G. (1995) · Nature · doi:10.1038/378390a0 · Cited by 1,151 · see citing works
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Zimmermann, W., Melnychenko, I., Wasmeier, G. H., Didié, M., Naito, H., Nixdorff, U., Heß, A., Budinský, L., Brune, K., Michaelis, B., et al. (2006) · Nature Medicine · doi:10.1038/nm1394 · Cited by 996 · see citing works
Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., & Breitman, M. L. (1994) · Genes & Development · doi:10.1101/gad.8.16.1897 · Cited by 985 · see citing works
Tissue Engineering of a Differentiated Cardiac Muscle Construct
Zimmermann, W.-H., Schneiderbanger, K., Schubert, P., Didié, M., Münzel, F., Heubach, J. F., Kostin, S., Neuhuber, W. L., & Eschenhagen, T. (2002) · Circulation Research · doi:10.1161/hh0202.103644 · Cited by 917 · see citing works
Characterization and Enrichment of Cardiomyocytes Derived From Human Embryonic Stem Cells
Xu, C., Police, S., Rao, N., & Carpenter, M. K. (2002) · Circulation Research · doi:10.1161/01.res.0000035254.80718.91 · Cited by 902 · see citing works
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance
Berry, M. F., Engler, A. J., Woo, Y.-P. J., Pirolli, T. J., Bish, L. T., Jayasankar, V., Morine, K., Gardner, T. J., Discher, D. E., & Sweeney, H. L. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01017.2005 · Cited by 692 · see citing works
Tissue engineering of vascularized cardiac muscle from human embryonic stem cells
Caspi, O., Lesman, A., Basevitch, Y., Gepstein, A., Arbel, G., Habib, I. H. M., Gepstein, L., & Levenberg, S. (2007) · Circulation Research · doi:10.1161/01.res.0000257776.05673.ff · Cited by 558 · see citing works
Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium.
Weber, K. T., Janicki, J. S., Shroff, S. G., Pick, R., Chen, R. M., & Bashey, R. I. (1988) · Circulation Research · doi:10.1161/01.res.62.4.757 · Cited by 556 · see citing works
Survival, Integration, and Differentiation of Cardiomyocyte Grafts
Reinecke, H., Zhang, M., Bartosek, T., & Murry, C. E. (1999) · Circulation · doi:10.1161/01.cir.100.2.193 · Cited by 516 · see citing works
Self-citationWhittaker, P., Kloner, R. A., Boughner, D. R., & Pickering, J. G. (1994) · Basic Research in Cardiology · doi:10.1007/bf00788278 · Cited by 496 · see citing works
Formation of Human Myocardium in the Rat Heart from Human Embryonic Stem Cells
Laflamme, M. A., Gold, J., Xu, C., Hassanipour, M., Rosler, E. S., Police, S., Muskheli, V., & Murry, C. E. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62041-x · Cited by 448 · see citing works
Self-citationStevens, K. R., Kreutziger, K. L., Dupras, S. K., Korte, F. S., Regnier, M., Muskheli, V., Nourse, M. B., Bendixen, K., Reinecke, H., & Murry, C. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908381106 · Cited by 422 · see citing works
Self-citationOptimization of cardiac cell seeding and distribution in 3D porous alginate scaffolds
Dar, A., Shachar, M., Leor, J., & Cohen, S. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10372 · Cited by 384 · see citing works
Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement
Fink, C., Ergün, S., Kralisch, D., Remmers, U., Weil, J., & Thomas Eschenhagen, A. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.5.669 · Cited by 378 · see citing works
Olivetti, G., Capasso, J. M., Sonnenblick, E. H., & Anversa, P. (1990) · Circulation Research · doi:10.1161/01.res.67.1.23 · Cited by 344 · see citing works
Velling, T., Risteli, J., Wennerberg, K., Mosher, D., & Johansson, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206286200 · Cited by 339 · see citing works
Katritsis, D. G., Sotiropoulou, P. A., Karvouni, E., Karabinos, I. K., Korovesis, S., Perez, S. A., Voridis, E. M., & Papamichail, M. (2005) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.20406 · Cited by 335 · see citing works
Kadler, K. E., Hojima, Y., & Prockop, D. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47783-6 · Cited by 324 · see citing works
Culture media for the differentiation of mesenchymal stromal cells
Vater, C., Kasten, P., & Stiehler, M. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.037 · Cited by 280 · see citing works
Paige, S. L., Osugi, T., Afanasiev, O. K., Pabon, L., Reinecke, H., & Murry, C. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011134 · Cited by 274 · see citing works
Self-citationCardiovascular ephrinB2 function is essential for embryonic angiogenesis
