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Engineering Adolescence: Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes
Open accessAbstract
The discovery of human pluripotent stem cells (hPSCs), including both human embryonic stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide range of scientific studies. The capability to direct the differentiation of hPSCs into functional cardiomyocytes has provided a platform for regenerative medicine, development, tissue engineering, disease modeling, and drug toxicity testing. Despite exciting progress, achieving the optimal benefits has been hampered by the immature nature of these cardiomyocytes. Cardiac maturation has long been studied in vivo using animal models; however, finding ways to mature hPSC cardiomyocytes is only in its initial stages. In this review, we discuss progress in promoting the maturation of the hPSC cardiomyocytes, in the context of our current knowledge of developmental cardiac maturation and in relation to in vitro model systems such as rodent ventricular myocytes. Promising approaches that have begun to be examined in hPSC cardiomyocytes include long-term culturing, 3-dimensional tissue engineering, mechanical loading, electric stimulation, modulation of substrate stiffness, and treatment with neurohormonal factors. Future studies will benefit from the combinatorial use of different approaches that more closely mimic nature’s diverse cues, which may result in broader changes in structure, function, and therapeutic applicability.
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“These values are comparable to those observed in tissues composed of immature cells where cell geometry, calcium handling, gap junction expression and spatial distribution, as well as other factors limit the conduction velocity when compared to mature tissues52,53.”
From A tissue-engineered scale model of the heart ventricle (2018) · cites this paper as [53]
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“Commonly, immature hPSC-CMs exhibit a positive chronotropic response to β-adrenergic stimulation but lack the positive inotropy characteristic of adult cardiomyocytes (Yang et al., 2014).”
From A human engineered mini-heart platform for mimicking ventricular pump function (2025) · cites this paper as Yang et al., 2014
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“However, these CMs are immature compared to their in vivo counterparts.”
From Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues (2023) · cites this paper as [10]
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“a number of major hallmarks have been regarded as a general consensus of the field, including myofibril maturation, electrophysiology, calcium handling, metabolic maturation, hypertrophy, and integration of physiology.10,37,38”
From Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues (2023) · cites this paper as [10]
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“Adult CMs are characterized by distinctive features including rod-like shape, polyploidy and organized myofibrils, mitochondrial networks, sarcoplasmic reticulum, and T-tubules.10,21”
From Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues (2023) · cites this paper as [10]
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“Biowire, with a more matured phenotype and a closer recapitulation of the adult native cardiac tissue, is considered to have more predictive power for cardiotoxicity screening [247].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [247]
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Cites
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell · doi:10.1016/j.cell.2010.07.002 · Cited by 2,454
Thyroid hormone and the cardiovascular system.
Klein, I., & Ojamaa, K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440707 · Cited by 2,300
Regulation of cardiac hypertrophy by intracellular signalling pathways
Heineke, J., & Molkentin, J. D. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1983 · Cited by 1,890
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
van Rooij, E., Sutherland, L. B., Qi, X., Richardson, J. A., Hill, J. A., & Olson, E. N. (2007) · Science · doi:10.1126/science.1139089 · Cited by 1,666
Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
