Ticagrelor Compared With Clopidogrel by Geographic Region in the Platelet Inhibition and Patient Outcomes (PLATO) Trial
Abstract
Background—: In the Platelet Inhibition and Patient Outcomes (PLATO) trial, a prespecified subgroup analysis showed a significant interaction between treatment and region ( P =0.045), with less effect of ticagrelor in North America than in the rest of the world. Methods and Results—: Reasons for the interaction were explored independently by 2 statistical groups. Systematic errors in trial conduct were investigated. Statistical approaches evaluated the likelihood of play of chance. Cox regression analyses were performed to quantify how much of the regional interaction could be explained by patient characteristics and concomitant treatments, including aspirin maintenance therapy. Landmark Cox regressions at 8 time points evaluated the association of selected factors, including aspirin dose, with outcomes by treatment. Systematic errors in trial conduct were ruled out. Given the large number of subgroup analyses performed and that a result numerically favoring clopidogrel in at least 1 of the 4 prespecified regions could occur with 32% probability, chance alone cannot be ruled out. More patients in the United States (53.6%) than in the rest of the world (1.7%) took a median aspirin dose ≥300 mg/d. Of 37 baseline and postrandomization factors explored, only aspirin dose explained a substantial fraction of the regional interaction. In adjusted analyses, both Cox regression with median maintenance dose and landmark techniques showed that, in patients taking low-dose maintenance aspirin, ticagrelor was associated with better outcomes compared with clopidogrel, with statistical superiority in the rest of the world and similar outcomes in the US cohort. Conclusions—: The regional interaction could arise from chance alone. Results of 2 independently performed analyses identified an underlying statistical interaction with aspirin maintenance dose as a possible explanation for the regional difference. The lowest risk of cardiovascular death, myocardial infarction, or stroke with ticagrelor compared with clopidogrel is associated with a low maintenance dose of concomitant aspirin. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00391872.
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International trials of various pharmacotherapies have sometimes found discordant results in patients enrolled in the United States than seen in overall trial results.
“International trials of various pharmacotherapies have sometimes found discordant results in patients enrolled in the United States than seen in overall trial results.19–32”
From REDUCE-IT USA: Results From the 3146 Patients Randomized in the United States (2020) · cites this paper as [20]
The reasons for discordant US results range from low numbers of patients enrolled in the United States to potential differences in background medical management or in patient risk profiles.
“The reasons range from low numbers of patients enrolled in the United States to potential differences in background medical management or in patient risk profiles.”
From REDUCE-IT USA: Results From the 3146 Patients Randomized in the United States (2020) · cites this paper as [20]
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Ticagrelor versus clopidogrel in patients with acute coronary syndromes
Wallentin, L., Becker, R. C., Budaj, A., Cannon, C. P., Emanuelsson, H., Held, C., Horrow, J., Husted, S., James, S., Katus, H., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904327 · Cited by 7,117 · see citing works
Self-citationAuthors Task Force Members, de Werf, F. V., Bax, J. J., Betriu, A., Blomström‐Lundqvist, C., Crea, F., Falk, V., Filippatos, G. S., Fox, K. A. A., Huber, K., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn416 · Cited by 2,294 · see citing works
Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E., Chavey, W. E., Fesmire, F. M., Hochman, J. S., Levin, T. N., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.181940 · Cited by 1,962 · see citing works
Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes
Bassand, J., Hamm, C. W., Ardissino, D., Boersma, E. H., Budaj, A., Fernández‐Avilés, F., Fox, K. A. A., Hasdai, D., Ohman, E. M., Wallentin, L. C., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm161 · Cited by 1,850 · see citing works