Gerety, S. S., & Anderson, D. J. (2002) · Development · doi:10.1242/dev.129.6.1397 · Cited by 263 · see citing works
Arts, T. G. J., Delhaas, T., Bovendeerd, P. H. M., Verbeek, X. A. A. M., & Prinzen, F. W. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00444.2004 · Cited by 252 · see citing works
ENDOTHELIAL-CARDIOMYOCYTE INTERACTIONS IN CARDIAC DEVELOPMENT AND REPAIR
Hsieh, P. C. H., Davis, M. E., Lisowski, L. K., & Lee, R. T. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124629 · Cited by 242 · see citing works
Zhu, W.-Z., Xie, Y., Moyes, K. W., Gold, J. D., Askari, B., & Laflamme, M. A. (2010) · Circulation Research · doi:10.1161/circresaha.110.223917 · Cited by 228 · see citing works
O’Connell, T. D., Ishizaka, S., Nakamura, A., Swigart, P. M., Rodrigo, M. C., Simpson, G. L., Cotecchia, S., Rokosh, G. D., Grossman, W., Foster, E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16100 · Cited by 205 · see citing works
Radisic, M., Park, H., Martens, T. P., Salazar-Lazzaro, J. E., Geng, W., Wang, Y., Langer, R., Freed, L. E., & Vunjak‐Novakovic, G. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31578 · Cited by 186 · see citing works
McDevitt, T. C., Laflamme, M. A., & Murry, C. E. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.09.007 · Cited by 183 · see citing works
Self-citationCalcium Handling in Human Embryonic Stem Cell-Derived Cardiomyocytes
Satin, J., Itzhaki, I., Rapoport, S., Schroder, E. A., Izu, L. T., Arbel, G., Beyar, R., Balke, C. W., Schiller, J., & Gepstein, L. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0591 · Cited by 174 · see citing works
Collagen in the scarless fetal skin wound: Detection with Picrosirius-polarization
Cuttle, L., Nataatmadja, M. I., Fraser, J. F., Kempf, M., Kimble, R. M., & Hayes, M. T. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130211.x · Cited by 171 · see citing works
O’Connell, T. D., Ishizaka, S., Nakamura, A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316100 · Cited by 169 · see citing works
VEGF Induces Differentiation of Functional Endothelium From Human Embryonic Stem Cells
Nourse, M. B., Halpin, D. E., Scatena, M., Mortisen, D. J., Tulloch, N. L., Hauch, K. D., Torok‐Storb, B., Ratner, B. D., Pabon, L., & Murry, C. E. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194233 · Cited by 169 · see citing works
Self-citationNf1 has an essential role in endothelial cells
Gitler, A. D., Zhu, Y., Ismat, F. A., Lu, M. M., Yamauchi, Y., Parada, L. F., & Epstein, J. A. (2002) · Nature Genetics · doi:10.1038/ng1059 · Cited by 168 · see citing works
Scaffold-Free Human Cardiac Tissue Patch Created from Embryonic Stem Cells
Stevens, K. R., Pabon, L., Muskheli, V., & Murry, C. E. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0151 · Cited by 164 · see citing works
Self-citationSTEM/TEM studies of collagen fibril assembly
Holmes, D. F., Graham, H. K., Trotter, J. A., & Kadler, K. E. (2001) · Micron · doi:10.1016/s0968-4328(00)00040-8 · Cited by 127 · see citing works
Cellular and molecular effects of mechanical stretch on vascular cells and cardiac myocytes
Shyu, K. (2009) · Clinical Science · doi:10.1042/cs20080163 · Cited by 125 · see citing works
Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width
Russell, B., Curtis, M. W., Koshman, Y. E., & Samarel, A. M. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.02.016 · Cited by 120 · see citing works
The role of mechanical forces in dextral rotation during cardiac looping in the chick embryo
Voronov, D. A., Alford, P. W., Xu, G., & Taber, L. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.04.033 · Cited by 120 · see citing works
Neuregulin 1 Sustains the Gene Regulatory Network in Both Trabecular and Nontrabecular Myocardium
Lai, D., Liu, X., Forrai, A., Wolstein, O., Michalicek, J., Ahmed, I. M., Garratt, A. N., Birchmeier, C., Zhou, M., Hartley, L., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.218693 · Cited by 110 · see citing works
Tobita, K., & Keller, B. B. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.3.h959 · Cited by 108 · see citing works
Shimko, V. F., & Claycomb, W. C. (2008) · Tissue Engineering Part A · doi:10.1089/ten.a.2007.0092 · Cited by 107 · see citing works
Mansour, H., de Tombe, P. P., Samarel, A. M., & Russell, B. (2004) · Circulation Research · doi:10.1161/01.res.0000121101.32286.c8 · Cited by 104 · see citing works
Adaptation of cardiac structure by mechanical feedback in the environment of the cell: a model study
