The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Administration of Cardiac Stem Cells in Patients With Ischemic Cardiomyopathy: The SCIPIO Trial: Surgical Aspects and Interim Analysis of Myocardial Function and Viability by Magnetic Resonance
Open accessAbstract
Background—: SCIPIO is a first-in-human, phase 1, randomized, open-label trial of autologous c-kit + cardiac stem cells (CSCs) in patients with heart failure of ischemic etiology undergoing coronary artery bypass grafting (CABG). In the present study, we report the surgical aspects and interim cardiac magnetic resonance (CMR) results. Methods and Results—: A total of 33 patients (20 CSC-treated and 13 control subjects) met final eligibility criteria and were enrolled in SCIPIO. CSCs were isolated from the right atrial appendage harvested and processed during surgery. Harvesting did not affect cardiopulmonary bypass, cross-clamp, or surgical times. In CSC-treated patients, CMR showed a marked increase in both LVEF (from 27.5±1.6% to 35.1±2.4% [ P =0.004, n=8] and 41.2±4.5% [ P =0.013, n=5] at 4 and 12 months after CSC infusion, respectively) and regional EF in the CSC-infused territory. Infarct size (late gadolinium enhancement) decreased after CSC infusion (by manual delineation: −6.9±1.5 g [−22.7%] at 4 months [ P =0.002, n=9] and −9.8±3.5 g [−30.2%] at 12 months [ P =0.039, n=6]). LV nonviable mass decreased even more (−11.9±2.5 g [−49.7%] at 4 months [ P =0.001] and −14.7±3.9 g [−58.6%] at 12 months [ P =0.013]), whereas LV viable mass increased (+11.6±5.1 g at 4 months after CSC infusion [ P =0.055] and +31.5±11.0 g at 12 months [ P =0.035]). Conclusions—: Isolation of CSCs from cardiac tissue obtained in the operating room is feasible and does not alter practices during CABG surgery. CMR shows that CSC infusion produces a striking improvement in both global and regional LV function, a reduction in infarct size, and an increase in viable tissue that persist at least 1 year and are consistent with cardiac regeneration. Clinical Trial Registration—: This study is registered with clinicaltrials.gov, trial number NCT00474461.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Bolli, R., Chugh, A. R., D'Amario, D., Loughran, J. H., Stoddard, M. F., Ikram, S., Beache, G. M., Wagner, S. G., Leri, A., Hosoda, T., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61590-0 · Cited by 1,288
Self-citationRetractedD’Amario, D., Cabral-da-Silva, M. C., Zheng, H., Fiorini, C., Goichberg, P., Steadman, E., Ferreira‐Martins, J., Sanada, F., Piccoli, M., Cappetta, D., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.240648 · Cited by 117
Self-citationRetractedHeart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Beltrami, A. P., Barlucchi, L., Torella, D., Baker, M., Limana, F., Chimenti, S., Kasahara, H., Rota, M., Musso, E., Urbanek, K., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00687-1 · Cited by 3,534
Self-citationKim, R. J., Wu, E., Rafael, A., Chen, E.-L., Parker, M. A., Simonetti, O., Klocke, F. J., Bonow, R. O., & Judd, R. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011163432003 · Cited by 3,306
Pfeffer, M. A., & Braunwald, E. (1990) · Circulation · doi:10.1161/01.cir.81.4.1161 · Cited by 2,877
Hendel, R. C., Patel, M. R., Kramer, C. M., Poon, M., Hendel, R. C., Carr, J. C., Gerstad, N. A., Gillam, L. D., Hodgson, J. M., Kim, R. J., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.003 · Cited by 1,288
Grothues, F., Smith, G. C., Moon, J. C. C., Bellenger, N. G., Collins, P., Klein, H. U., & Pennell, D. J. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02381-0 · Cited by 1,267
He, J., Ogden, L. G., Bazzano, L. A., Vupputuri, S., Loria, C., & Whelton, P. K. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.7.996 · Cited by 1,172 · cited 2×
“6 EF units) 12 months later, accompanied by a parallel increase in regional contractile function in the infarcted regions that were infused with CSCs; (4) this improvement in LV function was coupled with a concomitant decrease in infarct size, which was consistently observed with three different CMR methods (reduction…”
ResultInfluentialBearzi, C., Rota, M., Hosoda, T., Tillmanns, J., Nascimbene, A., De Angelis, A., Yasuzawa-Amano, S., Trofimova, I., Siggins, R. W., LeCapitaine, N., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706760104 · Cited by 980
Self-citation
Cited by
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
Braunwald, E. (2013) · JACC: Heart Failure · doi:10.1016/j.jchf.2012.10.002 · Cited by 730
Hippo signaling impedes adult heart regeneration
Heallen, T., Morikawa, Y., Leach, J., Tao, G., Willerson, J. T., Johnson, R. L., & Martin, J. F. (2013) · Development · doi:10.1242/dev.102798 · Cited by 458
Cardiac macrophages and their role in ischaemic heart disease
Frantz, S., & Nahrendorf, M. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu025 · Cited by 310
Qiao, L., Hu, S., Liu, S., Zhang, H., Ma, H., Huang, K., Li, Z., Su, T., Vandergriff, A., Tang, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123135 · Cited by 303
Metadata
- Authors
- Chugh, A. R., Beache, G. M., Loughran, J. H., Mewton, N., Elmore, J. B., Kajstura, J., Pappas, P., Tatooles, A., Stoddard, M. F., Lima, J. A. C., Slaughter, M. S., Anversa, P., & Bolli, R.
- Venue
- Circulation
- Published
- 2012-09-11
- Volume
- 126
- Issue
- 11_suppl_1
- Pages
- S54-64
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1999631700
- Cited by
- 434
- References
- 29
- FWCI
- 28.87
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Administration of Cardiac Stem Cells in Patients With Ischemic Cardiomyopathy: The SCIPIO Trial: Surgical Aspects and Interim Analysis of Myocardial Function and Viability by Magnetic Resonance. https://app.cochat.ai/papers/10.1161/circulationaha.112.092627
- The paper
- Chugh, A. R., Beache, G. M., Loughran, J. H., Mewton, N., Elmore, J. B., Kajstura, J., Pappas, P., Tatooles, A., Stoddard, M. F., Lima, J. A. C., Slaughter, M. S., Anversa, P., & Bolli, R. (2012). Administration of Cardiac Stem Cells in Patients With Ischemic Cardiomyopathy: The SCIPIO Trial: Surgical Aspects and Interim Analysis of Myocardial Function and Viability by Magnetic Resonance. Circulation. https://doi.org/10.1161/circulationaha.112.092627
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
