The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Heart Failure With Preserved Ejection Fraction: Mechanisms, Clinical Features, and Therapies
Open accessAbstract
The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the predominant form of HF in the developed world, and soon to reach epidemic proportions. It remains among the most challenging of clinical syndromes for the practicing clinician and scientist alike, with a multitude of proposed mechanisms involving the heart and other organs and complex interplay with common comorbidities. Importantly, its morbidity and mortality are on par with HF with reduced EF, and as the list of failed treatments continues to grow, HF with preserved EF clearly represents a major unmet medical need. The field is greatly in need of a more unified approach to its definition and view of the syndrome that engages integrative and reserve pathophysiology beyond that related to the heart alone. We need to reflect on prior treatment failures and the message this is providing, and redirect our approaches likely with a paradigm shift in how the disease is viewed. Success will require interactions between clinicians, translational researchers, and basic physiologists. Here, we review recent translational and clinical research into HF with preserved EF and give perspectives on its evolving demographics and epidemiology, the role of multiorgan deficiencies, potential mechanisms that involve the heart and other organs, clinical trials, and future directions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Two pathological characteristics markedly prevalent in patients with HFpEF are cardiac myocyte hypertrophy and cardiac fibrosis, as confirmed in a large, prospective analysis of HFpEF myocardial tissue.8,9”
From Reversal of contractile defects by mediating calcium homeostasis in human mini-heart models of heart failure with preserved ejection fraction (HFpEF) leads to first-in-human gene therapy clinical trial (2024) · cites this paper as [9]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292
Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction
Owan, T., Hodge, D. O., Herges, R. M., Jacobsen, S. J., Roger, V. L., & Redfield, M. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052256 · Cited by 4,209
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,739
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564
Yusuf, S., Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., Michelson, E. L., Olofsson, B., & Östergren, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14285-7 · Cited by 2,994
Spironolactone for heart failure with preserved ejection fraction
Pitt, B., Pfeffer, M. A., Assmann, S. F., Boineau, R., Anand, I. S., Claggett, B., Clausell, N., Desai, A. S., Diaz, R., Fleg, J. L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313731 · Cited by 2,809
Antlanger, M., Aschauer, S., Kopecky, C., Hecking, M., Kovarik, J. J., Werzowa, J. M., Mascherbauer, J., Genser, B., Säemann, M. D., & Bonderman, D. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000473868 · Cited by 2,808
A Controlled Trial of Renal Denervation for Resistant Hypertension
Bhatt, D. L., Kandzari, D. E., O'Neill, W. W., D'Agostino, R., Flack, J. M., Katzen, B. T., Leon, M. B., Liu, M., Mauri, L., Negoita, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402670 · Cited by 2,186
Irbesartan in patients with heart failure and preserved ejection fraction
Massie, B. M., Carson, P. E., McMurray, J. J., Komajda, M., McKelvie, R., Zile, M. R., Anderson, S., Donovan, M., Iverson, E., Staiger, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0805450 · Cited by 1,960
Outcome of Heart Failure with Preserved Ejection Fraction in a Population-Based Study
Bhatia, R. S., Tu, J. V., Lee, D. S., Austin, P. C., Fang, J., Haouzi, A., Gong, Y., & Liu, P. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051530 · Cited by 1,959
Heart-rate Recovery Immediately After Exercise as a Predictor of Mortality
Cole, C. R., Blackstone, E. H., Pashkow, F. J., Snader, C. E., & Lauer, M. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910283411804 · Cited by 1,935
Abraham, W. T., Adamson, P. B., Bourge, R. C., Aaron, M. F., Costanzo, M. R., Stevenson, L. W., Strickland, W., Neelagaru, S., Raval, N., Krueger, S., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60101-3 · Cited by 1,744
Flather, M. D., Shibata, M. C., Coats, A. J. S., van Veldhuisen, D. J., Parkhomenko, A. N., Borbola, J., Solal, A. C., Dumitrascu, D. L., Ferrari, R., Lechat, P. P., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi115 · Cited by 1,649
Zile, M. R., Baicu, C. F., & Gaasch, W. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032566 · Cited by 1,577
The perindopril in elderly people with chronic heart failure (PEP-CHF) study
Cleland, J. G. F. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl250 · Cited by 1,527
2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults
