Periodontal therapy and cardiovascular risk

Orlandi, Marco; Graziani, Filippo; D'Aiuto, Francesco

doi:10.1111/prd.12299

Cited by 155Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsDental Research and COVID-19

Periodontal therapy and cardiovascular risk

Orlandi, Marco, Graziani, Filippo, D'Aiuto, Francesco·2020·Periodontology 2000

DOI 10.1111/prd.12299

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Abstract

Cardiovascular diseases are the worldwide leading cause of mortality. Cardiovascular diseases are noncommunicable conditions with a complex pathogenesis, and their clinical manifestations include major cardiovascular events such as myocardial infarction and stroke. Epidemiologic evidence suggests a consistent association between periodontitis and increased risk of cardiovascular diseases. Some evidence supports a beneficial effect of the treatment of periodontitis on both surrogate and hard cardiovascular outcomes. This narrative review has been conducted as an update of the most recent evidence on the effects of periodontitis treatment on cardiovascular outcomes since the last commissioned review of the European Federation of Periodontology‐American Academy of Periodontology World Workshop in 2012. Newer evidence originating from published randomized controlled trials confirms a positive effect of periodontal treatment on surrogate measures of cardiovascular diseases, whereas there have been no randomized controlled trials investigating the effect of periodontal treatment on the incidence of cardiovascular disease events such as myocardial infarction and stroke. In conclusion, there is sufficient evidence from observational and experimental studies on surrogate cardiovascular measures to justify the design and conduct of appropriately powered randomized controlled trials investigating the effect of effective periodontal interventions on cardiovascular disease outcomes (ie, myocardial infarction and stroke) with adequate control of traditional cardiovascular risk factors.

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An increased bacterial burden could represent a plausible mechanism for increases in white blood cell counts, release of proinflammatory cytokines, and then resulting in sustained release of acute phase proteins such as CRP.
“An increased bacterial burden could represent a plausible mechanism for increases in white blood cell counts (Luthra et al., 2019), release of proinflammatory cytokines (interleukins) and then resulting in sustained release of acute phase proteins such as CRP (Tonetti et al., 2007; Orlandi et al., 2020) (Figure 6).”
From Treatment of periodontitis and <scp>C</scp> ‐reactive protein: A systematic review and meta‐analysis of randomized clinical trials (2023) · cites this paper as Orlandi et al., 2020
The association between periodontitis and CVD is independent of other risk factors such as age, gender, dyslipidemia, hypertension, diabetes, and lifestyle factors such as smoking.
“It has been proved that there is an association between periodontitis and CVD, and this relation has been reported to be independent of other risk factors such as age, gender, dyslipidemia, hypertension, diabetes, and lifestyle factors such as smoking [12, 13].”
From Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis (2024) · cites this paper as [13]

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Periodontitis and cardiovascular diseases: Consensus report
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“…burden could represent a plausible mechanism for increases in white blood cell counts (Luthra et al., 2019), release of proinflammatory cytokines (interleukins) and then resulting in sustained release of acute phase proteins such as CRP (Tonetti et al., 2007; Orlandi et al., 2020) (Figure 6).”
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Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis
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“It has been proved that there is an association between periodontitis and CVD, and this relation has been reported to be independent of other risk factors such as age, gender, dyslipidemia, hypertension, diabetes, and lifestyle factors such as smoking [12, 13].”
Background

New attachment formation by guided tissue regeneration
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Self-citation

Authors: Orlandi, M., Graziani, F., & D'Aiuto, F.
Affiliations: University College London (GB)
University of Pisa (IT)
Periodontology Unit UCL Eastman Dental Institute London UK
ORCID: Orlandi, Marco
Graziani, Filippo
Venue: Periodontology 2000
Publisher: Wiley
Published: 2020-05-08
Volume: 83
Issue: 1
Pages: 107-124
ISSN: 0906-6713 (ISSN-L)
1600-0757
DOI: 10.1111/prd.12299
OpenAlex: W3022133625
Cited by: 155
References: 237
Citations by year: 2026: 14 · 2025: 20 · 2024: 29 · 2023: 38 · 2022: 27 · 2021: 20 · 2020: 7
FWCI: 3.73
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Periodontology 2000 (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Institute for Health and Care Research (CL-2016-18-014)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords: periodontitis, periodontal treatment, cardiovascular risk, cardiovascular disease, myocardial infarction, stroke, cardiovascular risk factors, randomized controlled trials
MeSH terms: Cardiovascular Diseases, Humans, Myocardial Infarction, Periodontics, Periodontitis, Risk Factors

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Periodontal therapy and cardiovascular risk

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