The DOI matches its Crossref record; 127 of the 128 references it cites were found in a registry or an index.
Engineering Adolescence: Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes
Open accessAbstract
The discovery of human pluripotent stem cells (hPSCs), including both human embryonic stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide range of scientific studies. The capability to direct the differentiation of hPSCs into functional cardiomyocytes has provided a platform for regenerative medicine, development, tissue engineering, disease modeling, and drug toxicity testing. Despite exciting progress, achieving the optimal benefits has been hampered by the immature nature of these cardiomyocytes. Cardiac maturation has long been studied in vivo using animal models; however, finding ways to mature hPSC cardiomyocytes is only in its initial stages. In this review, we discuss progress in promoting the maturation of the hPSC cardiomyocytes, in the context of our current knowledge of developmental cardiac maturation and in relation to in vitro model systems such as rodent ventricular myocytes. Promising approaches that have begun to be examined in hPSC cardiomyocytes include long-term culturing, 3-dimensional tissue engineering, mechanical loading, electric stimulation, modulation of substrate stiffness, and treatment with neurohormonal factors. Future studies will benefit from the combinatorial use of different approaches that more closely mimic nature’s diverse cues, which may result in broader changes in structure, function, and therapeutic applicability.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These values are comparable to those observed in tissues composed of immature cells where cell geometry, calcium handling, gap junction expression and spatial distribution, as well as other factors limit the conduction velocity when compared to mature tissues52,53.”
From A tissue-engineered scale model of the heart ventricle (2018) · cites this paper as [53]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Commonly, immature hPSC-CMs exhibit a positive chronotropic response to β-adrenergic stimulation but lack the positive inotropy characteristic of adult cardiomyocytes (Yang et al., 2014).”
From A human engineered mini-heart platform for mimicking ventricular pump function (2025) · cites this paper as Yang et al., 2014
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“However, these CMs are immature compared to their in vivo counterparts.”
From Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues (2023) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“a number of major hallmarks have been regarded as a general consensus of the field, including myofibril maturation, electrophysiology, calcium handling, metabolic maturation, hypertrophy, and integration of physiology.10,37,38”
From Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues (2023) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“Adult CMs are characterized by distinctive features including rod-like shape, polyploidy and organized myofibrils, mitochondrial networks, sarcoplasmic reticulum, and T-tubules.10,21”
From Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues (2023) · cites this paper as [10]
In the citing paper
“Biowire, with a more matured phenotype and a closer recapitulation of the adult native cardiac tissue, is considered to have more predictive power for cardiotoxicity screening [247].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [247]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell · doi:10.1016/j.cell.2010.07.002 · Cited by 2,454
Thyroid hormone and the cardiovascular system.
Klein, I., & Ojamaa, K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440707 · Cited by 2,300
Regulation of cardiac hypertrophy by intracellular signalling pathways
Heineke, J., & Molkentin, J. D. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1983 · Cited by 1,890
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
van Rooij, E., Sutherland, L. B., Qi, X., Richardson, J. A., Hill, J. A., & Olson, E. N. (2007) · Science · doi:10.1126/science.1139089 · Cited by 1,666
Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
Zhang, J., Wilson, G. F., Soerens, A. G., Koonce, C. H., Yu, J., Palecek, S. P., Thomson, J. A., & Kamp, T. J. (2009) · Circulation Research · doi:10.1161/circresaha.108.192237 · Cited by 1,426
