Childhood obesity.

Lakshman, Rajalakshmi; Elks, Cathy E.; Ong, Ken K.

doi:10.1161/circulationaha.111.047738

Cited by 330Obesity, Physical Activity, DietObesity and Health PracticesBariatric Surgery and Outcomes

Childhood obesity.

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Lakshman, Rajalakshmi, Elks, Cathy E., Ong, Ken K.·2012·Circulation

DOI 10.1161/circulationaha.111.047738PMC PMC3785130

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Abstract

C hildhood obesity has important consequences for health and wellbeing both during childhood and also in later adult life.The rising prevalence of childhood obesity poses a major public health challenge in both developed and developing countries by increasing the burden of chronic noncommunicable diseases.Despite the urgent need for effective preventative strategies, there remains disagreement over its definition due to a lack of evidence on the optimal cut-offs linking childhood BMI to disease risks, and limited evidence on the most effective components of interventions to prevent childhood obesity.This article reviews the trends in childhood obesity, its genetic, nutritional and other risk factors, and preventative and treatment strategies.Particular emphasis is given to early-onset obesity in preschool children, which, as a precursor to later childhood and adult obesity, provides insights into the developmental and genetic origins of obesity and also offers the potential for early preventative approaches with long-lasting benefits.

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Risk factors for progression to type 2 diabetes include maternal age, prepartum and postpartum BMI, family history of type 2 diabetes, receipt of insulin for gestational diabetes, and fasting glucose level during pregnancy.
“The risk factors for progression to type 2 diabetes include maternal age, prepartum and postpartum BMI, family history of type 2 diabetes, receipt of insulin for gestational diabetes, and fasting glucose level during pregnancy.6,[24][25][26]”
From Association of Gestational Diabetes With Maternal Disorders of Glucose Metabolism and Childhood Adiposity (2018) · cites this paper as [26]
The 'Birth weight and antenatal factors' section discusses maternal obesity and pregnancy glycaemia as associated with offspring outcomes, not a mother's progression to type 2 diabetes. A search for postpartum diabetes after gestational diabetes and the listed risk factors found no passage addressing that progression. (LLM, conf=0.76)
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Babey, S. H., Hastert, T. A., Wolstein, J., & Diamant, A. L. (2010) · American Journal of Public Health · doi:10.2105/ajph.2010.192641 · Cited by 59 · see citing works
The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis
Askie, L. M., Baur, L. A., Campbell, K. J., Daniels, L., Hesketh, K. D., Magarey, A., Mihrshahi, S., Rissel, C. E., Simes, R. J., Taylor, B. J., et al. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-728 · Cited by 55 · see citing works
Phenotype of Infants of Mothers with Gestational Diabetes
Catalano, P. M., Thomas, A., Huston-Presley, L., & Amini, S. B. (2007) · Diabetes Care · doi:10.2337/dc07-s209 · Cited by 49 · see citing works
Breastfeeding, complementary (solid) foods, and long-term risk of obesity
Kramer, M. S. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29199 · Cited by 40 · see citing works
Systematic review of the effectiveness and cost-effectiveness of weight management schemes for the under fives: a short report
Bond, M., Wyatt, K. M., Lloyd, J., Welch, K., & Taylor, R. S. (2009) · Health Technology Assessment · doi:10.3310/hta13610 · Cited by 39 · see citing works
Comorbidities and microvascular complications of type 2 diabetes in children and adolescents
Dean, H., & Sellers, E. A. C. (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00340.x · Cited by 38 · see citing works
Reversing the tide of obesity
Dietz, W. H. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61218-x · Cited by 33 · see citing works
Does Early Growth Affect Long-Term Risk Factors for Cardiovascular Disease?
Singhal, A. (2010) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000281145 · Cited by 20 · see citing works
Commentary: Assessing the impact of breastfeeding on child health: where conventional methods alone fall short for reliably establishing causal inference
Brion, M. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp318 · Cited by 20 · see citing works
Stabilization in the prevalence of childhood obesity: a role for early nutrition?