Self-citationPredictors of 30-Day Mortality in the Era of Reperfusion for Acute Myocardial Infarction
Lee, K. L., Woodlief, L. H., Topol, E. J., Weaver, W. D., Betriu, A., Col, J. J., Simoons, M. L., Aylward, P. E., de Werf, F. V., & Califf, R. M. (1995) · Circulation · doi:10.1161/01.cir.91.6.1659 · Cited by 1,093 · see citing works
Boersma, E. H., Pieper, K. S., Steyerberg, E. W., Wilcox, R. G., Chang, W.-C., Lee, K. L., Akkerhuis, K. M., Harrington, R. A., Deckers, J. W., Armstrong, P. W., et al. (2000) · Circulation · doi:10.1161/01.cir.101.22.2557 · Cited by 962 · see citing works
Self-citationDose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes
The CURRENT–OASIS 7 Investigators (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909475 · Cited by 767 · see citing works
FitzGerald, G. A., Oates, J. A., Hawiger, J., Maas, R. L., Roberts, L. J., Lawson, J. A., & BRASH, A. R. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110814 · Cited by 662 · see citing works
Cannon, C. P., Husted, S., Harrington, R. A., Scirica, B. M., Emanuelsson, H., Peters, G. R., & Storey, R. F. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.053 · Cited by 496 · see citing works
Self-citationJames, S. K., Åkerblom, A., Cannon, C. P., Emanuelsson, H., Husted, S., Katus, H. A., Skene, A. M., Steg, P. G., Storey, R. F., Harrington, R. A., et al. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.01.003 · Cited by 404 · see citing works
Self-citationStorey, R. F., Angiolillo, D. J., Patil, S. B., Desai, B., Ecob, R., Husted, S., Emanuelsson, H., Cannon, C. P., Becker, R. C., & Wallentin, L. C. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.100 · Cited by 373 · see citing works
Self-citation2011 Writing Group Members, Wright, R. S., Anderson, J. L., Adams, C. D., Bridges, C. R., Casey, D. E., Ettinger, S. M., Fesmire, F. M., Ganiats, T. G., Jneid, H. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820f2f3e · Cited by 356 · see citing works
Wright, R. S., Anderson, J. L., Adams, C. D., Bridges, C. R., Casey, D. E., Ettinger, S. M., Fesmire, F. M., Ganiats, T. G., Jneid, H. M., Lincoff, A. M., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.009 · Cited by 341 · see citing works
Storey, R. F., Sanderson, H. M., White, A. E., May, J. A., Cameron, K. E., & Heptinstall, S. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02208.x · Cited by 289 · see citing works
Self-citationWarner, T. D., Nylander, S., & Whatling, C. A. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.03943.x · Cited by 249 · see citing works
Armstrong, P., Leadbeater, P. D. M., Chan, M. V., Kirkby, N. S., Jakubowski, J. A., Mitchell, J. A., & Warner, T. D. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04160.x · Cited by 203 · see citing works
Cattaneo, M., & Lecchi, A. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02356.x · Cited by 88 · see citing works
Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy
Armstrong, P. C. J., Dhanji, A.-R., Tucker, A., Mitchell, J. A., & Warner, T. D. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03714.x · Cited by 87 · see citing works
Fox, K. A. A. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1983 · Cited by 45 · see citing works
Pieper, K. S., Tsiatis, A. A., Davidian, M., Hasselblad, V., Kleiman, N. S., Boersma, E. H., Chang, W.-C., Griffin, J., Armstrong, P. W., Califf, R. M., et al. (2004) · Circulation · doi:10.1161/01.cir.0000112570.97220.89 · Cited by 36 · see citing works
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Research works printed but not linked: 2
- Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, Horrow J, Husted S, James S, Katus H, Mahaffey KW, Scirica BM, Skene A, Steg PG, Storey RF, Harrington RA; PLATO Investigators, Freij A, Thorse ´n M. Ticagrelor versus clopidogrel in patients with acute coronary syndromes [supplement]. N Engl J Med. 2009;361:1045-1057, e1-e34. http://www.nejm.org/doi/suppl/10.1056/NEJMoa0904327/suppl_file/ nejm_wallentin_1045sa1.pdf. Accessed June 10, 2011. · DOI
- Fox KA, Goodman S, Bigonzi F, Le Louer V, Cohen M. Inter-regional differences and outcome in unstable angina. Eur Heart J. 2000;21: 1433-1439.
