Metabolic syndrome in adolescence: can it be predicted from natal and parental profile? The Prediction of Metabolic Syndrome in Adolescence (PREMA) study
Abstract
BACKGROUND: There are well-established predisposing factors for the development of metabolic syndrome (MetS) in childhood or adolescence, but no specific risk profile has been identified as yet. The Prediction of Metabolic Syndrome in Adolescence (PREMA) study was conducted (1) to construct a classification score that could detect children at high risk for MetS in adolescence and (2) to test its predictive accuracy. METHODS AND RESULTS: In the derivation cohort (1270 children), data from natal and parental profile and from initial laboratory assessment at 6 to 8 years of age were used to detect independent predictors of MetS at 13 to 15 years of age according to the International Diabetes Federation definition. In the validation cohort (1091 adolescents), the discriminatory capacity of the derived prediction score was tested on an independent adolescent population. MetS was diagnosed in 105 adolescents in the derivation phase (8%), whereas birth weight <10th percentile (odds ratio, 6.02; 95% confidence interval, 2.53-10.12, P<0.001), birth head circumference <10th percentile (odds ratio, 4.15; 95% confidence interval, 2.04-7.14, P<0.001), and parental overweight or obesity (in at least 1 parent; odds ratio, 3.22; 95% confidence interval, 1.30-5.29, P<0.01) were independently associated with diagnosis of MetS in adolescence. Among adolescents in the validation cohort (86 [8%] with MetS), the presence of all these 3 predictors predicted MetS with a sensitivity of 91% and a specificity of 98%. CONCLUSIONS: The coexistence of low birth weight, small head circumference, and parental history of overweight or obesity may be useful for detection of children at risk of developing MetS in adolescence.
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Multiple factors that begin before birth and continue through delivery, such as low birth weight, small head circumference, gestational diabetes, and lack of breastfeeding, place children at risk for MetS in adolescence and adulthood.
“For example, multiple factors that begin before birth and continue through delivery, such as low birth weight, small head circumference, gestational diabetes, and lack of breastfeeding, place children at risk for MetS in adolescence and adulthood (65).”
From The CardioMetabolic Health Alliance (2015) · cites this paper as [65]
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Cites
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
Obesity in children and young people: a crisis in public health
Lobstein, T., Baur, L., & Uauy, R. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00133.x · Cited by 3,801 · cited 2× · see citing works
“4 Pregnancy smoking (%) 193 (17) 20 (19) 0.”
Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005) · Pediatrics · doi:10.1542/peds.2004-1808 · Cited by 2,303 · see citing works
The metabolic syndrome in children and adolescents ? an IDF consensus report
Zimmet, P., Alberti, K. G. M., Kaufman, F., Tajima, N., Silink, M., Arslanian, S., Wong, G., Bennett, P., Shaw, J., Caprio, S., et al. (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00271.x · Cited by 2,013 · see citing works
Progress and Challenges in Metabolic Syndrome in Children and Adolescents
Steinberger, J., Daniels, S. R., Eckel, R. H., Hayman, L. L., Lustig, R. H., McCrindle, B. W., & Mietus‐Snyder, M. (2009) · Circulation · doi:10.1161/circulationaha.108.191394 · Cited by 713 · see citing works
BARKER, D. J. P., Osmond, C., Simmonds, S. J., & Wield, G. (1993) · BMJ · doi:10.1136/bmj.306.6875.422 · Cited by 703 · see citing works
Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both?
Bavdekar, A., Yajnik, C. S., Fall, C. H. D., Bapat, S. A., Pandit, A. N., Deshpande, V., Bhave, S., Kellingray, S., & Joglekar, C. V. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2422 · Cited by 652 · see citing works
Fetal growth and coronary heart disease in South India
Stein, C., Fall, C., Kumaran, K., Osmond, C., Barker, D. J. P., & Cox, V. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04547-3 · Cited by 607 · see citing works
Predicting obesity in early adulthood from childhood and parental obesity
Magarey, A., Daniels, L., BOULTON, T. J. C., & Cockington, R. A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802251 · Cited by 526 · see citing works
Fetal growth and impaired glucose tolerance in men and women
Phipps, K. P., Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., & Clark, P. M. (1993) · Diabetologia · doi:10.1007/bf00399954 · Cited by 490 · see citing works
Child to adult body mass index in the 1958 British birth cohort: associations with parental obesity
Lake, J. K., Power, C., & Cole, T. J. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.5.376 · Cited by 367 · see citing works
Growth in utero, adult blood pressure, and arterial compliance.
