The DOI matches its Crossref record; 200 of the 201 references it cites were found in a registry or an index.
Pleiotropic Effects of Statins on the Cardiovascular System
Open accessAbstract
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis thereby upregulating the hepatic low-density lipoprotein (LDL) receptors and increasing the clearance of LDL-cholesterol. Statins may exert cardiovascular protective effects that are independent of LDL-cholesterol lowering called pleiotropic effects. Because statins inhibit the production of isoprenoid intermediates in the cholesterol biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins such as Rho and Rac, and their downstream effectors such as Rho kinase and nicotinamide adenine dinucleotide phosphate oxidases are also inhibited. In cell culture and animal studies, these effects alter the expression of endothelial nitric oxide synthase, the stability of atherosclerotic plaques, the production of proinflammatory cytokines and reactive oxygen species, the reactivity of platelets, and the development of cardiac hypertrophy and fibrosis. The relative contributions of statin pleiotropy to clinical outcomes, however, remain a matter of debate and are hard to quantify because the degree of isoprenoid inhibition by statins correlates to some extent with the amount of LDL-cholesterol reduction. This review examines some of the currently proposed molecular mechanisms for statin pleiotropy and discusses whether they could have any clinical relevance in cardiovascular disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Beyond the modification of blood lipid levels, in vitro and in vivo studies showed that statins exert beneficial cardioprotective pleiotropic effects [35, 36].”
From Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention (2023) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
3 retracted
Preoperative statin therapy for patients undergoing cardiac surgery
Liakopoulos, O. J., Kuhn, E. W., Slottosch, I., Wassmer, G., & Wahlers, T. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008493.pub2 · Cited by 145
RetractedPreoperative statin therapy for patients undergoing cardiac surgery
Kuhn, E. W., Slottosch, I., Wahlers, T., & Liakopoulos, O. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008493.pub3 · Cited by 53
RetractedPreoperative statin therapy for patients undergoing cardiac surgery
Kuhn, E. W., Slottosch, I., Wahlers, T., & Liakopoulos, O. J. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008493.pub4 · Cited by 21
RetractedOLSSON, A. G., McMurray, J. J. V., Thorgeirsson, G., Spaulding, C. M., Slattery, J., Pyörälà, K., Færgeman, O., Wright, R. S., Berg, K. M., Wilhelmsen, L., et al. (1994) · The Lancet · Cited by 8,467
Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
Shepherd, J., Cobbe, S. M., Ford, I., Isles, C. G., Lorimer, A. R., Macfarlane, P. W., McKillop, J. H., & Packard, C. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511163332001 · Cited by 7,449
Sacks, F. M., Pfeffer, M. A., Moye, L. A., Rouleau, J. L., Rutherford, J. D., Cole, T. G., Brown, L., Warnica, J. W., Arnold, J. M. O., Wun, C.-C., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351401 · Cited by 7,439
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Research works printed but not linked: 1
- 10.1056/NEJM199811053391902 · DOI · Paper page
Cited by
Sorted by citations
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz455 · Cited by 8,961
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854
Self-citationDementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Livingston, G., Huntley, J., Liu, K. Y., Costafreda, S. G., Selbæk, G., Alladi, S., Ames, D., Banerjee, S., Burns, A., Brayne, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01296-0 · Cited by 3,860
Xu, S., Ilyas, I., Little, P. J., Li, H., Kamato, D., Zheng, X., Luo, S., Li, Z., Liu, P., Han, J., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000096 · Cited by 1,205
The Role of Inflammation in Cardiovascular Disease
Henein, M. Y., Vancheri, S., Longo, G., & Vancheri, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112906 · Cited by 802
Mechanisms of Oxidative Stress in Metabolic Syndrome
