The DOI matches its Crossref record, with a small difference in title or year; 109 of the 109 references it cites were found in a registry or an index.
Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury
Open accessAbstract
The number of patients surviving with congenital heart disease (CHD) has soared over the last 3 decades. Adults constitute the fastest-growing segment of the CHD population, now outnumbering children. Research to date on the heart-brain intersection in this population has been focused largely on neurodevelopmental outcomes in childhood and adolescence. Mutations in genes that are highly expressed in heart and brain may cause cerebral dysgenesis. Together with altered cerebral perfusion in utero, these factors are associated with abnormalities of brain structure and brain immaturity in a significant portion of neonates with critical CHD even before they undergo cardiac surgery. In infancy and childhood, the brain may be affected by risk factors related to heart disease itself or to its interventional treatments. As children with CHD become adults, they increasingly develop heart failure, atrial fibrillation, hypertension, diabetes mellitus, and coronary disease. These acquired cardiovascular comorbidities can be expected to have effects similar to those in the general population on cerebral blood flow, brain volumes, and dementia. In both children and adults, cardiovascular disease may have adverse effects on achievement, executive function, memory, language, social interactions, and quality of life. Against the backdrop of shifting demographics, risk factors for brain injury in the CHD population are cumulative and synergistic. As neurodevelopmental sequelae in children with CHD evolve to cognitive decline or dementia during adulthood, a growing population of CHD can be expected to require support services. We highlight evidence gaps and future research directions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“many experience behavioral, emotional, cognitive and motor impairment suggesting widespread brain dysfunction that continues into adulthood (3–5).”
From Neonatal Brain Injury and Timing of Neurodevelopmental Assessment in Patients With Congenital Heart Disease (2018) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diamond, A. (2013) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143750 · Cited by 13,268
Lifetime Prevalence of Congenital Heart Disease in the General Population From 2000 to 2010
Marelli, A. J., Ionescu‐Ittu, R., Mackie, A. S., Guo, L., Dendukuri, N., & Kaouache, M. (2014) · Circulation · doi:10.1161/circulationaha.113.008396 · Cited by 1,278
Self-citationHofman, A., Ott, A., Breteler, M. M., Bots, M. L., Slooter, A. J., van Harskamp, F., van Duijn, C. N., Van Broeckhoven, C., & Grobbee, D. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09328-2 · Cited by 1,062
De novo mutations in histone-modifying genes in congenital heart disease
Zaidi, S., Choi, M., Wakimoto, H., Ma, L., Jiang, J., Overton, J. D., Romano-Adesman, A., Bjornson, R. D., Breitbart, R. E., Brown, K. K., et al. (2013) · Nature · doi:10.1038/nature12141 · Cited by 934
Self-citationKinney, H. C., Ann brody, B., Kloman, A. S., & Gilles, F. H. (1988) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-198805000-00003 · Cited by 888
Cardiovascular risk factors and cognitive decline in middle-aged adults
Knopman, D., Boland, L. L., Mosley, T., Howard, G., Liao, D., Szklo, M., McGovern, P., & Folsom, A. R. (2001) · Neurology · doi:10.1212/wnl.56.1.42 · Cited by 883
Abnormal brain development in newborns with congenital heart disease
