Cyclooxygenase inhibition and adverse remodeling during healing after myocardial infarction
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or over 2 millennia, physicians have strived to relieve pain, heal, and cause no harm.However, we depend on therapeutic drugs that have side effects and unknown pleiotropic effects.A host of publications and media coverage over the last 2 years alerted us to cardiovascular (CV) risks associated with chronic use of nonselective, nonsteroidal antiinflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors (COXIBs).The publicity elicited concern in patients taking these drugs for their valuable antipyretic, analgesic, and antiinflammatory properties and made physicians more vigilant about side effects such as gastrointestinal ulceration, inhibition of platelet aggregation and thrombosis, inhibition of uterine motility, inhibition of prostaglandin (PG)-mediated renal function, and hypersensitivity reactions.
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Long-term use of several NSAIDs is linked to adverse side-effects and a higher risk of cardiovascular disease.
“However, due to their adverse side-effects and increased cardiovascular disease (CVD) risk associated with chronic use of several NSAID [3], there is a critical need to identify natural products with anti-inflammatory properties.”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [3]
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Cites
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Research works printed but not linked: 1
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- Authors
- Jugdutt, B. I.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Jugdutt, Bodh I.
- Venue
- Circulation
- Published
- 2007-01-23
- Volume
- 115
- Issue
- 3
- Pages
- 288-291
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2107960414
- Cited by
- 41
- References
- 18
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 3 · 2013: 7 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- cyclooxygenase inhibition, COX-2 inhibitors, nonsteroidal anti-inflammatory drugs, myocardial infarction, cardiac remodeling, adverse drug reactions, cardiovascular risk, platelet aggregation, gastrointestinal ulceration, prostaglandins
- MeSH terms
- Celecoxib, Benzenesulfonamides, Animals, Anti-Inflammatory Agents, Non-Steroidal, Blood Pressure, Cardiovascular Diseases, Humans, Isoxazoles, Lactones, Myocardial Infarction, Prostaglandin-Endoperoxide Synthases, Pyrazoles, Risk Factors, Sulfonamides, Sulfones, Cyclooxygenase Inhibitors, Ventricular Remodeling
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