The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Bacteremia Associated With Toothbrushing and Dental Extraction
Open accessAbstract
Background— Antibiotic prophylaxis recommendations for the prevention of infective endocarditis are based in part on studies of bacteremia from dental procedures, but toothbrushing may pose a greater threat. The purpose of this study was to compare the incidence, duration, nature, and magnitude of endocarditis-related bacteremia from single-tooth extraction and toothbrushing and to determine the impact of amoxicillin prophylaxis on single-tooth extraction. Methods and Results— In this double-blind, placebo-controlled study, 290 subjects were randomized to (1) toothbrushing, (2) single-tooth extraction with amoxicillin prophylaxis, or (3) single-tooth extraction with identical placebo. Blood was drawn for bacterial culturing and identification at 6 time points before, during, and after these interventions. The focus of our analysis was on bacterial species reported to cause infective endocarditis. We identified 98 bacterial species, 32 of which are reported to cause endocarditis. Cumulative incidence of endocarditis-related bacteria from all 6 blood draws was 23%, 33%, and 60% for the toothbrushing, extraction-amoxicillin, and extraction-placebo groups, respectively ( P <0.0001). Significant differences were identified among the 3 groups at draws 2, 3, 4, and 5 (all P <0.05). Amoxicillin resulted in a significant decrease in positive cultures ( P <0.0001). Conclusions— Although amoxicillin has a significant impact on bacteremia resulting from a single-tooth extraction, given the greater frequency for oral hygiene, toothbrushing may be a greater threat for individuals at risk for infective endocarditis.
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Cites
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Self-citationBacterial Diversity in Human Subgingival Plaque
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Self-citationThe breadth of bacterial diversity in the human periodontal pocket and other oral sites
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Efficacy of antibiotic prophylaxis for prevention of native-valve endocarditis
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Self-citationRelationship of Bacteremia to Toothbrushing in Patients with Periodontitis
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Cited by
Otto, C. M., Nishimura, R. A., Bonow, R. O., Carabello, B. A., Erwin, J. P., Gentile, F., Jneid, H., Krieger, E. V., Mack, M., McLeod, C., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000923 · Cited by 3,686
Nishimura, R. A., Otto, C. M., Bonow, R. O., Carabello, B. A., Erwin, J. P., Fleisher, L. A., Jneid, H., Mack, M. J., McLeod, C. J., O’Gara, P. T., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.011 · Cited by 3,339
Otto, C. M., Nishimura, R. A., Bonow, R. O., Carabello, B. A., Erwin, J. P., Gentile, F., Jneid, H., Krieger, E. V., Mack, M., McLeod, C., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000932 · Cited by 2,449
Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009)
Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and by the International Society of Chemotherapy (ISC) for Infection and Cancer, Habib, G., Hoen, B., Tornos, P., Thuny, F., Prendergast, B., Vilacosta, I., Moreillon, P., de Jesus Antunes, M., Thilen, U., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp285 · Cited by 2,014
Fusobacterium nucleatum — symbiont, opportunist and oncobacterium
Brennan, C. A., & Garrett, W. S. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0129-6 · Cited by 1,205
Metadata
- Authors
- Lockhart, P. B., Brennan, M. T., Sasser, H. C., Fox, P. C., Paster, B. J., & Bahrani-Mougeot, F. K.
- Venue
- Circulation
- Published
- 2008-06-17
- Volume
- 117
- Issue
- 24
- Pages
- 3118-3125
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2072515653
- Cited by
- 851
- References
- 29
- FWCI
- 22.56
- Type
- journal article
- Language
- en
- Open access
- green
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