Miller, S. P., McQuillen, P. S., Hamrick, S., Xu, D., Glidden, D. V., Charlton, N., Karl, T., Azakie, A., Ferriero, D. M., Barkovich, A. J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067393 · Cited by 860
Self-citationBellinger, D. C., Jonas, R. A., Rappaport, L., Wypij, D., Wernovsky, G., Kuban, K., Barnes, P. D., Holmes, G. L., Hickey, P. R., Strand, R. D., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320901 · Cited by 803
Self-citationAggregation of vascular risk factors and risk of incident Alzheimer disease
Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000172914.08967.dc · Cited by 790
Procedural pain and brain development in premature newborns
Brummelte, S., GRUNAU, R. E., Chau, V., Poskitt, K. J., Brant, R., Vinall, J., Gover, A., Synnes, A. R., & Miller, S. P. (2012) · Annals of Neurology · doi:10.1002/ana.22267 · Cited by 735
Self-citation
Cited by
Sorted by citations
Rychik, J. R., Atz, A. M., Celermajer, D. S., Deal, B. J., Gatzoulis, M. Α., Gewillig, M. H. M. L., Hsia, T., Hsu, D. T., Kovacs, A. H., McCrindle, B. W., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000696 · Cited by 1,055
Self-citationGenetics and Genomics of Congenital Heart Disease
Zaidi, S., & Brueckner, M. K. (2017) · Circulation Research · doi:10.1161/circresaha.116.309140 · Cited by 612
Sood, E., Newburger, J. W., Anixt, J. S., Cassidy, A. R., Jackson, J. L., Jonas, R. A., Lisanti, A. J., Lopez, K. N., Peyvandi, S., Marino, B. S., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001211 · Cited by 266
Self-citationKovacs, A. H., Brouillette, J., Ibeziako, P. I., Jackson, J. L., Kasparian, N. A., Kim, Y. Y., Livecchi, T., Sillman, C., & Kochilas, L. K. (2022) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/hcq.0000000000000110 · Cited by 199
Recommendations for exercise in adolescents and adults with congenital heart disease
Tran, D., Maiorana, A., Ayer, J. G., Lubans, D. R., Davis, G. M., Celermajer, D. S., d’Udekem, Y., & Cordina, R. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.03.002 · Cited by 172
Advances in the Genetics of Congenital Heart Disease
Blue, G. M., Kirk, E. P., Giannoulatou, E., Sholler, G. F., Dunwoodie, S. L., Harvey, R. P., & Winlaw, D. S. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.060 · Cited by 174
Brain Injury and Neurodevelopmental Outcome in Congenital Heart Disease: A Systematic Review
Mebius, M. J., Kooi, E. M. W., Bilardo, C. M., & Bos, A. F. (2017) · PEDIATRICS · doi:10.1542/peds.2016-4055 · Cited by 166
Peyvandi, S., Chau, V., Guo, T., Xu, D., Glass, H. C., Synnes, A., Poskitt, K., Barkovich, A. J., Miller, S. P., & McQuillen, P. S. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.02.068 · Cited by 128
Self-citationHuisenga, D. C., Gemert, S. L. B., Bergen, A. V., Sweeney, J. K., & Hadders‐Algra, M. (2020) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14512 · Cited by 128
Ware, J., Butcher, J. L., Latal, B., Sadhwani, A., Rollins, C. K., Brosig, C. L., Butler, S., Eiler-Sims, P. B., Shade, C. U., & Wernovsky, G. (2020) · Cardiology in the Young · doi:10.1017/s1047951120003534 · Cited by 126
Lifespan Perspective on Congenital Heart Disease Research
Diller, G., Arvanitaki, A., Opotowsky, A. R., Jenkins, K. J., Moons, P., Kempny, A., Tandon, A. A., Redington, A. N., Khairy, P., Mital, S. R., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.03.012 · Cited by 114
Self-citationJohn, A. S., Jackson, J. L., Moons, P., Uzark, K., Mackie, A. S., Timmins, S., Lopez, K. N., Kovacs, A. H., & Gurvitz, M. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025278 · Cited by 108