Arts, T. G. J., Prinzen, F. W., Snoeckx, L. H. E. H., Rijcken, J. M., & Reneman, R. S. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80876-8 · Cited by 98 · see citing works
Xu, C., Police, S., Hassanipour, M., & Gold, J. D. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.631 · Cited by 94 · see citing works
Mechanical aspects of cardiac development
Taber, L. A. (1998) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00010-8 · Cited by 91 · see citing works
Borges, L. D. F., Gutierrez, P. S., Marana, H. R. C., & Taboga, S. R. (2006) · Micron · doi:10.1016/j.micron.2006.10.005 · Cited by 85 · see citing works
Design and fabrication of heart muscle using scaffold‐based tissue engineering
Blan, N. R., & Birla, R. K. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31642 · Cited by 78 · see citing works
Local Control of Excitation-Contraction Coupling in Human Embryonic Stem Cell-Derived Cardiomyocytes
Zhu, W., Santana, L. F., & Laflamme, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005407 · Cited by 75 · see citing works
Development of a Novel Bioreactor for the Mechanical Loading of Tissue-Engineered Heart Muscle
Birla, R. K., Huang, Y. C., & Dennis, R. G. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0359 · Cited by 70 · see citing works
STAT3-Mediated Activation of Myocardial Capillary Growth
Hilfiker‐Kleiner, D., Limbourg, A., & Drexler, H. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.05.002 · Cited by 64 · see citing works
Chacko, S. M., Khan, M., Kuppusamy, M. L., Pandian, R. P., Varadharaj, S., Selvendiran, K., Bratasz, A., Rivera, B. K., & Kuppusamy, P. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01311.2008 · Cited by 53 · see citing works
Molecular mechanisms in endothelial regulation of cardiac function
Kuruvilla, L., & Kartha, C. S. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1026061507004 · Cited by 49 · see citing works
Calcium Handling in Embryonic Stem Cell–Derived Cardiac Myocytes
Itzhaki, I., Schiller, J., Beyar, R., Satin, J., & Gepstein, L. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1380.017 · Cited by 45 · see citing works
Senyo, S. E., Koshman, Y. E., & Russell, B. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.070 · Cited by 44 · see citing works
Molecular mechanisms controlling the coupled development of myocardium and coronary vasculature
Bhattacharya, S., MacDonald, S. T., & Farthing, C. R. (2006) · Clinical Science · doi:10.1042/cs20060003 · Cited by 37 · see citing works
Mechanical effects of looping in the embryonic chick heart
Lin, I.-E., & Taber, L. A. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90007-8 · Cited by 32 · see citing works
Endothelial cells regulate cardiomyocyte development from embryonic stem cells
Chen, K., Bai, H., Arzigian, M., Gao, Y., Bao, J., Wu, W., Shen, W., Wu, L., & Wang, Z. Z. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22680 · Cited by 29 · see citing works
Cell therapy enhances function of remote non-infarcted myocardium
Moreno‐Gonzalez, A., Korte, F. S., Dai, J., Chen, K., Ho, B., Reinecke, H., Murry, C. E., & Regnier, M. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.07.030 · Cited by 26 · see citing works
Self-citationKira, Y., Nakaoka, T., Hashimoto, E., Okabe, F., Asano, S., & SEKINE, I. (1994) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00877334 · Cited by 26 · see citing works
Stevens, K. R., Rolle, M. W., Minami, E., Ueno, S., Nourse, M. B., Virag, J. A. I., Reinecke, H., & Murry, C. E. (2007) · Human Gene Therapy · doi:10.1089/hum.2006.161 · Cited by 19 · see citing works
Self-citationAlterations in sheep fetal right ventricular tissue with induced hemodynamic pressure overload
MONTGOMERY, M., Jiao, Y., Phillips, S. J., Singh, G. K., Xu, J., Balsara, R. K., & Litvin, J. (1998) · Basic Research in Cardiology · doi:10.1007/s003950050086 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Advanced maturation of human cardiac tissue grown from pluripotent stem cells
Ronaldson-Bouchard, K., Ma, S. P., Yeager, K., Chen, T., Song, L., Sirabella, D., Morikawa, K., Teles, D., Yazawa, M., & Vunjak-Novakovic, G. (2018) · Nature · doi:10.1038/s41586-018-0016-3 · Cited by 1,272 · see citing works
The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development
