The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Role of Autophagy in Vascular Biology
Open accessAbstract
There is increasing interest in the role of autophagic flux in maintaining normal vessel wall biology and a growing suspicion that autophagic dysregulation may be a common pathway through which vascular aging and associated pathologies develop. Within endothelial and smooth muscle cells, diverse but important triggers that range from oxidized lipids to β-amyloid seem to stimulate autophagosome formation potently. In addition, emerging evidence links autophagy to a wide array of vascular processes ranging from angiogenesis to calcification of the vessel wall. Alterations in autophagic flux are also increasingly being implicated in disease processes that include both atherosclerosis and pulmonary hypertension. Finally, recent insights point toward an important role of autophagy in the paracrine regulation of vasoactive substances from the endothelium. Here, we review the progress in understanding how autophagy can contribute to vascular biology and the emerging strategies to target this process for therapeutic benefit.
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Autophagy regulates lipid metabolism
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Autophagy in infection, inflammation and immunity
Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585
Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase
Ouimet, M., Franklin, V., Mak, E., Liao, X., Tabas, I., & Marcel, Y. L. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.023 · Cited by 774
Overexpression of Atg5 in mice activates autophagy and extends lifespan
Pyo, J.-O., Yoo, S.-M., Ahn, H.-H., Nah, J., Hong, S.-H., Kam, T.-I., Jung, S., & Jung, Y.-K. (2013) · Nature Communications · doi:10.1038/ncomms3300 · Cited by 721
Autophagy Links Inflammasomes to Atherosclerotic Progression
Razani, B., Feng, C., Coleman, T., Emanuel, R., Wen, H., Hwang, S., Ting, J. P., Virgin, H. W., Kastan, M. B., & Semenkovich, C. F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.011 · Cited by 601
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.
Lee, S.-J., Smith, A., Guo, L., Alastalo, T.-P., Li, M., Sawada, H., Liu, X., Chen, Z.-H., Ifedigbo, E., Jin, Y., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201005-0746oc · Cited by 217
Cited by
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919
Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors
Lopaschuk, G. D., & Verma, S. (2020) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2020.02.004 · Cited by 894
Self-citationVascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
Micro- and nanoplastics: A new cardiovascular risk factor?
Zhu, X., Wang, C., Duan, X., Liang, B., Genbo Xu, E., & Huang, Z. (2023) · Environment International · doi:10.1016/j.envint.2022.107662 · Cited by 273
Ketone body β -hydroxybutyrate is an autophagy-dependent vasodilator
McCarthy, C. G., Chakraborty, S., Singh, G., Yeoh, B. S., Schreckenberger, Z. J., Singh, A., Mell, B., Bearss, N. R., Yang, T., Cheng, X., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.149037 · Cited by 74
Metadata
- Authors
- Nussenzweig, S. C., Verma, S., & Finkel, T.
- Venue
- Circulation Research
- Published
- 2015-01-30
- Volume
- 116
- Issue
- 3
- Pages
- 480-488
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2119515848
- Cited by
- 244
- References
- 9
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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