Ilardi, D. L., Sanz, J. H., Cassidy, A. R., Sananes, R., Rollins, C. K., Shade, C. U., Carroll, G., & Bellinger, D. C. (2020) · Cardiology in the Young · doi:10.1017/s1047951120003546 · Cited by 106
“The First Thousand Days” Define a Fetal/Neonatal Neurology Program
Scher, M. S. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.683138 · Cited by 97
‘Big issues’ in neurodevelopment for children and adults with congenital heart disease
Verrall, C. E., Blue, G. M., Loughran‐Fowlds, A., Kasparian, N. A., Gécz, J., Walker, K., Dunwoodie, S. L., Cordina, R., Sholler, G. F., Badawi, N. A., et al. (2019) · Open Heart · doi:10.1136/openhrt-2018-000998 · Cited by 89
Unolt, M., Versacci, P., Anaclerio, S., Lambiase, C., Calcagni, G., Trezzi, M., Carotti, A., Crowley, T. B., Zackai, E. H., Goldmuntz, E., et al. (2018) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38662 · Cited by 87
Self-citationGuo, T., Chau, V., Peyvandi, S., Latal, B., McQuillen, P. S., Knirsch, W., Synnes, A. R., Feldmann, M., Naef, N., Chakravarty, M. M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.06.004 · Cited by 85
Self-citationPeyvandi, S., Kim, H., Lau, J. C. Y., Barkovich, A. J., Campbell, A., Miller, S. P., Xu, D., & McQuillen, P. S. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.08.019 · Cited by 84
Self-citationCongenital heart disease: A primer for the pediatric neuropsychologist
Cassidy, A. R., Ilardi, D. L., Bowen, S. R., Hampton, L., Heinrich, K. P., Loman, M. M., Sanz, J. H., & Wolfe, K. R. (2017) · Child Neuropsychology · doi:10.1080/09297049.2017.1373758 · Cited by 88
Cilia and Ciliopathies in Congenital Heart DiseasePreprint
Klena, N., Gibbs, B., & Lo, C. W. Y. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028266 · Cited by 79
Disruptions in the development of feeding for infants with congenital heart disease
Jones, C. E., Desai, H., Fogel, J. L., Negrin, K. A., Torzone, A., Willette, S., Fridgen, J. L., Doody, L. R., Morris, K. M., Engstler, K., et al. (2020) · Cardiology in the Young · doi:10.1017/s1047951120004382 · Cited by 71
Academic Outcomes in Children With Congenital Heart Defects
Oster, M. E., Watkins, S. E., Hill, K. D., Knight, J., & Meyer, R. E. (2017) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.116.003074 · Cited by 69
Asis‐Cruz, J. D., Donofrio, M. T., Vézina, G., & Limperopoulos, C. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.09.020 · Cited by 73
Fetal Brain Development in Congenital Heart Disease
Peyvandi, S., & Rollins, C. K. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.09.020 · Cited by 70
Optimizing Neurodevelopmental Outcomes in Neonates With Congenital Heart Disease
Ortinau, C. M., Smyser, C. D., Arthur, L., Gordon, E. E., Heydarian, H. C., Wolovits, J. S., Nedrelow, J. H., Marino, B. S., & Levy, V. Y. (2022) · PEDIATRICS · doi:10.1542/peds.2022-056415l · Cited by 67
Self-citationDe novo damaging variants associated with congenital heart diseases contribute to the connectome
Ji, W., Ferdman, D. J., Copel, J. A., Scheinost, D., Shabanova, V., Brueckner, M. K., Khokha, M. K., & Ment, L. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-63928-2 · Cited by 59
Huang, R., Wang, J., Xue, S., Qiu, X., Shi, H., Li, R., Qu, X., Yang, X., Liu, H., Li, N., et al. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.17834 · Cited by 56
Cao, J., Yao, D., Li, R., Guo, X., Hao, J., Xie, M., Li, J., Pan, D., Luo, X., Yu, Z., et al. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00772-y · Cited by 54
Everitt, I., Gerardin, J. F., Rodriguez, F. H., & Book, W. (2017) · Congenital Heart Disease · doi:10.1111/chd.12463 · Cited by 51