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Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.017 · Cited by 3,595 · see citing works
Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J., Costa, F., Jeppsson, A., Jüni, P., Kastrati, A., Kolh, P. H., Mauri, L., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx419 · Cited by 2,999 · see citing works
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O'Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., Franklin, B. A., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.019 · Cited by 2,625 · see citing works
Levine, G. N., Bates, E., Bittl, J. A., Brindis, R. G., Fihn, S. D., Fleisher, L. A., Granger, C. B., Lange, R. A., Mack, M. J., Mauri, L., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.03.513 · Cited by 1,648 · see citing works
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Lawton, J. S., Tamis‐Holland, J. E., Bangalore, S., Bates, E., Beckie, T. M., Bischoff, J. M., Bittl, J. A., Cohen, M. G., DiMaio, J. M., Don, C. W., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.09.006 · Cited by 1,651 · see citing works
Levine, G. N., Bates, E. R., Bittl, J. A., Brindis, R. G., Fihn, S. D., Fleisher, L. A., Granger, C. B., Lange, R. A., Mack, M. J., Mauri, L., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000404 · Cited by 1,355 · see citing works
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Schüpke, S., Neumann, F.-J., Menichelli, M., Mayer, K., Bernlochner, I., Wöhrle, J., Richardt, G., Liebetrau, C., Witzenbichler, B., Antoniucci, D., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1908973 · Cited by 816 · see citing works
Self-citationVranckx, P., Valgimigli, M., Jüni, P., Hamm, C. W., Steg, P. G., Heg, D., van Es, G. A., McFadden, E. P., Onuma, Y., van Meijeren, C., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31858-0 · Cited by 791 · see citing works
Amsterdam, E. A., WENGER, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H. M., Kelly, R. F., Kontos, M. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.016 · Cited by 780 · see citing works
Rao, S. V., O’Donoghue, M. L., Ruel, M., Rab, T., Tamis-Holland, J. E., Alexander, J. H., Baber, U., Baker, H., Cohen, M. G., Cruz-Ruiz, M., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001309 · Cited by 625 · see citing works
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Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J., Costa, F., Jeppsson, A., Jüni, P., Kastrati, A., Kolh, P. H., Mauri, L., et al. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx334 · Cited by 416 · see citing works
Self-citationRothwell, P. M., Cook, N. R., Gaziano, J. M., Price, J. F., Belch, J. F. F., Roncaglioni, M. C., Morimoto, T., & Mehta, Z. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31133-4 · Cited by 353 · see citing works
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Franchi, F., & Angiolillo, D. J. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.156 · Cited by 352 · see citing works
Self-citationLevine, G. N., Jeong, Y., Goto, S., Anderson, J. L., Huo, Y., Mega, J. L., Taubert, K. A., & Smith, S. C. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.104 · Cited by 337 · see citing works
Levine, G. N., Bates, E. R., Bittl, J. A., Brindis, R. G., Fihn, S. D., Fleisher, L. A., Granger, C. B., Lange, R. A., Mack, M. J., Mauri, L., et al. (2016) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2016.07.044 · Cited by 304 · see citing works
Aradi, D., Storey, R. F., Komócsi, A., Trenk, D., Gulba, D. C., Kiss, R. G., Husted, S., Bonello, L., Sibbing, D., Collet, J., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht375 · Cited by 275 · see citing works
Self-citationAnderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E., Chavey, W. E., Fesmire, F. M., Hochman, J. S., Levin, T. N., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828478ac · Cited by 273 · see citing works
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Dobesh, P. P., & Oestreich, J. H. (2014) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1477 · Cited by 236 · see citing works
