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Cited by 304

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

Open access
O'Donnell, Christopher J., Kavousi, Maryam, Smith, Albert V., Kardia, Sharon L.R., Feitosa, Mary F., Hwang, Shih-Jen, Sun, Yan V., Province, Michael A., Aspelund, Thor, Dehghan, Abbas, Hoffmann, Udo, Bielak, Lawrence F., Zhang, Qunyuan, Eiriksdottir, Gudny, van Duijn, Cornelia M., Fox, Caroline S., de Andrade, Mariza, Kraja, Aldi T., Sigurdsson, Sigurdur, Elias-Smale, Suzette E., Murabito, Joanne M., Launer, Lenore J., van der Lugt, Aad, Kathiresan, Sekar, the CARDIoGRAM Consortium, Krestin, Gabriel P., Herrington, David M., Howard, Timothy D., Liu, Yongmei, Post, Wendy, Mitchell, Braxton D., O'Connell, Jeffrey R., Shen, Haiqing, Shuldiner, Alan R., Altshuler, David, Elosua, Roberto, Salomaa, Veikko, Schwartz, Stephen M., Siscovick, David S., Voight, Benjamin F., Bis, Joshua C., Glazer, Nicole L., Psaty, Bruce M., Boerwinkle, Eric, Heiss, Gerardo, Blankenberg, Stefan, Zeller, Tanja, Wild, Philipp S., Schnabel, Renate B., Schillert, Arne, Ziegler, Andreas, Münzel, Thomas F., White, Charles C., Rotter, Jerome I., Nalls, Michael, Oudkerk, Matthijs, Johnson, Andrew D., Newman, Anne B., Uitterlinden, Andre G., Massaro, Joseph M., Cunningham, Julie, Harris, Tamara B., Hofman, Albert, Peyser, Patricia A., Borecki, Ingrid B., Cupples, L. Adrienne, Gudnason, Vilmundur, Witteman, Jacqueline C.M.·2011·Circulation
DOI 10.1161/circulationaha.110.974899
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Abstract

Background—: Coronary artery calcification (CAC) detected by computed tomography is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI). We sought to identify common genetic variants associated with CAC and further investigate their associations with MI. Methods and Results—: Computed tomography was used to assess quantity of CAC. A meta-analysis of genome-wide association studies for CAC was performed in 9961 men and women from 5 independent community-based cohorts, with replication in 3 additional independent cohorts (n=6032). We examined the top single-nucleotide polymorphisms (SNPs) associated with CAC quantity for association with MI in multiple large genome-wide association studies of MI. Genome-wide significant associations with CAC for SNPs on chromosome 9p21 near CDKN2A and CDKN2B (top SNP: rs1333049; P =7.58×10 −19 ) and 6p24 (top SNP: rs9349379, within the PHACTR1 gene; P =2.65×10 −11 ) replicated for CAC and for MI. Additionally, there is evidence for concordance of SNP associations with both CAC and MI at a number of other loci, including 3q22 ( MRAS gene), 13q34 ( COL4A1/COL4A2 genes), and 1p13 ( SORT1 gene). Conclusions—: SNPs in the 9p21 and PHACTR1 gene loci were strongly associated with CAC and MI, and there are suggestive associations with both CAC and MI of SNPs in additional loci. Multiple genetic loci are associated with development of both underlying coronary atherosclerosis and clinical events.

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Authors
O'Donnell, C. J., Kavousi, M., Smith, A. V., Kardia, S. L. R., Feitosa, M. F., Hwang, S.-J., Sun, Y. V., Province, M. A., Aspelund, T., Dehghan, A., Hoffmann, U., Bielak, L. F., Zhang, Q., Eiriksdottir, G., van Duijn, C. M., Fox, C. S., de Andrade, M., Kraja, A. T., Sigurdsson, S., Elias-Smale, S. E., Murabito, J. M., Launer, L. J., van der Lugt, A., Kathiresan, S., the CARDIoGRAM Consortium, Krestin, G. P., Herrington, D. M., Howard, T. D., Liu, Y., Post, W., Mitchell, B. D., O'Connell, J. R., Shen, H., Shuldiner, A. R., Altshuler, D., Elosua, R., Salomaa, V., Schwartz, S. M., Siscovick, D. S., Voight, B. F., Bis, J. C., Glazer, N. L., Psaty, B. M., Boerwinkle, E., Heiss, G., Blankenberg, S., Zeller, T., Wild, P. S., Schnabel, R. B., Schillert, A., Ziegler, A., Münzel, T. F., White, C. C., Rotter, J. I., Nalls, M., Oudkerk, M., Johnson, A. D., Newman, A. B., Uitterlinden, A. G., Massaro, J. M., Cunningham, J., Harris, T. B., Hofman, A., Peyser, P. A., Borecki, I. B., Cupples, L. A., Gudnason, V., & Witteman, J. C. M.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-12
Volume
124
Issue
25
Pages
2855-2864
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.110.974899
OpenAlex
W2146966456
Cited by
304
References
49
FWCI
12.61
Type
journal article
Language
en
Open access
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O'Donnell, C. J., Kavousi, M., Smith, A. V., Kardia, S. L. R., Feitosa, M. F., Hwang, S.-J., Sun, Y. V., Province, M. A., Aspelund, T., Dehghan, A., Hoffmann, U., Bielak, L. F., Zhang, Q., Eiriksdottir, G., van Duijn, C. M., Fox, C. S., de Andrade, M., Kraja, A. T., Sigurdsson, S., . . . Witteman, J. C. M. (2011). Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction. Circulation. https://doi.org/10.1161/circulationaha.110.974899

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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