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
Li, Q., Huang, Y., Spencer, C. I., Foley, A., Vedantham, V., Liu, L., Conway, S. J., Fu, J., & Srivastava, D. (2012) · Nature · doi:10.1038/nature11044 · Cited by 1,376
Laflamme, M. A., & Murry, C. E. (2011) · Nature · doi:10.1038/nature10147 · Cited by 1,272
Self-citationPatient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
Moretti, A., Bellin, M., Welling, A., Jung, C. B., Lam, J. T., Bott-Flügel, L., Dorn, T., Goedel, A., Höhnke, C., Hofmann, F., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908679 · Cited by 1,251
Heart repair by reprogramming non-myocytes with cardiac transcription factors
Song, K., Nam, Y., Luo, X., Qi, X., Tan, W. H., Huang, G. N., Acharya, A., Smith, C. L., Tallquist, M. D., Neilson, E. G., et al. (2012) · Nature · doi:10.1038/nature11139 · Cited by 1,162
Mummery, C., Ward-van Oostwaard, D., Doevendans, P., Spijker, R., van den Brink, S., Hassink, R., van der Heyden, M., Opthof, T., Pera, M., de la Riviere, A. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000068356.38592.68 · Cited by 1,001
Flagged first, then by citations
1 of the 128 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 938
Tsui, J. H., Leonard, A., Camp, N. D., Long, J. T., Nawas, Z., Chavanachat, R., Smith, A. S. T., Choi, J. S., Dong, Z., Ahn, E. H., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2021.120764 · Cited by 123
Self-citationPutten, R. M. E. M.-V., Mengarelli, I., Guan, K., Zegers, J. G., van Ginneken, A. C. G., Verkerk, A. O., & Wilders, R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00007 · Cited by 116
Ribeiro, A. J. S., Schwab, O., Mandegar, M. A., Ang, Y.-S., Conklin, B. R., Srivastava, D., & Pruitt, B. L. (2017) · Circulation Research · doi:10.1161/circresaha.116.310363 · Cited by 116
Miklas, J. W., Clark, E. C., Levy, S., Detraux, D., Leonard, A., Beussman, K. M., Showalter, M. R., Smith, A. S. T., Hofsteen, P., Yang, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12482-1 · Cited by 120
Self-citationHuman Induced Pluripotent Stem Cell–Derived Cardiomyocytes as Models for Cardiac Channelopathies
Garg, P., Garg, V., Shrestha, R., Sanguinetti, M. C., Kamp, T. J., & Wu, J. C. (2018) · Circulation Research · doi:10.1161/circresaha.118.311209 · Cited by 119
On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology
Shao, Y., Sang, J., & Fu, J. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.01.078 · Cited by 117
Ravenscroft, S., Pointon, A., Williams, A. W., Cross, M. J., & Sidaway, J. E. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw069 · Cited by 113
Making human cardiomyocytes up to date: Derivation, maturation state and perspectives
Kolanowski, T. J., Antos, C. L., & Guan, K. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.03.099 · Cited by 113
Magdy, T., Schuldt, A. J. T., Wu, J. C., Bernstein, D., & Burridge, P. W. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-053110 · Cited by 117
A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations
Cohn, R. L., Thakar, K., Lowe, A., Ladha, F. A., Pettinato, A. M., Romano, R., Meredith, E. K., Chen, Y.-S., Atamanuk, K., Huey, B. D., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.11.015 · Cited by 117
Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes
Zhu, R., Blazeski, A., Poon, E., Costa, K. D., Tung, L., & Boheler, K. R. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt507 · Cited by 110
Biology of the cardiac myocyte in heart disease
Peter, A. K., Bjerke, M. A., & Leinwand, L. A. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-01-0038 · Cited by 115
Cardiac Disorders and Pathophysiology of Sarcomeric Proteins
van der Velden, J., & Stienen, G. J. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00040.2017 · Cited by 117
Physiologically inspired cardiac scaffolds for tailored in vivo function and heart regeneration
Kaiser, N. J., & Coulombe, K. L. K. (2015) · Biomedical Materials · doi:10.1088/1748-6041/10/3/034003 · Cited by 111
Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells
Hernández, D., Millard, R. E., Sivakumaran, P., Wong, R. C. B., Crombie, D. E., Hewitt, A. W., Liang, H. H., Hung, S. S. C., Pébay, A., Shepherd, R. K., et al. (2015) · Stem Cells International · doi:10.1155/2016/1718041 · Cited by 108
The winding road to regenerating the human heart