Ohman, E. M., Roe, M. T., Steg, P. G., James, S. K., Povsic, T. J., White, J. A., Rockhold, F. W., Plotnikov, A. N., Mundl, H., Strony, J. T., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30751-1 · Cited by 223 · see citing works
Self-citationAspirin-free strategies in cardiovascular disease and cardioembolic stroke prevention
Capodanno, D., Mehran, R., Valgimigli, M., Baber, U., Windecker, S., Vranckx, P., Dangas, G., Rollini, F., Kimura, T., Collet, J., et al. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0049-1 · Cited by 215 · see citing works
Self-citationPark, D., Kwon, O., Jang, J., Yun, S., Park, H., Kang, D., Ahn, J., Lee, P. H., Lee, S., Park, S., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.041766 · Cited by 210 · see citing works
Jneid, H. M., Addison, D., Bhatt, D. L., Fonarow, G. C., Gokak, S. Z., Grady, K. L., Green, L. A., Heidenreich, P. A., Ho, P. M., Jurgens, C. Y., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.06.032 · Cited by 188 · see citing works
Badimón, L., Vilahur, G., Rocca, B., & Patrono, C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab003 · Cited by 179 · see citing works
Jneid, H. M., Addison, D., Bhatt, D. L., Fonarow, G. C., Gokak, S. Z., Grady, K. L., Green, L. A., Heidenreich, P. A., Ho, P. M., Jurgens, C. Y., et al. (2017) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/hcq.0000000000000032 · Cited by 169 · see citing works
You, S. C., Rho, Y., Bikdeli, B., Kim, J., Siapos, A., Weaver, J. C., Londhe, A. A., Cho, J., Park, J., Schuemie, M. J., et al. (2020) · JAMA · doi:10.1001/jama.2020.16167 · Cited by 165 · see citing works
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Capodanno, D., & Angiolillo, D. J. (2012) · Circulation · doi:10.1161/circulationaha.111.084996 · Cited by 166 · see citing works
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Teng, R. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0290-2 · Cited by 160 · see citing works
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Tomaniak, M., Chichareon, P., Onuma, Y., Deliargyris, E., Takahashi, K., Kogame, N., Modolo, R., Chang, C. C., Rademaker-Havinga, T. A. M., Storey, R. F., et al. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2019.3355 · Cited by 138 · see citing works
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Nanhwan, M. K., Ling, S., Kodakandla, M., Nylander, S., Ye, Y., & Birnbaum, Y. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304002 · Cited by 134 · see citing works
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Rosselló, X., Huo, Y., Pocock, S., de Werf, F. V., Chin, C. T., Danchin, N., Lee, S. W. L., Medina, J., Vega, A., & Bueno, H. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.07.039 · Cited by 133 · see citing works
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Management of antiplatelet therapy in patients undergoing neuroendovascular procedures
Kim, K. S., Fraser, J. F., Grupke, S. L., & Cook, A. M. (2017) · Journal of neurosurgery · doi:10.3171/2017.5.jns162307 · Cited by 123 · see citing works
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Angiolillo, D. (2012) · Drugs · doi:10.2165/11640880-000000000-00000 · Cited by 105 · see citing works
Self-citationEapen, Z. J., Reed, S. D., Li, Y., Kociol, R. D., Armstrong, P. W., Starling, R. C., McMurray, J. J. V., Massie, B. M., Swedberg, K. B., Ezekowitz, J. A., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.000265 · Cited by 117 · see citing works
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Nylander, S., & Schulz, R. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13429 · Cited by 110 · see citing works
Tanguay, J., Bell, A., Ackman, M. L., Bauer, R. D. C., Cartier, R., Chan, W., Douketis, J. D., Roussin, A., Schnell, G., Verma, S., et al. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.07.001 · Cited by 107 · see citing works
Vranckx, P., Valgimigli, M., Windecker, S., Steg, P. G., Hamm, C. W., Jüni, P., García‐García, H. M., van Es, G., & Serruys, P. W. J. C. (2016) · EuroIntervention · doi:10.4244/eijy15m11_07 · Cited by 107 · see citing works
