Stem cell secretome, regeneration, and clinical translation: a narrative review

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310 · see citing works

miRBase: integrating microRNA annotation and deep-sequencing data

Kozomara, A., & Griffiths-Jones, S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1027 · Cited by 3,042 · see citing works

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730 · see citing works

Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells

Gnecchi, M., He, H., Liang, O. D., Melo, L. G., Morello, F., Mu, H., Noiseux, N., Zhang, L., Pratt, R. E., Ingwall, J. S., et al. (2005) · Nature Medicine · doi:10.1038/nm0405-367 · Cited by 1,677 · see citing works

Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000305204.97355.0d · Cited by 1,174 · see citing works

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

Xin, H., Li, Y., Cui, Y., Yang, J. J., Zhang, Z. G., & Chopp, M. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.152 · Cited by 985 · see citing works

Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration

Talman, V., & Ruskoaho, H. J. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2431-9 · Cited by 921 · see citing works

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration

Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2018) · Theranostics · doi:10.7150/thno.29766 · Cited by 914 · see citing works

Moving beyond the glial scar for spinal cord repair

Bradbury, E. J., & Burnside, E. R. (2019) · Nature Communications · doi:10.1038/s41467-019-11707-7 · Cited by 748 · see citing works

Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs

Weiß, A. R. R., & Dahlke, M. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01191 · Cited by 695 · see citing works

Stem Cells Applications in Regenerative Medicine and Disease Therapeutics

Mahla, R. S. (2016) · International Journal of Cell Biology · doi:10.1155/2016/6940283 · Cited by 620 · see citing works

Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography−Tandem Mass Spectrometry

Tabb, D. L., Vega-Montoto, L., Rudnick, P. A., Variyath, A. M., Ham, A.-J. L., Bunk, D. M., Kilpatrick, L. E., Billheimer, D. D., Blackman, R. K., Cardasis, H. L., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr9006365 · Cited by 551 · see citing works

Induced Pluripotent Stem Cell Lines Derived From Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz‐Bourget, J., Frane, J. L., Tian, S., Nie, J., Jónsdóttir, G. A., Ruotti, V., Stewart, R. M., et al. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000305193.72586.39 · Cited by 514 · see citing works

Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration

Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., Akimoto, T., Higashi, Y., & Ochi, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.03.031 · Cited by 511 · see citing works

Spheroid Culture of Mesenchymal Stem Cells

Cesarz, Z., & Tamama, K. (2016) · Stem Cells International · doi:10.1155/2016/9176357 · Cited by 475 · see citing works

Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

Pawitan, J. A. (2014) · BioMed Research International · doi:10.1155/2014/965849 · Cited by 467 · see citing works

Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms

Mead, B., & Tomarev, S. I. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0428 · Cited by 464 · see citing works

Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

Qin, Y., Wang, L., Gao, Z., Chen, G., & Zhang, C. (2016) · Scientific Reports · doi:10.1038/srep21961 · Cited by 458 · see citing works

The Costs of using Unauthenticated, Over-Passaged Cell Lines: How Much more Data do we Need?

Hughes, P., Marshall, D., Reid, Y., Parkes, H., & Gelber, C. (2007) · BioTechniques · doi:10.2144/000112598 · Cited by 434 · see citing works

An Introduction to Hydrogels and Some Recent Applications

Bahram, M., Mohseni, N., & Moghtader, M. (2016) · InTech eBooks · doi:10.5772/64301 · Cited by 368 · see citing works

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

Ferguson, S. W., Wang, J., Lee, C. J., Liu, M., Neelamegham, S., Canty, J. M., & Nguyen, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-19581-x · Cited by 360 · see citing works

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

THIERS, B. H. (2008) · Yearbook of Dermatology and Dermatologic Surgery · doi:10.1016/s0093-3619(08)70914-6 · Cited by 348 · see citing works

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

Teixeira, F. G., Carvalho, M. M., Sousa, N., & Salgado, A. J. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1290-8 · Cited by 332 · see citing works

Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications

Eleuteri, S., & Fierabracci, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184597 · Cited by 302 · see citing works

Donor dendritic cell–derived exosomes promote allograft-targeting immune response

Liu, Q., Rojas-Canales, D. M., Divito, S. J., Shufesky, W. J., Stolz, D. B., Erdos, G., Sullivan, M. L. G., Gibson, G. A., Watkins, S. C., Larregina, A. T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84577 · Cited by 302 · see citing works

Hypoxic preconditioning enhances the therapeutic potential of the secretome from cultured human mesenchymal stem cells in experimental traumatic brain injury

Chang, C.-P., Chio, C.-C., Cheong, C.-U., Chao, C.-M., Cheng, B.-C., & Lin, M.-T. (2013) · Clinical Science · doi:10.1042/cs20120226 · Cited by 287 · see citing works

Stem cells as drug delivery methods: Application of stem cell secretome for regeneration

Tran, C., & Damaser, M. S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.007 · Cited by 280 · see citing works

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

Charoenviriyakul, C., Takahashi, Y., Morishita, M., Matsumoto, A., Nishikawa, M., & Takakura, Y. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.10.009 · Cited by 280 · see citing works

Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair

Han, C., Zhou, J., Liang, C., Liu, B., Pan, X., Zhang, Y., Wang, Y., Yan, B., Xie, W., Liu, F., et al. (2019) · Biomaterials Science · doi:10.1039/c9bm00101h · Cited by 278 · see citing works

A revealing review of mesenchymal stem cells therapy, clinical perspectives and Modification strategies

Saeedi, P., Halabian, R., & Imani Fooladi, A. A. (2019) · Stem Cell Investigation · doi:10.21037/sci.2019.08.11 · Cited by 251 · see citing works

Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing

Park, S.-R., Kim, J.-W., Jun, H., Roh, J. Y., Lee, H., & Hong, I. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.09.023 · Cited by 245 · see citing works

Current developments in LC-MS for pharmaceutical analysis

Beccaria, M., & Cabooter, D. (2020) · The Analyst · doi:10.1039/c9an02145k · Cited by 242 · see citing works

Emergence of the Stem Cell Secretome in Regenerative Engineering

Daneshmandi, L., Shah, S., Jafari, T., Bhattacharjee, M., Momah, D., Shemshaki, N. S., Lo, K. W. ‐., & Laurencin, C. T. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.04.013 · Cited by 230 · see citing works

A Good Manufacturing Practice–grade standard protocol for exclusively human mesenchymal stromal cell–derived extracellular vesicles

Pachler, K., Lener, T., Streif, D., Dunai, Z. A., Desgeorges, A., Feichtner, M., Oeller, M., Schallmoser, K., Rohde, E., & Gimona, M. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.01.001 · Cited by 222 · see citing works

Novel Cell-Free Strategy for Therapeutic Angiogenesis: In Vitro Generated Conditioned Medium Can Replace Progenitor Cell Transplantation

Santo, S. D., Yang, Z., von Ballmoos, M. C. W., Völzmann, J., Diehm, N., Baumgärtner, I., & Kalka, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005643 · Cited by 219 · see citing works

Overview of Protein Microarrays

Sutandy, F. X. R., Qian, J. X., Chen, C., & Zhu, H. (2013) · Current Protocols in Protein Science · doi:10.1002/0471140864.ps2701s72 · Cited by 218 · see citing works

Changes in Regenerative Capacity through Lifespan

Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works

Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

Luo, L., Tang, J., Nishi, K., Chen, Y., Dinh, P., Cores, J., Kudo, T., Zhang, J., Li, T., & Cheng, K. (2017) · Circulation Research · doi:10.1161/circresaha.116.310374 · Cited by 208 · see citing works

Stem cell-based regenerative medicine

Rajabzadeh, N., Fathi, E., & Farahzadi, R. (2019) · Stem Cell Investigation · doi:10.21037/sci.2019.06.04 · Cited by 201 · see citing works

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, R., Mellows, B., Sheard, J., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M.-T., Tomkins, J. E., Denecke, B., Musante, L., et al. (2019) · Stem cell research & therapeutics · doi:10.1186/s13287-019-1213-1 · Cited by 186 · see citing works

Degradation dynamics of microRNAs revealed by a novel pulse-chase approachPreprint

Marzi, M. J., Ghini, F., Cerruti, B., de Pretis, S., Bonetti, P., Giacomelli, C., Gorski, M. M., Kress, T. R., Pelizzola, M., Müller, H., et al. (2016) · Genome Research · doi:10.1101/gr.198788.115 · Cited by 184 · see citing works

Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics

Phelps, J., Sanati‐Nezhad, A., Ungrin, M., Duncan, N. A., & Sen, A. (2018) · Stem Cells International · doi:10.1155/2018/9415367 · Cited by 181 · see citing works

Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion

Park, B.-S., Kim, W., Choi, J., Kim, H.-K., Won, J.-H., Ohkubo, F., & Fukuoka, H. (2010) · Biomedical Research · doi:10.2220/biomedres.31.27 · Cited by 178 · see citing works

The potential and limitations of induced pluripotent stem cells to achieve wound healing

Gorecka, J., Kostiuk, V., Fereydooni, A., Gonzalez, L., Luo, J., Dash, B., Isaji, T., Ono, S., Liu, S., Lee, S.-R., et al. (2019) · Stem cell research & therapeutics · doi:10.1186/s13287-019-1185-1 · Cited by 168 · see citing works

Optimization of human mesenchymal stem cell manufacturing: the effects of animal/xeno-free media

Oikonomopoulos, A., van Deen, W. K., Manansala, A.-R., Lacey, P. N., Tomakili, T. A., Ziman, A. F., & Hommes, D. W. (2015) · Scientific Reports · doi:10.1038/srep16570 · Cited by 167 · see citing works

Stem cell-inspired secretome-rich injectable hydrogel to repair injured cardiac tissue

Waters, R., Alam, P., Pacelli, S., Chakravarti, A. R., Ahmed, R. P. H., & Paul, A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.12.025 · Cited by 165 · see citing works

Mesenchymal Stem Cell-Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis

Kay, A. G., Long, G., Tyler, G., Stefan, A. L., Broadfoot, S. J., Piccinini, A. M., Middleton, J., & Kehoe, O. (2017) · Scientific Reports · doi:10.1038/s41598-017-18144-w · Cited by 152 · see citing works

Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation

Sagaradze, G., Grigorieva, O., Nimiritsky, P., Basalova, N., Kalinina, N., Akopyan, Z., & Efimenko, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071656 · Cited by 147 · see citing works

Current applications of antibody microarrays

Chen, Z., Dodig‐Crnković, T., Schwenk, J. M., & Tao, S. (2018) · Clinical Proteomics · doi:10.1186/s12014-018-9184-2 · Cited by 121 · see citing works

Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF- κ B/TNF- α Signaling Pathway

Zhu, B. T., Zhang, L., Liang, C., Liu, B., Pan, X., Wang, Y., Zhang, Y., Zhang, Y., Xie, W., Yan, B., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9739258 · Cited by 121 · see citing works

Exosomes from adipose‑derived stem cells promote chondrogenesis and suppress inflammation by upregulating miR‑145 and miR‑221