Jessup, M. L., Abraham, W. T., Casey, D. E., Feldman, A. M., Francis, G. S., Ganiats, T. G., Konstam, M. A., MANCINI, D. M., Rahko, P. S., Silver, M. A., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192064 · Cited by 1,425
Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction
Lam, C. S. P., Roger, V. L., Rodeheffer, R. J., Borlaug, B. A., Enders, F., & Redfield, M. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.051 · Cited by 1,345
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction
Vasan, R. S., Larson, S., Benjamin, E. J., Evans, J. C., Reiss, C. K., & Levy, D. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00118-7 · Cited by 1,331
HFSA 2010 Comprehensive Heart Failure Practice Guideline
Heart Failure Society of America (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.04.004 · Cited by 1,304
New Concepts in Diastolic Dysfunction and Diastolic Heart Failure: Part I
Zile, M. R., & Brutsaert, D. L. (2002) · Circulation · doi:10.1161/hc1102.105289 · Cited by 1,185
Solomon, S. D., Zile, M. R., Pieske, B. M., Voors, A. A., Shah, A. M., Kraigher‐Krainer, E., Shi, V. C., Bransford, T. L., Takeuchi, M., Gong, J., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61227-6 · Cited by 1,171
Redfield, M. M., Chen, H. H., Borlaug, B. A., Semigran, M. J., Lee, K. L., Lewis, G. D., LeWinter, M. M., Rouleau, J. L., Bull, D. A., Mann, D. L., et al. (2013) · JAMA · doi:10.1001/jama.2013.2024 · Cited by 1,164
Exercise Hemodynamics Enhance Diagnosis of Early Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Nishimura, R. A., Sorajja, P., Lam, C. S. P., & Redfield, M. M. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.930701 · Cited by 1,119
Fonarow, G. C., Stough, W. G., Abraham, W. T., Albert, N. M., Gheorghiade, M., Greenberg, B., O’Connor, C. M., Sun, J. L., Yancy, C. W., & Young, J. B. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.064 · Cited by 1,092
Kawaguchi, M., Hay, I., Fetics, B. J., & Kass, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048123.22359.a0 · Cited by 929
Self-citationYancy, C. W., Lopatin, M., Stevenson, L. W., De Marco, T., & Fonarow, G. C. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.022 · Cited by 927
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Takimoto, E., Champion, H. C., Li, M., Belardi, D. F., Ren, S. V., Rodríguez, E. R., Bedja, D., Gabrielson, K. L., Wang, Y., & Kass, D. A. (2005) · Nature Medicine · doi:10.1038/nm1175 · Cited by 902
Self-citationEffective arterial elastance as index of arterial vascular load in humans.
Kelly, R. P., Ting, C.-T., Yang, T. M., Liu, C. P., Maughan, W. L., Chang, M.-S., & Kass, D. A. (1992) · Circulation · doi:10.1161/01.cir.86.2.513 · Cited by 832
Self-citationTrends in Patients Hospitalized With Heart Failure and Preserved Left Ventricular Ejection Fraction
Steinberg, B. A., Zhao, X., Heidenreich, P. A., Peterson, E. D., Bhatt, D. L., Cannon, C. P., Hernandez, A. F., & Fonarow, G. C. (2012) · Circulation · doi:10.1161/circulationaha.111.080770 · Cited by 776
Edelmann, F., Wachter, R., Schmidt, A. G., Kraigher‐Krainer, E., Colantonio, C., Kamke, W., Duvinage, A., Stahrenberg, R., Durstewitz, K., Löffler, M., et al. (2013) · JAMA · doi:10.1001/jama.2013.905 · Cited by 761
Impaired Systolic Function by Strain Imaging in Heart Failure With Preserved Ejection Fraction
Kraigher‐Krainer, E., Shah, A. M., Gupta, D. K., Santos, Â. B. S., Claggett, B. L., Pieske, B. M., Zile, M. R., Voors, A. A., Lefkowitz, M., Packer, M., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.052 · Cited by 751
Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Olson, T. P., Lam, C. S. P., Flood, K. S., Lerman, A., Johnson, B. D., & Redfield, M. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.077 · Cited by 733
van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Kupreishvili, K., Ijsselmuiden, A. J. J., Schalkwijk, C. G., Bronzwaer, J. G. F., Diamant, M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.728550 · Cited by 723
Borlaug, B. A., Melenovsky, V., Russell, S. D., Kessler, K., Pacak, K., Becker, L. C., & Kass, D. A. (2006) · Circulation · doi:10.1161/circulationaha.106.632745 · Cited by 699
Self-citationAther, S., Chan, W., Bozkurt, B., Aguilar, D. A., Ramasubbu, K., Zachariah, A., Wehrens, X. H. T., & Deswal, A. M. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.040 · Cited by 692
Kitzman, D. W., Higginbotham, M. B., Cobb, F. R., Sheikh, K. H., & Sullivan, M. J. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90832-t · Cited by 687
Lee, D. S., Gona, P. N., Vasan, R. S., Larson, M. G., Benjamin, E. J., Wang, T. J., Tu, J. V., & Levy, D. A. (2009) · Circulation · doi:10.1161/circulationaha.108.815944 · Cited by 681
Edelmann, F., Gelbrich, G., Düngen, H., Fröhling, S., Wachter, R., Stahrenberg, R., Binder, L., Töpper, A., Lashki, D. J., Schwarz, S., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.054 · Cited by 677
Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure
van Heerebeek, L., Borbély, A., Niessen, H. W. M., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Linke, W. A., Laarman, G. J., & Paulus, W. J. (2006) · Circulation · doi:10.1161/circulationaha.105.587519 · Cited by 655
