The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cardiac Histological Substrate in Patients With Clinical Phenotype of Brugada Syndrome
Abstract
Background— The role of structural heart disease and sodium channel dysfunction in the induction of electrical instability in Brugada syndrome is still debated. Methods and Results— We studied 18 consecutive patients (15 males, 3 females; mean age 42.0±12.4 years) with clinical phenotype of Brugada syndrome and normal cardiac structure and function on noninvasive examinations. Clinical presentation was ventricular fibrillation in 7 patients, sustained polymorphic ventricular tachycardia in 7, and syncope in 4. All patients underwent cardiac catheterization, coronary and ventricular angiography, biventricular endomyocardial biopsy, and DNA screening of the SCN5A gene. Biopsy samples were processed for histology, electron microscopy, and molecular screening for viral genomes. Microaneurysms were detected in the right ventricle in 7 patients and also in the left ventricle in 4 of them. Histology showed a prevalent or localized right ventricular myocarditis in 14 patients, with detectable viral genomes in 4; right ventricular cardiomyopathy in 1 patient; and cardiomyopathic changes in 3. Genetic studies identified 4 carriers of SCN5A gene mutations that cause in vitro abnormal function of mutant proteins. In these patients, myocyte cytoplasm degeneration was present at histology, whereas terminal dUTP nick end-labeling assay showed a significant increase of apoptotic myocytes in right and left ventricle versus normal controls ( P =0.014 and P =0.013, respectively). Conclusions— Despite an apparently normal heart at noninvasive evaluation, endomyocardial biopsy detected structural alterations in all 18 patients with Brugada syndrome. Mutations in the SCN5A gene, identified in 4 of the 18 patients, may have induced concealed structural abnormalities of myocardiocytes that accounted for paroxysmal arrhythmic manifestations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Brugada, P., & Brugada, J. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90253-j · Cited by 3,331
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
Chen, Q., Kirsch, G. E., Zhang, D., Brugada, R., Brugada, J., Brugada, P., Potenza, D., Moya, A., Borggrefe, M., Breithardt, G., et al. (1998) · Nature · doi:10.1038/32675 · Cited by 1,831
Myocarditis. A histopathologic definition and classification.
Aretz, H. T., Billingham, M. E., Edwards, W. D., Factor, S. M., Fallon, J. T., Fenoglio, J. J., Olsen, E. G. J., & Schöen, F. J. (1987) · PubMed · Cited by 1,324
Natural History of Brugada Syndrome: Insights for Risk Stratification and Management
Priori, S. G., Napolitano, C., Gasparini, M., Pappone, C., Bella, P. D., Giordano, U., Bloise, R., Giustetto, C., De Nardis, R., Grillo, M., et al. (2002) · Circulation · doi:10.1161/hc1102.105288 · Cited by 1,034
Self-citationProposed Diagnostic Criteria for the Brugada Syndrome: Consensus Report
Wilde, A. A. M., Antzelevitch, C., Borggrefe, M., Brugada, J., Brugada, R., Brugada, P., Corrado, D., Hauer, R. N. W., Kass, R. S., Nademanee, K., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034169.45752.4a · Cited by 827
Self-citationSodium Channel Mutations and Susceptibility to Heart Failure and Atrial Fibrillation
Olson, T. M. (2005) · JAMA · doi:10.1001/jama.293.4.447 · Cited by 554
SCN5A Mutation Associated With Dilated Cardiomyopathy, Conduction Disorder, and Arrhythmia
McNair, W. P., Ku, L., Taylor, M. R. G., Fain, P. R., Dao, D., Wolfel, E., Mestroni, L., & the Familial Cardiomyopathy Registry Research Group (2004) · Circulation · doi:10.1161/01.cir.0000144458.58660.bb · Cited by 447
Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia
Mallat, Z., Tedgui, A., Fontaliran, F., Frank, R., Durigon, M., & Fontaine, G. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351604 · Cited by 415
Ventricular fibrillation without apparent heart disease: Description of six cases
Martini, B., Nava, A., Thiene, G., Buja, G. F., Canciani, B., Scognamiglio, R., Daliento, L., & Dalla Volta, S. (1989) · American Heart Journal · doi:10.1016/0002-8703(89)90011-2 · Cited by 366
Intracellular Na+ regulation in cardiac myocytes
Bers, D. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00656-9 · Cited by 306
Cited by
2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease
Pelliccia, A., Sharma, S., Gati, S., Bäck, M., Börjesson, M., Caselli, S., Collet, J.-P., Corrado, D., Drezner, J. A., Halle, M., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehaa605 · Cited by 1,958
Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H., Darrieux, F. C. C., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., et al. (2019) · Heart Rhythm · doi:10.1016/j.hrthm.2019.05.007 · Cited by 846
Self-citationFibrosis and Cardiac Arrhythmias
de Jong, S., van Veen, T. A. B., van Rijen, H. V. M., & de Bakker, J. M. T. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318207a35f · Cited by 360
The pathophysiological mechanism underlying Brugada syndrome
Wilde, A. A. M., Postema, P. G., Di Diego, J. M., Viskin, S., Morita, H., Fish, J. M., & Antzelevitch, C. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.07.012 · Cited by 345
ANTZELEVITCH, C. (2006) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2006.00507.x · Cited by 303
Metadata
- Authors
- Frustaci, A., Priori, S. G., Pieroni, M., Chimenti, C., Napolitano, C., Rivolta, I., Sanna, T., Bellocci, F., & Russo, M. A.
- Venue
- Circulation
- Published
- 2005-12-13
- Volume
- 112
- Issue
- 24
- Pages
- 3680-3687
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2108813711
- Cited by
- 364
- References
- 22
- FWCI
- 16.12
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cardiac Histological Substrate in Patients With Clinical Phenotype of Brugada Syndrome. https://app.cochat.ai/papers/10.1161/circulationaha.105.520999
- The paper
- Frustaci, A., Priori, S. G., Pieroni, M., Chimenti, C., Napolitano, C., Rivolta, I., Sanna, T., Bellocci, F., & Russo, M. A. (2005). Cardiac Histological Substrate in Patients With Clinical Phenotype of Brugada Syndrome. Circulation. https://doi.org/10.1161/circulationaha.105.520999
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