Zhao, C., Chen, J., Peng, W., Yuan, B., Bi, Q., & Xu, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.10982 · Cited by 119 · see citing works

Improved Function and Myocardial Repair of Infarcted Heart by Intracoronary Injection of Mesenchymal Stem Cell-Derived Growth Factors

Nguyen, B.-K., Maltais, S., Perrault, L. P., Tanguay, J., Tardif, J., Stevens, L., Borie, M., Harel, F., Mansour, S., & Noiseux, N. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9171-0 · Cited by 113 · see citing works

Oxygen Tension Regulates Human Mesenchymal Stem Cell Paracrine Functions

Paquet, J., Deschepper, M., Moya, A., Logeart‐Avramoglou, D., Boisson‐Vidal, C., & Petite, H. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0180 · Cited by 102 · see citing works

Changes in the secretome of tri-dimensional spheroid-cultured human mesenchymal stem cells in vitro by interleukin-1 priming

Redondo‐Castro, E., Cunningham, C. J., Miller, J., Brown, H. C., Allan, S. M., & Pinteaux, E. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0753-5 · Cited by 101 · see citing works

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF

Martins, L. F., Costa, R. O., Pedro, J. R., Aguiar, P., Serra, S. C., Teixeira, F. G., Sousa, N., Salgado, A. J., & Almeida, R. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-03592-1 · Cited by 97 · see citing works

Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via paracrine mechanisms

Wang, Y., Guo, Z., Sun, X., Xu, X., & Peng, J. C. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.155442 · Cited by 96 · see citing works

Biologic Therapies for the Treatment of Knee Osteoarthritis

Delanois, R. E., Etcheson, J. I., Sodhi, N., Henn, R. F., Gwam, C. U., George, N. E., & Mont, M. A. (2018) · The Journal of Arthroplasty · doi:10.1016/j.arth.2018.12.001 · Cited by 86 · see citing works

CD133 Identifies a Human Bone Marrow Stem/Progenitor Cell Sub-population With a Repertoire of Secreted Factors That Protect Against Stroke

Bakondi, B., Shimada, I. S., Perry, A. S., Munoz, J. R., Ylöstalo, J., Howard, A., Gregory, C. A., & Spees, J. L. (2009) · Molecular Therapy · doi:10.1038/mt.2009.185 · Cited by 85 · see citing works

Protein microarrays for antibody profiling: Specificity and affinity determination on a chip

Poetz, O., Ostendorp, R., Brocks, B., Schwenk, J. M., Stoll, D., Joos, T. O., & Templin, M. F. (2005) · PROTEOMICS · doi:10.1002/pmic.200401299 · Cited by 83 · see citing works

The Applications and Features of Liquid Chromatography‐Mass Spectrometry in the Analysis of Traditional Chinese Medicine

Pang, B.-Y., Zhu, Y., Lu, L.-Q., Gu, F., & Chen, H. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/3837270 · Cited by 81 · see citing works

Secretome from hypoxia-conditioned adipose-derived mesenchymal stem cells promotes the healing of gastric mucosal injury in a rodent model

Xia, X., Chiu, P. W. Y., Lam, P. K., Chin, W., Ng, E. K., & Lau, J. Y. W. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.10.009 · Cited by 70 · see citing works

The superiority of conditioned medium derived from rapidly expanded mesenchymal stem cells for neural repair

Chen, Y.-T., Tsai, M., Hsieh, N. N., Lo, M.-J., Lee, M.-J., Cheng, H., & Huang, W. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1491-7 · Cited by 54 · see citing works

Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis

Venugopal, C., Shamir, C., Senthilkumar, S., Babu, J. V., Sonu, P. K., Nishtha, K. J., Rai, K. S., Shobha, K., & Dhanushkodi, A. (2018) · Current Gene Therapy · doi:10.2174/1566523218666180125091952 · Cited by 51 · see citing works

Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury

Shologu, N., Scully, M., Laffey, J. G., & O’Toole, D. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102996 · Cited by 51 · see citing works

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

Gutbier, S., May, P., Berthelot, S., Krishna, A., Trefzer, T., Behbehani, M., Efremova, L., Delp, J., Gstraunthaler, G., Waldmann, T., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2326-5 · Cited by 49 · see citing works

Secretome of Human Fetal Mesenchymal Stem Cell Ameliorates Replicative Senescence

Wang, B., Lee, W., Huang, B., Zhang, J., Wu, T., Jiang, X., Wang, C. C., & Li, G. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0079 · Cited by 44 · see citing works

Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media

Guo, L., Rolfe, A., Wang, X., Tai, W., Cheng, Z.-J., Cao, K., Chen, X.-M., Xu, Y.-S., Sun, D.-M., Li, J.-H., et al. (2016) · Molecular Brain · doi:10.1186/s13041-016-0233-3 · Cited by 42 · see citing works

In-Depth Proteomic Quantification of Cell Secretome in Serum-Containing Conditioned Medium

Weng, Y., Sui, Z., Shan, Y., Jiang, H., Zhou, Y., Zhu, X., Liang, Z., Zhang, L., & Zhang, Y. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00910 · Cited by 40 · see citing works

Comparison of Teratoma Formation between Embryonic Stem Cells and Parthenogenetic Embryonic Stem Cells by Molecular Imaging

Tao, H., Chen, X., Wei, A., Song, X., Wang, W., Liang, L., Zhao, Q., Han, Z., Han, Z., Wang, X., et al. (2018) · Stem Cells International · doi:10.1155/2018/7906531 · Cited by 35 · see citing works

Embryonic Versus Adult Stem Cells

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The conditioned medium of human mesenchymal stromal cells reduces irradiation-induced damage in cardiac fibroblast cells

