The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1- and microRNA-155 –Dependent Pathway During Atherosclerosis
Abstract
Background—: Atherosclerosis is a chronic inflammatory vascular disease driven by the subendothelial accumulation of macrophages. The mechanism regulating the inflammatory response in macrophages during atherogenesis remains unclear. Because microRNAs (miRNAs) play a crucial role in cellular signaling by posttranscriptional regulation of gene expression, we studied the miRNA expression profiles during the progression of atherosclerosis. Methods and Results—: Using an miRNA real-time polymerase chain reaction array, we found that macrophage-derived miR-342-5p and miR-155 are selectively upregulated in early atherosclerotic lesions in Apoe −/− mice. miR-342-5p directly targets Akt1 through its 3′-untranslated region. Akt1 suppression by miR-342-5p induces proinflammatory mediators such as Nos2 and II6 in macrophages via the upregulation of miR-155 . The local application of an miR-342-5p antagomir inhibits the development of atherosclerosis in partially ligated carotid arteries. In atherosclerotic lesions, the miR-342-5p antagomir upregulated Akt1 expression and suppressed the expression of miR-155 and Nos2 . This reduced Nos2 expression was associated with a diminished generation of nitrotyrosine in the plaques. Furthermore, systemic treatment with an inhibitor of miR-342-5p reduced the progression of atherosclerosis in the aorta of Apoe −/− mice. Conclusions—: Macrophage-derived miR-342-5p promotes atherosclerosis and enhances the inflammatory stimulation of macrophages by suppressing the Akt1 -mediated inhibition of miR-155 expression. Therefore, targeting miR-342-5p may offer a promising strategy to treat atherosclerotic vascular disease.
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MicroRNA-155 is induced during the macrophage inflammatory response
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Pathophysiology of Atherosclerosis
Jebari-Benslaiman, S., Galicia-García, U., Larrea-Sebal, A., Olaetxea, J. R., Alloza, I., Vandenbroeck, K., Benito-Vicente, A., & Martín, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063346 · Cited by 1,010
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MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Schober, A., Nazari-Jahantigh, M., Wei, Y., Bidzhekov, K., Gremse, F., Grommes, J., Megens, R. T. A., Heyll, K., Noels, H., Hristov, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3487 · Cited by 630
Self-citationCytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Ramji, D. P., & Davies, T. S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.04.003 · Cited by 469
Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection
Hou, Z., Qin, X., Hu, Y., Zhang, X., Li, G., Wu, J., Li, J., Sha, J., Chen, J., Xia, J., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314635 · Cited by 334
Metadata
- Authors
- Wei, Y., Nazari-Jahantigh, M., Chan, L., Zhu, M., Heyll, K., Corbalán-Campos, J., Hartmann, P., Thiemann, A., Weber, C., & Schober, A.
- Venue
- Circulation
- Published
- 2013-04-16
- Volume
- 127
- Issue
- 15
- Pages
- 1609-1619
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1991536401
- Cited by
- 234
- References
- 10
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wei, Y., Nazari-Jahantigh, M., Chan, L., Zhu, M., Heyll, K., Corbalán-Campos, J., Hartmann, P., Thiemann, A., Weber, C., & Schober, A. (2013). The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1- and microRNA-155 –Dependent Pathway During Atherosclerosis. Circulation. https://doi.org/10.1161/circulationaha.112.000736
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