Cited by 842Cardiac Valve Diseases and TreatmentsCardiac Imaging and DiagnosticsAortic Disease and Treatment Approaches

Calcific Aortic Valve Disease: Not Simply a Degenerative Process: A Review and Agenda for Research From the National Heart and Lung and Blood Institute Aortic Stenosis Working Group Executive Summary: Calcific Aortic Valve Disease – 2011 Update

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Rajamannan, Nalini M., Evans, Frank J., Aikawa, Elena, Grande-Allen, K. Jane, Demer, Linda L., Heistad, Donald D., Simmons, Craig A., Masters, Kristyn S. +6 more·2011·Circulation

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Crossref · 10.1161/circulationaha.110.006767

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  • Calcific aortic stenosis results from an active biology that promotes fibrosis and calcification of the valve leaflets, rather than being a passive degenerative process.

    “Although long considered to be a passive and degenerative process, it is now clear that calcific AS results from an active biology that promotes fibrosis and calcification of the valve leaflets1.”

    From Calcific aortic stenosis (2016) · cites this paper as [1]

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Research works printed but not linked: 2

  1. [51]O'Brien KD Kuusisto J Reichenbach DD Ferguson M Giachelli C Alpers CE Otto CM Osteopontin is expressed in human aortic valvular lesions Circulation 1995 92 2163 2168 7554197
  2. [55]Rajamannan NM Subramaniam M Rickard D Stock SR Donovan J Springett M Orszulak T Fullerton DA Tajik AJ Bonow RO Spelsberg T Human aortic valve calcification is associated with an osteoblast phenotype Circulation 2003 107 17 2181 2184 see comment 12719282 PMC3922288

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Authors
Rajamannan, N. M., Evans, F. J., Aikawa, E., Grande-Allen, K. J., Demer, L. L., Heistad, D. D., Simmons, C. A., Masters, K. S., Mathieu, P., O'Brien, K. D., Schoen, F. J., Towler, D. A., Yoganathan, A. P., & Otto, C. M.
Affiliations
  • University of Iowa (US)
  • From the Division of Cardiology and Pathology: Feinberg School of Medicine, Chicago IL (N.M.R.); National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda MD (F.J.E.); Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.); Rice University, Houston TX (K.J.G.-A.); David Geffen School of Medicine at UCLA, Los Angeles, CA (L.L.D.); Cardiovascular Center and Department of Internal Medicine, University of Iowa Carver College of...
Corresponding author
Rajamannan, Nalini M.
Venue
Circulation
Published
2011-10-18
Volume
124
Issue
16
Pages
1783-1791
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2151796223
Cited by
842
References
91
Citations by year
2026: 49 · 2025: 42 · 2024: 34 · 2023: 44 · 2022: 49 · 2021: 63 · 2020: 60 · 2019: 65 · 2018: 69 · 2017: 65 · 2016: 59 · 2015: 65 · 2014: 80 · 2013: 56 · 2012: 36
FWCI
39.15
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Canadian Institutes of Health Research (102721_1)
  • National Heart, Lung, and Blood Institute (HL069229, R21HL081558, P01HL062984, R01HL081138, R01HL088651, HL088651, HL-62984, HL081138, R01HL069229, R01HL081202, R01HL085591, R01HL093281, 3R01HL085591S1)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
Keywords
calcific aortic valve disease, aortic valve calcification, degeneration, aortic stenosis, pathogenesis
MeSH terms
Aortic Valve, Aortic Valve Stenosis, Calcinosis, Humans, Rheumatic Heart Disease, United States, National Heart, Lung, and Blood Institute (U.S.)

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