Chen, Z.-Y., Hu, Y., Hu, X.-F., & Cheng, L. (2018) · Journal of Radiation Research · doi:10.1093/jrr/rry048 · Cited by 29 · see citing works

Antioxidant action of hypoxic conditioned media from adipose-derived stem cells in the hepatic injury of expressing higher reactive oxygen species

Hong, H., Kim, O., Kwak, B. J., Choi, H. J., im, K.-H., Ahn, J., & Kim, S. (2019) · Annals of Surgical Treatment and Research · doi:10.4174/astr.2019.97.4.159 · Cited by 21 · see citing works

Therapeutic Window, a Critical Developmental Stage for Stem Cell Therapies

Li, S. C., Han, Y., Dethlefs, B. A., & Loudon, W. G. (2010) · Current Stem Cell Research & Therapy · doi:10.2174/157488810793351730 · Cited by 21 · see citing works

A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of the Proteins Secreted by Human Adipose-Derived Mesenchymal Stem Cells

Nakashima, Y., Nahar, S., Miyagi‐Shiohira, C., Kinjo, T., Toyoda, Z., Kobayashi, N., Saitoh, I., Watanabe, M., Fujita, J., & Noguchi, H. (2018) · Cell Transplantation · doi:10.1177/0963689718795096 · Cited by 19 · see citing works

Stem cell industry update: 2012 to 2016 reveals accelerated investment, but market capitalization and earnings lag

Ng, M. K., Song, S., Piuzzi, N. S., Ng, K., Gwam, C. U., Mont, M. A., & Muschler, G. F. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.07.006 · Cited by 18 · see citing works

Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes

Xu, X., Li, D., Li, X., Shi, Q., & Ju, X. (2017) · BMC Immunology · doi:10.1186/s12865-017-0232-x · Cited by 18 · see citing works

Regenerative potential of the cartilaginous tissue in mesenchymal stem cells: update, limitations, and challenges

da Cruz, I. B. M., Severo, A. L., Azzolin, V. F., Garcia, L. F. M., Kuhn, A., & Lech, O. (2016) · Revista Brasileira de Ortopedia (English Edition) · doi:10.1016/j.rboe.2016.11.005 · Cited by 17 · see citing works

Bone mesenchymal stem cell‐conditioned medium attenuates the effect of oxidative stress injury on NSCs by inhibiting the Notch1 signaling pathway

Niu, Y., Xia, X., Song, P., Fang, H., Dong, F., Tao, H., Yang, C., & Shen, C. (2019) · Cell Biology International · doi:10.1002/cbin.11126 · Cited by 15 · see citing works

Proteome Profiling of Membrane-Free Stem Cell Components by Nano-LS/MS Analysis and Its Anti-Inflammatory Activity

Saralamma, V. V. G., Vetrivel, P., Kim, S. M., Ha, S. E., Lee, H. J., Lee, S. J., Kim, Y. S., Pak, J. E., Lee, H. J., Heo, J., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/4683272 · Cited by 15 · see citing works

Exploiting Human CD34+ Stem Cell–conditioned Medium for Tissue Repair

Mintz, P. J., Huang, K., Reebye, V., Nteliopoulos, G., Lai, H., Sætrom, P., Kasahara, N., Jensen, S. L., Pai, M., Gordon, M. Y., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.194 · Cited by 12 · see citing works

Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors

Noguchi, H., Miyagi‐Shiohira, C., Nakashima, Y., Kinjo, T., Kobayashi, N., Saitoh, I., Watanabe, M., Shapiro, A. M. J., & Kin, T. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.01.011 · Cited by 11 · see citing works

Proteomic Analysis of Secreted Proteins from Cell Microenvironment

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Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?

Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 205 · see citing works

Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

Bar, J. K., Lis-Nawara, A., & Grelewski, P. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112018 · Cited by 142 · see citing works

Adipogenesis or osteogenesis: destiny decision made by mechanical properties of biomaterials

Su, T., Xu, M., Lu, F., & Chang, Q. (2022) · RSC Advances · doi:10.1039/d2ra02841g · Cited by 56 · see citing works

Secretome Analysis: Reading Cellular Sign Language to Understand Intercellular Communication

Wu, W., & Krijgsveld, J. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100692 · Cited by 34 · see citing works

Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Potential Therapeutic Strategy for Acute Kidney Injury

Li, J.-K., Yang, C., Su, Y., Luo, J., Luo, M.-H., Huang, D.-L., Tu, G.-W., & Luo, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.684496 · Cited by 33 · see citing works

A Novel Deer Antler‐Inspired Bone Graft Triggers Rapid Bone Regeneration

Li, S., Yang, Y., Yu, B., Gao, X., Gao, X., Nie, S., Qin, T., Hao, Y., Guo, L., Wu, H., et al. (2024) · Advanced Materials · doi:10.1002/adma.202411571 · Cited by 27 · see citing works

Induced Pluripotent (iPSC) and Mesenchymal (MSC) Stem Cells for In Vitro Disease Modeling and Regenerative Medicine

Panferov, E., Dodina, M., Reshetnikov, V. V., Ryapolova, A., Ivanov, R. A., Karabelsky, A. V., & Minskaia, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125617 · Cited by 25 · see citing works

Strategies to improve the therapeutic efficacy of mesenchymal stem cell‐derived extracellular vesicle (MSC-EV): a promising cell-free therapy for liver disease

Zheng, L., Gong, H., Zhang, J., Guo, L., Zhai, Z., Xia, S., Hu, Z., Chang, J., Jiang, Y., Huang, X., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1322514 · Cited by 25 · see citing works