Jeong, H. S., Hong, S. J., Cho, S.-A., Kim, J.-H., Cho, J. Y., Lee, S. H., Joo, H. J., Park, J. H., Yu, C. W., & Lim, D. (2017) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2017.05.064 · Cited by 105 · see citing works
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Kazi, D. S., Garber, A. M., Shah, R. U., Dudley, R. A., Mell, M. W., Rhee, C., Moshkevich, S., Boothroyd, D. B., Owens, D. K., & Hlatky, M. A. (2014) · Annals of Internal Medicine · doi:10.7326/m13-1999 · Cited by 104 · see citing works
Cao, D., Chandiramani, R., Chiarito, M., Claessen, B. E. P. M., & Mehran, R. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa824 · Cited by 98 · see citing works
Antiplatelet and Anticoagulation Therapy for Acute Coronary Syndromes
Bhatt, D. L., Hulot, J., Moliterno, D. J., & Harrington, R. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302737 · Cited by 97 · see citing works
Self-citationVaduganathan, M., Bhatt, D. L., Cryer, B., Liu, Y., Hsieh, W.-H., Doros, G. D., Cohen, M. C., Lanas, Á., Schnitzer, T. J., Shook, T., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.12.068 · Cited by 93 · see citing works
Self-citationHeart Failure Around the World
Tromp, J., Ferreira, J. P., Janwanishstaporn, S., Shah, M., Greenberg, B., Zannad, F. M., & Lam, C. S. P. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1585 · Cited by 93 · see citing works
Naidu, S. S., Krucoff, M. W., Rutledge, D. R., Mao, V. W., Zhao, W., Qing, Z., Wilburn, O., Sudhir, K., Simonton, C. A., & Hermiller, J. B. (2012) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2012.02.014 · Cited by 92 · see citing works
Medical Management After Coronary Stent Implantation
Brilakis, E. S., PATEL, V. G., & Banerjee, S. (2013) · JAMA · doi:10.1001/jama.2013.7086 · Cited by 90 · see citing works
Schunkert, H., Boening, A., von Scheidt, M., Lanig, C., Gusmini, F., de Waha, A., Kuna, C., Fach, A., Grothusen, C., Oberhoffer, M. M., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz185 · Cited by 92 · see citing works
A Critical Appraisal of Aspirin in Secondary Prevention
Gargiulo, G., Windecker, S., Vranckx, P., Gibson, C. M., Mehran, R., & Valgimigli, M. (2016) · Circulation · doi:10.1161/circulationaha.116.023952 · Cited by 89 · see citing works
G-Protein–Coupled Receptors Signaling Pathways in New Antiplatelet Drug Development
Gurbel, P. A., Kuliopulos, A., & Tantry, U. S. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303412 · Cited by 88 · see citing works
The Changing Landscape of Randomized Clinical Trials in Cardiovascular Disease
Jones, W. S., Roe, M. T., Antman, E. M., Pletcher, M. J., Harrington, R. A., Rothman, R. L., Oetgen, W. J., Rao, S. V., Krucoff, M. W., Curtis, L. H., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.07.781 · Cited by 86 · see citing works
Self-citationAntiplatelet therapy: new pharmacological agents and changing paradigms
Capodanno, D., Ferreiro, J. L., & Angiolillo, D. J. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12219 · Cited by 83 · see citing works
Self-citationGross, A. S., Harry, A., Clifton, C. S., & Pasqua, O. E. D. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15242 · Cited by 79 · see citing works
Floyd, C. N., Passacquale, G., & Ferro, A. (2012) · Clinical Pharmacokinetics · doi:10.2165/11630740-000000000-00000 · Cited by 75 · see citing works
New Directions in Antiplatelet Therapy
Ferreiro, J., & Angiolillo, D. (2012) · Circulation. Cardiovascular Interventions · doi:10.1161/circinterventions.111.966176 · Cited by 69 · see citing works
Self-citationCrescente, M., Menke, L., Chan, M. V., Armstrong, P. C. J., & Warner, T. D. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14196 · Cited by 70 · see citing works
Clinical implications of drug–drug interactions with P2Y12 receptor inhibitors
Siller-Matula, J. M., Trenk, D., Krähenbühl, S., Michelson, A. D., & Delle‐Karth, G. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12445 · Cited by 66 · see citing works
Diagnosis and Management of Ischemic Heart Disease
Franchini, M., Cervellin, G., & Lippi, G. (2013) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1333543 · Cited by 65 · see citing works