Masenga, S. K., Kabwe, L. S., Chakulya, M., & Kirabo, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097898 · Cited by 816
Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
Marchio, P., Guerra‐Ojeda, S., Vila, J. M., Aldasoro, M., Víctor, V. M., & Mauricio, M. D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8563845 · Cited by 651
Duan, Y., Gong, K., Xu, S., Zhang, F., Meng, X., & Han, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01125-5 · Cited by 538
Polypill strategy in secondary cardiovascular prevention
Castellano, J. M., Pocock, S. J., Bhatt, D. L., Quesada, A. J., Owen, R., Fernandez-Ortiz, A., Sanchez, P. L., Marin Ortuño, F., Vazquez Rodriguez, J. M., Domingo-Fernández, A., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2208275 · Cited by 334
Platelet-derived chemokines in inflammation and atherosclerosis
Bakogiannis, C., Sachse, M., Stamatelopoulos, K. S., & Stellos, K. (2017) · Cytokine · doi:10.1016/j.cyto.2017.09.013 · Cited by 281
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
Wu, X., Xu, M., Geng, M., Chen, S., Little, P. J., Xu, S., & Weng, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01439-y · Cited by 295
Paone, S., Baxter, A. A., Hulett, M. D., & Poon, I. K. H. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2983-9 · Cited by 281
Drug-microbiota interactions: an emerging priority for precision medicine
Zhao, Q. C., Chen, Y., Huang, W., Zhou, H., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01619-w · Cited by 309
Lipid management in patients with chronic kidney disease
Ferro, C. J., Mark, P. B., Kanbay, M., Sarafidis, P. A., Heine, G. H., Rossignol, P., Massy, Z. A., Mallamaci, F., Valdivielso, J. M., Małyszko, J., et al. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0072-9 · Cited by 281
Effect of statins on atherosclerotic plaque
Almeida, S. O., & Budoff, M. J. (2019) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2019.01.001 · Cited by 275
Madhavan, M. V., Bikdeli, B., Gupta, A., Jiménez, D., Burton, J., Der-Nigoghossian, C. A., Chuich, T., Nouri, S. N., Dreyfus, I., Driggin, E., et al. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1713152 · Cited by 265
Ai, X., Yu, P., Peng, L., Luo, L., Liu, J., Li, S., Lai, X., Luan, F., & Meng, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762654 · Cited by 235
Wei, G., Lu, K., Umar, M., Zhu, Z., Lu, W. W., Speakman, J. R., Chen, Y., Tong, L., & Chen, D. (2023) · Bone Research · doi:10.1038/s41413-023-00301-9 · Cited by 248
Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD)
Battineni, G., Sagaro, G. G., Chintalapudi, N., Amenta, F., Tomassoni, D., & Tayebati, S. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094798 · Cited by 230
Olmastroni, E., Molari, G., De Beni, N., Colpani, O., Galimberti, F., Gazzotti, M., Zambon, A., Catapano, A. L., & Casula, M. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab208 · Cited by 197
Chu, C., Tseng, P., Stubbs, B., Chen, T., Tang, C.-H., Li, D., Yang, W., Chen, Y., Wu, C.-K., Veronese, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24248-8 · Cited by 191
Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms and Strategies for Cardioprotection
Morelli, M. B., Bongiovanni, C., Pra, S. D., Miano, C., Sacchi, F., Lauriola, M., & D’Uva, G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.847012 · Cited by 195
Giugliano, R. P., Pedersen, T. R., Saver, J. L., Sever, P. S., Keech, A. C., Bohula, E. A., Murphy, S. A., Wasserman, S. M., Honarpour, N., Wang, H., et al. (2020) · Stroke · doi:10.1161/strokeaha.119.027759 · Cited by 184
Gupta, A., Madhavan, M. V., Poterucha, T. J., DeFilippis, E. M., Hennessey, J. A., Redfors, B., Eckhardt, C. M., Bikdeli, B., Platt, J., Nalbandian, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21553-1 · Cited by 183
Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy
Vinci, P., Panizon, E., Tosoni, L. M., Cerrato, C., Pellicori, F., Mearelli, F., Biasinutto, C., Fiotti, N., Girolamo, F. G. D., & Biolo, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111687 · Cited by 188
Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Galli, M., Niccoli, G., Maria, G. L. D., Brugaletta, S., Montone, R. A., Vergallo, R., Benenati, S., Magnani, G., D’Amario, D., Porto, I., et al. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00953-4 · Cited by 177