Fontes, K., Rohlicek, C. V., Saint‐Martin, C., Gilbert, G., Easson, K., Majnemer, A., Marelli, A. J., Chakravarty, M. M., & Brossard‐Racine, M. (2019) · Human Brain Mapping · doi:10.1002/hbm.24615 · Cited by 53
Self-citationCortical Dysmaturation in Congenital Heart Disease
Leonetti, C., Back, S. A., Gallo, V., & Ishibashi, N. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.003 · Cited by 49
MEF2C loss-of-function mutation contributes to congenital heart defects
Qiao, X.-H., Wang, F., Zhang, X.-L., Huang, R., Xue, S., Wang, J., Qiu, X., Liu, X., & Yang, Y. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.21353 · Cited by 46
Neurocognitive Impairment and Its Long-term Impact on Adults With Congenital Heart Disease
Cohen, S. B., & Earing, M. G. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.08.002 · Cited by 44
Khanna, A. D., Duca, L. M., Kay, J. D., Shore, J. H., Kelly, S. L., & Crume, T. (2019) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2019.05.023 · Cited by 44
Feldmann, M., Hagmann, C. F., de Vries, L. S., Disselhoff, V., Pushparajah, K., Logeswaran, T., Jansen, N. J. G., Breur, J. M. P. J., Knirsch, W., Benders, M. J. N. L., et al. (2022) · Pediatric Research · doi:10.1038/s41390-022-02063-2 · Cited by 43
Engineer, A., Saiyin, T., Greco, E. R., & Feng, Q. (2019) · Antioxidants · doi:10.3390/antiox8100436 · Cited by 45
White Matter Injury and Structural Anomalies in Infants with Prenatal Opioid Exposue
Merhar, S. L., Parikh, N. A., Braimah, A., Poindexter, B. B., Tkach, J. A., & Kline‐Fath, B. M. (2019) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6282 · Cited by 43
Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease
Barkhuizen, M., Abella, R. F., Vles, J. S. H., Zimmermann, L. J. I., Gazzolo, D., & Gavilanes, A. W. D. (2020) · Pediatric Cardiology · doi:10.1007/s00246-020-02440-w · Cited by 43
Learning and Memory in Adolescents with Critical Biventricular Congenital Heart Disease
Cassidy, A. R., Newburger, J. W., & Bellinger, D. C. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000443 · Cited by 41
Self-citationImpaired Cardiac Function and Cognitive Brain Aging
van der Velpen, I. F., Yancy, C. W., Sorond, F. A., & Sabayan, B. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.07.008 · Cited by 41
Pike, N. A., Roy, B., Gupta, R., Singh, S., Woo, M. A., Halnon, N. J., Lewis, A. B., & Kumar, R. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24215 · Cited by 43
Peyvandi, S., & Donofrio, M. T. (2018) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2018.05.005 · Cited by 41
Public Health Approach to Improve Outcomes for Congenital Heart Disease Across the Life Span
Jenkins, K. J., Botto, L. D., Correa, A., Foster, E., Kupiec, J. K., Marino, B. S., Oster, M. E., Stout, K., & Honein, M. A. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.009450 · Cited by 41
Self-citationNeurocognitive and psychosocial outcomes in adult congenital heart disease: a lifespan approach
Kovacs, A. H., & Bellinger, D. C. (2020) · Heart · doi:10.1136/heartjnl-2016-310862 · Cited by 41
Variations in practice in cardiac neurodevelopmental follow-up programs
Miller, T. A., Sadhwani, A., Sanz, J. H., Sood, E., Ilardi, D. L., Newburger, J. W., Goldberg, C. S., Wypij, D., Gaynor, J. W., & Marino, B. S. (2020) · Cardiology in the Young · doi:10.1017/s1047951120003522 · Cited by 41
Self-citationBorn to Age: When Adult Congenital Heart Disease Converges With Geroscience
Moons, P., & Marelli, A. J. (2022) · JACC Advances · doi:10.1016/j.jacadv.2022.100012 · Cited by 42
Self-citationA novel NR2F2 loss-of-function mutation predisposes to congenital heart defect