Rolland‐Cachera, M., & Péneau, S. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.64 · Cited by 14 · see citing works
Is there a path for approval of an antiobesity drug
Downey, M., Still, C. D., & Sharma, A. M. (2011) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32834a8726 · Cited by 10 · see citing works

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Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works
Incidence of Childhood Obesity in the United States
Cunningham, S. A., Kramer, M. R., & Narayan, K. M. V. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1309753 · Cited by 723 · see citing works
Association of Gestational Diabetes With Maternal Disorders of Glucose Metabolism and Childhood Adiposity
Lowe, W. L., Scholtens, D. M., Lowe, L. P., Kuang, A., Nodzenski, M., Talbot, O., Catalano, P. M., Linder, B., Brickman, W. J., Clayton, P., et al. (2018) · JAMA · doi:10.1001/jama.2018.11628 · Cited by 591 · see citing works
Childhood and Adolescent Obesity in the United States: A Public Health Concern
Sanyaolu, A., Okorie, C., Qi, X., Locke, J., & Rehman, S. (2019) · Global Pediatric Health · doi:10.1177/2333794x19891305 · Cited by 471 · see citing works
Differences in gut microbiota composition between obese and lean children: a cross-sectional study
Bervoets, L., Hoorenbeeck, K. V., Kortleven, I., Noten, C. V., Hens, N., Vael, C., Goossens, H., Desager, K., & Vankerckhoven, V. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-10 · Cited by 452 · see citing works
Global increased cesarean section rates and public health implications: A call to action
Angolile, C. M., Max, B. L., Mushemba, J., & Mashauri, H. L. (2023) · Health Science Reports · doi:10.1002/hsr2.1274 · Cited by 321 · see citing works
Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement
Eslam, M., Alkhouri, N., Vajro, P., Baumann, U., Weiss, R., Socha, P., Marcus, C., Lee, W. S., Kelly, D. A., Porta, G., et al. (2021) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(21)00183-7 · Cited by 281 · see citing works
Phentermine and topiramate for the management of obesity: a review
Uwaifo, G. I., Cosentino, & Conrad, A. O. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s31443 · Cited by 242 · see citing works
Determinants of sugar‐sweetened beverage consumption in young children: a systematic review
Paes, V. M., Hesketh, K. R., O’Malley, C. L., Moore, H. J., Summerbell, C. D., Griffin, S. J., van Sluijs, E. M. F., Ong, K. K., & Lakshman, R. (2015) · Obesity Reviews · doi:10.1111/obr.12310 · Cited by 222 · see citing works
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Short sleep duration and large variability in sleep duration are independently associated with dietary risk factors for obesity in Danish school children
Kjeldsen, J. S., Hjorth, M. F., Andersen, R., Michaelsen, K. F., Tetens, I., Astrup, A. V., Chaput, J., & Sjödin, A. M. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.147 · Cited by 209 · see citing works
Socioeconomic position and childhood-adolescent weight status in rich countries: a systematic review, 1990–2013
Lapresa, L. B., Miqueléiz, E., Albaladejo, R., Villanueva, R., Santos, J. M., & Regidor, E. (2015) · BMC Pediatrics · doi:10.1186/s12887-015-0443-3 · Cited by 192 · see citing works
The intestinal microbiota composition and weight development in children: the KOALA Birth Cohort Study