How to diagnose diastolic heart failure
Paulus, W. J., Brutsaert, D. L., Gillebert, T. C., Rademakers, F., Stanislas, U., Leite-Moreira, A. F., Om, H., Zh, J., Kaufmann, P. A., Mandinov, L., et al. (1998) · Ghent University Academic Bibliography (Ghent University) · Cited by 649
Westermann, D., Lindner, D., Kasner, M., Zietsch, C., Savvatis, K., Escher, F., von Schlippenbach, J., Skurk, C., Steendijk, P., Riad, A., et al. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.931451 · Cited by 644
How to diagnose diastolic heart failure
European Study Group on Diastolic H (1998) · European Heart Journal · doi:10.1053/euhj.1998.1057 · Cited by 616
Ahmed, A., Rich, M. W., Fleg, J. L., Zile, M. R., Young, J. B., Kitzman, D. W., Love, T. E., Aronow, W. S., Adams, K. F., & Gheorghiade, M. (2006) · Circulation · doi:10.1161/circulationaha.106.628347 · Cited by 605
Nohria, A., Hasselblad, V., Stebbins, A., Pauly, D. F., Fonarow, G. C., Shah, M., Yancy, C. W., Califf, R. M., Stevenson, L. W., & Hill, J. A. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.08.072 · Cited by 593
Bourge, R. C., Abraham, W. T., Adamson, P. B., Aaron, M. F., Aranda, J. M., Magalski, A., Zile, M. R., Smith, A. L., Smart, F. W., O’Shaughnessy, M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.061 · Cited by 549
Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction
van Heerebeek, L., Hamdani, N., Falcão‐Pires, I., Leite-Moreira, A. F., Begieneman, M. P. V., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Laarman, G. J., Somsen, G. A., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.076075 · Cited by 545
Lam, C. S. P., Roger, V. L., Rodeheffer, R. J., Bursi, F., Borlaug, B. A., Ommen, S. R., Kass, D. A., & Redfield, M. M. (2007) · Circulation · doi:10.1161/circulationaha.106.659763 · Cited by 544
Self-citationCardiomyocyte stiffness in diastolic heart failure
Borbély, A., van der Velden, J., Papp, Z., Bronzwaer, J. G. F., Edes, I., Stienen, G. J. M., & Paulus, W. J. (2005) · Circulation · doi:10.1161/01.cir.0000155257.33485.6d · Cited by 536
Nagendran, J., Archer, S. L., Soliman, D., Gurtu, V., Moudgil, R., Haromy, A., Aubin, C. S., Webster, L., Rebeyka, I. M., Ross, D. B., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.655266 · Cited by 528
Chronic vagus nerve stimulation: A new and promising therapeutic approach for chronic heart failure
De Ferrari, G. M., Crijns, H. J. G. M., Borggrefe, M., Milasinovic, G., Smid, J., Zabel, M., Gavazzi, A., Sanzo, A., Dennert, R., Kuschyk, J., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq391 · Cited by 523
Lewis, G. D., Shah, R. V., Shahzad, K., Camuso, J. M., Pappagianopoulos, P. P., Hung, J., Tawakol, A. A., Gerszten, R. E., Systrom, D. M., Bloch, K. D., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.716373 · Cited by 511
Yu, C., Lin, H., Yang, H., Kong, S., Zhang, Q., & Lee, S. W.-L. (2002) · Circulation · doi:10.1161/hc1002.105185 · Cited by 510
Gu, J., Noè, A., Chandra, P., Al‐Fayoumi, S., Ligueros‐Saylan, M., Sarangapani, R., Maahs, S., Ksander, G. M., Rigel, D. F., Jeng, A. Y., et al. (2009) · The Journal of Clinical Pharmacology · doi:10.1177/0091270009343932 · Cited by 505
Heart Failure With a Normal Ejection Fraction
Zile, M. R., Gaasch, W. H., Carroll, J. D., Feldman, M. D., Aurigemma, G. P., Schaer, G. L., Ghali, J. K., & Liebson, P. R. (2001) · Circulation · doi:10.1161/hc3201.094226 · Cited by 494
Melenovský, V., Borlaug, B. A., Rosen, B. D., Hay, I., Ferrucci, L., Morell, C., Lakatta, E. G., Najjar, S. S., & Kass, D. A. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.050 · Cited by 482
Self-citationPulmonary Capillary Wedge Pressure Augments Right Ventricular Pulsatile Loading
Tedford, R. J., Hassoun, P. M., Mathai, S. C., Girgis, R. E., Russell, S. D., Thiemann, D. R., Cingolani, O. H., Mudd, J. O., Borlaug, B. A., Redfield, M. M., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.051540 · Cited by 479
Self-citationInflammatory Markers and Incident Heart Failure Risk in Older Adults
Kalogeropoulos, A., Georgiopoulou, V., Psaty, B. M., Rodondi, N., Smith, A. L., Harrison, D. G., Liu, Y., Hoffmann, U., Bauer, D. C., Newman, A. B., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.045 · Cited by 478
Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction
Westermann, D., Kašner, M., Paul Steendijk, A., Spillmann, F., Riad, A., Weitmann, K., Hoffmann, W. U., Poller, W. C., Pauschinger, M., Schultheiss, H., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.716886 · Cited by 471
Renal Sympathetic Denervation for Treatment of Drug-Resistant Hypertension
Esler, M., Krum, H., Schlaich, M. P., Schmieder, R. E., Böhm, M., & Sobotka, P. A. (2012) · Circulation · doi:10.1161/circulationaha.112.130880 · Cited by 462
Left Ventricular Amyloid Deposition in Patients With Heart Failure and Preserved Ejection Fraction