Martyn, C. N., Barker, D. J. P., Jespersen, S., Greenwald, S. E., Osmond, C., & Berry, C. L. (1995) · Heart · doi:10.1136/hrt.73.2.116 · Cited by 362 · see citing works
Visceral Fat, Waist Circumference, and BMI: Impact of Race/ethnicity
Carroll, J. F., Chiapa, A. L., Rodriquez, M., Phelps, D. R., Cardarelli, K., Vishwanatha, J. K., Bae, S., & Cardarelli, R. (2008) · Obesity · doi:10.1038/oby.2007.92 · Cited by 362 · see citing works
Maffeis, C., Talamini, G., & Tatò, L. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800655 · Cited by 314 · see citing works
Lawlor, D. A., Ronalds, G., Clark, H. R., Smith, G. D., & Leon, D. A. (2005) · Circulation · doi:10.1161/circulationaha.104.528356 · Cited by 298 · see citing works
Mi, J., Law, C., Zhang, K., Osmond, C., Stein, C., & Barker, D. J. P. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-4-200002150-00002 · Cited by 296 · see citing works
Impact of parental BMI on the manifestation of overweight 5–7 year old children
Danielzik, S., Langnäse, K., Mast, M., Spethmann, C., & Müller, M. J. (2002) · European Journal of Nutrition · doi:10.1007/s00394-002-0367-1 · Cited by 243 · see citing works
The Use of BMI and Waist Circumference as Surrogates of Body Fat Differs by Ethnicity
Lear, S. A., Humphries, K. H., Kohli, S., & Birmingham, C. L. (2007) · Obesity · doi:10.1038/oby.2007.334 · Cited by 240 · see citing works
Rich-Edwards, J. W., KLEINMAN, K. P., Michels, K. B., Stampfer, M. J., Manson, J. E., Rexrode, K. M., Hibert, E. N. L., & Willett, W. C. (2005) · BMJ · doi:10.1136/bmj.38434.629630.e0 · Cited by 218 · see citing works
Nobili, V., Alisi, A., Panera, N., et al. (2008) · PubMed · Cited by 171 · see citing works
McCrindle, B. W., Mietus‐Snyder, M., Steinberger, J., Daniels, S. R., Eckel, R. H., & Hayman, L. L. (2009) · Cited by 138 · see citing works
Parental and perinatal factors associated with childhood obesity in north-east Italy.
Maffeis, C., Micciolo, R., Must, A., Zaffanello, M., & Pinelli, L. (1994) · PubMed · Cited by 113 · see citing works
Lifshitz, F. (2009) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4008/jcrpe.v1i2.35 · Cited by 110 · see citing works
Development of Overweight in Children in Relation to Parental Weight and Socioeconomic Status
Semmler, C., Ashcroft, J., van Jaarsveld, C. H. M., Carnell, S., & Wardle, J. (2009) · Obesity · doi:10.1038/oby.2008.621 · Cited by 107 · see citing works
Floyd, Z. E., Wang, Z. Q., Kilroy, G. E., & Cefalu, W. T. (2008) · Metabolism · doi:10.1016/j.metabol.2008.04.006 · Cited by 95 · see citing works
Hirschler, V., Bugna, J., Roque, M., Gilligan, T., & González, C. D. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2008.08.003 · Cited by 89 · see citing works
Metabolic syndrome in obese children born large for gestational age
Wang, X., Liang, L. Y., Junfen, F. U., et al. (2007) · The Indian Journal of Pediatrics · doi:10.1007/s12098-007-0108-9 · Cited by 88 · see citing works
IGFs and Binding Proteins in Short Children with Intrauterine Growth Retardation
Cutfield, W. S., Hofman, P. L., Vickers, M. H., Breier, B. H., Blum, W. F., & Robinson, E. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8188 · Cited by 88 · see citing works
Clinical aspects of obesity in childhood and adolescence—diagnosis, treatment and prevention
Kiess, W., Reich, A., Müller, G., Meyer, K., Galler, A., Bennek, J., & Kratzsch, J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801704 · Cited by 77 · see citing works
Small for gestational age status is associated with metabolic syndrome in overweight children
Reinehr, T., Kleber, M., & Toschke, A. M. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0914 · Cited by 77 · see citing works
Birth Weight, Family History of Diabetes, and Metabolic Syndrome in Children and Adolescents
Guerrero‐Romero, F., Aradillas-García, C., Simental‐Mendía, L. E., Monreal‐Escalante, E., Mendoza, E. D. L. C., & Rodríguez‐Morán, M. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.11.043 · Cited by 73 · see citing works
Epidemiological Survey for the Prevalence of Overweight and Abdominal Obesity in Greek Adolescents
Tzotzas, T., Kapantais, E., Τζιόμαλος, Κ., et al. (2008) · Obesity · doi:10.1038/oby.2008.247 · Cited by 72 · see citing works
Sociodemographic determinants of low birthweight in Greece: a population study
Lekea‐Karanika, Tzoumaka‐Bakoula, & Matsaniotis (1999) · Paediatric and Perinatal Epidemiology · doi:10.1046/j.1365-3016.1999.00158.x · Cited by 70 · see citing works
Ozaki, R., Qiao, Q., Wong, G., Chan, M. H. M., So, W., Tong, P. C. Y., Ho, C. S., Ko, G. T. C., Kong, A. P. S., Lam, C. W. K., et al. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2006.100453 · Cited by 58 · see citing works
Walden, R. V., Taylor, S., Hansen, N. I., Poole, W. K., Stoll, B. J., Abuelo, D. N., & Vohr, B. R. (2007) · PEDIATRICS · doi:10.1542/peds.2007-0354 · Cited by 57 · see citing works
Maternal Waist Circumference and the Prediction of Children's Metabolic Syndrome
Hirschler, V. (2007) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.161.12.1205 · Cited by 49 · see citing works
Is a diagnosis of metabolic syndrome applicable to children?