Scheepers, L. E. J. M., Penders, J., Mbakwa, C. A., Thijs, C., Mommers, M., & Arts, I. C. W. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.178 · Cited by 162 · see citing works
Sleep and cardiometabolic risk in children and adolescents
Quist, J. S., Sjödin, A. M., Chaput, J., & Hjorth, M. F. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.09.001 · Cited by 165 · see citing works
Treatment of Pediatric Obesity: An Umbrella Systematic Review
Rajjo, T. I., Mohammed, K. S., Alsawas, M., Ahmed, A. T., Farah, W. H., Asi, N., Almasri, J., Prokop, L. J., & Murad, M. H. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2574 · Cited by 159 · see citing works
Maternal obesity, gestational diabetes, breastfeeding and childhood overweight at age 2 years
Bider-Canfield, Z., Martinez, M. P., Wang, X., Yu, W., Bautista, M. P., Brookey, J., Page, K. A., Buchanan, T. A., & Xiang, A. H. (2016) · Pediatric Obesity · doi:10.1111/ijpo.12125 · Cited by 157 · see citing works
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Paes, V. M., Ong, K. K., & Lakshman, R. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-007396 · Cited by 145 · see citing works
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Sugar-Sweetened Beverages and Children's Health
Scharf, R. J., & DeBoer, M. D. (2015) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-032315-021528 · Cited by 141 · see citing works
Dynamics of childhood growth and obesity: development and validation of a quantitative mathematical model
Hall, K. D., Butte, N. F., Swinburn, B. A., & Chow, C. C. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70051-2 · Cited by 138 · see citing works
Prevalence of childhood and adolescent overweight and obesity in Asian countries: a systematic review and meta-analysis
Mazidi, M., Banach, M., & Kengne, A. P. (2018) · Archives of Medical Science · doi:10.5114/aoms.2018.79001 · Cited by 140 · see citing works
Novel Insights in the Metabolic Syndrome in Childhood and Adolescence
Bussler, S., Penke, M., Flemming, G. M. C., Elhassan, Y., Kratzsch, J., Sergeyev, E., Lipek, T., Vogel, M., Spielau, U., Körner, A., et al. (2017) · Hormone Research in Paediatrics · doi:10.1159/000479510 · Cited by 129 · see citing works
Childhood Obesity Incidence in the United States: A Systematic Review
Cheung, P. C., Cunningham, S. A., Narayan, K. M. V., & Kramer, M. R. (2016) · Childhood Obesity · doi:10.1089/chi.2015.0055 · Cited by 117 · see citing works
Role of Dietary Factors, Food Habits, and Lifestyle in Childhood Obesity Development
Verduci, E., Bronský, J., Embleton, N. D., Gerasimidis, K., Indrio, F., Köglmeier, J., de Koning, B., Lapillonne, A., Moltu, S. J., Norsa, L., et al. (2021) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003075 · Cited by 124 · see citing works
BMI Trajectories Associated With Resolution of Elevated Youth BMI and Incident Adult Obesity
Buscot, M., Thomson, R. J., Juonala, M., Sabin, M. A., Burgner, D. P., Lehtimäki, T. J., Hutri‐Kähönen, N., Viikari, J. S. A., Jokinen, E. V., Tossavainen, P. H., et al. (2017) · PEDIATRICS · doi:10.1542/peds.2017-2003 · Cited by 106 · see citing works
GLP‐1 agonists for obesity and type 2 diabetes in children: Systematic review and meta‐analysis
Chadda, K. R., Cheng, T. S., & Ong, K. K. (2020) · Obesity Reviews · doi:10.1111/obr.13177 · Cited by 103 · see citing works
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Habitual sleep variability, mediated by nutrition intake, is associated with abdominal obesity in adolescents