Mohammed, S. F., Mirzoyev, S. A., Edwards, W. D., Doǧan, A., Grogan, D. R., Dunlay, S. M., Roger, V. L., Gertz, M. A., Dispenzieri, A. A., Zeldenrust, S. R., et al. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.11.004 · Cited by 460
Takimoto, E., Champion, H. C., Li, M., Ren, S. V., Rodríguez, E. R., Tavazzi, B., Lazzarino, G., Paolocci, N., Gabrielson, K. L., Wang, Y., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci21968 · Cited by 446
Self-citationCardiac Structure and Function in Heart Failure With Preserved Ejection Fraction
Shah, A. M., Shah, S. J., Anand, I. S., Sweitzer, N. K., O’Meara, E., Heitner, J. F., Sopko, G. S., Li, G., Assmann, S. F., McKinlay, S. M., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000887 · Cited by 437
Yusuf, S., Pfeffer, Swedberg, K. B., Granger, C. B., Held, P. H., McMurray, J. J. V., Michelson, E. L., Olofsson, B., & Östergren, J. (2003) · Cited by 431
van Veldhuisen, D. J., Linssen, G. C. M., Jaarsma, T., van Gilst, W. H., Hoes, A. W., Tijssen, J. G. P., Paulus, W. J., Voors, A. A., & Hillege, H. L. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.12.044 · Cited by 415
Exercise Training in Older Patients With Heart Failure and Preserved Ejection Fraction
Kitzman, D. W., Brubaker, P. H., Morgan, T. M., Stewart, K. P., & Little, W. C. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.958785 · Cited by 410
Krüger, M., Kötter, S., Grützner, A., Lang, P. M., Andresen, C., Redfield, M. M., Butt, E., dos Remedios, C. G., & Linke, W. A. (2008) · Circulation Research · doi:10.1161/circresaha.108.184408 · Cited by 408
Abdominal contributions to cardiorenal dysfunction in congestive heart failure.
Verbrugge, F. H., Dupont, M., Steels, P., Grieten, L., Malbrain, M., Tang, W. H. W., & Mullens, W. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.04.070 · Cited by 380
Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction
Klapholz, M., Maurer, M. S., Lowe, A. M., Messineo, F. C., Meisner, J. S., Mitchell, J. E., Kalman, J., Phillips, R. A., Steingart, R. M., Brown, E. J., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.040 · Cited by 371
Kitzman, D. W., Brubaker, P. H., Herrington, D. M., Morgan, T. M., Stewart, K. P., Hundley, W. G., Abdelhamed, A., & Haykowsky, M. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.04.033 · Cited by 369
Borbély, A., Falcão‐Pires, I., van Heerebeek, L., Hamdani, N., Edes, I. F., Gavina, C., Leite-Moreira, A. F., Bronzwaer, J. G. F., Papp, Z., van der Velden, J., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.193326 · Cited by 369
Yamamoto, K., Origasa, H., & Hori, M. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs141 · Cited by 366
A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo
Davis, J., Burr, A. R., Davis, G. F., Birnbaumer, L., & Molkentin, J. D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.08.017 · Cited by 362
Novel Baroreflex Activation Therapy in Resistant Hypertension
Scheffers, I. J. M., Kroon, A. A., Schmidli, J., Jordan, J., Tordoir, J. H. M., Mohaupt, M. G., Luft, F. C., Haller, H. G., Menne, J., Engeli, S., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.089 · Cited by 356
Fisher, P. W., Salloum, F. N., Das, A., Hyder, H., & Kukreja, R. C. (2005) · Circulation · doi:10.1161/01.cir.0000160359.49478.c2 · Cited by 350
Unlocking the Mysteries of Diastolic Function
Lester, S. J., Tajik, A. J., Nishimura, R. A., Oh, J. K., Khandheria, B. K., & Seward, J. B. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.061 · Cited by 348
Kitzman, D. W., Nicklas, B. J., Kraus, W. E., Lyles, M. F., Eggebeen, J., Morgan, T. M., & Haykowsky, M. J. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00004.2014 · Cited by 345
Phan, T. T., Abozguia, K., Shivu, G. N., Mahadevan, G., Ahmed, I., Williams, L. K., Dwivedi, G., Patel, K., Paul Steendijk, A., Ashrafian, H., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.012 · Cited by 339
Yip, G. W., Wang, M., Zhang, Y., Fung, J. W. H., Ho, P. Y., & Sanderson, J. E. (2002) · Heart · doi:10.1136/heart.87.2.121 · Cited by 338
Linke, W. A., & Hamdani, N. (2014) · Circulation Research · doi:10.1161/circresaha.114.301286 · Cited by 337
Koitabashi, N., Danner, T., Zaiman, A., Pinto, Y. M., Rowell, J., Mankowski, J. L., Zhang, D., Nakamura, T., Takimoto, E., & Kass, D. A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44824 · Cited by 335
Self-citationKašner, M., Westermann, D., López, B., Gaub, R., Escher, F., Kühl, U., Schultheiß, H., & Tschöpe, C. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.024 · Cited by 330
Lahmers, S. M., Wu, Y., Call, D. R., Labeit, S., & Granzier, H. (2004) · Circulation Research · doi:10.1161/01.res.0000115522.52554.86 · Cited by 313
Yamasaki, R., Wu, Y., McNabb, M., Greaser, M. L., Labeit, S., & Granzier, H. (2002) · Circulation Research · doi:10.1161/01.res.0000021115.24712.99 · Cited by 307
Hamdani, N., Franssen, C., Lourenço, A. P., Falcão‐Pires, I., Fontoura, D., Leite, S., Plettig, L., López, B., Ottenheijm, C. A. C., Becher, P. M., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000539 · Cited by 307
