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Cited by 228Heart Rate Variability and Autonomic ControlPhysical Activity and HealthCardiovascular and exercise physiology

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Physical Activity and Heart Rate Variability in Older Adults: The Cardiovascular Health Study

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Soares-Miranda, Luisa, Sattelmair, Jacob, Chaves, Paulo, Duncan, Glen E., Siscovick, David S., Stein, Phyllis K., Mozaffarian, Dariush·2014·Circulation
DOI 10.1161/circulationaha.113.005361PMC PMC4038662
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Abstract

BACKGROUND: Cardiac mortality and electrophysiological dysfunction both increase with age. Heart rate variability (HRV) provides indices of autonomic function and electrophysiology that are associated with cardiac risk. How habitual physical activity among older adults prospectively relates to HRV, including nonlinear indices of erratic sinus patterns, is not established. We hypothesized that increasing the levels of both total leisure-time activity and walking would be prospectively associated with more favorable time-domain, frequency-domain, and nonlinear HRV measures in older adults. METHODS AND RESULTS: We evaluated serial longitudinal measures of both physical activity and 24-hour Holter HRV over 5 years among 985 older US adults in the community-based Cardiovascular Health Study. After multivariable adjustment, greater total leisure-time activity, walking distance, and walking pace were each prospectively associated with specific, more favorable HRV indices, including higher 24-hour standard deviation of all normal-to-normal intervals (Ptrend=0.009, 0.02, 0.06, respectively) and ultralow-frequency power (Ptrend=0.02, 0.008, 0.16, respectively). Greater walking pace was also associated with a higher short-term fractal scaling exponent (Ptrend=0.003) and lower Poincaré ratio (Ptrend=0.02), markers of less erratic sinus patterns. CONCLUSIONS: Greater total leisure-time activity, and walking alone, as well, were prospectively associated with more favorable and specific indices of autonomic function in older adults, including several suggestive of more normal circadian fluctuations and less erratic sinoatrial firing. Our results suggest potential mechanisms that might contribute to lower cardiovascular mortality with habitual physical activity later in life.

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  1. 10.1249/MSS.0b013e3181994a91 · DOI
  2. 10.1016/1047-2797(91)90005-W · DOI · Paper page

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Metadata

Authors
Soares-Miranda, L., Sattelmair, J., Chaves, P., Duncan, G. E., Siscovick, D. S., Stein, P. K., & Mozaffarian, D.
Affiliations
  • From the Department of Epidemiology, Harvard School of Public Health, Boston, MA (L.S.-M., J.S., D.M.); Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal (L.S.-M.); Benjamin Leon Center for Geriatric Research and Education and Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL (P.C.); Department of Epidemiology, University of Washington, Seattle, WA (G.E.D., D.S.S.); Department of Medicine,...
  • Brigham and Women's Hospital (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-05-27
Volume
129
Issue
21
Pages
2100-2110
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.113.005361
PMC
PMC4038662
OpenAlex
W1997588201
Cited by
228
References
54
Citations by year
2026: 8 · 2025: 20 · 2024: 21 · 2023: 20 · 2022: 25 · 2021: 23 · 2020: 31 · 2019: 18 · 2018: 6 · 2017: 20 · 2016: 15 · 2015: 15 · 2014: 5
FWCI
12.60
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01hc085082-026, n01hc085081-021, n01hc085079-024, n01hc085083-027, n01hc085080-026, n01hc085086-022, n01hc55222-0-0-0)
  • National Institute on Aging (R56AG023629, AG023629, R01AG023629)
  • National Heart, Lung, and Blood Institute (N01 HC085086, N0-1-HC-85239, N01 HC085079, N01 HC085083, N01 HC085080, N01 HC55222, HHSN268201200036C, N01HC085082, U01HL080295, N01 HC055222, N01 HC085081, HL080295, R01HL080295)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
heart rate variability, physical activity, older adults, leisure-time activities, walking, walking speed, autonomic function, fractal scaling exponent, circadian rhythm, cardiovascular mortality, nonlinear HRV measures
MeSH terms
Aged, Cardiovascular Diseases, Cross-Sectional Studies, Female, Follow-Up Studies, Health Status, Heart Rate, Humans, Leisure Activities, Longitudinal Studies, Male, Motor Activity, Prospective Studies, Electrocardiography, Ambulatory, Walking

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