Gerbin, K. A., & Murry, C. E. (2015) · Cardiovascular Pathology · doi:10.1016/j.carpath.2015.02.004 · Cited by 107
Self-citationMaturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes
Wu, P., Deng, G., Sai, X., Guo, H., Huang, H., & Zhu, P. (2020) · Bioscience Reports · doi:10.1042/bsr20200833 · Cited by 113
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
Murphy, S. A., Miyamoto, M., Kervadec, A., Kannan, S., Tampakakis, E., Kambhampati, S., Lin, B. L., Paek, S., Andersen, P., Lee, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21957-z · Cited by 107
Zhang, W., Kong, C., Tống, M. P., Chooi, W. H., Huang, N., Li, R. A., & Chan, B. P. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.058 · Cited by 106
Onódi, Z., Visnovitz, T., Kiss, B., Hambalkó, S., Koncz, A., Ágg, B., Váradi, B., Tóth, V. É., Nagy, R. N., Gergely, T. G., et al. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.12.007 · Cited by 110
Matsa, E., Ahrens, J. H., & Wu, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00036.2015 · Cited by 105
Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids
Richards, D., Tan, Y. J., Coyle, R. C., Li, Y., Xu, R., Yeung, N., Parker, A., Menick, D. R., Tian, B., & Mei, Y. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b02093 · Cited by 108
Huang, C., Maia-Joca, R. P. M., Ong, C. S., Wilson, I., DiSilvestre, D. A., Tomaselli, G. F., & Reich, D. H. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.10.001 · Cited by 107
Gouveia, P., Rosa, S. C., Ricotti, L., Abecasis, B., de Almeida, H. V., Monteiro, L. M., Nunes, J., Carvalho, F. S., Serra, M., Luchkin, S. Y., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.048 · Cited by 105
Cho, G.-S., Lee, D. I., Tampakakis, E., Murphy, S. A., Andersen, P., Uosaki, H., Chelko, S. P., Chakir, K., Hong, I., Seo, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.040 · Cited by 101
Ergir, E., Oliver-De La Cruz, J., Fernandes, S., Cassani, M., Niro, F., Pereira-Sousa, D., Vrbský, J., Vinarský, V., Perestrelo, A. R., Debellis, D., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-22225-w · Cited by 99
Micropost arrays for measuring stem cell-derived cardiomyocyte contractility
Beussman, K. M., Rodriguez, M. L., Leonard, A., Taparia, N., Thompson, C. R., & Sniadecki, N. J. (2015) · Methods · doi:10.1016/j.ymeth.2015.09.005 · Cited by 99
Haginiwa, S., & Ieda, M. (2017) · Cardiac and vascular biology · doi:10.1007/978-3-319-56106-6_6 · Cited by 98
Towards chamber specific heart-on-a-chip for drug testing applications
Zhao, Y., Rafatian, N., Wang, E. Y., Wu, Q., Lai, B., Lu, R. X. Z., Savoji, H., & Radisic, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.12.002 · Cited by 100
Wickramasinghe, N. M., Sachs, D. M., Shewale, B., Gonzalez, D. M., Dhanan-Krishnan, P., Torre, D., LaMarca, E. A., Raimo, S., Dariolli, R., Serasinghe, M. N., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.02.011 · Cited by 102
Han, J., Wu, Q., Younan Xia, A., Wagner, M. B., & Xu, C. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.04.014 · Cited by 98
Guo, Y., Jardin, B. D., Zhou, P., Sethi, I., Akerberg, B. N., Toepfer, C. N., Ai, Y., Li, Y., Ma, Q., Guatimosim, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06347-2 · Cited by 96
Cardiac regeneration using pluripotent stem cells—Progression to large animal models
Chong, J. J. H., & Murry, C. E. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.06.005 · Cited by 96
Self-citationStem Cell Technology in Cardiac Regeneration: A Pluripotent Stem Cell Promise
Duelen, R., & Sampaolesi, M. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.029 · Cited by 97
Striated muscle function, regeneration, and repair
Shadrin, I. Y., Khodabukus, A., & Bursac, N. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2285-z · Cited by 106
Li, Y., Asfour, H., & Bursac, N. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.04.027 · Cited by 98
Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip
Veldhuizen, J., Cutts, J., Brafman, D. A., Migrino, R. Q., & Nikkhah, M. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120195 · Cited by 95
Tan, Y. J., Richards, D., Xu, R., Stewart‐Clark, S., Mani, S. K., Borg, T. K., Menick, D. R., Tian, B., & Mei, Y. (2015) · Nano Letters · doi:10.1021/nl502227a · Cited by 98
Ma, R., Liang, J., Huang, W. C., Guo, L., Cai, W., Wang, L., Paul, C., Yang, H., Kim, H. W., & Wang, Y. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6766 · Cited by 93
