The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases
Open accessAbstract
Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.
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Citations
Cites
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BackgroundMitochondrial Fission, Fusion, and Stress
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BackgroundInfluentialAutophagy and the Integrated Stress Response
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Cited by
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., & Murphy, M. P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.009 · Cited by 752
Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive Physiology · doi:10.1002/cphy.c160006 · Cited by 718
The Aging Cardiovascular System
Paneni, F., Diaz Cañestro, C., Libby, P., Lüscher, T. F., & Camici, G. G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.064 · Cited by 618
Wang, Y., Li, L., Zhao, W., Dou, Y., An, H., Tao, H., Xu, X., Jia, Y., Lu, S., Zhang, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02037 · Cited by 361
Impaired GAPDH‐induced mitophagy contributes to the pathology of Huntington's disease
Hwang, S., Disatnik, M., & Mochly‐Rosen, D. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505256 · Cited by 153
Self-citation
Metadata
- Authors
- Kornfeld, O. S., Hwang, S., Disatnik, M.-H., Chen, C.-H., Qvit, N., & Mochly-Rosen, D.
- Venue
- Circulation Research
- Published
- 2015-05-22
- Volume
- 116
- Issue
- 11
- Pages
- 1783-1799
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1943357032
- Cited by
- 212
- References
- 28
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Kornfeld, O. S., Hwang, S., Disatnik, M.-H., Chen, C.-H., Qvit, N., & Mochly-Rosen, D. (2015). Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases. Circulation Research. https://doi.org/10.1161/circresaha.116.305432
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