Promoting Successful Cognitive Aging: A Ten-Year Update
Krivanek, T. J., Gale, S. A., McFeeley, B. M., Nicastri, C. M., & Daffner, K. R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201462 · Cited by 189
Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity
Jędrejko, K., Lazur, J., & Muszyńska, B. (2021) · Foods · doi:10.3390/foods10112634 · Cited by 172
Cholesterol and beyond - The role of the mevalonate pathway in cancer biology
Göbel, A., Rauner, M., Hofbauer, L. C., & Rachner, T. D. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188351 · Cited by 175
Pleiotropic effects of statins: A focus on cancer
Ahmadi, M., Amiri, S., Pecic, S., Machaj, F., Rosik, J., Łoś, M., Alizadeh, J., Mahdian, R., Rosa, S. C. D. S., Schaafsma, D., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165968 · Cited by 167
New insight into dyslipidemia‐induced cellular senescence in atherosclerosis
Xiang, Q., Tian, F., Xu, J. R., Du, X., Zhang, S., & Liu, L. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12866 · Cited by 169
P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology
Stokes, L., Layhadi, J. A., Bibič, L., Dhuna, K., & Fountain, S. J. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00291 · Cited by 150
Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer
Morofuji, Y., Nakagawa, S., Ujifuku, K., Fujimoto, T., Otsuka, K., Niwa, M., & Tsutsumi, K. (2022) · Pharmaceuticals · doi:10.3390/ph15020151 · Cited by 163
Jeong, A., Suazo, K. F., Wood, W. G., Distefano, M. D., & Li, L. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1458070 · Cited by 152
The Many Roles of Cholesterol in Sepsis: A Review
Hofmaenner, D. A., Kleyman, A., Press, A. T., Bauer, M. W., & Singer, M. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202105-1197tr · Cited by 152
Understanding the molecular mechanisms of statin pleiotropic effects
German, C. A., & Liao, J. K. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03492-6 · Cited by 160
Self-citationPravastatin for early‐onset pre‐eclampsia: a randomised, blinded, placebo‐controlled trial
Ahmed, A., Williams, D. J., Cheed, V., Middleton, L., Ahmad, S., Wang, K., Vince, A., Hewett, P. W., Spencer, K., Khan, K. S., et al. (2019) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16013 · Cited by 140
Cohen, H., Cuadrado, M. J., Erkan, D., Duarte‐García, A., Isenberg, D. A., Knight, J. S., Ortel, T. L., Rahman, A., Salmon, J. E., Tektonidou, M. G., et al. (2020) · Lupus · doi:10.1177/0961203320950461 · Cited by 170
Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics
He, L., Zhang, C., Chen, Q., Wang, L., & Huang, Y. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108152 · Cited by 141
Oxidized low‐density lipoprotein in inflammation‐driven thrombosis
Obermayer, G., Afonyushkin, T., & Binder, C. J. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13925 · Cited by 134
Hope, H. F., Binkley, G. M., Fenton, S. A. M., Kitas, G. D., Verstappen, S. M. M., & Symmons, D. P. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0201196 · Cited by 148
Guedeney, P., Claessen, B. E. P. M., Kalkman, D. N., Aquino, M. B., Sorrentino, S., Giustino, G., Farhan, S., Vogel, B., Sartori, S., Montalescot, G., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.01.077 · Cited by 134
Let thy food be thy medicine….when possible
Witkamp, R. F., & van Norren, K. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.026 · Cited by 131
Sagris, Μ., Antonopoulos, A. S., Simantiris, S., Oikonomou, E. K., Siasos, G., Tsioufis, K. P., & Tousoulis, D. (2022) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeac174 · Cited by 127
Storck, E. M., Morales‐Sanfrutos, J., Serwa, R. A., Panyain, N., Lanyon‐Hogg, T., Tolmachova, T., Ventimiglia, L. N., Martin‐Serrano, J., Seabra, M. C., Wójciak‐Stothard, B., et al. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0237-6 · Cited by 121
New Insights Into Targeting Membrane Lipids for Cancer Therapy
Preta, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.571237 · Cited by 132
Statins: Could an old friend help in the fight against COVID‐19?