International differences in treatment effect: do they really exist and why?†
Pocock, S., Calvo, G., Marrugat, J., Prasad, K., Tavazzi, L., Wallentin, L. C., Zannad, F. M., & Garcia, A. A. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht071 · Cited by 65 · see citing works
Self-citationYun, J. E., Kim, Y. J., Park, J. J., Kim, S., Park, K., Cho, M. S., Nam, G., & Park, D. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012078 · Cited by 64 · see citing works
Clinical evidence for oral antiplatelet therapy in acute coronary syndromes
Wiviott, S. D., & Steg, P. G. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60213-6 · Cited by 64 · see citing works
Larmore, C. J., Effron, M. B., Molife, C., DeKoven, M., Zhu, Y. E., Lu, J., Karkare, S. U., Lieu, H. D., Lee, W. C., & Vetrovec, G. W. (2015) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.26279 · Cited by 64 · see citing works
Gremmel, T., Yanachkov, I. B., Yanachkova, M. I., Wright, G. E., Wider, J. M., Undyala, V. V. R., Michelson, A. D., Frelinger, A. L., & Przyklenk, K. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306885 · Cited by 64 · see citing works
Johnston, A., Jones, W. S., & Hernandez, A. F. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0749-2 · Cited by 62 · see citing works
Tobbia, P., Brodie, B. R., Witzenbichler, B., Metzger, C., Guagliumi, G., Yu, J., Kellett, M. A., Stuckey, T., Fahy, M. P., Mehran, R., et al. (2013) · EuroIntervention · doi:10.4244/eijv8i10a176 · Cited by 59 · see citing works
Newer agents in antiplatelet therapy: a review
Holinstat, M. A., & Yeung, J. (2012) · Journal of Blood Medicine · doi:10.2147/jbm.s25421 · Cited by 57 · see citing works
Caroff, J., Aubert, L., Lavenu‐Bombled, C., Figueiredo, S., Habchi, K., Cortese, J., Eugène, F., Ognard, J., Tahon, F., Forestier, G., et al. (2022) · Journal of NeuroInterventional Surgery · doi:10.1136/neurintsurg-2021-018601 · Cited by 55 · see citing works
Vranckx, P., Valgimigli, M., Odutayo, A., Serruys, P. W. J. C., Hamm, C. W., Steg, P. G., Heg, D., Fadden, E. P. M., Onuma, Y., Benit, E., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.119.015560 · Cited by 53 · see citing works
Modern Management of ST-Segment Elevation Myocardial Infarction
Frampton, J., DeVries, J. T., Welch, T. D., & Gersh, B. J. (2018) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2018.08.005 · Cited by 52 · see citing works
Overview of pleiotropic effects of platelet P2Y12 receptor inhibitors
Koziński, M., Ostrowska, M., Fabiszak, T., Navarese, E. P., Paciorek, P., Grześk, G., Kubica, J., & Adamski, P. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-11-0915 · Cited by 51 · see citing works
New Approaches to Inhibiting Platelets and Coagulation
Depta, J. P., & Bhatt, D. L. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124438 · Cited by 51 · see citing works
Association of Discharge Aspirin Dose With Outcomes After Acute Myocardial Infarction
Xian, Y., Wang, T. Y., McCoy, L. A., Effron, M. B., Henry, T. D., Bach, R. G., Zettler, M. E., Baker, B., Fonarow, G. C., & Peterson, E. D. (2015) · Circulation · doi:10.1161/circulationaha.114.014992 · Cited by 51 · see citing works
Advocating cardiovascular precision medicine with P2Y12 receptor inhibitors
Winter, M., Grove, E. L., Caterina, R. D., Gorog, D. A., Ahrens, I., Geisler, T., Gurbel, P. A., Tantry, U. S., Navarese, E. P., & Siller-Matula, J. M. (2017) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw044 · Cited by 50 · see citing works
Rescuing clinical trials in the United States and beyond: A call for action
Eapen, Z. J., Vavalle, J. P., Granger, C. B., Harrington, R. A., Peterson, E. D., & Califf, R. M. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.02.003 · Cited by 45 · see citing works
Self-citationSardar, P., Udell, J. A., Chatterjee, S., Bansilal, S., Mukherjee, D., & Farkouh, M. E. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001577 · Cited by 44 · see citing works
Novel agents for anti-platelet therapy
Ji, X., & Hou, M. (2011) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-4-44 · Cited by 45 · see citing works
