Calcific Aortic Valve Disease: Not Simply a Degenerative Process: A Review and Agenda for Research From the National Heart and Lung and Blood Institute Aortic Stenosis Working Group Executive Summary: Calcific Aortic Valve Disease – 2011 Update
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Calcific aortic stenosis results from an active biology that promotes fibrosis and calcification of the valve leaflets, rather than being a passive degenerative process.
“Although long considered to be a passive and degenerative process, it is now clear that calcific AS results from an active biology that promotes fibrosis and calcification of the valve leaflets1.”
From Calcific aortic stenosis (2016) · cites this paper as [1]
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Flagged first, then by citations
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- [55]Rajamannan NM Subramaniam M Rickard D Stock SR Donovan J Springett M Orszulak T Fullerton DA Tajik AJ Bonow RO Spelsberg T Human aortic valve calcification is associated with an osteoblast phenotype Circulation 2003 107 17 2181 2184 see comment 12719282 PMC3922288
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- Authors
- Rajamannan, N. M., Evans, F. J., Aikawa, E., Grande-Allen, K. J., Demer, L. L., Heistad, D. D., Simmons, C. A., Masters, K. S., Mathieu, P., O'Brien, K. D., Schoen, F. J., Towler, D. A., Yoganathan, A. P., & Otto, C. M.
- Affiliations
- University of Iowa (US)
- From the Division of Cardiology and Pathology: Feinberg School of Medicine, Chicago IL (N.M.R.); National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda MD (F.J.E.); Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.); Rice University, Houston TX (K.J.G.-A.); David Geffen School of Medicine at UCLA, Los Angeles, CA (L.L.D.); Cardiovascular Center and Department of Internal Medicine, University of Iowa Carver College of...
- Corresponding author
- Rajamannan, Nalini M.
- ORCID
- Venue
- Circulation
- Published
- 2011-10-18
- Volume
- 124
- Issue
- 16
- Pages
- 1783-1791
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3306614
- OpenAlex
- W2151796223
- Cited by
- 842
- References
- 91
- Citations by year
- 2026: 49 · 2025: 42 · 2024: 34 · 2023: 44 · 2022: 49 · 2021: 63 · 2020: 60 · 2019: 65 · 2018: 69 · 2017: 65 · 2016: 59 · 2015: 65 · 2014: 80 · 2013: 56 · 2012: 36
- FWCI
- 39.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research (102721_1)
- National Heart, Lung, and Blood Institute (HL069229, R21HL081558, P01HL062984, R01HL081138, R01HL088651, HL088651, HL-62984, HL081138, R01HL069229, R01HL081202, R01HL085591, R01HL093281, 3R01HL085591S1)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Keywords
- calcific aortic valve disease, aortic valve calcification, degeneration, aortic stenosis, pathogenesis
- MeSH terms
- Aortic Valve, Aortic Valve Stenosis, Calcinosis, Humans, Rheumatic Heart Disease, United States, National Heart, Lung, and Blood Institute (U.S.)
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