APPLICATION OF MULTIPOTENT MESENCHYMAL STEM CELL SECRETOME IN THE TREATMENT OF ADJUVANT ARTHRITIS AND CONTACT-ALLERGIC DERMATITIS IN ANIMAL MODELS

Александровна, Г. П., Sarycheva, M. V., Dolzhikov, A. A., Bondarev, V. P., Stefanova, M., Soldatov, V. O., Nadezhdin, S. V., Корокин, М. В., Pokrovsky, M. V., & Burda, Y. E. (2021) · Pharmacy & Pharmacology · doi:10.19163/2307-9266-2020-8-6-416-425 · Cited by 23 · see citing works

Mesenchymal Stem Cell Secretome: Potential Applications in Human Infertility Caused by Hormonal Imbalance, External Damage, or Immune Factors

Kavaldzhieva, K., Mladenov, N., Markova, M. D., & Belemezova, K. (2025) · Biomedicines · doi:10.3390/biomedicines13030586 · Cited by 23 · see citing works

Engineerable mesenchymal stem cell-derived extracellular vesicles as promising therapeutic strategies for pulmonary fibrosis

Chen, Y., Li, M., Yang, J., Chen, Y., & Wang, J. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04490-4 · Cited by 22 · see citing works

Secretome as a Tool to Treat Neurological Conditions: Are We Ready?

da Silva, A. V., Serrenho, I., Araújo, B. S. G. D. S. P., Carvalho, A. M., & Baltazar, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216544 · Cited by 22 · see citing works

Engineering Innervated Musculoskeletal Tissues for Regenerative Orthopedics and Disease Modeling

Zhou, Z., Liu, J., Xiong, T., Liu, Y., Tuan, R. S., & Li, Z. A. (2024) · Small · doi:10.1002/smll.202310614 · Cited by 19 · see citing works

Insights into the role of mesenchymal stem cells in cutaneous medical aesthetics: from basics to clinics

Li, J., Liu, Y., Zhang, R., Yang, Q., Xiong, W., He, Y., & Ye, Q. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03774-5 · Cited by 18 · see citing works

New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury

Ezquer, F. E., Huang, Y.-L., & Ezquer, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052669 · Cited by 17 · see citing works

TNF-α and IFN-γ prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction

Huang, Y., Zhang, Q., Cao, W., Zhang, Q., Wang, L., & Lai, D. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00309-y · Cited by 15 · see citing works

Efficacy of Mesenchymal Stem Cells from Human Exfoliated Deciduous Teeth and their Derivatives in Inflammatory Diseases Therapy

Su, J., Ge, X., Jiang, N., Zhang, Z., & Wu, X. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220417153309 · Cited by 14 · see citing works

Revolutionizing orofacial pain management: the promising potential of stem cell therapy

Ren, K., Vickers, R., Murillo, J., & Ruparel, N. B. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1239633 · Cited by 12 · see citing works

Human Neuromuscular Junction on a Chip: Impact of Amniotic Fluid Stem Cell Extracellular Vesicles on Muscle Atrophy and NMJ Integrity

Gatti, M., Dittlau, K. S., Beretti, F., Yedigaryan, L., Zavatti, M., Cortelli, P., Palumbo, C., Bertucci, E., Bosch, L. V. D., Sampaolesi, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054944 · Cited by 11 · see citing works

Mesenchymal stromal cell secretome in scaffold-based drug delivery: Advances, applications, and future directions

Ramakrishnan, P., Jalaludeen, A. M., Vinayagam, S., Gnanasekaran, L., Thirumurugan, D., Rajamohan, R., & Sundaram, T. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147919 · Cited by 10 · see citing works

Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated Cell Survival

Muñiz-García, A., Wilm, B., Murray, P. A., & Cross, M. J. (2022) · Cells · doi:10.3390/cells11233750 · Cited by 10 · see citing works

Modulating the release of bioactive molecules of human mesenchymal stromal cell secretome: Heparinization of hyaluronic acid-based hydrogels

Palumbo, F. S., Fiorica, C., Carreca, A. P., Iannolo, G., Pitarresi, G. L., Amico, G., Giammona, G., Conaldi, P. G., & Chinnici, C. M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.123904 · Cited by 9 · see citing works

Comparing the healing properties of intra-articular injection of human dental pulp stem cells and cell-free-secretome on induced knee osteoarthritis in male rats

Nowzari, F., Zare, M., Tanideh, N., Meimandi-Parizi, A., Kavousi, S., Saneian, S. M., Zare, S., Koohi‐Hosseinabadi, O., Ghaemmaghami, P., Dehghanian, A., et al. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102055 · Cited by 9 · see citing works

Stem Cell Therapy for Diseases of Livestock Animals: An In-Depth Review

Narasimha, R. B., Shreya, S., Anand, V., Yadav, V. K., Rath, P. K., Mishra, B. P., Kancharla, S., Kolli, P., Mandadapu, G., Kumar, S., et al. (2025) · Veterinary Sciences · doi:10.3390/vetsci12010067 · Cited by 9 · see citing works

Standardization to Characterize the Complexity of Vessel Network Using the Aortic Ring Model

Wolint, P., Hofmann, S., von Atzigen, J., Böni, R., Miescher, I., Giovanoli, P., Calcagni, M., Emmert, M. Y., & Buschmann, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010291 · Cited by 7 · see citing works