Zhang, J., Wilson, G. F., Soerens, A. G., Koonce, C. H., Yu, J., Palecek, S. P., Thomson, J. A., & Kamp, T. J. (2009) · Circulation Research · doi:10.1161/circresaha.108.192237 · Cited by 1,426
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
Li, Q., Huang, Y., Spencer, C. I., Foley, A., Vedantham, V., Liu, L., Conway, S. J., Fu, J., & Srivastava, D. (2012) · Nature · doi:10.1038/nature11044 · Cited by 1,376
Laflamme, M. A., & Murry, C. E. (2011) · Nature · doi:10.1038/nature10147 · Cited by 1,272
Self-citationPatient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
Moretti, A., Bellin, M., Welling, A., Jung, C. B., Lam, J. T., Bott-Flügel, L., Dorn, T., Goedel, A., Höhnke, C., Hofmann, F., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908679 · Cited by 1,251
Heart repair by reprogramming non-myocytes with cardiac transcription factors
Song, K., Nam, Y., Luo, X., Qi, X., Tan, W. H., Huang, G. N., Acharya, A., Smith, C. L., Tallquist, M. D., Neilson, E. G., et al. (2012) · Nature · doi:10.1038/nature11139 · Cited by 1,162
Mummery, C., Ward-van Oostwaard, D., Doevendans, P., Spijker, R., van den Brink, S., Hassink, R., van der Heyden, M., Opthof, T., Pera, M., de la Riviere, A. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000068356.38592.68 · Cited by 1,001
Cited by
Sorted by citations
Items 401–500 of 938
Afzal, J. M., Liu, Y., Du, W., Suhail, Y., Zong, P., Feng, J., Ajeti, V., Sayyad, W. A., Nikolaus, J., Yankova, M. P., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111146 · Cited by 26
Esmaeili, H., Patino-Guerrero, A., Nelson, R. A., Karamanova, N., Fisher, T. M., Zhu, W., Perreault, F., Migrino, R. Q., & Nikkhah, M. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01256 · Cited by 26
Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration
Cao, H., Kang, B. J., Lee, C.-A., Shung, K. K., & Hsiai, T. K. (2015) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2015.2431681 · Cited by 26
Lee, J. E., Smeriglio, P., Chu, C. R., & Bhutani, N. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0696-x · Cited by 26
Cardiac macrotissues-on-a-plate models for phenotypic drug screens
Meyer, T., Tiburcy, M., & Zimmermann, W. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.03.002 · Cited by 26
Substrate stiffness modulates the maturation of human pluripotent stem-cell-derived hepatocytes
Mittal, N., Tasnim, F., Yue, C., Qu, Y., Phan, D., Choudhury, Y., Tan, M.-H., & Yu, H. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00475 · Cited by 25
Erñst, P., Bidwell, P. A., Dora, M., Thomas, D. D., & Kamdar, F. D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.986107 · Cited by 26
A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids
Burnham, M. P., Harvey, R., Sargeant, R., Fertig, N., & Haddrick, M. (2020) · SLAS DISCOVERY · doi:10.1177/2472555220975332 · Cited by 25
Ribeiro, M. C., Rivera‐Arbeláez, J. M., Cofiño‐Fabrés, C., Schwach, V., Slaats, R. H., ten Den, S. A., Vermeul, K., van den Berg, A., Pérez-Pomares, J. M., Segerink, L. I., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020214 · Cited by 25
Κιτσαρά, Μ., Revet, G., Vartanian-Grimaldi, J.-S., Simon, A., Minguy, M., Miche, A., Humblot, V., Dufour, T., & Agbulut, O. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1008436 · Cited by 25
Vascularisation for cardiac tissue engineering: the extracellular matrix
Patra, C., Boccaccini, A. R., & Engel, F. B. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-05-0480 · Cited by 25
Benzoni, P., Ginestra, P. S., Altomare, L., Fiorentino, A., Nardo, L. D., Ceretti, E., & Dell’Era, P. (2016) · Procedia CIRP · doi:10.1016/j.procir.2015.09.004 · Cited by 25
Phenotypic assays for analyses of pluripotent stem cell–derived cardiomyocytes
Pešl, M., Přibyl, J., Caluori, G., Čmiel, V., Aćimović, I., Jelínková, Š., Dvořák, P., Stárek, Z., Skládal, P., & Rotrekl, V. (2016) · Journal of Molecular Recognition · doi:10.1002/jmr.2602 · Cited by 26
Optogenetics gets to the heart: A guiding light beyond defibrillation
Crocini, C., Ferrantini, C., Pavone, F. S., & Sacconi, L. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.05.002 · Cited by 25
Hansen, K. J., Favreau, J. T., Gershlak, J. R., Laflamme, M. A., Albrecht, D. R., & Gaudette, G. R. (2017) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2017.0190 · Cited by 25
Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient
Dal-Pra, S., Hodgkinson, C. P., & Dzau, V. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223842 · Cited by 25