Qiao, X.-H., Wang, Q., Wang, J., Liu, X., Xu, Y., Huang, R., Xue, S., Li, Y., Zhang, M., Qu, X., et al. (2017) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2017.12.003 · Cited by 38
Association of Isolated Congenital Heart Disease with Fetal Brain Maturation
Jaimes, C. E., Rofeberg, V., Stopp, C. D., Ortinau, C. M., Gholipour, A., Friedman, K. G., Tworetzky, W., Estroff, J. A., Newburger, J. W., Wypij, D., et al. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6635 · Cited by 38
Self-citationFactors Associated With Attendance for Cardiac Neurodevelopmental Evaluation
Ortinau, C. M., Wypij, D., Ilardi, D. L., Rofeberg, V., Miller, T. A., Donohue, J. E., Reichle, G., Seed, M., Elhoff, J. J., Alexander, N., et al. (2023) · PEDIATRICS · doi:10.1542/peds.2022-060995 · Cited by 37
Self-citationBrain volumes in adults with congenital heart disease correlate with executive function abilities
Naef, N., Schlosser, L., Brugger, P., Greutmann, M., Oxenius, A., Wehrle, F. M., Kottke, R., Latal, B., & Tuura, R. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00424-1 · Cited by 37
Altered white matter microstructure is related to cognition in adults with congenital heart disease
Ehrler, M., Schlosser, L., Brugger, P., Greutmann, M., Oxenius, A., Kottke, R., Tuura, R., & Latal, B. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa224 · Cited by 38
Abnormal Extracardiac Development in Fetuses With Congenital Heart Disease
Dovjak, G. O., Zalewski, T., Mlczoch, E., Ulm, P. A., Berger‐Kulemann, V., Weber, M., Prayer, D., Kasprian, G. J., & Ulm, B. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.09.1358 · Cited by 36
Frailty and Cognitive Function in Middle-Aged and Older Adults With Congenital Heart Disease
Daelman, B., Bulck, L. V., Luyckx, K., Kovacs, A. H., Bruaene, A. V. D., Ladouceur, M., Yang, H., Moon, J. R., Schmidt, A., Lykkeberg, B., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.01.021 · Cited by 35
A Novel MEF2C Loss-of-Function Mutation Associated with Congenital Double Outlet Right Ventricle
Lu, C.-X., Wang, W., Wang, Q., Liu, X., & Yang, Y. (2018) · Pediatric Cardiology · doi:10.1007/s00246-018-1822-y · Cited by 35
Trajectories of care in congenital heart disease – the long arm of disease in the womb
Marelli, A. J. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13048 · Cited by 35
Self-citationNeuroimaging and Neurodevelopmental Outcomes Among Individuals With Complex Congenital Heart Disease
Phillips, K., Callaghan, B. L., Rajagopalan, V., Akram, F., Newburger, J. W., & Kasparian, N. A. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.09.824 · Cited by 34
Self-citationJackson, J. L., Gerardo, G. M., Monti, J. D., Schofield, K. A., & Vannatta, K. A. (2017) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsx154 · Cited by 34
Werner, O., Louali, F. E., Fouilloux, V., Amédro, P., & Ovaert, C. (2019) · Congenital Heart Disease · doi:10.1111/chd.12777 · Cited by 33
Maria, M. V. D., Barrett, C., Rafferty, C., Wolfe, K. R., Kelly, S. L., Liptzin, D. R., Brigham, D., & Younoszai, A. K. (2019) · Congenital Heart Disease · doi:10.1111/chd.12769 · Cited by 32
Marino, B. S., Sood, E., Cassidy, A. R., Miller, T. A., Sanz, J. H., Bellinger, D. C., Newburger, J. W., & Goldberg, C. S. (2020) · Cardiology in the Young · doi:10.1017/s1047951120003510 · Cited by 32
Self-citationRobson, V. K., Stopp, C. D., Wypij, D., Dunbar‐Masterson, C., Bellinger, D. C., DeMaso, D. R., Rappaport, L., & Newburger, J. W. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2018.08.069 · Cited by 32
Self-citationLeft–right patterning in congenital heart disease beyond heterotaxy
