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Cited by 262

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Triggering of Acute Cardiovascular Disease and Potential Preventive Strategies

Open access
Tofler, Geoffrey H., Muller, James E.·2006·Circulation
DOI 10.1161/circulationaha.105.596189
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Abstract

T he last 2 decades have seen major advances in under- standing of the mechanism of onset and treatment of acute coronary syndromes.It has become accepted that acute myocardial infarction (MI), sudden cardiac death, and stroke can be triggered by stressors such as heavy physical exertion and severe emotional stress; the clinical implications that can be derived from the findings of triggering remain uncertain, however.The triggering studies were stimulated by observations of a circadian variation and morning peak in MI, sudden cardiac death, and stroke that indicated that events did not occur randomly.1 In a 1989 review in Circulation, 1 we stated that although the primary value of recognizing the circadian variation of acute coronary events was the emphasis that could be placed on pharmacological protection during the morning hours, the main significance was the support it provided for the broader concept that the onset of coronary thrombosis at any time of the day is frequently triggered by activities of the patient.The aim of the present review is to update current knowledge about triggering of acute cardiovascular disease (CVD), place it in the context of advances in understanding of the mechanisms of onset, and suggest a 5-faceted strategy to protect against the pathophysiological effects of triggering.The rationale for such a strategy is discussed, with areas for further research highlighted.

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Metadata

Authors
Tofler, G. H., & Muller, J. E.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-10-24
Volume
114
Issue
17
Pages
1863-1872
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.105.596189
OpenAlex
W2150690763
Cited by
262
References
12
FWCI
10.06
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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