Rodrigues-Díez, R. R., Tejera‐Muñoz, A., Márquez‐Expósito, L., Rayego‐Mateos, S., Santos‐Sanchez, L., Marchant, V. A., Tejedor-Santamaria, L., Ramos, A. M., Ortíz, A., Egido, J., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15166 · Cited by 121
Compliance With Guideline-Directed Medical Therapy in Contemporary Coronary Revascularization Trials
Pinho‐Gomes, A., Azevedo, L. F., Ahn, J., Park, S., Hamza, T. H., Farkouh, M. E., Serruys, P. W. J. C., Milojevic, M., Kappetein, A. P., Stone, G. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.068 · Cited by 125
Sadutto, D., Andreu, V., Ilo, T., Akkanen, J., & Picó, Y. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116353 · Cited by 116
Bukhari, S., Yaghi, S. R., & Bashir, Z. S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12154999 · Cited by 123
Role of oxidative stress in calcific aortic valve disease and its therapeutic implications
Greenberg, H. Z. E., Zhao, G., Shah, A. M., & Zhang, M. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab142 · Cited by 115
Emerging views of statin pleiotropy and cholesterol lowering
Yu, D., & Liao, J. K. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab032 · Cited by 113
Self-citationEstablished and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention
Michaeli, D. T., Michaeli, J. C., Albers, S., Boch, T., & Michaeli, T. (2023) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-023-00594-5 · Cited by 109
“Beyond the modification of blood lipid levels, in vitro and in vivo studies showed that statins exert beneficial cardioprotective pleiotropic effects [35, 36].”
BackgroundThe Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins
Murphy, C., Deplazes, E., Cranfield, C. G., & Garcia, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228745 · Cited by 119
Targeting the apelin system for the treatment of cardiovascular diseases
Chapman, F. A., Maguire, J. J., Newby, D. E., Davenport, A. P., & Dhaun, N. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad171 · Cited by 104
“78 Statins induce kruppel-like factor 2, an important regulator of endothelial cell homeostasis, and subsequently production of endothelial nitric oxide synthase and thrombomodulin.”
BackgroundFu, X., Sun, Z., Long, Q., Tan, W., Ding, H., Liu, X., Wu, L., Wang, Y., & Zhang, W. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154385 · Cited by 103
Statin Use and In‐Hospital Mortality in Patients With Diabetes Mellitus and COVID‐19
Saeed, O., Castagna, F., Agalliu, I., Xue, X., Patel, S. R., Rochlani, Y. M., Kataria, R., Vukelic, S., Sims, D. B., Alvarez, C., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.018475 · Cited by 101
Lipoproteins and cancer: The role of HDL-C, LDL-C, and cholesterol-lowering drugs
Patel, K. K., & Kashfi, K. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114654 · Cited by 105
Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure
Snelson, M., Muralitharan, R. R., Liu, C., Markó, L., Forslund, S. K., Marques, F. Z., & Tang, W. H. W. (2025) · Circulation Research · doi:10.1161/circresaha.125.325516 · Cited by 118
The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis
Pirillo, A., Bonacina, F., Norata, G. D., & Catapano, A. L. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0715-0 · Cited by 97
Statin treatment, oxidative stress and inflammation in a Danish population
Sørensen, A. L., Hasselbalch, H. C., Nielsen, C. H., Poulsen, H. E., & Ellervik, C. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101088 · Cited by 97
Pneumonia prevention in the elderly patients: the other sides
Chebib, N., Cuvelier, C., Malézieux-Picard, A., Parent, T., Roux, X., Fassier, T., Müller, F., & Prendki, V. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01437-7 · Cited by 113
Zhou, X., Kim, S. U., Yip, T. C., Petta, S., Nakajima, A., Tsochatzis, E. A., Boursier, J., Bugianesi, E., Hagström, H., Chan, W., et al. (2024) · Gut · doi:10.1136/gutjnl-2024-333074 · Cited by 94