Human cardiomyocytes undergo enhanced maturation in embryonic stem cell-derived organoid transplants
Varzideh, F., Pahlavan, S., Ansari, H., Halvaei, M., Sawa Kostin, D., Feiz, M.-S., Latifi, H., Aghdami, N., Braun, T. W., & Baharvand, H. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.033 · Cited by 97
Jiang, Y., Park, P., hong, S., & Ban, K. (2018) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2018.0143 · Cited by 100
Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes
Eschenhagen, T., Mummery, C. L., & Knollmann, B. C. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv017 · Cited by 95
Zuppinger, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.11.036 · Cited by 97
Native cardiac environment and its impact on engineering cardiac tissue
Schwach, V., & Passier, R. C. (2019) · Biomaterials Science · doi:10.1039/c8bm01348a · Cited by 92
Lee, D. S., Chen, J.-H., Lundy, D. J., Liu, C.-H., Hwang, S.-M., Pabon, L., Shieh, R.-C., Chen, C.-C., Wu, S.-N., Yan, Y.-T., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.042 · Cited by 91
Self-citationAndrysiak, K., Stępniewski, J., & Dulak, J. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02536-z · Cited by 93
Veldhuizen, J., Chavan, R., Moghadas, B., Park, J. G., Kodibagkar, V. D., Migrino, R. Q., & Nikkhah, M. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121336 · Cited by 93
Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research
Kroll, K. T., Chabria, M., Wang, K., Häusermann, F., Schuler, F., & Polonchuk, L. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.07.003 · Cited by 89
Kerscher, P., Turnbull, I. C., Hodge, A. J., Kim, J., Seliktar, D., Easley, C. J., Costa, K. D., & Lipke, E. A. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.011 · Cited by 88
Zhang, M., Schulte, J. S., Heinick, A., Piccini, I., Rao, J., Quaranta, R., Zeuschner, D., Malan, D., Kim, K.-P., Röpke, A., et al. (2015) · Stem Cells · doi:10.1002/stem.1964 · Cited by 90
LaBarge, W., Mattapally, S., Kannappan, R., Fast, V. G., Pretorius, D., Berry, J. L., & Zhang, J. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219442 · Cited by 94
Transcriptomic profiling reveals p53 as a key regulator of doxorubicin-induced cardiotoxicity
McSweeney, K. M., Bozza, W. P., Alterovitz, W.-L., & Zhang, B. (2019) · Cell Death Discovery · doi:10.1038/s41420-019-0182-6 · Cited by 86
Zhuang, R. Z., Lock, R., Liu, B., & Vunjak-Novakovic, G. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00885-3 · Cited by 84
Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes
Besser, R. R., Ishahak, M., Mayo, V., Carbonero, D., Claure, I., & Agarwal, A. (2017) · Theranostics · doi:10.7150/thno.19441 · Cited by 87
Bioengineering approaches to treat the failing heart: from cell biology to 3D printing
Yadid, M., Oved, H., Silberman, E., & Dvir, T. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00603-7 · Cited by 83
Hayes, H. B., Nicolini, A. M., Arrowood, C. A., Chvatal, S. A., Wolfson, D. W., Cho, H. C., Sullivan, D. D., Chal, J., Fermini, B., Clements, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48174-5 · Cited by 83
Yan, W., Xia, Y., Zhao, H., Xu, X., Ma, X., & Tao, L. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.12.009 · Cited by 83
Pioner, J. M., Racca, A. W., Klaiman, J. M., Yang, K., Guan, X., Pabon, L., Muskheli, V., Zaunbrecher, R. J., Macadangdang, J. R., Jeong, M. Y., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.04.006 · Cited by 88
Self-citationWang, P., Thissen, H. W., & Kingshott, P. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.08.054 · Cited by 83
Metabolic remodeling in early development and cardiomyocyte maturation
Kreipke, R. E., Wang, Y., Miklas, J. W., Mathieu, J., & Ruohola‐Baker, H. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.004 · Cited by 85
Big bottlenecks in cardiovascular tissue engineering
Huang, N. F., Serpooshan, V., Morris, V. B., Sayed, N., Pardon, G., Abilez, O. J., Nakayama, K. H., Pruitt, B. L., Wu, S. M., Yoon, Y., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0202-8 · Cited by 82
Wang, X., Wang, L., Wu, Q., Bao, F., Yang, H., Qiu, X., & Chang, J. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b17754 · Cited by 82
Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration
Zhao, M., Ye, S., Su, J., & Garg, V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594226 · Cited by 83