Comparative Transcriptome Landscape of Mouse and Human Hearts
Anzai, T., Yamagata, T., & Uosaki, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00268 · Cited by 27
Stem Cells and Their Cardiac Derivatives for Cardiac Tissue Engineering and Regenerative Medicine
Roshanbinfar, K., Esser, T. U., & Engel, F. B. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8193 · Cited by 25
Kim, Y. S., Yoon, J. W., Kim, D., Choi, S., Kim, H. K., Youm, J. B., Han, J., Heo, S. C., Hyun, S., Seo, J.-W., et al. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00746-8 · Cited by 25
Robinson, P. J., Sparrow, A. J., Psaras, Y., Steeples, V., Simon, J. N., Broyles, C. N., Chang, Y., Brook, F. A., Wang, Y., Blease, A., et al. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.04.008 · Cited by 24
Human Stem Cell-Derived Cardiac Model of Chronic Drug Exposure
Nunes, S. S., Feric, N. T., Pahnke, A., Miklas, J. W., Li, M., Coles, J. G., Gagliardi, M., Keller, G. M., & Radisic, M. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00496 · Cited by 26
Christidi, E., Huang, H., & Brunham, L. R. (2018) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2018.06.002 · Cited by 24
Li, Q., Wang, J., Wu, Q., Cao, N., & Yang, H. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0340 · Cited by 24
Modelling genetic diseases for drug development: Hypertrophic cardiomyopathy
Santini, L., Palandri, C., Nediani, C., Cerbai, E., & Coppini, R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105176 · Cited by 24
Tadano, K., Miyagawa, S., Takeda, M., Tsukamoto, Y., Kazusa, K., Takamatsu, K., Akashi, M., & Sawa, Y. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.05.007 · Cited by 24
Cheng, S., Brenière-Letuffe, D., Ahola, V., Wong, A. O. T., Keung, H. Y., Gurung, B., Zheng, Z., Costa, K. D., Lieu, D. K., Keung, W., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106302 · Cited by 23
Jiang, X., Lian, X., Wei, K., Zhang, J., Yu, K., Li, H., Ma, H., Cai, Y., & Pang, L. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03961-4 · Cited by 23
Lu, Y., Liu, Y., Yan, Y., Fooladi, S., & Qyang, Y. (2025) · Biophysical Reviews · doi:10.1007/s12551-024-01267-6 · Cited by 25
Cardiac Regeneration with Human Pluripotent Stem Cell-Derived Cardiomyocytes
Park, M., & Yoon, Y. (2018) · Korean Circulation Journal · doi:10.4070/kcj.2018.0312 · Cited by 25
Zhang, F., Qiu, H., Dong, X., Zhang, X., Wang, C., Li, X., Zhang, X., Na, J., Zhou, J., & Wang, C. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac002 · Cited by 23
Reilly, L., Munawar, S., Zhang, J., Crone, W. C., & Eckhardt, L. L. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.966094 · Cited by 25
Visone, R., Lozano-Juan, F., Marzorati, S., Rivolta, M. W., Pesenti, E. A., Redaelli, A. C. L., Sassi, R., Rasponi, M., & Occhetta, P. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac108 · Cited by 23
A Review on the Applications of Natural Biodegradable Nano Polymers in Cardiac Tissue Engineering
Aziz, R., Falanga, M., Purenović, J., Mancini, S., Lamberti, P., & Guida, M. (2023) · Nanomaterials · doi:10.3390/nano13081374 · Cited by 23
Cardiac organoid: multiple construction approaches and potential applications
Yang, Z., Zhang, Y., Wang, J., Yin, J., Wang, Z., & Pei, R. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00783a · Cited by 23
Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Bezzerides, V. J., Zhang, D., & Pu, W. T. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-1113 · Cited by 25
Hodgson, P., Ireland, J., & Grunow, B. (2018) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2018.04.009 · Cited by 23
Engineering hiPSC cardiomyocyte in vitro model systems for functional and structural assessment
Roest, A. S. V., Pardon, G., Castillo, E. A., Blair, C. A., & Pruitt, B. L. (2018) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2018.12.001 · Cited by 23
Varzideh, F., Mahmoudi, E., & Pahlavan, S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28926 · Cited by 23
Lodrini, A. M., Barile, L., Rocchetti, M., & Altomare, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020507 · Cited by 24
Werley, C. A., Chien, M., Gaublomme, J. T., Shekhar, K., Butty, V. L., Yi, B. A., Kralj, J. M., Bloxham, B., Boyer, L. A., Regev, A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172671 · Cited by 23
