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G-Protein–Coupled Receptors in Heart Disease
Open accessAbstract
GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of cardiac function in both health and disease and thus represent one of the largest class of surface receptors targeted by drugs. Several antagonists of GPCRs, such as βARs (β-adrenergic receptors) and Ang II (angiotensin II) receptors, are now considered standard of therapy for a wide range of cardiovascular disease, such as hypertension, coronary artery disease, and heart failure. Although the mechanism of action for GPCRs was thought to be largely worked out in the 80s and 90s, recent discoveries have brought to the fore new and previously unappreciated mechanisms for GPCR activation and subsequent downstream signaling. In this review, we focus on GPCRs most relevant to the cardiovascular system and discuss traditional components of GPCR signaling and highlight evolving concepts in the field, such as ligand bias, β-arrestin–mediated signaling, and conformational heterogeneity.
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1 retracted
Baillie, G. S., Sood, A., McPhee, I., Gall, I., Perry, S. J., Lefkowitz, R. J., & Houslay, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262787199 · Cited by 358
Retracted2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
Packer, M., Bristow, M. R., Cohn, J. N., Colucci, W. S., Fowler, M. B., Gilbert, E. M., & Shusterman, N. H. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605233342101 · Cited by 4,649
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304
Crystal structure of the β2 adrenergic receptor–Gs protein complex
Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature · doi:10.1038/nature10361 · Cited by 3,009
Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712
The structure and function of G-protein-coupled receptors
Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature · doi:10.1038/nature08144 · Cited by 2,534
Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467
Research works printed but not linked: 1
- 10.1016/S0895-7061(00)86965-4 · DOI
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Zhang, M., Chen, T., Lu, X., Lan, X., Chen, K., & Lu, S. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01803-6 · Cited by 540
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Masuho, I., Santhanam, B., Muntean, B. S., Skamangas, N. K., Chavali, S., Tesmer, J. J. G., Babu, M. M., & Martemyanov, K. A. (2020) · Cell · doi:10.1016/j.cell.2020.08.052 · Cited by 167
Ballante, F., Kooistra, A. J., Kampen, S., de Graaf, C., & Carlsson, J. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000246 · Cited by 169
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Lee, D., Kim, M.-T., & Han, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116735 · Cited by 178
Physiological and pathological roles of protein kinase A in the heart
Liu, Y., Chen, J., Fontes, S. K., Bautista, E. N., & Cheng, Z. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab008 · Cited by 170
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Gilbert, G., Demydenko, K., Dries, E., Puertas, R. D., Jin, X., Sipido, K. R., & Roderick, H. L. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035428 · Cited by 151
Cheng, H., Liu, J., Tan, Y., Feng, W., & Peng, C. Y. (2021) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2021.10.003 · Cited by 140
Nash, C. A., Wei, W., Irannejad, R., & Smrcka, A. V. (2019) · eLife · doi:10.7554/elife.48167 · Cited by 113
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Oliver, E., Mayor, F., & D’Ocón, P. (2019) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2019.04.006 · Cited by 108
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Jiang, H., Galtes, D., Wang, J., & Rockman, H. A. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00210.2022 · Cited by 104
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Zhang, X., Chen, C., Ling, C., Luo, S., Xiong, Z., Liu, X., Liao, C., Xie, P., Liu, Y., Zhang, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05370-y · Cited by 79
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Zhang, Z., Lv, T., Wang, X., Wu, M., Zhang, R., Yang, X., Fu, Y., & Liu, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116567 · Cited by 79
Ramms, D. J., Raimondi, F., Arang, N., Herberg, F. W., Taylor, S. S., & Gutkind, J. S. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000269 · Cited by 73
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Ma, K., Gao, W., Xu, H., Liang, W., & Ma, G. (2022) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1155/2022/3239057 · Cited by 69
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Lymperopoulos, A., Cora, N., Maning, J., Brill, A. R., & Sizova, A. (2021) · FEBS Journal · doi:10.1111/febs.15771 · Cited by 60
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Xu, X., Lu, W.-J., Shi, J., Su, Y.-L., Liu, Y.-C., Wang, L., Xiao, C.-X., Chen, C., & Lu, Q. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108720 · Cited by 33
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Yuan, L., Li, Y., Chen, M., Xue, L., Wang, J., Ding, Y., Zhang, J., Wu, S., Ye, Q., Zhang, S., et al. (2022) · Foods · doi:10.3390/foods11152332 · Cited by 30
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Martin, R., Sun, Y., MacKinnon, S., Cuccia, L., Pagé, V., Hébert, T. E., & Tanny, J. C. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00048-20 · Cited by 22
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Heianza, Y., Tiwari, S., Wang, X., Watrous, J. D., Rexrode, K. M., Hu, F. B., Alotaibi, M., Jain, M., Sun, Q., Manson, J. E., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae525 · Cited by 20
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Carter, K. T., Shah, E., Waite, J., Rana, D., & Zhao, Z.-Q. (2024) · Cells · doi:10.3390/cells13232001 · Cited by 22
Zhou, L., Guo, Z., Wang, B., Wu, Y., Li, Z., Yao, H., Fang, R., Yang, H., Cao, H., & Cui, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.652315 · Cited by 20
Díaz, Y. D. L. M. Z., & Arnspang, E. C. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1455153 · Cited by 22
Szukiewicz, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062501 · Cited by 23
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RetractedDongdem, J. T., Etornam, A. E., Beletaa, S., Alidu, I., Kotey, H., & Wezena, C. A. (2024) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2024/2005589 · Cited by 20
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Lymperopoulos, A., Borges, J. I., & Stoicovy, R. A. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115904 · Cited by 18
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Metadata
- Authors
- Wang, J., Gareri, C., & Rockman, H. A.
- Affiliations
- From the Department of Medicine (J.W., C.G., H.A.R.)
- Duke University (US)
- Venue
- Circulation Research
- Published
- 2018-08-31
- Volume
- 123
- Issue
- 6
- Pages
- 716-735
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC6205195
- OpenAlex
- W2889986213
- Cited by
- 303
- References
- 259
- Citations by year
- 2026: 28 · 2025: 32 · 2024: 57 · 2023: 49 · 2022: 47 · 2021: 45 · 2020: 31 · 2019: 14
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-10-25)
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL075443, R01HL056687)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- G protein-coupled receptors, heart disease, cardiac function, beta-adrenergic receptors, angiotensin II receptor, G protein-coupled receptor signaling, ligand bias, β-arrestin signaling, conformational heterogeneity, heart failure, hypertension, coronary artery disease, cardiovascular drug targets
- MeSH terms
- Animals, Cardiovascular Agents, Fibroblasts, Heart Failure, Heart Ventricles, Humans, Signal Transduction, Ventricular Function, Ventricular Remodeling, Myocytes, Cardiac, Myocytes, Smooth Muscle, Endothelial Cells, Receptors, G-Protein-Coupled
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