Statin Therapy May Be Associated With Lower Mortality in Patients With Diastolic Heart Failure
Fukuta, H., Sane, D. C., Brucks, S., & Little, W. C. (2005) · Circulation · doi:10.1161/circulationaha.104.519876 · Cited by 298
Baicu, C. F., Zile, M. R., Aurigemma, G. P., & Gaasch, W. H. (2005) · Circulation · doi:10.1161/01.cir.0000164273.57823.26 · Cited by 289
Contractile Behavior of the Left Ventricle in Diastolic Heart Failure
Aurigemma, G. P., Zile, M. R., & Gaasch, W. H. (2006) · Circulation · doi:10.1161/circulationaha.104.481465 · Cited by 257
Lewis, E. F., Lamas, G. A., O’Meara, E., Granger, C. B., Dunlap, M. E., McKelvie, R. S., Probstfield, J. L., Young, J. B., Michelson, E. L., Halling, K., et al. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.10.012 · Cited by 252
TRPC Channels As Effectors of Cardiac Hypertrophy
Eder, P., & Molkentin, J. D. (2011) · Circulation Research · doi:10.1161/circresaha.110.225888 · Cited by 251
Heart Failure With a Normal Ejection Fraction
Burkhoff, D., Maurer, M. S., & Packer, M. (2003) · Circulation · doi:10.1161/01.cir.0000053947.82595.03 · Cited by 245
Abnormal Haemodynamic Response to Exercise in Heart Failure with Preserved Ejection Fraction
Bhella, P. S., Prasad, A., Heinicke, K., Hastings, J. L., Arbab-Zadeh, A., Adams-Huet, B., Pacini, E. L., Shibata, S., Palmer, M. D., Newcomer, B. R., et al. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr133 · Cited by 238
Ventricular–Vascular Interaction in Heart Failure
Borlaug, B. A., & Kass, D. A. (2011) · Cardiology Clinics · doi:10.1016/j.ccl.2011.06.004 · Cited by 225
Self-citationDeswal, A. M., Richardson, P. A., Bozkurt, B., & Mann, D. L. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.04.007 · Cited by 219
Kass, D. A., Champion, H. C., & Beavo, J. A. (2007) · Circulation Research · doi:10.1161/circresaha.107.162511 · Cited by 217
Self-citationPhan, T. T., Shivu, G. N., Abozguia, K., Davies, C., Nassimizadeh, M., Jimenez, D., Weaver, R., Ahmed, I., & Frenneaux, M. P. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.877720 · Cited by 215
Collier, P. H., Watson, C. J., Voon, V., Phelan, D. M. J., Jan, A., Mak, G. J., Martos, R., Baugh, J. A., Ledwidge, M. T., & McDonald, K. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr079 · Cited by 213
Burke, M. A., Katz, D. H., Beussink‐Nelson, L., Selvaraj, S., Gupta, D. K., Fox, J. M., Chakrabarti, S., Sauer, A. J., Rich, J. D., Freed, B. H., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000854 · Cited by 209
Conraads, V. M., Metra, M., Otto Kamp, B., Keulenaer, G. W. D., Pieske, B. M., Zamorano, J. L., Vardas, P. E., Böhm, M., & Cas, L. D. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr161 · Cited by 209
How do Patients with Heart Failure with Preserved Ejection Fraction Die?
Chan, M. M. Y., & Lam, C. S. P. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft062 · Cited by 207
S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding
Alegre‐Cebollada, J., Kosuri, P., Giganti, D. O., Eckels, E. C., Rivas‐Pardo, J. A., Hamdani, N., Warren, C. M., Solaro, R. J., Linke, W. A., & Fernández, J. M. (2014) · Cell · doi:10.1016/j.cell.2014.01.056 · Cited by 204
Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium
Smith, C. S., Bottomley, P. A., Schulman, S. P., Gerstenblith, G., & Weiss, R. G. (2006) · Circulation · doi:10.1161/circulationaha.106.613646 · Cited by 204
Glezeva, N., & Baugh, J. A. (2013) · Heart Failure Reviews · doi:10.1007/s10741-013-9405-8 · Cited by 194
Lepore, J. J., Maroo, A. P., Bigatello, L. M., DEC, G. W., Zapol, W. M., Bloch, K. D., & Semigran, M. J. (2005) · CHEST Journal · doi:10.1378/chest.127.5.1647 · Cited by 193
Vinereanu, D., Nicolaides, E., Tweddel, A. C., & Fraser, A. G. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2005.02.003 · Cited by 191
Alterations in the determinants of diastolic suction during pacing tachycardia
Bell, S. P., Nyland, L., Tischler, M. D., McNabb, M., Granzier, H., & LeWinter, M. M. (2000) · Circulation Research · doi:10.1161/01.res.87.3.235 · Cited by 190
Haykowsky, M. J., Brubaker, P. H., Morgan, T. M., Kritchevsky, S., Eggebeen, J., & Kitzman, D. W. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt011 · Cited by 189
Hamdani, N., Krysiak, J., Kreußer, M. M., Neef, S., dos Remedios, C. G., Maier, L. S., Krüger, M., Backs, J., & Linke, W. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300105 · Cited by 186
Bishu, K. G., Hamdani, N., Mohammed, S. F., Krüger, M., Ohtani, T., Ogut, O., Brozovich, F. V., Burnett, J. C. J., Linke, W. A., & Redfield, M. M. (2011) · Circulation · doi:10.1161/circulationaha.111.048520 · Cited by 186
Shah, S. J., Heitner, J. F., Sweitzer, N. K., Anand, I. S., Kim, H.-Y., Harty, B. J., Boineau, R., Clausell, N., Desai, A. S., Díaz, R., et al. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.972794 · Cited by 185
Heart Failure With Preserved Ejection Fraction
Loffredo, F. S., Nikolova, A., Pancoast, J. R., & Lee, R. T. (2014) · Circulation Research · doi:10.1161/circresaha.115.302929 · Cited by 184