New developments and applications of human organoids
Andersson-Rolf, A., & Clevers, H. C. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-00974-0 · Cited by 25
Three-dimensional scaffold-free microtissues engineered for cardiac repair
Patino-Guerrero, A., Veldhuizen, J., Zhu, W., Migrino, R. Q., & Nikkhah, M. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01528h · Cited by 22
Monitoring the maturation of the sarcomere network: a super-resolution microscopy-based approach
Skorska, A., Johann, L., Chabanovska, O., Vasudevan, P., Kussauer, S., Hillemanns, M., Wolfien, M., Jonitz‐Heincke, A., Wolkenhauer, O., Bader, R., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04196-3 · Cited by 24
Cho, K.-W., Andrade, M., Bae, S., Kim, S., Kim, J. E., Jang, E. Y., Lee, S., Husain, A., Sutliff, R. L., Calvert, J. W., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.061131 · Cited by 22
Pan, Z., Ebert, A., & Liang, P. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02486-y · Cited by 22
Camman, M., Joanne, P., Agbulut, O., & Hélary, C. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.040 · Cited by 24
Engineering Myocardial Tissue Patches with Hierarchical Structure–Function
Roberts, E. G., Lee, E. L., Backman, D. E., Buczek‐Thomas, J. A., Emani, S. M., & Wong, J. Y. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-014-1210-6 · Cited by 22
Stem cell therapy for cardiac regeneration: past, present, and future
Gill, J., Rehsia, S. K., Verma, E., Sareen, N., & Dhingra, S. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0202 · Cited by 21
Progress of organoid platform in cardiovascular research
Du, X., Jia, H., Chang, Y., Zhao, Y., & Song, J. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.043 · Cited by 21
Perspectives of induced pluripotent stem cells for cardiovascular system regeneration
Csöbönyeiová, M., Polák, Š., & Danišovič, Ľ. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370214565976 · Cited by 22
Biophysical stimulation for in vitro engineering of functional cardiac tissues
Korolj, A., Wang, E. Y., Civitarese, R., & Radisic, M. (2017) · Clinical Science · doi:10.1042/cs20170055 · Cited by 22
Geraets, I. M. E., Chanda, D., van Tienen, F. H. J., van den Wijngaard, A., Kamps, R., Neumann, D., Liu, Y., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.12.025 · Cited by 21
Dynamic Clamp in Electrophysiological Studies on Stem Cell–Derived Cardiomyocytes—Why and How?
Verkerk, A. O., & Wilders, R. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000955 · Cited by 22
Pretorius, D., Kahn-Krell, A. M., Lou, X., Fast, V. G., Berry, J. L., Kamp, T. J., & Zhang, J. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.670504 · Cited by 21
Kamdar, F. D., Kamdar, A. K., Koyano‐Nakagawa, N., Garry, M. G., & Garry, D. J. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.04.010 · Cited by 21
Calcium and voltage mapping in hiPSC-CM monolayers
Herron, T. J. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.02.004 · Cited by 21
Shan, C., Xia, Y., Wu, Z., & Zhao, J. (2023) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2023.09.002 · Cited by 21
Cardiac Tissue Engineering: Inclusion of Non-cardiomyocytes for Enhanced Features
Munawar, S., & Turnbull, I. C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.653127 · Cited by 20
Pang, J. K. S., Ho, B. X., Chan, W., & Soh, B.-S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.788955 · Cited by 20
Review Insights In Cardiac Tissue Engineering: Cells, Scaffolds, and Pharmacological Agents.
Boroumand, S., Haeri, A., Nazeri, N., & Rabbani, S. (2021) · PubMed Central · doi:10.22037/ijpr.2021.114730.15012 · Cited by 20
Oguntuyo, K., Schuftan, D. R., Guo, J., Simmons, D. W., Bhagavan, D., Moreno, J. D., Kang, P. W., Miller, E. W., Silva, J. R., & Huebsch, N. (2022) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2022.0053 · Cited by 21
Dynamic mechanobiology of cardiac cells and tissues: Current status and future perspective
Wang, C., Ramahdita, G., Genin, G. M., Huebsch, N., & Ma, Z. (2023) · Biophysics Reviews · doi:10.1063/5.0141269 · Cited by 20
Medicinal Chemistry Approaches to Heart Regeneration
Schade, D., & Plowright, A. T. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00446 · Cited by 21
Disease modeling and functional screening using engineered heart tissue