He, F., Bixler, E. O., Liao, J., Berg, A. S., Kawasawa, Y. I., Fernández‐Mendoza, J., Vgontzas, A. N., & Liao, D. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.07.028 · Cited by 100 · see citing works
Liraglutide effects in a paediatric (7‐11 y) population with obesity: A randomized, double‐blind, placebo‐controlled, short‐term trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics
Mastrandrea, L. D., Witten, L. M., Petri, K. C. C., Hale, P. M., Hedman, H. K., & Riesenberg, R. A. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12495 · Cited by 98 · see citing works
Determinants of Change in Physical Activity in Children 0–6 years of Age: A Systematic Review of Quantitative Literature
Hesketh, K. R., O’Malley, C. L., Paes, V. M., Moore, H. J., Summerbell, C. D., Ong, K. K., Lakshman, R., & van Sluijs, E. M. F. (2016) · Sports Medicine · doi:10.1007/s40279-016-0656-0 · Cited by 89 · see citing works
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The association between obesity and academic performance in youth: a systematic review
Santana, C. C. A., Hill, J. O., Azevedo, L. B., Gunnarsdottir, T., & do Prado, W. L. (2017) · Obesity Reviews · doi:10.1111/obr.12582 · Cited by 82 · see citing works
Genetics of non-syndromic childhood obesity and the use of high-throughput DNA sequencing technologies
da Fonseca, A. C. P., Mastronardi, C. A., Johar, A., Arcos‐Burgos, M., & Paz-Filho, G. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.04.026 · Cited by 82 · see citing works
Maternal metabolic factors during pregnancy predict early childhood growth trajectories and obesity risk: the CANDLE Study
Hu, Z., Tylavsky, F. A., Han, J. C., Koçak, M., Fowke, J. H., Davis, R. L., LeWinn, K. Z., Bush, N. R., & Zhao, Q. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0326-z · Cited by 79 · see citing works
Michigan cohorts to determine associations of maternal pre-pregnancy body mass index with pregnancy and infant gastrointestinal microbial communities: Late pregnancy and early infancy
Sugino, K. Y., Paneth, N., & Comstock, S. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213733 · Cited by 74 · see citing works
Population-Based Studies on the Epidemiology of Insulin Resistance in Children
van der Aa, M. P., FARSANI, S. F. F., Knibbe, C. A. J., de Boer, A., & van der Vorst, M. M. J. (2015) · Journal of Diabetes Research · doi:10.1155/2015/362375 · Cited by 73 · see citing works
Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review
Zhao, X. Y., Gang, X., Liu, Y., Sun, C., Han, Q., & Wang, G. (2016) · Journal of Diabetes Research · doi:10.1155/2016/8160545 · Cited by 70 · see citing works
The associations of the gut microbiome composition and short-chain fatty acid concentrations with body fat distribution in children
Wei, Y., Liang, J., Su, Y., Wang, J., Amakye, W. K., Pan, J., Chu, X., Ma, B., Song, Y., Li, Y., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.11.014 · Cited by 67 · see citing works
Whole-grain intake favorably affects markers of systemic inflammation in obese children: A randomized controlled crossover clinical trial
Hajihashemi, P., Azadbakht, L., Hashemipor, M., Kelishadi, R., & Esmaillzadeh, A. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300582 · Cited by 66 · see citing works
2-Aminoadipic acid (2-AAA) as a potential biomarker for insulin resistance in childhood obesity