ВПЛИВ КОНДИЦІОНОВАНИХ СЕРЕДОВИЩ ВІД КУЛЬТУР ГЛІАЛЬНИХ КЛІТИН НА РЕПРОДУКТИВНУ СИСТЕМУ САМИЦЬ ЩУРІВ РІЗНОГО ВІКУ

Nesteruk, H., Alabedalkarim, N. M., Колот, Н. В., Комароми, Н. А., Protsenko, O. S., & Легач, Є. (2022) · PROBLEMS OF ENDOCRINE PATHOLOGY · doi:10.21856/j-pep.2022.2.13 · Cited by 7 · see citing works

Caloric Restriction Mimetics as Priming Agents of Mesenchymal Stem Cells Secretome to Enhance Regenerative Responses to Parkinson’s Disease

Carneiro-Pereira, B., Ferreira-Antunes, F., Campos, J., Salgado, A. J., & Sampaio‐Marques, B. (2025) · Molecules · doi:10.3390/molecules30112260 · Cited by 6 · see citing works

Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury

Ullah, M. M., Collett, J. A., Monroe, J. C., Traktuev, D. O., Coleman, M., March, K. L., & Basile, D. P. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03736-x · Cited by 6 · see citing works

Neuronal Differentiation and Exosome Profiling of Dental Pulp Stem Cells: Unveiling Their Potential for Nerve Repair

Lopes, B., Sousa, P., Moreira, A. D. S., Sousa, A. C., Rêma, A., Atayde, L. M., Salgado, A. J., Geuna, S., Alvites, R., & Maurício, A. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199723 · Cited by 5 · see citing works

The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Model

Cuadra, B., Silva, V., Huang, Y.-L., Díaz, Y., Rivas, C., Molina, C., Simon, V., Bono, M. R., Morales, B., Rosemblatt, M. S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042073 · Cited by 5 · see citing works

Whole secretome of mesenchymal stem cells is fully incorporated in lipid bicontinuous cubic phases

Barata‐Antunes, S., Sousa, R. A., Salgado, A. J., & Silva, B. F. B. (2025) · Frontiers in Medical Engineering · doi:10.3389/fmede.2025.1397406 · Cited by 5 · see citing works

Development and characterization of a double-layered lyophilized carrageenan/polyurethane bioactive dressing loaded with secretome of mesenchymal stem cells for chronic wound healing

Sadeghi-Avalshahr, A., Nazarnezhad, S., Noughabi, M. K., Hassanzadeh, H., Namaei‐Ghasemnia, N., & Jalali, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145725 · Cited by 4 · see citing works

Identifying the Efficacy of Extracellular Vesicles in Osteogenic Differentiation: An EV-Lution in Regenerative Medicine

Brown, S. V., Dewitt, S., Clayton, A., & Waddington, R. J. (2022) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2022.849724 · Cited by 4 · see citing works

Isolation, Expansion, and Characterization of Rat Hair Follicle Stem Cells and Their Secretome: Insights into Wound Healing Potential

Sousa, P., Lopes, B., Sousa, A. C., Coelho, A., Moreira, A. D. S., Rêma, A., Gonçalves-Maia, M., Amorim, I., Alvites, R., Alves, N. M., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12122854 · Cited by 4 · see citing works

Secretome from hypoxic mesenchymal stem cells as a potential therapy for ischemic stroke: Investigations on VEGF and GFAP expression

Silvana, S., Japardi, I., Rusda, M., Daulay, R. S., Putra, A., Mangunatmadja, I., Darlan, D. M., Sofyani, S., & Andreas, Y. (2024) · Narra J · doi:10.52225/narra.v4i3.1181 · Cited by 4 · see citing works

Decoded cardiopoietic cell secretome linkage to heart repair biosignature

Garmany, A., Arrell, D. K., Yamada, S., Jeon, R., Behfar, A., Park, S., & Terzic, A. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae067 · Cited by 4 · see citing works

Cells Versus Cell-Derived Signals in Cardiac Regenerative Therapy: A Comparative Analysis of Mechanisms and Clinical Evidence

Soczyńska, J., Gawełczyk, W., Majcherczyk, K., Rydzek, J., Muzyka, A., Żołyniak, M., & Woźniak, S. (2025) · Cells · doi:10.3390/cells14211674 · Cited by 3 · see citing works

Therapeutic Implications of Stem Cell Secretome

Huey, H. J., Teng, C. C. J., Kukumberg, M., & Rufaihah, A. J. (2024) · Journal of Stem Cell Therapy and Transplantation · doi:10.29328/journal.jsctt.1001039 · Cited by 3 · see citing works

Modulating cellular deformability via 3D dextran hydrogel cultivation to regulate the microcirculation of mesenchymal stem cells in murine spleen and liver

Zhu, X., Wang, Z., Shi, Y., Yao, S., He, F., Cong, X., & Teng, F. (2025) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2025.104987 · Cited by 3 · see citing works

Growth factors of hypoxia Freeze-Dried Adipose Stem Cell- Conditioned Medium (FD ASC-CM) and Fresh Adipose Stem Cell Conditioned-Medium (FR ASC-CM): a comparative study

Putri, W. E., Endaryanto, A., Tinduh, D., Rantam, F. A., Alinda, M. D., & Prakoeswa, C. R. S. (2021) · Bali Medical Journal · doi:10.15562/bmj.v10i2.2588 · Cited by 3 · see citing works

Proteins Derived From MRL/MpJ Tendon Provisional Extracellular Matrix and Secretome Promote Pro-Regenerative Tenocyte BehaviorPreprint

Marvin, J. C., Liu, E. J., Chen, H. H., Shiovitz, D. A., & Andarawis‐Puri, N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.08.602500 · Cited by 3 · see citing works

