Circadian rhythm and cardiovascular disease
Abstract
The demonstration of a circadian variation in frequency of onset of myocardial infarction, sudden cardiac death, and stroke provides an opportunity to gain insight into the mechanism of transformation from chronic stable to acute unstable manifestation of cardiovascular disease. Contributing physiologic changes that exhibit a morning peak include arterial pressure, heart rate, and vascular tone, which promote plaque rupture, together with increased platelet reactivity and reduced fibrinolytic activity. The study of circadian rhythm also has implications for triggering of disease onset by external stressors. Further study of this area will provide insight into new approaches to prevent disease onset.
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Circadian oscillations have been reported for physiological CVD regulation including heart rate and blood pressure, for cardiac disorders including arrhythmias, and there is circadian variation in frequency of onset of myocardial infarction and sudden cardiac death.
“Circadian oscillations have been reported for both physiological CVD regulation including heart rate and blood pressure 57, for cardiac disorders including arrythmias 58, 59, and there is circadian variation in frequency of onset of myocardial infarction and sudden cardiac death 19, 60.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [59]
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The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387 · see citing works
- Authors
- Shaw, E., & Tofler, G. H.
- Affiliations
- Royal North Shore Hospital (AU)
- Corresponding author
- Tofler, Geoffrey H.
- Venue
- Current Atherosclerosis Reports
- Published
- 2009-06-14
- Volume
- 11
- Issue
- 4
- Pages
- 289-295
- ISSN
- 1523-3804 (ISSN-L)
- 1534-6242
- OpenAlex
- W1994321363
- Cited by
- 55
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Atherosclerosis Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- circadian rhythm, cardiovascular disease, myocardial infarction, sudden cardiac death, stroke, morning surge, arterial pressure, heart rate, vascular tone, plaque rupture, platelet reactivity, fibrinolysis, disease onset, stressors, disease prevention
- MeSH terms
- Blood Pressure, Cardiovascular Diseases, Circadian Rhythm, Humans, Risk Factors, Stress, Physiological, Platelet Activation
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