Sorushanova, A., Delgado, L. M., Wu, Z., Shologu, N., Kshirsagar, A., Raghunath, R., Mullen, A. M., Bayon, Y., Pandit, A. S., Raghunath, M., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801651 · Cited by 1,156 · see citing works
Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
Nunes, S. S., Miklas, J. W., Liu, J., Aschar-Sobbi, R., Xiao, Y., Zhang, B., Jiang, J., Massé, S., Gagliardi, M., Hsieh, A., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2524 · Cited by 952 · see citing works
Engineering Adolescence: Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes
Yang, X., Pabon, L., & Murry, C. E. (2014) · Circulation Research · doi:10.1161/circresaha.114.300558 · Cited by 939 · see citing works
Self-citationCardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Karbassi, E., Fenix, A. M., Marchianò, S., Muraoka, N., Nakamura, K., Yang, X., & Murry, C. E. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0331-x · Cited by 763 · see citing works
Self-citationBurridge, P. W., Keller, G., Gold, J. D., & Wu, J. C. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.12.013 · Cited by 670 · see citing works
Cardiomyocyte Maturation: New Phase in Development
Guo, Y., & Pu, W. T. (2020) · Circulation Research · doi:10.1161/circresaha.119.315862 · Cited by 653 · see citing works
Tiburcy, M., Hudson, J. E., Balfanz, P., Schlick, S. F., Meyer, T., Liao, M.-L. C., Levent, E., Raad, F. S., Zeidler, S., Wingender, E., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024145 · Cited by 650 · see citing works
A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling
Zhao, Y., Rafatian, N., Feric, N. T., Cox, B. J., Aschar-Sobbi, R., Wang, E. Y., Aggarwal, P., Zhang, B., Conant, G., Ronaldson-Bouchard, K., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.042 · Cited by 610 · see citing works
Zhang, B., Montgomery, M., Chamberlain, M. D., Ogawa, S., Korolj, A., Pahnke, A., Wells, L. A., Massé, S., Kim, J., Reis, L., et al. (2016) · Nature Materials · doi:10.1038/nmat4570 · Cited by 593 · see citing works
Zhang, D., Shadrin, I. Y., Lam, J., Xian, H.-Q., Snodgrass, H. R., & Bursac, N. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.026 · Cited by 565 · see citing works
Lewis-Israeli, Y. R., Wasserman, A. H., Gabalski, M. A., Volmert, B. D., Ming, Y., Ball, K. A., Yang, W., Zou, J., Ni, G., Pajares, N., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25329-5 · Cited by 536 · see citing works
Karakikes, I., Ameen, M., Termglinchan, V., & Wu, J. C. (2015) · Circulation Research · doi:10.1161/circresaha.117.305365 · Cited by 478 · see citing works
Mills, R. J., Titmarsh, D. M., Koenig, X., Parker, B. L., Ryall, J. G., Quaife-Ryan, G. A., Voges, H. K., Hodson, M. P., Ferguson, C., Drowley, L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707316114 · Cited by 478 · see citing works
Menasché, P., Vanneaux, V., Hagège, A. A., Bel, A., Cholley, B., Parouchev, A., Cacciapuoti, I., Al‐Daccak, R., Benhamouda, N., Blons, H., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.047 · Cited by 459 · see citing works
Ruan, J.-L., Tulloch, N. L., Razumova, M. V., Saiget, M., Muskheli, V., Pabon, L., Reinecke, H., Regnier, M., & Murry, C. E. (2016) · Circulation · doi:10.1161/circulationaha.114.014998 · Cited by 467 · see citing works
Self-citationShadrin, I. Y., Allen, B. W., Qian, Y., Jackman, C. P., Carlson, A. L., Juhas, M. E., & Bursac, N. (2017) · Nature Communications · doi:10.1038/s41467-017-01946-x · Cited by 420 · see citing works
Hirt, M. N., Hansen, A., & Thomas Eschenhagen, A. (2014) · Circulation Research · doi:10.1161/circresaha.114.300522 · Cited by 426 · see citing works
Human Engineered Heart Tissue: Analysis of Contractile Force
Mannhardt, I., Breckwoldt, K., Letuffe-Brenière, D., Schaaf, S., Schulz, H., Neuber, C., Benzin, A., Werner, T., Eder, A., Schulze, T., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.04.011 · Cited by 398 · see citing works
Lu, T., Lin, B., Kim, J. K., Sullivan, M. L. G., Tobita, K., Salama, G., & Yang, L. (2013) · Nature Communications · doi:10.1038/ncomms3307 · Cited by 370 · see citing works
Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology
Schaaf, S., Shibamiya, A., Mewe, M., Eder, A., Stöhr, A., Hirt, M. N., Rau, T., Zimmermann, W.-H., Conradi, L., Eschenhagen, T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026397 · Cited by 365 · see citing works
Hirt, M. N., Boeddinghaus, J., Mitchell, A. N., Schaaf, S., Börnchen, C., Müller, C., Schulz, H., Hübner, N., Stenzig, J., Stoehr, A., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.05.009 · Cited by 355 · see citing works
Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells
Yang, X., Rodriguez, M. L., Leonard, A., Sun, L., Fischer, K. A., Wang, Y., Ritterhoff, J., Zhao, L., Kolwicz, S. C., Pabon, L., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.08.013 · Cited by 301 · see citing works
Self-citation3D bioprinted functional and contractile cardiac tissue constructs
Wang, Z., Lee, S. J., Cheng, H.-J., Yoo, J. J., & Atala, A. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.02.007 · Cited by 301 · see citing works
Electrical and mechanical stimulation of cardiac cells and tissue constructs
Stoppel, W. L., Kaplan, D. L., & Black, L. D. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.07.009 · Cited by 290 · see citing works
Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues
Herron, T. J., Lee, P., & Jalife, J. (2012) · Circulation Research · doi:10.1161/circresaha.111.247494 · Cited by 290 · see citing works
Differentiation of cardiomyocytes and generation of human engineered heart tissue
Breckwoldt, K., Letuffe-Brenière, D., Mannhardt, I., Schulze, T., Ulmer, B., Werner, T., Benzin, A., Klampe, B., Reinsch, M. C., Laufer, S., et al. (2017) · Nature Protocols · doi:10.1038/nprot.2017.033 · Cited by 272 · see citing works
Translation of Human iPSCs: From Clinical Trial in a Dish to Precision Medicine
Sayed, N., Liu, C., & Wu, J. C. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.01.083 · Cited by 263 · see citing works
Giacomelli, E., Bellin, M., Sala, L., van Meer, B. J., Tertoolen, L. G. J., Orlova, V. V., & Mummery, C. L. (2017) · Development · doi:10.1242/dev.143438 · Cited by 280 · see citing works
The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential
Watt, S. M., Gullo, F., van der Garde, M., Markeson, D., Camicia, R., Khoo, C. P., & Zwaginga, J. J. (2013) · British Medical Bulletin · doi:10.1093/bmb/ldt031 · Cited by 273 · see citing works
Kuppusamy, K. T., Jones, D. C., Sperber, H., Madan, A., Fischer, K. A., Rodriguez, M. L., Pabon, L., Zhu, W., Tulloch, N. L., Yang, X., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424042112 · Cited by 265 · see citing works
Self-citationImmaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem?
Veerman, C. C., Kosmidis, G., Mummery, C. L., Casini, S., Verkerk, A. O., & Bellin, M. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0533 · Cited by 270 · see citing works
Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model
Riegler, J., Tiburcy, M., Ebert, A., Tzatzalos, E., Raaz, U., Abilez, O. J., Shen, Q., Kooreman, N. G., Neofytou, E. A., Chen, V. C., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.306985 · Cited by 255 · see citing works
Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues
Feric, N. T., & Radisic, M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.019 · Cited by 247 · see citing works
Mihic, A., Li, J., Miyagi, Y., Gagliardi, M., Li, S.-H., Zu, J., Weisel, R. D., Keller, G., & Li, R.-K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.052 · Cited by 248 · see citing works
Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function
Liau, B., Christoforou, N., Leong, K. W., & Bursac, N. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.050 · Cited by 235 · see citing works
Musunuru, K., Sheikh, F., Gupta, R. M., Houser, S. R., Maher, K. O., Milan, D. J., Terzic, A., & Wu, J. C. (2018) · Circulation Genomic and Precision Medicine · doi:10.1161/hcg.0000000000000043 · Cited by 230 · see citing works
Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses
Huebsch, N., Loskill, P., Deveshwar, N., Spencer, C. I., Judge, L. M., Mandegar, M. A., Fox, C. B., Mohamed, T., Ma, Z., Mathur, A., et al. (2016) · Scientific Reports · doi:10.1038/srep24726 · Cited by 227 · see citing works
Engineering Cardiac Muscle Tissue
Weinberger, F., Mannhardt, I., & Eschenhagen, T. (2017) · Circulation Research · doi:10.1161/circresaha.117.310738 · Cited by 225 · see citing works
Paik, D. T., Chandy, M., & Wu, J. C. (2019) · Pharmacological Reviews · doi:10.1124/pr.116.013003 · Cited by 216 · see citing works
Dahlmann, J., Krause, A., Möller, L., Kensah, G., Möwes, M., Diekmann, A., Martin, U., Kirschning, A., Gruh, I., & Dräger, G. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.008 · Cited by 208 · see citing works
