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Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy
Abstract
Fast breath-hold cardiovascular magnetic resonance (CMR) shows excellent results for interstudy reproducibility of left ventricular (LV) volumes, ejection fraction, and mass, which are thought to be superior to results of 2-dimensional echocardiography. However, there is no direct comparison of the interstudy reproducibility of both methods in the same subjects. A total of 60 subjects (normal volunteers [n = 20], or patients with heart failure [n = 20] or LV hypertrophy [n = 20]) underwent 2 CMRs and 2 echocardiographic studies for assessment of LV volumes, function, and mass. The interstudy reproducibility coefficient of variability was superior for CMR in all groups for all parameters. Statistical significance was reached for end-systolic volume (4.4% to 9.2% vs 13.7% to 20.3%, p <0.001), ejection fraction (2.4% to 7.3% vs 8.6% to 19.4%, p <0.001), and mass (2.8% to 4.8% vs 11.6% to 15.7% p <0.001), with a trend for end-diastolic volume (2.9% to 4.9% vs 5.5% to 10.5%, p = 0.17). The superior interstudy reproducibility resulted in considerably lower calculated sample sizes (reductions of 55% to 93%) required by CMR compared with echocardiography to show clinically relevant changes in LV dimensions and function. Thus, CMR has excellent interstudy reproducibility in normal, dilated, and hypertrophic hearts, and is superior to 2-dimensional echocardiography.
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CMR has improved interstudy reproducibility compared with echocardiography, allowing significantly smaller sample sizes for clinical trials seeking changes in LV mass.
“Prior studies show that, due to improved interstudy reproducibility of CMR, sample sizes for clinical trials that seek to look for changes in LV mass can be significantly smaller as compared with echocardiography.17”
From Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure (2025) · cites this paper as [17]
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Metadata
- Authors
- Grothues, F., Smith, G. C., Moon, J. C. C., Bellenger, N. G., Collins, P., Klein, H. U., & Pennell, D. J.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 90
- Issue
- 1
- Pages
- 29-34
- ISSN
- 0002-9149
- Cited by
- 1,267
- References
- 1
- Language
- en
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