Cited by 939Smoking Behavior and CessationNitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

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Cardiovascular Effects of Secondhand Smoke: Nearly as Large as Smoking

Barnoya, Joaquin, Glantz, Stanton A.·2005·Circulation

DOI 10.1161/circulationaha.104.492215

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Abstract

Background— Secondhand smoke increases the risk of coronary heart disease by ≈30%. This effect is larger than one would expect on the basis of the risks associated with active smoking and the relative doses of tobacco smoke delivered to smokers and nonsmokers. Methods and Results— We conducted a literature review of the research describing the mechanistic effects of secondhand smoke on the cardiovascular system, emphasizing research published since 1995, and compared the effects of secondhand smoke with the effects of active smoking. Evidence is rapidly accumulating that the cardiovascular system—platelet and endothelial function, arterial stiffness, atherosclerosis, oxidative stress, inflammation, heart rate variability, energy metabolism, and increased infarct size—is exquisitely sensitive to the toxins in secondhand smoke. The effects of even brief (minutes to hours) passive smoking are often nearly as large (averaging 80% to 90%) as chronic active smoking. Conclusions— The effects of secondhand smoke are substantial and rapid, explaining the relatively large risks that have been reported in epidemiological studies.

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Authors: Barnoya, J., & Glantz, S. A.
Affiliations: From the Center for Tobacco Control Research and Education, Cardiovascular Research Institute, and Division of Cardiology, University of California, San Francisco.
University of California, San Francisco (US)
ORCID: Glantz, Stanton A.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-05-24
Volume: 111
Issue: 20
Pages: 2684-2698
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.104.492215
OpenAlex: W1979836769
Cited by: 939
References: 167
Citations by year: 2026: 16 · 2025: 23 · 2024: 32 · 2023: 34 · 2022: 25 · 2021: 25 · 2020: 29 · 2019: 44 · 2018: 42 · 2017: 41 · 2016: 47 · 2015: 55 · 2014: 57 · 2013: 69 · 2012: 73
FWCI: 27.98
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: passive smoking, coronary artery disease, cardiovascular effects, platelet function, endothelial function, arterial stiffness, atherosclerosis, oxidative stress, inflammation, heart rate variability, energy metabolism, myocardial infarct size
MeSH terms: Cardiovascular Diseases, Endothelium, Vascular, Heart Rate, Humans, Mitochondria, Risk, Smoking, Tobacco Smoke Pollution, Vascular Resistance, Platelet Activation, Oxidative Stress

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Cardiovascular Effects of Secondhand Smoke: Nearly as Large as Smoking

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