Gabriel, G. C., & Lo, C. W. Y. (2020) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31768 · Cited by 33
CASZ1 loss-of-function mutation associated with congenital heart disease
Huang, R., Xue, S., Wang, J., Gu, J.-Y., Xu, J.-H., Li, Y.-J., Li, N., Yang, X.-X., Liu, H., Zhang, X., et al. (2016) · Gene · doi:10.1016/j.gene.2016.09.044 · Cited by 31
Reich, B., Heye, K., Tuura, R., Beck, I., Wetterling, K., Hahn, A., Hofmann, K., Schranz, D., Akintürk, H., Latal, B., et al. (2017) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2017.09.014 · Cited by 30
Huang, Y., Xu, N., Huang, S.-T., Wang, Z., Cao, H., Yu, X., & Chen, Q. (2021) · Journal of PeriAnesthesia Nursing · doi:10.1016/j.jopan.2020.08.004 · Cited by 30
Abell, B., Eagleson, K. J., Auld, B. C., Bora, S., Justo, R. N., Parsonage, W. A., Sharma, P., Kularatna, S., & McPhail, S. (2023) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.15698 · Cited by 30
Blue, G. M., Ip, E., Walker, K., Kirk, E. P., Loughran‐Fowlds, A., Sholler, G. F., Dunwoodie, S. L., Harvey, R. P., Giannoulatou, E., Badawi, N. A., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.03.021 · Cited by 29
Neurocognition in Adult Congenital Heart Disease: How to Monitor and Prevent Progressive Decline
Keir, M., Ebert, P. L., Kovacs, A. H., Smith, J., Kwan, E., Field, T. S., Brossard‐Racine, M., & Marelli, A. J. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.06.020 · Cited by 28
Self-citationNeurodevelopmental Outcomes in Infants With Cardiac Surgery Associated Acute Kidney Injury
Pande, C. K., Noll, L. M., Afonso, N. S., Serrano, F., Monteiro, S. A., Guffey, D., Puri, K., Achuff, B.-J., Akcan‐Arikan, A., & Shekerdemian, L. S. (2022) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2022.03.020 · Cited by 28
Ohuchi, H., Kawata, M., Uemura, H., Akagi, T., Yao, A., Senzaki, H., Kasahara, S., Ichikawa, H., Motoki, H., Syoda, M., et al. (2022) · Circulation Journal · doi:10.1253/circj.cj-22-0134 · Cited by 29
Kessler, N., Feldmann, M., Schlosser, L., Rometsch, S., Brugger, P., Kottke, R., Knirsch, W., Oxenius, A., Greutmann, M., & Latal, B. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.02.061 · Cited by 27
Adults With Mild‐to‐Moderate Congenital Heart Disease Demonstrate Measurable Neurocognitive Deficits
Perrotta, M. L., Saha, P., Zawadzki, R. S., Beidelman, M., Ingelsson, E., Lui, G. K., & Priest, J. R. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015379 · Cited by 27
Claessens, N. H. P., Breur, J. M. P. J., Groenendaal, F., Asperen, R. M. W., Stegeman, R., Haas, F., Dudink, J., de Vries, L. S., Jansen, N. J. G., & Benders, M. J. N. L. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101672 · Cited by 26
Effectiveness of Repair of Aortic Coarctation in Neonates: A Long-Term experience
Minotti, C., Scioni, M., Castaldi, B., Guariento, A., Biffanti, R., Salvo, G. D., Vida, V. L., & Padalino, M. A. (2021) · Pediatric Cardiology · doi:10.1007/s00246-021-02685-z · Cited by 26
Clinical Risk Assessment and Prediction in Congenital Heart Disease Across the Lifespan
Opotowsky, A. R., Khairy, P., Diller, G., Kasparian, N. A., Brophy, J. M., Jenkins, K. J., Lopez, K. N., McCoy, A. B., Moons, P., Ollberding, N. J., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.02.055 · Cited by 26
Self-citationEDUCATIONAL SERIES IN CONGENITAL HEART DISEASE: Prenatal diagnosis of congenital heart disease
Hunter, L. E., & Seale, A. N. (2018) · Echo Research and Practice · doi:10.1530/erp-18-0027 · Cited by 27
Kovacs, A. H., Kaufman, T. M., & Broberg, C. S. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2018.07.016 · Cited by 26