da Rocha, A. M., Campbell, K. F., Mironov, S. V., Jiang, J., Mundada, L. V., Guerrero‐Serna, G., Jalife, J., & Herron, T. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13590-y · Cited by 82
Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium
Lü, K., Seidel, T., Cao-Ehlker, X., Dorn, T., Batcha, A. M. N., Poch, C. M., Semmler, M., Volk, T., Moretti, A., Dendorfer, A., et al. (2021) · Theranostics · doi:10.7150/thno.54999 · Cited by 88
Roshanzadeh, A., Oyunbaatar, N., Ganjbakhsh, S. E., Park, S., Kim, D., Kanade, P. P., Lee, S., Lee, D., & Kim, E. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121175 · Cited by 84
Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling
Guo, Y., Cao, Y., Jardin, B. D., Sethi, I., Ma, Q., Moghadaszadeh, B., Troiano, E. C., Mazumdar, N., Trembley, M. A., Small, E. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008861118 · Cited by 80
Kanda, Y., Yamazaki, D., Osada, T., Yoshinaga, T., & Sawada, K. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.10.010 · Cited by 79
Lin, Y., Linask, K. L., Mallon, B. S., Johnson, K. R., Klein, M. G., Beers, J. K., Xie, W., Du, Y., Liu, C., Lai, Y., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0428 · Cited by 79
Roest, A. S. V., Liu, C., Morck, M. M., Kooiker, K. B., Jung, G., Song, D., Dawood, A., Jhingran, A., Pardon, G., Ranjbarvaziri, S., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025030118 · Cited by 77
Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes
Sun, X., & Nunes, S. S. (2015) · Methods · doi:10.1016/j.ymeth.2015.11.005 · Cited by 77
ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
Miki, K., Deguchi, K., Nakanishi-Koakutsu, M., Lucena-Cacace, A., Kondo, S., Fujiwara, Y., Hatani, T., Sasaki, M., Naka, Y., Okubo, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23816-3 · Cited by 76
Burridge, P. W., Sharma, A., & Wu, J. C. (2015) · Annual Review of Genetics · doi:10.1146/annurev-genet-112414-054911 · Cited by 78
Human cardiomyocyte generation from pluripotent stem cells: A state-of-art
Talkhabi, M., Aghdami, N., & Baharvand, H. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.12.023 · Cited by 76
Eschenhagen, T., & Carrier, L. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2214-0 · Cited by 82
Shaheen, N., Shiti, A., Huber, I., Shinnawi, R., Arbel, G., Gepstein, A., Setter, N., Goldfracht, I., Gruber, A., Chorna, S. V., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.04.006 · Cited by 76
Vuckovic, S., Dinani, R., Nollet, E. E., Kuster, D. W. D., Buikema, J. W., Houtkooper, R. H., Nabben, M., van der Velden, J., & Goversen, B. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03021-9 · Cited by 78
Ebert, A., Joshi, A. U., Andorf, S., Dai, Y., Sampathkumar, S., Chen, H., Li, Y., Garg, P., Toischer, K., Hasenfuss, G. P., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.313973 · Cited by 75
CRISPR/Cas9‐Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent Stem Cells
Sharma, A., Toepfer, C. N., Ward, T. L., Wasson, L. K., Agarwal, R., Conner, D. A., Hu, J. H., & Seidman, C. E. (2018) · Current Protocols in Human Genetics · doi:10.1002/cphg.52 · Cited by 76
Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy
Bertero, A., Fields, P., Smith, A. S. T., Leonard, A., Beussman, K. M., Sniadecki, N. J., Kim, D., Tse, H., Pabon, L., Shendure, J., et al. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201902117 · Cited by 77
Self-citationZhou, Y., Wang, L., Liu, Z., Alimohamadi, S., Yin, C., Liu, J., & Li, Q. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.005 · Cited by 72
Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy
Hanses, U., Kleinsorge, M., Roos, L., Yigit, G., Li, Y., Barbarics, B., El‐Battrawy, I., Lan, H., Tiburcy, M., Hindmarsh, R., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.044794 · Cited by 74
Lewandowski, J., Rozwadowska, N., Kolanowski, T. J., Malcher, A., Zimna, A., Rugowska, A., Fiedorowicz, K., Łabędź, W., Kubaszewski, Ł., Chojnacka, K., et al. (2018) · Cell Transplantation · doi:10.1177/0963689718779346 · Cited by 75
Iseoka, H., Miyagawa, S., Fukushima, S., Saito, A., Masuda, S., Yajima, S., Ito, E., Sougawa, N., Takeda, M., Harada, A., et al. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0535 · Cited by 71
Tabei, R., Kawaguchi, S., Kanazawa, H., Tohyama, S., Hirano, A., Handa, N., Hishikawa, S., Teratani, T., Kunita, S., Fukuda, J., et al. (2018) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2018.11.002 · Cited by 71