Lee, H., Jang, H. B., Kim, W., Park, K. J., Kim, K. Y., Park, S. I., & Lee, H. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-49578-z · Cited by 63 · see citing works
Anthropometric assessment of children’s nutritional status: a new approach based on an adaptation of Waterlow’s classification
Ferreira, H. D. S. (2020) · BMC Pediatrics · doi:10.1186/s12887-020-1940-6 · Cited by 60 · see citing works
FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis
Liu, C., Mou, S., & Cai, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082133 · Cited by 59 · see citing works
Association between gestational PFAS exposure and Children's adiposity in a diverse population
Bloom, M. S., Commodore, S., Ferguson, P. L., Neelon, B., Pearce, J. L., Baumer, A., Newman, R., Grobman, W. A., Tita, A., Roberts, J. R., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111820 · Cited by 59 · see citing works
Musculoskeletal pain in schoolchildren across puberty: a 3-year follow-up study
Sperotto, F., Brachi, S., Vittadello, F., & Zulian, F. (2015) · Pediatric Rheumatology · doi:10.1186/s12969-015-0014-z · Cited by 56 · see citing works
The Effect of Maternal Overweight and Obesity Pre-Pregnancy and During Childhood in the Development of Obesity in Children and Adolescents: A Systematic Literature Review
Mannino, A., Sarapis, K., & Moschonis, G. (2022) · Nutrients · doi:10.3390/nu14235125 · Cited by 58 · see citing works
Whole grain diet reduces systemic inflammation
Xu, Y., Wan, Q., Feng, J., Du, L., Li, K., & Zhou, Y. (2018) · Medicine · doi:10.1097/md.0000000000012995 · Cited by 60 · see citing works
Associations between Infant Feeding Practice Prior to Six Months and Body Mass Index at Six Years of Age
Imai, C. M., Gunnarsdóttir, I., Þórisdóttir, B., Halldorsson, T. I., & Þórsdóttir, I. (2014) · Nutrients · doi:10.3390/nu6041608 · Cited by 54 · see citing works
Association between a school‐based intervention and adiposity outcomes in adolescents: The Italian “ EAT ” project
Ermetici, F., Zelaschi, R., Briganti, S., Dozio, E., Gaeta, M., Ambrogi, F., Pelissero, G., Tettamanti, G., Romanelli, M. M. C., Carruba, M. O., et al. (2016) · Obesity · doi:10.1002/oby.21365 · Cited by 53 · see citing works
Risk Factors, Clinical Consequences, Prevention, and Treatment of Childhood Obesity
Shaban Mohamed, M. A., AbouKhatwa, M. M., Saifullah, A. A., Hareez Syahmi, M., Mosaad, M., Elrggal, M. E., Dehele, I. S., & Elnaem, M. H. (2022) · Children · doi:10.3390/children9121975 · Cited by 52 · see citing works
Dietary protein intake and quality in early life
Lind, M. V., Larnkjær, A., Mølgaard, C., & Michaelsen, K. F. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000338 · Cited by 52 · see citing works
Children with Intellectual Disability Are Vulnerable to Overweight and Obesity: A Cross-Sectional Study among Chinese Children
Wang, J., Gao, Y., Kwok, H. H. M., Huang, Y., Li, S., & Li, L. (2018) · Childhood Obesity · doi:10.1089/chi.2018.0015 · Cited by 52 · see citing works
Socio‐economic status and overweight or obesity among school‐age children in sub‐ S aharan A frica – a systematic review
Fruhstorfer, B. H., Mousoulis, C., Uthman, O. A., & Robertson, W. (2016) · Clinical Obesity · doi:10.1111/cob.12130 · Cited by 51 · see citing works
The relation of physical activity, sedentary behaviors, and academic achievement is mediated by fitness and bedtime.
