The DOI matches its Crossref record; 258 of the 259 references it cites were found in a registry or an index.
G-Protein–Coupled Receptors in Heart Disease
Open accessAbstract
GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of cardiac function in both health and disease and thus represent one of the largest class of surface receptors targeted by drugs. Several antagonists of GPCRs, such as βARs (β-adrenergic receptors) and Ang II (angiotensin II) receptors, are now considered standard of therapy for a wide range of cardiovascular disease, such as hypertension, coronary artery disease, and heart failure. Although the mechanism of action for GPCRs was thought to be largely worked out in the 80s and 90s, recent discoveries have brought to the fore new and previously unappreciated mechanisms for GPCR activation and subsequent downstream signaling. In this review, we focus on GPCRs most relevant to the cardiovascular system and discuss traditional components of GPCR signaling and highlight evolving concepts in the field, such as ligand bias, β-arrestin–mediated signaling, and conformational heterogeneity.
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“Adrenergic receptors are crucially involved in heart disease147 and platelet function148.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [147]
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1 retracted
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Gut microbiota and cardiovascular disease.
Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051
G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery
Zhang, M., Chen, T., Lu, X., Lan, X., Chen, K., & Lu, S. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01803-6 · Cited by 540
G Protein-Coupled Receptors: A Century of Research and Discovery
Liu, S., Anderson, P. J., Rajagopal, S., Lefkowitz, R. J., & Rockman, H. A. (2024) · Circulation Research · doi:10.1161/circresaha.124.323067 · Cited by 196
Self-citationCardiac Fibrosis and Fibroblasts
Kurose, H. (2021) · Cells · doi:10.3390/cells10071716 · Cited by 178
A Global Map of G Protein Signaling Regulation by RGS Proteins
Masuho, I., Santhanam, B., Muntean, B. S., Skamangas, N. K., Chavali, S., Tesmer, J. J. G., Babu, M. M., & Martemyanov, K. A. (2020) · Cell · doi:10.1016/j.cell.2020.08.052 · Cited by 167
Metadata
- Authors
- Wang, J., Gareri, C., & Rockman, H. A.
- Affiliations
- From the Department of Medicine (J.W., C.G., H.A.R.)
- Duke University (US)
- Venue
- Circulation Research
- Published
- 2018-08-31
- Volume
- 123
- Issue
- 6
- Pages
- 716-735
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC6205195
- OpenAlex
- W2889986213
- Cited by
- 303
- References
- 259
- Citations by year
- 2026: 28 · 2025: 32 · 2024: 57 · 2023: 49 · 2022: 47 · 2021: 45 · 2020: 31 · 2019: 14
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-10-25)
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL075443, R01HL056687)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- G protein-coupled receptors, heart disease, cardiac function, beta-adrenergic receptors, angiotensin II receptor, G protein-coupled receptor signaling, ligand bias, β-arrestin signaling, conformational heterogeneity, heart failure, hypertension, coronary artery disease, cardiovascular drug targets
- MeSH terms
- Animals, Cardiovascular Agents, Fibroblasts, Heart Failure, Heart Ventricles, Humans, Signal Transduction, Ventricular Function, Ventricular Remodeling, Myocytes, Cardiac, Myocytes, Smooth Muscle, Endothelial Cells, Receptors, G-Protein-Coupled
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