Kolanowski, T. J., Busek, M., Schubert, M., Dmitrieva, A., Binnewerg, B., Pöche, J., Fisher, K., Schmieder, F., Grünzner, S., Hansen, S., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.11.044 · Cited by 75
Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering
Montero, P., Flandes‐Iparraguirre, M., Musquiz, S., Pérez-Araluce, M., Plano, D., Sanmartín, C., Orive, G., Gavira, J. J., Prósper, F., & Mazo, M. M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00955 · Cited by 72
Gentillon, C., Li, D., Duan, M., Yu, W., Preininger, M. K., Jha, R., Rampoldi, A., Saraf, A. P., Gibson, G. C., Qu, C., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.05.003 · Cited by 69
Preininger, M. K., Jha, R., Maxwell, J. T., Wu, Q., Singh, M., Wang, B., Dalal, A. S., McEachin, Z. T., Rossoll, W., Hales, C. M., et al. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.026823 · Cited by 68
Bielawski, K. S., Leonard, A., Bhandari, S., Murry, C., & Sniadecki, N. J. (2016) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2016.0257 · Cited by 68
Self-citationScalise, M., Marino, F., Salerno, L., Cianflone, E., Molinaro, C., Salerno, N., Angelis, A. D., Viglietto, G., Urbanek, K., & Torella, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413180 · Cited by 68
Human induced pluripotent stem cell-derived fiber-shaped cardiac tissue on a chip
Morimoto, Y., Mori, S., Sakai‐Takemura, F., & Takeuchi, S. (2016) · Lab on a Chip · doi:10.1039/c6lc00422a · Cited by 67
High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model
Conant, G., Lai, B. F. L., Lu, R. X. Z., Korolj, A., Wang, E. Y., & Radisic, M. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9736-2 · Cited by 71
Nano‐Enabled Approaches for Stem Cell‐Based Cardiac Tissue Engineering
Kharaziha, M., Memić, A., Akbari, M., Brafman, D. A., & Nikkhah, M. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600088 · Cited by 69
From engineered heart tissue to cardiac organoid
Cho, J., Lee, H., Rah, W., Chang, H., & Yoon, Y. (2022) · Theranostics · doi:10.7150/thno.67661 · Cited by 70
Phelan, D., Anderson, D. J., Howden, S. E., Wong, R. C. B., Hickey, P. F., Pope, K., Wilson, G. R. A., Pébay, A., Davis, A. M., Petrou, S., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw160 · Cited by 66
Baldassarre, A. D., Cimetta, E., Bollini, S., Gaggi, G., & Ghinassi, B. (2018) · Cells · doi:10.3390/cells7060048 · Cited by 69
Regulation of cardiomyocyte maturation during critical perinatal window
Kannan, S., & Kwon, C. (2018) · The Journal of Physiology · doi:10.1113/jp276754 · Cited by 69
Use of Human iPSC-CMs in Nonclinical Regulatory Studies for Cardiac Safety Assessment
Yang, X., Ribeiro, A. J. S., Pang, L., & Strauss, D. G. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac095 · Cited by 65
Self-citationKijlstra, J. D., Hu, D., Mittal, N., Kausel, E., van der Meer, P., Garakani, A., & Domian, I. J. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.10.017 · Cited by 66
Metadata
- Authors
- Yang, X., Pabon, L., & Murry, C. E.
- Affiliations
- University of Washington (US)
- Venue
- Circulation Research
- Published
- 2014-01-31
- Volume
- 114
- Issue
- 3
- Pages
- 511-523
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3955370
- OpenAlex
- W2033765226
- Semantic Scholar
- d50fb63e8e68ab0d845e62dbf5f9c8c2470174d7
- Cited by
- 939
- References
- 128
- Citations by year
- 2026: 31 · 2025: 44 · 2024: 60 · 2023: 76 · 2022: 76 · 2021: 96 · 2020: 99 · 2019: 106 · 2018: 85 · 2017: 103 · 2016: 68 · 2015: 76 · 2014: 19
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U01HL100405, P01HL094374, R01HL084642)
- National Institute of General Medical Sciences (P01GM081619)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- human pluripotent stem cells, cardiomyocyte maturation, human embryonic stem cells, induced pluripotent stem cells, cardiac differentiation, 3D tissue engineering, mechanical loading, electrical stimulation, substrate stiffness, neurohormonal factors, disease modeling, drug toxicity testing, regenerative medicine
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Genetic Engineering, Humans, Time Factors, Models, Animal, Myocytes, Cardiac, Pluripotent Stem Cells, Induced Pluripotent Stem Cells, Cell Engineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