Kosmala, W., Holland, D. J., Rojek, A., Wright, L. M., Przewłocka‐Kosmala, M., & Marwick, T. H. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.043 · Cited by 183
European Study Group on Diastolic Heart Failure
Paulus, W. J. (1998) · Cited by 183
Modulation of Titin-Based Stiffness by Disulfide Bonding in the Cardiac Titin N2-B Unique Sequence
Grützner, A., Garcia-Manyes, S., Kötter, S., Badilla, C. L., Fernández, J. M., & Linke, W. A. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.05.037 · Cited by 182
Robbins, I. M., Hemnes, A. R., Pugh, M. E., Brittain, E. L., Zhao, D. X.-M., Piana, R. N., Fong, P. P., & Newman, J. H. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000468 · Cited by 180
Matsubara, J., Sugiyama, S., Nozaki, T., Sugamura, K., Konishi, M., Ohba, K., Matsuzawa, Y., Akiyama, E., Yamamoto, E., Sakamoto, K., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.018 · Cited by 175
Heart Failure With Preserved Ejection Fraction in Outpatients With Unexplained Dyspnea
Pěnička, M., Bartúnek, J., Trakalova, H., Hrabáková, H., Maruskova, M., Karásek, J., & Kočka, V. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.11.076 · Cited by 173
Badenhorst, D. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00733-2 · Cited by 166
Dryer, S. E., & Reiser, J. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00298.2010 · Cited by 165
Mechanisms of Exercise-Induced Cardioprotection
Powers, S. K., Smuder, A. J., Kavazis, A. N., & Quindry, J. C. (2014) · Physiology · doi:10.1152/physiol.00030.2013 · Cited by 158
Salloum, F. N., Chau, V. Q., Hoke, N. N., Abbate, A., Varma, A., Ockaili, R. A., Toldo, S. A., & Kukreja, R. C. (2009) · Circulation · doi:10.1161/circulationaha.108.843979 · Cited by 156
Brubaker, P. H., Joo, K.-C., Stewart, K. P., Fray, B., Moore, B., & Kitzman, D. W. (2006) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200603000-00007 · Cited by 147
Rationale and study design of the INcrease Of Vagal TonE in Heart Failure study: INOVATE-HF
Hauptman, P. J., Schwartz, P. J., Gold, M. R., Borggrefe, M., van Veldhuisen, D. J., Starling, R. C., & Mann, D. L. (2012) · American Heart Journal · doi:10.1016/j.ahj.2012.03.021 · Cited by 143
Liu, C. P., Ting, C.-T., Lawrence, W., Maughan, W. L., Chang, M.-S., & Kass, D. A. (1993) · Circulation · doi:10.1161/01.cir.88.4.1893 · Cited by 142
Self-citationCardiac transthyretin amyloidosis
Dungu, J. N., Anderson, L. J., Whelan, C. J., & Hawkins, P. N. (2012) · Heart · doi:10.1136/heartjnl-2012-301924 · Cited by 140
Diagnostic Criteria for Diastolic Heart Failure
Yturralde, R. F., & Gaasch, W. H. (2005) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.02.007 · Cited by 132
Reil, J., Hohl, M., Reil, G., Granzier, H. L. M., Kratz, M. T., Kazakov, A., Fries, P., Müller, A., Lenski, M., Custodis, F., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs218 · Cited by 130
Costs for Heart Failure With Normal vs Reduced Ejection Fraction
Liao, L. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.1.112 · Cited by 130
Edelmann, F., Stahrenberg, R., Gelbrich, G., Durstewitz, K., Angermann, C. E., Düngen, H., Scheffold, T., Zugck, C., Maisch, B., Regitz‐Zagrosek, V., et al. (2011) · Clinical Research in Cardiology · doi:10.1007/s00392-011-0305-4 · Cited by 127
Wachter, R., Schmidt‐Schweda, S., Westermann, D., Post, H., Edelmann, F., Kasner, M., Lüers, C., Paul Steendijk, A., Hasenfuss, G. P., Tschöpe, C., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp341 · Cited by 124
Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction
Bishu, K. G., Deswal, A. M., Chen, H. H., LeWinter, M. M., Lewis, G. D., Semigran, M. J., Borlaug, B. A., McNulty, S. E., Hernandez, A. F., D, E. B. M., et al. (2012) · American Heart Journal · doi:10.1016/j.ahj.2012.08.014 · Cited by 120
González, A., López, B., Querejeta, R., Zubillaga, E., Echeverría, T., & Dı́ez, J. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.149112 · Cited by 119
Kranias, E. G., & Bers, D. M. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6191-2_20 · Cited by 118
Titin Determines the Frank-Starling Relation in Early Diastole
Helmes, M., Lim, C. C., Liao, R., Bharti, A. K., Cui, L., & Sawyer, D. B. (2003) · The Journal of General Physiology · doi:10.1085/jgp.20028652 · Cited by 116
Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes
Sag, C. M., Wagner, S., & Maier, L. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.035 · Cited by 112
Forfia, P. R., Lee, M., Tunin, R. S., Mahmud, M., Champion, H. C., & Kass, D. A. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.066 · Cited by 111
Self-citationRainer, P. P., Hao, S. B., Vanhoutte, D., Lee, D. I., Koitabashi, N., Molkentin, J. D., & Kass, D. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302653 · Cited by 108
Self-citationAnalysis of left ventricular diastolic function
Yamamoto, K., Redfield, M. M., & Nishimura, R. A. (1996) · Heart · doi:10.1136/hrt.75.6_suppl_2.27 · Cited by 105