Antiplatelet agents for chronic kidney disease
Natale, P., Palmer, S. C., Saglimbene, V. M., Ruospo, M., Razavian, M., Craig, J. C., Jardine, M., Webster, A. C., & Strippoli, G. F. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008834.pub4 · Cited by 45 · see citing works
Levine, G. N., Jeong, Y., Goto, S., Anderson, J. L., Huo, Y., Mega, J. L., Taubert, K. A., & Smith, S. C. (2014) · Global Heart · doi:10.1016/j.gheart.2014.08.001 · Cited by 43 · see citing works
Angiolillo, D. J., & Ferreiro, J. L. (2013) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-013-0022-7 · Cited by 42 · see citing works
Self-citationHistorical Lessons in Translational Medicine
Fitzgerald, D. J., & FitzGerald, G. A. (2013) · Circulation Research · doi:10.1161/circresaha.111.300271 · Cited by 44 · see citing works
Teng, R., Maya, J. F., & Butler, K. A. (2012) · Platelets · doi:10.3109/09537104.2012.748185 · Cited by 42 · see citing works
Aspirin, Clopidogrel, and Ticagrelor in Acute Coronary Syndromes
Berger, J. S. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.04.055 · Cited by 41 · see citing works
Binsaleh, N. K., Wigley, C. A., Whitehead, K. A., van Rensburg, M., Reynisson, J., Pilkington, L. I., Barker, D. L. A., Jones, S., & Dempsey‐Hibbert, N. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.11.014 · Cited by 41 · see citing works
Is aspirin useful in primary prevention?
Cleland, J. G. F. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht287 · Cited by 40 · see citing works
Platelet Function Testing in Contemporary Clinical and Interventional Practice
Franchi, F., Rollini, F., Cho, J. R., Ferrante, E., & Angiolillo, D. J. (2014) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-014-0300-y · Cited by 40 · see citing works
Self-citationMoertl, D., Chen, L., Coyle, D., Wells, G. A., & Steiner, S. (2012) · Thrombosis and Haemostasis · doi:10.1160/th11-08-0586 · Cited by 39 · see citing works
Buccheri, S., Capodanno, D., James, S. K., & Angiolillo, D. J. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1680637 · Cited by 39 · see citing works
Self-citationTicagrelor: clinical development and future potential
Sanderson, N. C., Parker, W. A., & Storey, R. F. (2021) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2202044 · Cited by 39 · see citing works
Self-citationYu, J., Mehran, R., Dangas, G., Claessen, B. E. P. M., Baber, U., Xu, K., Parise, H., Fahy, M. P., Lansky, A. J., Witzenbichler, B., et al. (2012) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2012.07.016 · Cited by 38 · see citing works
Khin, N. A., Yang, P., Hung, H., Maung-U, K., Chen, Y.-F., Meeker-O’Connell, A., Okwesili, P., Yasuda, S. U., Ball, L. K., Sm, H., et al. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.70 · Cited by 37 · see citing works
- Authors
- Mahaffey, K. W., Wojdyla, D. M., Carroll, K., Becker, R. C., Storey, R. F., Angiolillo, D. J., Held, C., Cannon, C. P., James, S., Pieper, K. S., Horrow, J., Harrington, R. A., & Wallentin, L.
- Affiliations
- Uppsala University (SE)
- ORCID
- Venue
- Circulation
- Published
- 2011-08-02
- Volume
- 124
- Issue
- 5
- Pages
- 544-554
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2085260510
- Cited by
- 434
- References
- 20
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 10 · 2023: 13 · 2022: 19 · 2021: 19 · 2020: 16 · 2019: 29 · 2018: 20 · 2017: 32 · 2016: 37 · 2015: 38 · 2014: 52 · 2013: 55 · 2012: 68
- FWCI
- 40.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- Duke Clinical Research Institute
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Keywords
- ticagrelor, clopidogrel, PLATO trial, regional interaction, platelet aggregation inhibition, antiplatelet therapy, cardiovascular mortality, myocardial infarction, stroke, subgroup analysis
- MeSH terms
- Clopidogrel, Ticagrelor, Adenosine, Aged, Aspirin, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Risk Factors, Ticlopidine, United States, Global Health, Proportional Hazards Models, Stroke, Purinergic P2Y Receptor Antagonists
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