The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Cardiac macrophages and their role in ischaemic heart disease
Open accessAbstract
Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI). Different macrophage phenotypes likely promote myocardial health vs. disease. Infarct macrophages are inflammatory and derive from circulating monocytes produced by the haematopoietic system. These cells are centrally involved in inflammatory tissue remodelling, resolution of inflammation during post-MI healing, and left ventricular remodelling. Presumably, macrophages interact with myocytes, endothelial cells, and fibroblasts. Although macrophages are primarily recruited to the ischaemic myocardium, the remote non-ischaemic myocardium macrophage population changes dynamically after MI. Macrophages' known roles in defending the steady state and their pathological actions in other disease contexts provide a road map for exploring cardiac macrophages and their phenotypes, functions, and therapeutic potential. In our review, we summarize recent insights into the role of cardiac macrophages, focus on their actions after ischaemia, and highlight emerging research topics.
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Cites
1 retracted
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Cited by
The role of macrophages in the resolution of inflammation
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Metadata
- Authors
- Frantz, S., & Nahrendorf, M.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-02-05
- Volume
- 102
- Issue
- 2
- Pages
- 240-248
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2089477170
- Cited by
- 310
- References
- 78
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Frantz, S., & Nahrendorf, M. (2014). Cardiac macrophages and their role in ischaemic heart disease. Cardiovascular Research. https://doi.org/10.1093/cvr/cvu025
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