Goldfracht, I., Efraim, Y., Shinnawi, R., Kovalev, E., Huber, I., Gepstein, A., Arbel, G., Shaheen, N., Tiburcy, M., Zimmermann, W. H., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.016 · Cited by 222 · see citing works
Naturally Engineered Maturation of Cardiomyocytes
Scuderi, G. J., & Butcher, J. T. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00050 · Cited by 200 · see citing works
Kawamura, M., Miyagawa, S., Fukushima, S., Saito, A., Miki, K., Ito, E., Sougawa, N., Kawamura, T., Daimon, T., Shimizu, T., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000366 · Cited by 199 · see citing works
Hayakawa, T., Kunihiro, T., Ando, T., Kobayashi, S., Matsui, E., Yada, H., Kanda, Y., Kurokawa, J., & Furukawa, T. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.09.010 · Cited by 195 · see citing works
Leonard, A., Bertero, A., Powers, J. D., Beussman, K. M., Bhandari, S., Regnier, M., Murry, C. E., & Sniadecki, N. J. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.03.016 · Cited by 191 · see citing works
Self-citationKensah, G., Roa Lara, A., Dahlmann, J., Zweigerdt, R., Schwanke, K., Hegermann, J., Skvorc, D., Gawol, A., Azizian, A., Wagner, S., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs349 · Cited by 193 · see citing works
Dynamic culture yields engineered myocardium with near-adult functional output
Jackman, C. P., Carlson, A. L., & Bursac, N. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.024 · Cited by 188 · see citing works
Lemoine, M. D., Mannhardt, I., Breckwoldt, K., Prondzynski, M., Flenner, F., Ulmer, B. M., Hirt, M. N., Neuber, C., Horváth, A., Kloth, B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05600-w · Cited by 184 · see citing works
Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium
Turnbull, I. C., Karakikes, I., Serrao, G. W., Backeris, P., Lee, J., Xie, C., Senyei, G., Gordon, R. E., Li, R. A., Akar, F. G., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-228007 · Cited by 184 · see citing works
Li, R. A., Keung, W., Cashman, T. J., Backeris, P. C., Johnson, B. V., Bardot, E. S., Wong, A. O. T., Chan, P. K. W., Chan, C. W. Y., & Costa, K. D. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.024 · Cited by 175 · see citing works
Lee, P., Klos, M., Bollensdorff, C., Hou, L., Ewart, P., Kamp, T. J., Zhang, J., Bizy, A., Guerrero‐Serna, G., Kohl, P. K., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.262535 · Cited by 175 · see citing works
Collagen and Elastin Biomaterials for the Fabrication of Engineered Living Tissues
Miranda-Nieves, D., & Chaikof, E. L. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00250 · Cited by 175 · see citing works
Biomaterials to Enhance Stem Cell Function in the Heart
Segers, V. F. M., & Lee, R. T. (2011) · Circulation Research · doi:10.1161/circresaha.111.249052 · Cited by 172 · see citing works
Biomaterials in Cardiovascular Research: Applications and Clinical Implications
Jaganathan, S. K., Supriyanto, E., Murugesan, S., Balaji, A., & Asokan, M. K. (2014) · BioMed Research International · doi:10.1155/2014/459465 · Cited by 171 · see citing works
The local microenvironment limits the regenerative potential of the mouse neonatal heart
Notari, M., Ventura-Rubio, A., Bedford-Guaus, S. J., Jorba, I., Mulero, L., Navajas, D., Martí, M., & Raya, Á. (2018) · Science Advances · doi:10.1126/sciadv.aao5553 · Cited by 169 · see citing works
Hydrogels for cardiac tissue engineering
Camci‐Unal, G., Annabi, N., Dokmeci, M. R., Liao, R., & Khademhosseini, A. (2014) · NPG Asia Materials · doi:10.1038/am.2014.19 · Cited by 170 · see citing works
Endothelial cell–cardiomyocyte crosstalk in heart development and disease
Colliva, A., Braga, L., Giacca, M., & Zacchigna, S. (2019) · The Journal of Physiology · doi:10.1113/jp276758 · Cited by 170 · see citing works
Tzatzalos, E., Abilez, O. J., Shukla, P., & Wu, J. C. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.010 · Cited by 162 · see citing works
Distilling complexity to advance cardiac tissue engineering
Ogle, B. M., Bursac, N., Domian, I. J., Huang, N. F., Menasché, P., Murry, C. E., Pruitt, B. L., Radisic, M., Wu, J. C., Wu, S. M., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad2304 · Cited by 163 · see citing works
Self-citationKadota, S., Pabon, L., Reinecke, H., & Murry, C. E. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.10.009 · Cited by 155 · see citing works
Self-citationCan We Engineer a Human Cardiac Patch for Therapy?