Bruch, C., Gradaus, R., Gunia, S., BREITHARDT, G. E., & Wichter, T. (2003) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(03)00634-5 · Cited by 104
Hoekstra, T., Lesman‐Leegte, I., van Veldhuisen, D. J., Sanderman, R., & Jaarsma, T. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr072 · Cited by 103
PLiu, C., TTing, C., WLawrence, LMaughan, W., SChang, M., & AKass, D. (1993) · Circulation · Cited by 102
Mechanism of Acute Mechanical Benefit From VDD Pacing in Hypertrophied Heart
Pak, P. H., Maughan, W. L., Baughman, K. L., Kieval, R. S., & Kass, D. A. (1998) · Circulation · doi:10.1161/01.cir.98.3.242 · Cited by 101
Self-citation[Cardiac Transthyretin Amyloidosis].
Manganiello, C. F. (2020) · PubMed · Cited by 96
Tiller, D., Ruß, M., Greiser, K. H., Nuding, S., Ebelt, H., Kluttig, A., Kors, J. A., Thiery, J., Bruegel, M., Haerting, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059225 · Cited by 90
Yip, G. W., Ho, P. P. Y., Woo, K. S., & Sanderson, J. E. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00378-1 · Cited by 87
Shah, K. B., Kop, W. J., Christenson, R. H., Diercks, D. B., Henderson, S., Hanson, K., Li, S.-Y., & deFilippi, C. R. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.159277 · Cited by 85
Direct Left Atrial Pressure Monitoring in Severe Heart Failure: Long-Term Sensor Performance
the HOMEOSTASIS Investigators, Troughton, R. W., Ritzema, J., Eigler, N. L., Melton, I., Krum, H., Adamson, P. B., Kar, S., Shah, P. K., Whiting, J. S., et al. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9229-z · Cited by 82
Shah, S. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.010 · Cited by 79
Zile, M. R., & Baicu, C. F. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9472-1 · Cited by 71
Tsai, E. J., Liu, Y., Koitabashi, N., Bedja, D., Danner, T., Jasmin, J.-F., Lisanti, M. P., Friebe, A., Takimoto, E., & Kass, D. A. (2011) · Circulation Research · doi:10.1161/circresaha.111.259242 · Cited by 70
Self-citationMiura, M., Shiba, N., Nochioka, K., Takada, T., Takahashi, J. A., Kohno, H., & Shimokawa, H. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs001 · Cited by 69
Pressure-volume relation analysis of mouse ventricular function
Cingolani, O. H., & Kass, D. A. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00781.2011 · Cited by 67
Self-citationDecreased Cardiac Functional Reserve in Heart Failure With Preserved Systolic Function
Norman, H. S., Oujiri, J., LaRue, S., Chapman, C. B., Margulies, K. B., & Sweitzer, N. K. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.11.004 · Cited by 66
Pérez, N. G., Piaggio, M. R., Ennis, I. L., Garciarena, C. D., Morales, C., Escudero, E. M., Cingolani, O. H., de Cingolani, G. C., Yang, X.-P., & Cingolani, H. E. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087759 · Cited by 61
DIASTOLIC DYSFUNCTION IN THE ELDERLY
Kitzman, D. W. (2000) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70164-8 · Cited by 59
Hamdani, N., Paulus, W. J., van Heerebeek, L., Borbély, A., Boontje, N. M., Zuidwijk, M. J., Bronzwaer, J. G. F., Simonides, W. S., Niessen, H. W. M., Stienen, G. J. M., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp189 · Cited by 57
Ruşinaru, D., Buiciuc, O., Houpe, D., & Tribouilloy, C. M. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.529 · Cited by 51
Invasive Assessment of Pulmonary Hypertension
Borlaug, B. A. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000983 · Cited by 49
Pressure-overload magnitude-dependence of the anti-hypertrophic efficacy of PDE5A inhibition
Nagayama, T., Hsu, S., Zhang, M., Koitabashi, N., Bedja, D., Gabrielson, K. L., Takimoto, E., & Kass, D. A. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.12.008 · Cited by 48
Self-citationMangla, A., Kane, J., Beaty, E., Richardson, D., Powell, L. H., & Calvin, J. E. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.08.014 · Cited by 41
Lopshire, J. C., & Zipes, D. P. (2014) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-014-9547-7 · Cited by 39
Abraham, W. T. (2013) · EP Europace · doi:10.1093/europace/eut105 · Cited by 38
Puntawangkoon, C., Kitzman, D. W., Kritchevsky, S. B., Hamilton, C. A., Nicklas, B. J., Leng, X., Brubaker, P. H., & Hundley, W. G. (2009) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-11-48 · Cited by 37
Reil, J., Reil, G., & Böhm, M. (2009) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2009.09.002 · Cited by 32
Circulating Biomarkers in Patients with Heart Failure and Preserved Ejection Fraction
O’Meara, E., de Denus, S., Rouleau, J. L., & Desai, A. S. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0160-x · Cited by 30
Novel Therapies for Heart Failure: Focus on Anti‐Inflammatory Strategies
Ramasubbu, K., Oliveira, G., & Torre‐Amione, G. (2006) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2006.04790.x · Cited by 26
Kass, D. A., Chen, C.-H., Talbot, M. W., Rochitte, C. E., Lima, J. A. C., Berger, R. D., & Calkins, H. G. (1999) · Circulation · doi:10.1161/01.cir.100.8.807 · Cited by 24
Self-citationReview: Heart failure with preserved ejection fraction in African Americans.
