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Cited by 353

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Continuous Improvements in “Chain of Survival” Increased Survival After Out-of-Hospital Cardiac Arrests: A Large-Scale Population-Based Study

Open access
Iwami, Taku, Nichol, Graham, Hiraide, Atsushi, Hayashi, Yasuyuki, Nishiuchi, Tatsuya, Kajino, Kentaro, Morita, Hiroshi, Yukioka, Hidekazu, Ikeuchi, Hisashi, Sugimoto, Hisashi, Nonogi, Hiroshi, Kawamura, Takashi·2009·Circulation

Abstract

Background— The impact of ongoing efforts to improve the “chain of survival” for out-of-hospital cardiac arrest (OHCA) is unclear. The objective of this study was to evaluate the incremental effect of changes in prehospital emergency care on survival after OHCA. Methods and Results— This prospective, population-based observational study involved consecutive patients with OHCA from May 1998 through December 2006. The primary outcome measure was 1-month survival with favorable neurological outcome. Multiple logistic regression analysis was used to assess factors that were potentially associated with better neurological outcome. Among 42 873 resuscitation-attempted adult OHCAs, 8782 bystander-witnessed arrests of presumed cardiac origin were analyzed. The median time interval from collapse to call for medical help, first cardiopulmonary resuscitation, and first shock shortened from 4 (interquartile range [IQR] 2 to 11) to 2 (IQR 1 to 5) minutes, from 9 (IQR 5 to 13) to 7 (IQR 3 to 11) minutes, and from 19 (IQR 13 to 22) to 9 (IQR 7 to 12) minutes, respectively. Neurologically intact 1-month survival after witnessed ventricular fibrillation increased from 6% (6/96) to 16% (49/297; P <0.001). Among all witnessed OHCAs, earlier cardiopulmonary resuscitation (odds ratio per minute 0.89, 95% confidence interval 0.85 to 0.93) and earlier intubation (odds ratio per minute 0.96, 95% confidence interval 0.94 to 0.99) were associated with better neurological outcome. For ventricular fibrillation, only earlier shock was associated with better outcome (odds ratio 0.84, 95% confidence interval 0.80 to 0.88). Conclusions— Data from a large, population-based cohort demonstrate a continuous increase in OHCA survival with improvement in the chain of survival. The incremental benefit of early advanced care on OHCA survival is also suggested.

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Crossref · 10.1161/circulationaha.108.802058

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Metadata

Authors
Iwami, T., Nichol, G., Hiraide, A., Hayashi, Y., Nishiuchi, T., Kajino, K., Morita, H., Yukioka, H., Ikeuchi, H., Sugimoto, H., Nonogi, H., & Kawamura, T.
Venue
Circulation
Published
2009-02-10
Volume
119
Issue
5
Pages
728-734
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2050957972
Cited by
353
References
34
FWCI
29.79
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Continuous Improvements in “Chain of Survival” Increased Survival After Out-of-Hospital Cardiac Arrests: A Large-Scale Population-Based Study. https://app.cochat.ai/papers/10.1161/circulationaha.108.802058
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Iwami, T., Nichol, G., Hiraide, A., Hayashi, Y., Nishiuchi, T., Kajino, K., Morita, H., Yukioka, H., Ikeuchi, H., Sugimoto, H., Nonogi, H., & Kawamura, T. (2009). Continuous Improvements in “Chain of Survival” Increased Survival After Out-of-Hospital Cardiac Arrests: A Large-Scale Population-Based Study. Circulation. https://doi.org/10.1161/circulationaha.108.802058

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