Zhang, J. J., Zhu, W., Radisic, M., & Vunjak‐Novakovic, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.311213 · Cited by 156 · see citing works
Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation
Godier-Furnémont, A., Tiburcy, M., Wagner, E., Dewenter, M., Lämmle, S., El‐Armouche, A., Lehnart, S. E., Vunjak‐Novakovic, G., & Zimmermann, W. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.055 · Cited by 157 · see citing works
Increased afterload induces pathological cardiac hypertrophy: a new in vitro model
Hirt, M. N., Sörensen, N. A., Bartholdt, L. M., Boeddinghaus, J., Schaaf, S., Eder, A., Vollert, I., Stöhr, A., Schulze, T., Witten, A., et al. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0307-z · Cited by 154 · see citing works
Abilez, O. J., Tzatzalos, E., Yang, H., Zhao, M., Jung, G., Zöllner, A. M., Tiburcy, M., Riegler, J., Matsa, E., Shukla, P., et al. (2017) · Stem Cells · doi:10.1002/stem.2732 · Cited by 156 · see citing works
Smith, A. S. T., Macadangdang, J., Leung, W., Laflamme, M., & Kim, D.-H. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.002 · Cited by 137 · see citing works
Human induced pluripotent stem cells and their use in drug discovery for toxicity testing
Scott, C. W., Peters, M. F., & Dragan, Y. P. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.02.020 · Cited by 149 · see citing works
Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2
Lee, S., Park, C., Han, J. W., Kim, J. Y., Cho, K.-W., Kim, S., Kim, S., Lee, S.-J., Oh, S. Y., Tanaka, Y., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.309833 · Cited by 147 · see citing works
Vascularization strategies of engineered tissues and their application in cardiac regeneration
Sun, X., Altalhi, W., & Nunes, S. S. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.06.001 · Cited by 146 · see citing works
Ye, L., Zimmermann, W., Garry, D. J., & Zhang, J. J. (2013) · Circulation Research · doi:10.1161/circresaha.113.300216 · Cited by 143 · see citing works
Biomaterial based cardiac tissue engineering and its applications
Huyer, L. D., Montgomery, M., Zhao, Y., Xiao, Y., Conant, G., Korolj, A., & Radisic, M. (2015) · Biomedical Materials · doi:10.1088/1748-6041/10/3/034004 · Cited by 145 · see citing works
Complex Tissue and Disease Modeling using hiPSCs
Passier, R., Orlova, V., & Mummery, C. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.02.011 · Cited by 142 · see citing works
Fong, A. H., Romero-López, M., Heylman, C. M., Keating, M., Tran, D. D., Sobrino, A., Tran, A. Q., Pham, H. H., Fimbres, C., Gershon, P. D., et al. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0027 · Cited by 140 · see citing works
Vascular cells improve functionality of human cardiac organoids
Voges, H. K., Foster, S. R., Reynolds, L., Parker, B. L., Devilée, L., Quaife-Ryan, G. A., Fortuna, P. R. J., Mathieson, E., Fitzsimmons, R., Lor, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112322 · Cited by 139 · see citing works
Galdos, F. X., Guo, Y., Paige, S. L., VanDusen, N. J., Wu, S. M., & Pu, W. T. (2017) · Circulation Research · doi:10.1161/circresaha.116.309040 · Cited by 131 · see citing works
Kaiser, N. J., Kant, R. J., Minor, A. J., & Coulombe, K. L. K. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01112 · Cited by 132 · see citing works
Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution
Majid, Q. A., Fricker, A. T. R., Gregory, D. A., Davidenko, N., Hernández‐Cruz, O., Jabbour, R. J., Owen, T. J., Basnett, P., Lukasiewicz, B., Stevens, M. M., et al. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.554597 · Cited by 135 · see citing works
Ruan, J.-L., Tulloch, N. L., Saiget, M., Paige, S. L., Razumova, M. V., Regnier, M., Tung, K. W. C., Keller, G. M., Pabon, L., Reinecke, H., et al. (2015) · Stem Cells · doi:10.1002/stem.2036 · Cited by 131 · see citing works
Self-citationRedd, M. A., Zeinstra, N., Qin, W., Wei, W., Martinson, A., Wang, Y., Wang, R. K., Murry, C. E., & Zheng, Y. Y. (2019) · Nature Communications · doi:10.1038/s41467-019-08388-7 · Cited by 131 · see citing works
Self-citationControlling the structural and functional anisotropy of engineered cardiac tissues
Bian, W., Jackman, C. P., & Bursac, N. (2014) · Biofabrication · doi:10.1088/1758-5082/6/2/024109 · Cited by 130 · see citing works
Hulot, J., Stillitano, F., Salem, J., Kovacic, J. C., Fuster, V., & Hajjar, R. J. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt390 · Cited by 127 · see citing works
Wang, Q., Yang, H., Bai, A., Jiang, W., Li, X., Wang, X., Mao, Y., Lü, C., Qian, R., Guo, F., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.035 · Cited by 124 · see citing works
Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue
Serpooshan, V., Chen, P., Wu, H., Lee, S., Sharma, A., Hu, D. A., Venkatraman, S., Ganesan, A., Usta, O. B., Yarmush, M. L., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.037 · Cited by 124 · see citing works
Use of Flow, Electrical, and Mechanical Stimulation to Promote Engineering of Striated Muscles
Rangarajan, S., Madden, L. R., & Bursac, N. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0966-4 · Cited by 122 · see citing works
