The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Plasma Oxidized Low-Density Lipoprotein, a Strong Predictor for Acute Coronary Heart Disease Events in Apparently Healthy, Middle-Aged Men From the General Population
Abstract
BACKGROUND: Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory response in the arterial vessel wall. METHODS AND RESULTS: In a prospective, nested, case-control study, the association between plasma oxLDL and risk of an acute coronary heart disease (CHD) event was investigated in men without prevalent CHD or diabetes mellitus at baseline. Subjects came from 2 population-based MONICA/KORA Augsburg surveys conducted in the years 1989-1990 and 1994-1995 with follow-up in 1998 (mean+/-SD follow-up time, 5.6+/-2.6 years). OxLDL was determined by ELISA in 88 men with incident CHD and in 258 age- and survey-matched controls. Hazard ratios (HRs) were estimated from conditional logistic-regression models with matching for age and survey. Baseline mean plasma oxLDL concentrations were significantly higher in subjects who subsequently experienced an event compared with controls (mean+/-SD, 110+/-32 versus 93+/-28 U/L; P< or =0.001). After adjustment for smoking, hypertension, obesity, physical activity, education, and alcohol consumption, the HR for a future CHD event in a comparison of the upper tertile of the oxLDL distribution with the lower tertile was 4.25 (95% confidence interval, 2.09 to 8.63; P<0.001). Plasma oxLDL was the strongest predictor of CHD events compared with a conventional lipoprotein profile and other traditional risk factors for CHD. When both oxLDL and C-reactive protein were simultaneously assessed in the same model, they still predicted future CHD events even after multivariable adjustment. CONCLUSIONS: Elevated concentrations of oxLDL are predictive of future CHD events in apparently healthy men. Thus, oxLDL may represent a promising risk marker for clinical CHD complications and should be evaluated in further studies.
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“Plasma levels of oxidized LDL predict acute coronary heart disease in relatively healthy individuals and in patients with coronary heart disease, and is a prognostic marker for subclinical atherosclerosis (47).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [47]
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“In this regard, it has been highlighted that oxidized LDL particles might play a role in atherosclerosis onset and progression, given their ability to induce endothelial dysfunction and macrophagic transformation into foam cells, following phagocytosis of LDLs [204,205].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [205]
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Cited by
Sorted by citations
Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations
Vasan, R. S. (2006) · Circulation · doi:10.1161/circulationaha.104.482570 · Cited by 1,212
Biological markers of oxidative stress: Applications to cardiovascular research and practice
Ho, E. C., Galougahi, K. K., Liu, C., Bhindi, R., & Figtree, G. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.07.006 · Cited by 834
Reactive oxygen species in cardiovascular disease
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Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms
Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx227 · Cited by 762
The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors: A Randomized Trial
Covas, M.-I., Nyyssönen, K., Poulsen, H. E., Kaikkonen, J., Zunft, H.-J. F., Kiesewetter, H., Gaddi, A., de la Torre, R., Mursu, J., Bäumler, H., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-5-200609050-00006 · Cited by 758
Metadata
- Authors
- Meisinger, C., Baumert, J., Khuseyinova, N., Loewel, H., & Koenig, W.
- Affiliations
- Universität Ulm (DE)
- From GSF the National Research Center for Environment and Health (C.M., J.B., H.L.), Institute of Epidemiology, Neuherberg; the Central Hospital of Augsburg (C.M., H.L.), MONICA/KORA Myocardial Infarction Registry, Augsburg; and the Department of Internal Medicine II–Cardiology (N.K., W.K), University of Ulm Medical Center, Ulm, Germany.
- Venue
- Circulation
- Published
- 2005-08-02
- Volume
- 112
- Issue
- 5
- Pages
- 651-657
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2143064104
- Cited by
- 434
- References
- 48
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 20 · 2019: 17 · 2018: 23 · 2017: 14 · 2016: 18 · 2015: 21 · 2014: 26 · 2013: 29 · 2012: 29
- FWCI
- 27.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidized LDL, acute coronary heart disease, cardiovascular risk prediction, risk indicators, middle-aged men, C-reactive protein, inflammation
- MeSH terms
- Acute Disease, Coronary Disease, Humans, Lipoproteins, LDL, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Reference Values, Regression Analysis, Biomarkers
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