Proteomic analysis of secreted proteins derived from amniotic fluid stem cells

Phermthai, T., Chuaynarong, P., Wichitwiengrat, S., Phermthai, K., Roytrakul, S., Chitthira, T., & Thongbopit, S. (2025) · Cell and Tissue Research · doi:10.1007/s00441-025-03984-0 · Cited by 2 · see citing works

The Combined Effects on Human Dental Pulp Stem Cells of Fast-Set or Premixed Hydraulic Calcium Silicate Cements and Secretome Regarding Biocompatibility and Osteogenic Differentiation

Ha, Y.-J., Lee, D., & Kim, S. (2024) · Materials · doi:10.3390/ma17020305 · Cited by 2 · see citing works

Cervical tuberculosis treated with closed system abscess evacuation, and percutaneous laser disc decompression combined with secretome derived from umbilical cord mesenchymal stem cells: A case report

Rahyussalim, A. J., Putra, M. N. S., Nasser, M. K., Kusuma, B. W., Kurniawati, T., & Canintika, A. F. (2024) · International Journal of Surgery Case Reports · doi:10.1016/j.ijscr.2024.109764 · Cited by 2 · see citing works

Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome

Sridharan, D., Dougherty, J. A., Ahmed, U., Sanghvi, S. K., Alvi, S. B., Park, K. H., Islam, H., Knoblaugh, S. E., Singh, H., Kirby, E. D., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03792-3 · Cited by 2 · see citing works

Microneedling combined with concentrated adipose-derived mesenchymal stem cells secretome alleviate facial skin aging features: A double-blind, randomized controlled trial

Suseno, L. S., Japranata, V. V., Legiawati, L., Sitohang, I. B. S., Yusharyahya, S. N., Liem, I. K., Pawitan, J. A., Putri, I. S., & Kurniawati, T. (2025) · Journal of Cutaneous and Aesthetic Surgery · doi:10.25259/jcas_78_2025 · Cited by 2 · see citing works

Mesenchymal stem cell secretome ameliorates over-expression of soluble fms-like tyrosine kinase-1 (sFlt-1) and fetal growth restriction (FGR) in animal SLE model

Bachnas, M. A., Dekker, G., Mudigdo, A., Purwanto, B., Sulistyowati, S., Dachlan, E. G., Akbar, M. I. A., Chouw, A., Sartika, C. R., & Widjiati, W. (2023) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2023.2279931 · Cited by 1 · see citing works

Gene expression profiles of angiogenesis markers and microRNA-128 from the secretome of umbilical cord mesenchymal stem cells from Macaca fascicularis

Utama, H. A. N., Mariya, S. S., Rinendyaputri, R., Dumingan, A., Purwaningtyas, Y. R., Intan, P. R., Renitia, G. I., Idrus, H. H., Ayuningtyas, W., Noverina, R., et al. (2025) · Veterinary World · doi:10.14202/vetworld.2025.558-564 · Cited by 1 · see citing works

Selective Paracrine Modulation of Stromal Cells: Wharton’s Jelly MSC Secretome Enhances Adipose-Derived MSC Functionality While Maintaining Dermal Fibroblast Quiescence

Stoyanova, T., Topalova, L., Kyurkchiev, S., Komsa‐Penkova, R., Todinova, S. J., & Altankov, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010095 · Cited by 1 · see citing works

Molecular Pathophysiology of Ischemic Stroke and Mesenchymal Stem Cell Based Therapeutic Strategies for Neural Tissue Regeneration: A Pre-clinical and Clinical Perspective

Ishaque, A., Qazi, R., Salim, A., Malick, T. S., & Asif, Z. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11071-2 · Cited by 1 · see citing works

Engineered Stem Cell-Derived Exosomes for Precision Regenerative Medicine: Molecular Targeting, Cargo Optimization, and Therapeutic Applications

Putri, G. F. T., Widyawati, D., Husna, F. A., Hanifah, R., & Tsaqifah, N. A. (2026) · International Journal of Cell and Biomedical Science · doi:10.59278/cbs.v5i13.85 · Cited by 1 · see citing works

Stem cell–derived secretome: a novel strategy for wound healing

Sousa, P., Sousa, A. C., Moreira, A. D. S., Lopes, B., Alvites, R., Alves, N. M., Geuna, S., & Maurício, A. C. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1839998 · Cited by 1 · see citing works

Influence of conditioned media from glial cell cultures on contractility of uterine in rats of different ages

Nesteruk, H., Alabedalkarim, N. M., Комароми, Н. А., Tkachenko, N., Protsenko, O. S., & Легач, Е. И. (2022) · Reproductive Endocrinology · doi:10.18370/2309-4117.2022.63.85-90 · Cited by 1 · see citing works

The non-protein fraction of embryonic stem cell secretome exerts antibacterial effects against antibiotic-resistant bacterial strains

Kaigorodov, D. G., & Kaigorodova, A. D. (2022) · Russian Journal of Infection and Immunity · doi:10.15789/2220-7619-npf-1940

The therapeutic potential of mesenchymal stem cells in COVID-19: Present and future

Sari, M. I., Putra, I. B., & Wijaya, D. W. (2023) · Research Results in Pharmacology · doi:10.18413/rrpharmacology.9.10031

Engineered adult stem cells: Current clinical trials status of disease treatment

Han, P., Moran, C. S., Liu, C., Griffiths, R. E., Zhou, Y., & Ivanovski, S. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.02.007

New developments in erectile dysfunction treatments: A role for regenerative medicine

Ashari, F. Y., Yufi, A. Z., & Cennikon, P. (2023) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2023.20.2.2259

Pretreatment with Inflammatory Factors Altered the Secretome of Human Amniotic Epithelial Cells