Syväoja, H. J., Kankaanpää, A., Kallio, J., Hakonen, H., Kulmala, J., Hillman, C. H., Pesonen, A.-K., & Tammelin, T. H. (2018) · Journal of Physical Activity and Health · doi:10.1123/jpah.2017-0135 · Cited by 50 · see citing works
BMI, Waist Circumference Reference Values for Chinese School-Aged Children and Adolescents
Song, P., Li, X., Gašević, D., Flores, A., & Yu, Z. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13060589 · Cited by 49 · see citing works
The effect of a multi-disciplinary obesity intervention compared to usual practice in those ready to make lifestyle changes: design and rationale of Whanau Pakari
Anderson, Y. C., Wynter, L. E., Moller, K. R., Cave, T. L., Dolan, G. M. S., Grant, C. C., STEWART, J. M., Cutfield, W. S., & Hofman, P. L. (2015) · BMC Obesity · doi:10.1186/s40608-015-0068-y · Cited by 48 · see citing works
Mitochondrial DNA methylation and copy number predict body composition in a young female population
Bordoni, L., Smerilli, V., Nasuti, C., & Gabbianelli, R. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02150-9 · Cited by 47 · see citing works
Effects of Maternal Dietary Patterns during Pregnancy on Early Childhood Growth Trajectories and Obesity Risk: The CANDLE Study
Hu, Z., Tylavsky, F. A., Koçak, M., Fowke, J. H., Han, J. C., Davis, R. L., LeWinn, K. Z., Bush, N. R., Sathyanarayana, S., Karr, C. J., et al. (2020) · Nutrients · doi:10.3390/nu12020465 · Cited by 54 · see citing works
Associations Between Genetic Obesity Susceptibility and Early Postnatal Fat and Lean Mass
Elks, C. E., Heude, B., de Zegher, F., Barton, S. J., Clément, K., Inskip, H. M., Koudou, Y. A., Cooper, C. C., Dunger, D. B., Ibáñez, L., et al. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2014.1619 · Cited by 44 · see citing works
Self-citation
The GReat-Child™ Trial: A Quasi-Experimental Intervention on Whole Grains with Healthy Balanced Diet to Manage Childhood Obesity in Kuala Lumpur, Malaysia
Koo, H. C., Poh, B. K., & Talib, R. A. (2018) · Nutrients · doi:10.3390/nu10020156 · Cited by 45 · see citing works
The predictive value of anthropometric indices for cardiometabolic risk factors in Chinese children and adolescents: A national multicenter school-based study
Li, Y., Zou, Z., Luo, J., Ma, J., Ma, Y., Jin, J., Zhang, X., Luo, C., Wang, H., Zhao, H., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227954 · Cited by 44 · see citing works
Early colonization of the gut microbiome and its relationship with obesity
Dreyer, J. L., & Liebl, A. L. (2018) · Human Microbiome Journal · doi:10.1016/j.humic.2018.08.002 · Cited by 44 · see citing works
Altered Gut Microbiota and Shift in Bacteroidetes between Young Obese and Normal‐Weight Korean Children: A Cross‐Sectional Observational Study
Shin, S., & Cho, K. Y. (2020) · BioMed Research International · doi:10.1155/2020/6587136 · Cited by 44 · see citing works
Impact of body size and physical activity during adolescence and adult life on overall and cause-specific mortality in a large cohort study from Iran
Etemadi, A., Abnet, C. C., Kamangar, F., Islami, F., Khademi, H., Pourshams, A., Poustchi, H., Bagheri, M., Sohrabpour, A. A., Aliasgar, A., et al. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9883-6 · Cited by 43 · see citing works
Parental pre‐pregnancy BMI is a dominant early‐life risk factor influencing BMI of offspring in adulthood.
Rath, S. R., Marsh, J. A., Newnham, J. P., Zhu, K., Atkinson, H. C., Mountain, J., Oddy, W. H., Hughes, I. P., Harris, M., Leong, G. M., et al. (2016) · Obesity Science & Practice · doi:10.1002/osp4.28 · Cited by 43 · see citing works
Trends and correlates of overweight/obesity in Czech adolescents in relation to family socioeconomic status over a 12-year study period (2002–2014)
Sigmund, E., Baďura, P., Sigmundová, D., Voráčová, J., Zacpal, J., Kalman, M., Pavelka, J., Vokáčová, J., Hobza, V., & Hamřík, Z. (2018) · BMC Public Health · doi:10.1186/s12889-017-5013-1 · Cited by 42 · see citing works
Hormony tarczycy i otyłość: znana, lecz słabo rozpoznana relacja
García‐Solís, P., García, O. P., Hernández‐Puga, G., Tusie, A. A. S., Sáenz-Luna, C. E., Hernández-Montiel, H. L., & Solís‐S, J. C. (2018) · Endokrynologia Polska · doi:10.5603/ep.2018.0032 · Cited by 42 · see citing works
Characterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance
Wu, S., Gao, H., Ma, Y., Fu, L., Zhang, C., & Luo, X. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12233 · Cited by 40 · see citing works
Cardiovascular Risk Factors in Young Adults
Tran, D.-M. T., & Zimmerman, L. M. (2014) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000150 · Cited by 40 · see citing works
Assessment of health-related quality of life and psychological well-being of children and adolescents with obesity enrolled in a New Zealand community-based intervention programme: An observational study
Anderson, Y. C., Wynter, L. E., Treves, K. F., Grant, C. C., Stewart, J. M., Cave, T. L., Wouldes, T. A., Derraik, J. G. B., Cutfield, W. S., & Hofman, P. L. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015776 · Cited by 39 · see citing works
Maternal Blood Pressure Rise During Pregnancy and Offspring Obesity Risk at 4 to 7 Years Old: The Jiaxing Birth Cohort
Zheng, J., Liu, H., Ong, K. K., Huang, T., Guan, Y., Huang, Y., Yang, B., Wang, F., & Li, D. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01500 · Cited by 39 · see citing works
Self-citation
Trends of Underweight and Overweight/Obesity Among Japanese Schoolchildren From 2003 to 2012, Defined by Body Mass Index and Percentage Overweight Cutoffs
Shirasawa, T., Ochiai, H., Nanri, H., Nishimura, R., Ohtsu, T., Hoshino, H., Tajima, N., & Kokaze, A. (2015) · Journal of Epidemiology · doi:10.2188/jea.je20140144 · Cited by 38 · see citing works
Evaluation of the relationship between serum adropin levels and blood pressure in obese children
Altıncık, A., & Sayın, O. (2015) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2015-0051 · Cited by 37 · see citing works
Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Elevated Lipoprotein‐Associated Phospholipase A2 Plasma Activity Levels
Kheirandish‐Gozal, L., Philby, M. F., Qiao, Z., Khalyfa, A., & Gozal, D. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004923 · Cited by 37 · see citing works
Programming of Appetite Control during Breastfeeding as a Preventative Strategy against the Obesity Epidemic
Hassiotou, F., & Geddes, D. T. (2014) · Journal of Human Lactation · doi:10.1177/0890334414526950 · Cited by 37 · see citing works
Physical fitness in relation to later body composition in pre-school children
Henriksson, P., Leppänen, M. H., Henriksson, H., Nyström, C. D., Cadenas‐Sánchez, C., Ek, A. E., Ruiz, J. R., Ortega, F. B., & Löf, M. (2018) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2018.11.024 · Cited by 35 · see citing works
Intergenerational and early life influences on the well-being of Australian Aboriginal and Torres Strait Islander children: overview and selected findings fromFootprints in Time, the Longitudinal Study of Indigenous Children
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Authors: Lakshman, R., Elks, C. E., & Ong, K. K.
Affiliations: University of Cambridge (GB)
ORCID: Lakshman, Rajalakshmi
Ong, Ken K.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-10-02
Volume: 126
Issue: 14
Pages: 1770-1779
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.111.047738
PMC: PMC3785130
OpenAlex: W4210243588
Cited by: 318
References: 91
Citations by year: 2026: 4 · 2025: 9 · 2024: 12 · 2023: 31 · 2022: 20 · 2021: 30 · 2020: 31 · 2019: 25 · 2018: 31 · 2017: 29 · 2016: 31 · 2015: 27 · 2014: 19 · 2013: 17 · 2012: 1
FWCI: 3.13
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust (087636)
Medical Research Council (MC_EX_G0701655, MC_EX_MR/J000361/1)
Economic and Social Research Council (ES/G007462/1)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords: childhood obesity, preschool children, obesity prevention, obesity risk factors, genetic risk factors, nutritional risk factors, BMI cutoffs, non-communicable diseases, early-onset obesity, obesity treatment
MeSH terms: Adolescent, Age Factors, Child, Child, Preschool, Developing Countries, Humans, Obesity, United States, Body Mass Index, Young Adult

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