Hoving, L. R., Katiraei, S., Heijink, M., Pronk, A. C. M., van der Wee-Pals, L. J. A., Streefland, T. C. M., Giera, M. A., van Dijk, K. W., & van Harmelen, V. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700942 · Cited by 93
Nitric oxide-enhancing or -releasing agents as antithrombotic drugs
Gresele, P., Momi, S., & Guglielmini, G. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.05.030 · Cited by 97
Hu, N., Chen, C., Wang, J., Huang, J. M., Yao, D., & Li, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011107 · Cited by 93
Das, D., Shruthi, N. R., Banerjee, A., Jothimani, G., Duttaroy, A. K., & Pathak, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1221438 · Cited by 90
Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice
Dutta, N. K., Bruiners, N., Zimmerman, M. D., Tan, S., Dartois, V. A., Gennaro, M. L., & Karakousis, P. C. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz517 · Cited by 90
Statins reduce vascular inflammation in atherogenesis: A review of underlying molecular mechanisms
Liberale, L., Carbone, F., Montecucco, F., & Sahebkar, A. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105735 · Cited by 91
Nasr, S. H., Rashidijahanabad, Z., Ramadan, S., Kauffman, N., Parameswaran, N., Zinn, K. R., Qian, C., Arora, R., Agnew, D., & Huang, X. (2020) · Nanoscale · doi:10.1039/d0nr00308e · Cited by 93
Strassheim, D., Gerasimovskaya, E. V., Irwin, D. C., Dempsey, E. C., Stenmark, K. R., & Karoor, V. (2019) · Cells · doi:10.3390/cells8060551 · Cited by 88
Aberrations in Lipid Expression and Metabolism in Psoriasis
Nowowiejska, J., Baran, A. M., & Flisiak, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126561 · Cited by 88
Ramanathan, N., Tan, E. T., Loh, L. J., Soh, B.-S., & Yap, W. N. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0244-4 · Cited by 92
Erythrocyte oxidative stress and thrombosis
Bettiol, A., Galora, S., Argento, F. R., Fini, E., Emmi, G., Mattioli, I., Bagni, G., Fiorillo, C., & Becatti, M. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.25 · Cited by 96
Mußbacher, M., Schossleitner, K., Kral-Pointner, J. B., Salzmann, M., Schrammel, A., & Schmid, J. A. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01023-9 · Cited by 86
Oesterle, A., & Liao, J. K. (2018) · Current Vascular Pharmacology · doi:10.2174/1570161116666180817155058 · Cited by 82
Self-citationNLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy
Parsamanesh, N., Moossavi, M., Bahrami, A., Fereidouni, M., Barreto, G. E., & Sahebkar, A. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.05.006 · Cited by 87
The MEK5/ERK5 Pathway in Health and Disease
Paudel, R., Fusi, L., & Schmidt, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147594 · Cited by 85
Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS
Yin, G., Huang, J., Petela, J., Jiang, H., Zhang, Y., Gong, S., Wu, J., Liu, B., Shi, J., & Gao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01441-4 · Cited by 98
Targeting Mitochondrial Calcium Handling and Reactive Oxygen Species in Heart Failure
Dietl, A., & Maack, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0347-7 · Cited by 89
Trinkmann, F., Saur, J., Borggrefe, M. M., & Akın, İ. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010069 · Cited by 84
Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments
Morris, G., Puri, B. K., OLIVE, L. S., Carvalho, A. F., Berk, M., Walder, K. R., Gustad, L. T., & Maes, M. H. J. (2020) · BMC Medicine · doi:10.1186/s12916-020-01749-w · Cited by 88
Caligiuri, G. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz132 · Cited by 83
Leisegang, M. S., Bibli, S., Günther, S., Pflüger‐Müller, B., Oo, J. A., Höper, C., Seredinski, S., Yekelchyk, M., Schmitz‐Rixen, T., Schürmann, C., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz393 · Cited by 83
Bland, A. R., Payne, F. M., Ashton, J. C., Jamialahmadi, T., & Sahebkar, A. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105986 · Cited by 82
The Health Costs of Cost-Sharing
Chandra, A., Flack, E., & Obermeyer, Z. (2021) · National Bureau of Economic Research · doi:10.3386/w28439 · Cited by 87
Paciullo, F., Momi, S., & Gresele, P. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1676863 · Cited by 83
Chen, P., Wu, M., He, Y., Jiang, B., & He, M. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01510-8 · Cited by 89
Boban, M. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13868 · Cited by 80
Zhang, Y., Wang, Y., Zhang, L., Xia, L., Zheng, M., Zeng, Z., Liu, Y., Yarovinsky, T. O., Ostriker, A. C., Fan, X., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316951 · Cited by 79
Effect of statin therapy on SARS-CoV-2 infection-related mortality in hospitalized patients
Masana, L., Correig, E., Rodríguez-Borjabad, C., Anoro, E., Arroyo, J. A., Jericó, C. R., Pedragosa, À., Miret, M., Näf, S., Pardo, A., et al. (2020) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvaa128 · Cited by 78
Silveira, É. A., Vaseghi, G., Santos, A. S. E. A. D. C., Kliemann, N., Masoudkabir, F., Noll, M. A., Mohammadifard, N., Sarrafzadegan, N., & de Oliveira, C. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239042 · Cited by 84
Vassalle, C., Maltinti, M., & Sabatino, L. (2020) · Molecules · doi:10.3390/molecules25112653 · Cited by 79
From Mitochondria to Atherosclerosis: The Inflammation Path
Suarez-Rivero, J. M., Pastor‐Maldonado, C. J., Povea-Cabello, S., Álvarez-Córdoba, M., Villalón-García, I., Talaverón-Rey, M., Suárez-Carrillo, A., Munuera-Cabeza, M., & Sánchez-Alcázar, J. A. (2021) · Biomedicines · doi:10.3390/biomedicines9030258 · Cited by 78
Preeclampsia: Linking Placental Ischemia with Maternal Endothelial and Vascular Dysfunction
Bakrania, B. A., Spradley, F. T., Drummond, H. A., LaMarca, B. B., Ryan, M. J., & Granger, J. P. (2020) · Comprehensive physiology · doi:10.1002/cphy.c200008 · Cited by 118
Ramaswami, U., Humphries, S. E., Priestley-Barnham, L., Green, P., Wald, D. S., Capps, N. E., Anderson, M., Dale, P., & Morris, A. A. M. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.09.005 · Cited by 75
Zhang, X., Qin, Y., Wan, X., Liu, H., Lv, C., Ruan, W., He, L., Lü, L., & Guo, X. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02727-3 · Cited by 75
Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients
Diaz‐Arocutipa, C., Melgar-Talavera, B., Yarasca, Á. A., Saravia-Bartra, M. M., Cazorla, P., Padilla, O. I. B., & Hernández, A. V. (2021) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2021.08.004 · Cited by 74
Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension
Fulton, D. J., Li, X., Bordán, Z., Haigh, S. B., Bentley, A., Chen, F., & Barman, S. A. (2017) · Antioxidants · doi:10.3390/antiox6030054 · Cited by 77
Tavakkoli, A., Johnston, T. P., & Sahebkar, A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107483 · Cited by 73
Metadata
- Authors
- Oesterle, A., Laufs, U., & Liao, J. K.
- Affiliations
- University of Chicago (US)
- Venue
- Circulation Research
- Published
- 2017-01-06
- Volume
- 120
- Issue
- 1
- Pages
- 229-243
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC5467317
- OpenAlex
- W2570787279
- Semantic Scholar
- a6f953b7ad2110e4c1c93c3e33f8539676113484
- Cited by
- 1,247
- References
- 201
- Citations by year
- 2026: 120 · 2025: 136 · 2024: 144 · 2023: 142 · 2022: 159 · 2021: 177 · 2020: 150 · 2019: 100 · 2018: 79 · 2017: 37
- FWCI
- 21.24
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-09-27)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL136962, R01HL052233)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- statins, pleiotropy, cardioprotection, Rho kinase, NADPH oxidase, endothelial nitric oxide synthase, prenylation, atherosclerotic plaque stability, inflammation, platelet reactivity, cardiac hypertrophy, fibrosis, LDL cholesterol lowering
- MeSH terms
- Animals, Cardiovascular Diseases, Cardiovascular System, Clinical Trials as Topic, Humans, Cholesterol, LDL, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Genetic Pleiotropy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