Cao, W., Zhang, Q., Huang, Y., Zhang, Q., & Lai, D. (2024) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2024.0065

Human Dental Pulp Stem Cell Secretome Protects Motor Neurons Through Antioxidant and Trophic Factors Mediated Cell Survival MechanismsPreprint

Shobha, K., Venugopal, C., Maiya, K., Mata, S., Prabhu, P., Mahesh, P., Raghunathan, T., Balaji, P., Mishrilal, N., Velu, S., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4863520

Creation of Bioengineered Reproductive Organs: A Future Fertility Treatment Option?

de Miguel–Gómez, L., Sehiç, E., & Hellström, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00291-1

Umbilical cord-derived secretome induces apoptosis and reduces proliferation in cancer cells

Awan, S. J., Manuwar, M., Shahzadi, M., Hafeez, S., & Kausar, H. (2025) · International Journal of Applied and Experimental Biology · doi:10.56612/ijaaeb.v1i1.116

Advanced Drug Delivery TechnologiesPreprint

Çetin, E. Ö., Erisik, D., TAŞKIRAN, A., Çalışkan, E. E., Demirtürk, E., AYDIN, Y. Ç., & Uyanıkgil, Y. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5080254

Additional file 1 of TNF-α and IFN-γ prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction

Huang, Y., Zhang, Q., Cao, W., Zhang, Q., Wang, L., & Lai, P. D. (2023) · Figshare · doi:10.6084/m9.figshare.24628120

Additional file 1 of Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury

Ullah, M. M., Collett, J. A., Monroe, J. C., Traktuev, D. O., Coleman, M., March, K. L., & Basile, D. P. (2024) · Figshare · doi:10.6084/m9.figshare.25687535

Additional file 3 of Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome

Sridharan, D., Dougherty, J. A., Ahmed, U., Sanghvi, S. K., Alvi, S. B., Park, K. H., Islam, H., Knoblaugh, S. E., Singh, H., Kirby, E. D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26739513

Future Acne Therapy MSC Secretome as an Antimicrobial Agent: Literature Review

Putri, M. I., Marlina, M., & Sudji, I. R. (2025) · JURNAL BIOLOGI TROPIS · doi:10.29303/jbt.v25i4a.10622

Secretome-Assisted Regenerative Therapy for Hyaluronic Acid Filler-Induced Vascular Occlusion: A Case Report

Tovar, J. S., & Sandoval, J. L. F. (2026) · Cureus · doi:10.7759/cureus.101978

A preliminary preclinical assessment of macromolecular crowding in tissue engineering

Spanoudes, K., Cubillo, L. T., Korntner, S. H., Gaspar, D., & Zeugolis, D. I. (2026) · Science Progress · doi:10.1177/00368504251406914

Développement de bioencres naturelles enrichies par les composants de la gelée de Wharton pour la bioimpression 3D

Nassif, L. A. (2024) · theses.fr (ABES) · doi:10.70675/097bd21ezaf34z4cacz9735z35b020d4825d

Stem cell-derived secretome and dental pulp stem cells enhance sciatic nerve regeneration in a rat sciatic neurotmesis model using chitosan nerve conduits

Lopes, B. G., Sousa, A. C., Moreira, A. D. S., Sousa, P., Prada, J., Pires, I. C. R., Teixeira-Silva, B., João, F., Amado, S., Raimondo, S., et al. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1778085

Effectiveness of Secretome on Accelerating Wound Epithelialization Resulting from Sports Injuries among Athletes at the University of Education (UPI) Bandung: A Pilot Experimental Study

Adiprama, G. S. P., Sutedja, E., & Hamda, M. E. (2026) · Jurnal Locus Penelitian dan Pengabdian · doi:10.58344/locus.v5i4.5754

Future perspectives on mesenchymal stromal cell-derived secretomes in knee osteoarthritis

Muruganandam, A., Jeyaraman, N., Sukumaran, A. M., Ramasubramanian, S., Devanand, V., Nallakumarasamy, A., Muthu, S., & Jeyaraman, M. (2026) · World Journal of Stem Cells · doi:10.4252/wjsc.v18.i4.117271

Advanced lyophilized mesenchymal stem cell-conditioned medium formulation improves therapeutic efficacy in skin wound repair

Chen, X., Li, B., Gu, W., Li, M., & Zhang, Z. (2026) · Regenerative Biomaterials · doi:10.1093/rb/rbag140

Human Amniotic Membrane-Derived Mesenchymal Stem Cell-Conditioned Saline as an Injectable Formulation Improves Ovarian Antioxidant Status and Preimplantation Embryo Development

Ra, K., Kim, E. Y., Kang, S. K., Kim, G. A., & Park, S. C. (2026) · Biomedicines · doi:10.3390/biomedicines14071522

Availability and Pricing of Orthobiologic Knee Injections Vary by Practice Type but Not by Community Socioeconomic Vulnerability in Suburban New York

Tauro, T. M., Hershfeld, B. E., Chen, K., Lampert, R., Bitterman, A. D., Cohn, R. M., & Sgaglione, N. A. (2026) · Arthroscopy Sports Medicine and Rehabilitation · doi:10.1002/ars2.70074

Stem cell conditioned medium for cell-free therapies.

Vackovcá, I., & Kubinová, Š. (2016) · PubMed · Cited by 5 · see citing works

Current Status of the Applications of Conditioned Media Derived from Mesenchymal Stem Cells for Regenerative Medicine

Smolinská, V., Boháč, M., & Danišovič, Ľ. (2023) · Physiological Research · doi:10.33549/physiolres.935186 · Cited by 41 · see citing works

Therapeutic Implications of Stem Cell Secretome

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