Madonna, R., Laake, L. W. V., Bøtker, H. E., Davidson, S. M., Caterina, R. D., Engel, F. B., Eschenhagen, T., Fernandez-Aviles, F., Hausenloy, D. J., Hulot, J., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz010 · Cited by 118 · see citing works
Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as Models for Cardiac Channelopathies
Garg, P., Garg, V., Shrestha, R., Sanguinetti, M. C., Kamp, T. J., & Wu, J. C. (2018) · Circulation Research · doi:10.1161/circresaha.118.311209 · Cited by 114 · see citing works
Tsui, J. H., Leonard, A., Camp, N. D., Long, J. T., Nawas, Z., Chavanachat, R., Smith, A. S. T., Choi, J. S., Dong, Z., Ahn, E. H., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2021.120764 · Cited by 117 · see citing works
Self-citationGerbin, K. A., Yang, X., Murry, C. E., & Coulombe, K. L. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131446 · Cited by 119 · see citing works
Self-citationRavenscroft, S., Pointon, A., Williams, A. W., Cross, M. J., & Sidaway, J. E. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw069 · Cited by 113 · see citing works
Masumoto, H., Nakane, T., Tinney, J. P., Yuan, F., Ye, F., Kowalski, W. J., Minakata, K., Sakata, R., Yamashita, J. K., & Keller, B. B. (2016) · Scientific Reports · doi:10.1038/srep29933 · Cited by 114 · see citing works
Miklas, J. W., Clark, E. C., Levy, S., Detraux, D., Leonard, A., Beussman, K. M., Showalter, M. R., Smith, A. S. T., Hofsteen, P., Yang, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12482-1 · Cited by 116 · see citing works
Self-citationBiology of the cardiac myocyte in heart disease
Peter, A. K., Bjerke, M. A., & Leinwand, L. A. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-01-0038 · Cited by 109 · see citing works
Campostrini, G., Meraviglia, V., Giacomelli, E., van Helden, R. W. J., Yiangou, L., Davis, R. P., Bellin, M., Orlova, V. V., & Mummery, C. L. (2021) · Nature Protocols · doi:10.1038/s41596-021-00497-2 · Cited by 111 · see citing works
On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology
Shao, Y., Sang, J., & Fu, J. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.01.078 · Cited by 113 · see citing works
Materials Science and Tissue Engineering: Repairing the Heart
Radisic, M., & Christman, K. L. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.05.003 · Cited by 109 · see citing works
Cardiac Regeneration and Stem Cells
Zhang, Y., Mignone, J., & MacLellan, W. R. (2015) · Physiological Reviews · doi:10.1152/physrev.00021.2014 · Cited by 107 · see citing works
Magdy, T., Schuldt, A. J. T., Wu, J. C., Bernstein, D., & Burridge, P. W. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-053110 · Cited by 112 · see citing works
Huebsch, N., Charrez, B., Neiman, G., Siemons, B. A., Boggess, S. C., Wall, S., Charwat, V., Jæger, K. H., Cleres, D., Telle, Å., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00884-4 · Cited by 109 · see citing works
Physiologically inspired cardiac scaffolds for tailored in vivo function and heart regeneration
Kaiser, N. J., & Coulombe, K. L. K. (2015) · Biomedical Materials · doi:10.1088/1748-6041/10/3/034003 · Cited by 108 · see citing works
Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform
Zhao, Y., Rafatian, N., Wang, E. Y., Feric, N. T., Lai, B., Knee‐Walden, E. J., Backx, P. H., & Radisic, M. (2019) · Matrix Biology · doi:10.1016/j.matbio.2019.04.001 · Cited by 108 · see citing works
- Authors
- Tulloch, N. L., Muskheli, V., Razumova, M. V., Korte, F. S., Regnier, M., Hauch, K. D., Pabon, L., Reinecke, H., & Murry, C. E.
- Affiliations
- University of Washington (US)
- Venue
- Circulation Research
- Published
- 2011-06-24
- Volume
- 109
- Issue
- 1
- Pages
- 47-59
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3140796
- OpenAlex
- W2163068618
- Cited by
- 666
- References
- 72
- Citations by year
- 2026: 12 · 2025: 28 · 2024: 26 · 2023: 30 · 2022: 27 · 2021: 59 · 2020: 42 · 2019: 56 · 2018: 43 · 2017: 66 · 2016: 57 · 2015: 51 · 2014: 54 · 2013: 57 · 2012: 45
- FWCI
- 54.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1u24dk076126-01, 5r01hl064387-10)
- National Heart, Lung, and Blood Institute (R01-HL064387, R01 HL64387, T32HL007312, P01HL094374, R01HL084642)
- National Institute of General Medical Sciences (P01GM081619)
- National Institute of Diabetes and Digestive and Kidney Diseases (U24-DK076126)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- mechanical loading, vascularization, cardiomyocyte hypertrophy, cardiomyocyte proliferation, myofibrillogenesis, collagen matrix, endothelial cells, stromal cells, Starling curve, heart development, regenerative therapy, human embryonic stem cell-derived cardiomyocytes, iPSC-derived cardiomyocytes
- MeSH terms
- Animals, Animals, Newborn, Biomechanical Phenomena, Cells, Cultured, Extracellular Matrix, Humans, Rats, Inbred F344, Stress, Mechanical, Coculture Techniques, Tissue Engineering, Myocytes, Cardiac, Pluripotent Stem Cells, Endothelial Cells, Cell Proliferation, Rats, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
