Anti-inflammatory and antinociceptive activities of methanolic extract from red seaweed Dichotomaria obtusata
Open accessAbstract
The aim of the present work was to investigate the anti-inflammatory and antinociceptive effects of methanolic extract from D. obtusata using classic models in mice (croton oil-induced ear edema and acetic acid-induced writhing) and a phospholipase A2 activity test. Qualitative analysis of the chemical composition of seaweed was also determined by extraction with solvents of increasing polarity and precipitation and color tests. Results of qualitative chemical study showed the presence of lactonic and phenolic compounds, reduced carbohydrates, other sugars, flavonoids, fatty compounds, triterpenes and steroids. The extract inhibited mouse ear edema in a dose-dependent manner with an efficacy higher than 90% and a mean effective dose of 4.87µg/ear, while intraperitoneal administration presented a moderate activity. The extract did not inhibit phospholipase A2 activity. In the writhing test, the intraperitoneal administration of the extract showed a strong antinociceptive activity (80.2%), while the oral route showed a lower efficacy. In conclusion, this study demonstrated the anti-inflammatory and antinociceptive effects of methanol extract of D. obtusata in experimental models, suggesting its therapeutic potential in the treatment of peripheral painful and/or inflammatory pathologies.
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Several studies have demonstrated that some extracts and compounds from a wide variety of algae have potential anti-inflammatory compounds.
“Several studies have demonstrated that some extracts and compounds from a wide variety of algae have potential anti-inflammatory compounds.”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [66]
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- Authors
- García Delgado, N., Frías Vázquez, A. I., Cabrera Sánchez, H., Soto del Valle, R. M., Sierra Gómez, Y., & Suárez Alfonso, A. M.
- Affiliations
- Center of Marine Bioproducts (CEBIMAR), Cuba
- University of Havana, Cuba
- Faculty of Medical Sciences Dr. Salvador Allende, Cuba
- Venue
- Brazilian Journal of Pharmaceutical Sciences
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2013-03
- Volume
- 49
- Issue
- 1
- Pages
- 65-74
- ISSN
- 1984-8250 (ISSN-L)
- OpenAlex
- W1996113375
- Cited by
- 19
- References
- 39
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 1
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Journal of Pharmaceutical Sciences (publishedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- red seaweed, methanol extract, anti-inflammatory activity, antinociceptive activity, ear edema, acetic acid-induced writhing, phospholipase A2 inhibition, flavonoids, phenolic compounds, triterpenoids, steroids, marine natural products
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