The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Composition of Carotid Atherosclerotic Plaque Is Associated With Cardiovascular Outcome: A Prognostic Study
Abstract
Background— Identification of patients at risk for primary and secondary manifestations of atherosclerotic disease progression is based mainly on established risk factors. The atherosclerotic plaque composition is thought to be an important determinant of acute cardiovascular events, but no prospective studies have been performed. The objective of the present study was to investigate whether atherosclerotic plaque composition is associated with the occurrence of future vascular events. Methods and Results— Atherosclerotic carotid lesions were collected from patients who underwent carotid endarterectomy and were subjected to histological examination. Patients underwent clinical follow-up yearly, up to 3 years after carotid endarterectomy. The primary outcome was defined as the composite of a vascular event (vascular death, nonfatal stroke, nonfatal myocardial infarction) and vascular intervention. The cumulative event rate at 1-, 2-, and 3-year follow-up was expressed by Kaplan–Meier estimates, and Cox proportional hazards regression analyses were performed to assess the independence of histological characteristics from general cardiovascular risk factors. During a mean follow-up of 2.3 years, 196 of 818 patients (24%) reached the primary outcome. Patients whose excised carotid plaque revealed plaque hemorrhage or marked intraplaque vessel formation demonstrated an increased risk of primary outcome (risk difference=30.6% versus 17.2%; hazard ratio [HR] with [95% confidence interval]=1.7 [1.2 to 2.5]; and risk difference=30.0% versus 23.8%; HR=1.4 [1.1 to 1.9], respectively). Macrophage infiltration (HR=1.1 [0.8 to 1.5]), large lipid core (HR=1.1 [0.7 to 1.6]), calcifications (HR=1.1 [0.8 to 1.5]), collagen (HR=0.9 [0.7 to 1.3]), and smooth muscle cell infiltration (HR=1.3 [0.9 to 1.8]) were not associated with clinical outcome. Local plaque hemorrhage and increased intraplaque vessel formation were independently related to clinical outcome and were independent of clinical risk factors and medication use. Conclusions— The local atherosclerotic plaque composition in patients undergoing carotid endarterectomy is an independent predictor of future cardiovascular events.
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Cites
Inflammation, Atherosclerosis, and Coronary Artery Disease
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Self-citationCoronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly
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Intraplaque Hemorrhage and Progression of Coronary Atheroma
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Cited by
Thrombosis formation on atherosclerotic lesions and plaque rupture
Badimon, L., & Vilahur, G. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12296 · Cited by 697
Inflammatory processes in cardiovascular disease: a route to targeted therapies
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The Myth of the “Vulnerable Plaque”
Arbab-Zadeh, A., & Fuster, V. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.11.041 · Cited by 434
Erratum: Inflammatory processes in cardiovascular disease: a route to targeted therapies
Ruparelia, N., Chai, J. T., Fisher, E. A., & Choudhury, R. P. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.33 · Cited by 363
Saam, T., Hetterich, H., Hoffmann, V., Yuan, C., Dichgans, M., Poppert, H., Koeppel, T., Hoffmann, U., Reiser, M. F., & Bamberg, F. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.015 · Cited by 314
Metadata
- Authors
- Hellings, W. E., Peeters, W., Moll, F. L., Piers, S. R. D., van Setten, J., Van der Spek, P. J., de Vries, J.-P. P. M., Seldenrijk, K. A., De Bruin, P. C., Vink, A., Velema, E., de Kleijn, D. P. V., & Pasterkamp, G.
- Venue
- Circulation
- Published
- 2010-05-04
- Volume
- 121
- Issue
- 17
- Pages
- 1941-1950
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2124008781
- Cited by
- 447
- References
- 28
- FWCI
- 27.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hellings, W. E., Peeters, W., Moll, F. L., Piers, S. R. D., van Setten, J., Van der Spek, P. J., de Vries, J.-P. P. M., Seldenrijk, K. A., De Bruin, P. C., Vink, A., Velema, E., de Kleijn, D. P. V., & Pasterkamp, G. (2010). Composition of Carotid Atherosclerotic Plaque Is Associated With Cardiovascular Outcome: A Prognostic Study. Circulation. https://doi.org/10.1161/circulationaha.109.887497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