Shah, S. (2012) · PubMed · Cited by 18
Observational Studies of Statins in Heart Failure with Preserved Systolic Function
Fukuta, H., & Little, W. C. (2008) · Heart Failure Clinics · doi:10.1016/j.hfc.2008.01.005 · Cited by 16
Kobayashi, M., Sakurai, S., Takaseya, T., Shiose, A., Kim, H.-I., Fujiki, M., Karimov, J. H., Dessoffy, R., MASSIELLO, A. L., Borowski, A. G., et al. (2012) · Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery · doi:10.1097/imi.0b013e31826f14ff · Cited by 15
Therapeutic potential of renal sympathetic denervation in patients with chronic heart failure
Böhm, M., Ewen, S., Linz, D., Reil, J.-C., Schirmer, S. H., Ukena, C., & Mahfoud, F. (2013) · EuroIntervention · doi:10.4244/eijv9sra21 · Cited by 13
Sildenafil and Exercise Capacity in Heart Failure
Guazzi, M., Bandera, F., & Forfia, P. R. (2013) · JAMA · doi:10.1001/jama.2013.7437 · Cited by 11
Solomon, S. D., Zile, M. R., Pieske, B. M., Voors, A. A., Shah, A. M., Kraigher‐Krainer, E., Shi, V. C., Bransford, T. L., Takeuchi, M., Gong, J., et al. (2012) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2012.10.006 · Cited by 6
Cited by
Sorted by citations
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap
Shah, S. J., Kitzman, D. W., Borlaug, B. A., van Heerebeek, L., Zile, M. R., Kass, D. A., & Paulus, W. J. (2016) · Circulation · doi:10.1161/circulationaha.116.021884 · Cited by 1,003
Self-citationNitrosative stress drives heart failure with preserved ejection fraction
Schiattarella, G. G., Altamirano, F. J., Tong, D., French, K. M., Villalobos, E., Kim, S. Y., Luo, X., Jiang, N., May, H. I., Wang, Z. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1100-z · Cited by 956
Self-citationKitzman, D. W., Brubaker, P., Morgan, T., Haykowsky, M., Hundley, G., Kraus, W. E., Eggebeen, J., & Nicklas, B. J. (2016) · JAMA · doi:10.1001/jama.2015.17346 · Cited by 921
Cardioimmunology: the immune system in cardiac homeostasis and disease
Świrski, F. K., & Nahrendorf, M. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0065-8 · Cited by 905
Obesity, Hypertension, and Cardiac Dysfunction
Mouton, A. J., Li, X., Hall, M. E., & Hall, J. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.312321 · Cited by 561
Metadata
- Authors
- Sharma, K., & Kass, D. A.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Circulation Research
- Published
- 2014-06-20
- Volume
- 115
- Issue
- 1
- Pages
- 79-96
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4146618
- OpenAlex
- W2527933700
- Cited by
- 508
- References
- 178
- Citations by year
- 2026: 21 · 2025: 21 · 2024: 42 · 2023: 31 · 2022: 36 · 2021: 48 · 2020: 53 · 2019: 44 · 2018: 53 · 2017: 63 · 2016: 42 · 2015: 43 · 2014: 10
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL114910, P01HL077180, R01HL119012, HL-077180, HL-119012, HL114910, T32HL007227)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- heart failure with preserved ejection fraction, left ventricular ejection fraction, heart failure pathophysiology, multiple organ failure, heart failure epidemiology, translational research, clinical trials, unmet medical needs
- MeSH terms
- Diastole, Energy Metabolism, Exercise Therapy, Heart Failure, Humans, Hypertension, Pulmonary, Inflammation, Stroke Volume, Systole, Ventricular Function, Left, Cyclic GMP-Dependent Protein Kinases, Muscle, Skeletal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