Pergher, R. N. Q., de Melo, M. E., Halpern, A., Mancini, M. C., & Infantil, L. D. O. (2010) · Jornal de Pediatria · doi:10.2223/jped.1983 · Cited by 49 · see citing works
Frontini, M., Srinivasan, S. R., Xu, J.-H., et al. (2004) · BMC Pediatrics · doi:10.1186/1471-2431-4-22 · Cited by 40 · see citing works
Low birth weight and blood pressure
Lenfant, C. J. M. (2008) · Metabolism · doi:10.1016/j.metabol.2008.07.013 · Cited by 38 · see citing works
Head size at birth and long-term mortality from coronary heart disease
Risnes, K. R., Nilsen, T. I. L., Romundstad, P., & VATTEN, L. J. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp169 · Cited by 37 · see citing works
Stergiou, G. S., Karpettas, N., Panagiotakos, D. B., & Vazeou, A. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2010.59 · Cited by 36 · cited 1× · see citing works
“Maternal age (years) 28±6 HDL (mg/dl) 53±10 Pregnancy smoking (%) 197 (18) Triglycerides (mg/dl) 88±31 Pregnancy alcohol consumption (%) 99 (9) Non-HDL cholesterol (mg/dl) 108±15 Premature delivery (%) 110 (10) Total/HDL cholesterol ratio 3±1 Caesarian section (%) 524 (48) First pregnancy (%) 403 (37) Breast-feeding f…”
Abe, Y., Kikuchi, T., Nagasaki, K., Hiura, M., Tanaka, Y., Ogawa, Y., & Uchiyama, M. (2007) · Hypertension Research · doi:10.1291/hypres.30.627 · Cited by 33 · see citing works
Tzotzas, T., Kapantais, E., Τζιόμαλος, Κ., et al. (2011) · PubMed · Cited by 30 · see citing works
Reduced foetal growth and growth hormone secretion in adult life
Flanagan, D., Moore, V., Godsland, I. F., et al. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00718.x · Cited by 26 · see citing works
O diagnóstico de síndrome metabólica é aplicável às crianças?
Pergher, R. N. Q., de Melo, M. E., Halpern, A., & Mancini, M. C. (2010) · Jornal Vascular Brasileiro · doi:10.1590/s0021-75572010000200004 · Cited by 15 · see citing works
First body fat percentiles for 607 children from Thessaloniki-Northern Greece.
Papandreou, D., Malindretos, P., & Rousso, I. (2010) · PubMed · Cited by 11 · see citing works
Marques (1997) · doi:10.1002/(sici)1096-9136(199708)14:8
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- Phillips DI, Barker DJ. Association between low birthweight and high resting pulse in adult life: is the sympathetic nervous system involved in pro- gramming the insulin resistance syndrome? Diabet Med. 1997;14:673-677.
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The CardioMetabolic Health Alliance
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- Authors
- Efstathiou, S. P., Skeva, I. I., Zorbala, E., Georgiou, E., & Mountokalakis, T. D.
- Affiliations
- Hygeia Hospital (GR)
- From the Center for Cardiovascular Disease Prevention, Hygeias Melathron Infirmary, Athens, Greece.
- ORCID
- Georgiou, Evangelos
- Venue
- Circulation
- Published
- 2012-02-21
- Volume
- 125
- Issue
- 7
- Pages
- 902-910
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2046603484
- Cited by
- 79
- References
- 47
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 12 · 2012: 2
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- metabolic syndrome, adolescence, risk scoring, low birth weight, birth head circumference, parental obesity, parental overweight, childhood obesity, risk factors
- MeSH terms
- Adolescent, Birth Weight, Child, Cross-Sectional Studies, Humans, Obesity, Parents, Predictive Value of Tests, Prospective Studies, Cohort Studies, Odds Ratio, Metabolic Syndrome
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