Mills, R. J., Voges, H. K., Porrello, E. R., & Hudson, J. E. (2017) · Current Opinion in Physiology · doi:10.1016/j.cophys.2017.08.003 · Cited by 20
Notbohm, J., Napiwocki, B. N., de Lange, W. J., Stempien, A., Saraswathibhatla, A., Craven, R., Salick, M. R., Ralphe, J. C., & Crone, W. C. (2019) · Experimental Mechanics · doi:10.1007/s11340-019-00473-8 · Cited by 20
Collagen Type I Containing Hybrid Hydrogel Enhances Cardiomyocyte Maturation in a 3D Cardiac Model
Edalat, S. G., Jang, Y., Kim, J., & Park, Y. (2019) · Polymers · doi:10.3390/polym11040687 · Cited by 20
Hayoun, D., Korover, N., Etzion, S., Ofir, R., Lichtenstein, R. G., & Cohen, S. (2019) · Polymers for Advanced Technologies · doi:10.1002/pat.4602 · Cited by 21
Medicinal Biotechnology for Disease Modeling, Clinical Therapy, and Drug Discovery and Development
Duelen, R., Corvelyn, M., Tortorella, I., Leonardi, L., Chai, Y. C., & Sampaolesi, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-22141-6_5 · Cited by 23
Isolation of Cardiomyocytes Undergoing Mitosis With Complete Cytokinesis
Milliron, H.-Y., Weiland, M. J., Kort, E. J., & Jovinge, S. V. (2019) · Circulation Research · doi:10.1161/circresaha.119.314908 · Cited by 20
Kadowaki, H., Akazawa, H., Ishida, J., & Komuro, I. (2020) · Circulation Journal · doi:10.1253/circj.cj-20-0467 · Cited by 20
de Sande, D. V. V., Kopljar, I., Alaerts, M., Teisman, A. C. H., Gallacher, D. J., Loeys, B., Snyders, D. J., Leybaert, L., Lu, H. R., & Labro, A. J. (2021) · Channels · doi:10.1080/19336950.2021.1871815 · Cited by 20
Guo, J., Tian, X. Y., Barth, M., Xian, W., Ruppenthal, S., Schaefers, H., Chen, Z., Moretti, A., Laugwitz, K., & Lipp, P. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab195 · Cited by 20
Song, M.-H., Choi, S., Noh, J.-M., Joo, H. J., Park, C., Cha, J., Ahn, T. H., Ko, T. H., Choi, J., Na, J. E., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121133 · Cited by 21
Lemcke, H., Skorska, A., Lang, C. I., Johann, L., & David, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082819 · Cited by 20
Fermini, B., & Bell, D. C. (2022) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2022.107184 · Cited by 21
Zhou, J., Cui, B., Wang, X., Wang, H., Zheng, J., Guo, F., Sun, Y., Fan, H., Shen, J., Su, J., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03312-9 · Cited by 19
Hodge, A. J., Zhong, J., & Lipke, E. A. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25849 · Cited by 19
Preininger, M. K., Singh, M., & Xu, C. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-45457-3_10 · Cited by 21
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Nadkarni, R. R., Abed, S., Cox, B., Bhatia, S., Lau, J. T., Surette, M. G., & Draper, J. S. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.07.024 · Cited by 19
Matrix-guided control of mitochondrial function in cardiac myocytes
Lyra‐Leite, D. M., Andres, A. M., Cho, N., Petersen, A. P., Ariyasinghe, N. R., Kim, S. S., Gottlieb, R. A., & McCain, M. L. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.08.007 · Cited by 19
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Metadata
- Authors
- Yang, X., Pabon, L., & Murry, C. E.
- Affiliations
- University of Washington (US)
- Venue
- Circulation Research
- Published
- 2014-01-31
- Volume
- 114
- Issue
- 3
- Pages
- 511-523
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3955370
- OpenAlex
- W2033765226
- Semantic Scholar
- d50fb63e8e68ab0d845e62dbf5f9c8c2470174d7
- Cited by
- 939
- References
- 128
- Citations by year
- 2026: 31 · 2025: 44 · 2024: 60 · 2023: 76 · 2022: 76 · 2021: 96 · 2020: 99 · 2019: 106 · 2018: 85 · 2017: 103 · 2016: 68 · 2015: 76 · 2014: 19
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U01HL100405, P01HL094374, R01HL084642)
- National Institute of General Medical Sciences (P01GM081619)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- human pluripotent stem cells, cardiomyocyte maturation, human embryonic stem cells, induced pluripotent stem cells, cardiac differentiation, 3D tissue engineering, mechanical loading, electrical stimulation, substrate stiffness, neurohormonal factors, disease modeling, drug toxicity testing, regenerative medicine
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Genetic Engineering, Humans, Time Factors, Models, Animal, Myocytes, Cardiac, Pluripotent Stem Cells, Induced Pluripotent Stem Cells, Cell Engineering
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