Exercise and the organ-brain axis: Regulation of neurological disorders by emerging exerkines
Dai, Y., Dou, X., Nie, B., Sun, Y., Chen, P., Fu, C., Zhang, X., Chu, Y., Gao, Q., Ge, Y., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107913 · Cited by 27
Neurologic outcome after fetal inflammatory response syndrome: Trimester-specific considerations
Scher, M. S. (2020) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2020.101137 · Cited by 25
The Mammillary Bodies: A Review of Causes of Injury in Infants and Children
Meys, K. M. E., de Vries, L. S., Groenendaal, F., Vann, S. D., & Lequin, M. H. (2022) · American Journal of Neuroradiology · doi:10.3174/ajnr.a7463 · Cited by 25
Jackson, J. L., Grant, V., Barnett, K. S., Ball, M. K., Khalid, O. M., Texter, K. M., Laney, B., & Hoskinson, K. R. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.11.001 · Cited by 25
Easson, K., Rohlicek, C. V., Houde, J.-C., Gilbert, G., Saint-Martin, C., Fontes, K., Majnemer, A., Marelli, A., Wintermark, P., Descoteaux, M., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2019.116255 · Cited by 25
Self-citationAdults With Complex Congenital Heart Disease: Cerebrovascular Considerations for the Neurologist
Smith, J., Andrade, J. G., Human, D. G., & Field, T. S. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00329 · Cited by 24
Wang, F., Liu, A., Brophy, J. M., Cohen, S., Abrahamowicz, M., Paradis, G., & Marelli, A. J. (2020) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006490 · Cited by 24
Self-citationFourdain, S., Caron-Desrochers, L., Simard, M., Provost, S., Doussau, A., Gagnon, K., Dagenais, L., Presutto, É., Prud’homme, J., Boudreault-Trudeau, A., et al. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.539451 · Cited by 24
MRI studies of brain size and growth in individuals with congenital heart disease
Bonthrone, A. F., Kelly, C. J., Ng, I. H. X., & Counsell, S. J. (2021) · Translational Pediatrics · doi:10.21037/tp-20-282 · Cited by 25
Calderon, J., Newburger, J. W., & Rollins, C. K. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.826349 · Cited by 24
Self-citationAcute Neurologic Injury in Children Admitted to the Cardiac Intensive Care Unit
Bell, J., Sáenz, L., Domnina, Y. A., Baust, T. B., Panigrahy, A., Bell, M. J., Camprubí-Camprubí, M., & Sánchez-de-Toledo, J. (2019) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2018.12.027 · Cited by 23
Schlosser, L., Kessler, N., Feldmann, M., Wehrle, F. M., Rometsch, S., Greutmann, M., Oxenius, A., Brugger, P., & Latal, B. (2021) · Cardiology in the Young · doi:10.1017/s1047951121002705 · Cited by 22
HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle
Li, L., Wang, J., Liu, X., Liu, H., Shi, H., Yang, X., Li, N., Li, Y., Huang, R., Xue, S., et al. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2865 · Cited by 24
Cognitive Function in Pediatric Hypoplastic Left Heart Syndrome: Systematic Review and Meta-Analysis
Siciliano, R. E., Prussien, K. V., Lee, C. A., Patel, N. J., Murphy, L. K., Compas, B. E., & Jordan, L. C. (2019) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsz021 · Cited by 21
Clinical Factors Associated with Cerebral Metabolism in Term Neonates with Congenital Heart Disease
Harbison, A. L., Votava‐Smith, J. K., del Castillo, S., Kumar, S. R., Lee, V., Schmithorst, V. J., Lai, H., O’Neil, S., Blüml, S., Paquette, L. B., et al. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.12.061 · Cited by 21
Silvestro, A. D., Krüger, B. D., Steger, C., Feldmann, M., Payette, K., Krüger, J., Kottke, R., Hagmann, C. F., Bosshart, M., Bürki, C., et al. (2022) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezac138 · