The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice
Open accessAbstract
Rationale: Stem cell therapy faces several challenges. It is difficult to grow, preserve, and transport stem cells before they are administered to the patient. Synthetic analogs for stem cells represent a new approach to overcome these hurdles and hold the potential to revolutionize regenerative medicine. Objective: We aim to fabricate synthetic analogs of stem cells and test their therapeutic potential for treatment of acute myocardial infarction in mice. Methods and Results: We packaged secreted factors from human bone marrow–derived mesenchymal stem cells (MSC) into poly(lactic-co-glycolic acid) microparticles and then coated them with MSC membranes. We named these therapeutic particles synthetic MSC (or synMSC). synMSC exhibited a factor release profile and surface antigens similar to those of genuine MSC. synMSC promoted cardiomyocyte functions and displayed cryopreservation and lyophilization stability in vitro and in vivo. In a mouse model of acute myocardial infarction, direct injection of synMSC promoted angiogenesis and mitigated left ventricle remodeling. Conclusions: We successfully fabricated a synMSC therapeutic particle and demonstrated its regenerative potential in mice with acute myocardial infarction. The synMSC strategy may provide novel insight into tissue engineering for treating multiple diseases.
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Cites
Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
Lai, R. C., Chen, T. S., & Lim, S. K. (2011) · Regenerative Medicine · doi:10.2217/rme.11.35 · Cited by 553
Cited by
Challenges and advances in clinical applications of mesenchymal stromal cells
Zhou, T., Yuan, Z., Weng, J., Pei, D., Du, X., He, C., & Lai, P. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01037-x · Cited by 712
Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., Zhang, X., Wu, G., & Zhou, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17620 · Cited by 455
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Dinh, P.-U. C., Paudel, D., Brochu, H., Popowski, K. D., Gracieux, M. C., Cores, J., Huang, K., Hensley, M. T., Harrell, E., Vandergriff, A. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14344-7 · Cited by 435
Self-citationQiao, L., Hu, S., Liu, S., Zhang, H., Ma, H., Huang, K., Li, Z., Su, T., Vandergriff, A., Tang, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123135 · Cited by 303
Self-citationStem cell secretome, regeneration, and clinical translation: a narrative review
Gwam, C., Mohammed, N., & Ma, X. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5030 · Cited by 72
Metadata
- Authors
- Luo, L., Tang, J., Nishi, K., Yan, C., Dinh, P.-U., Cores, J., Kudo, T., Zhang, J., Li, T.-S., & Cheng, K.
- Venue
- Circulation Research
- Published
- 2017-05-26
- Volume
- 120
- Issue
- 11
- Pages
- 1768-1775
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2603453711
- Cited by
- 208
- References
- 1
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Luo, L., Tang, J., Nishi, K., Yan, C., Dinh, P.-U., Cores, J., Kudo, T., Zhang, J., Li, T.-S., & Cheng, K. (2017). Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice. Circulation Research. https://doi.org/10.1161/circresaha.116.310374
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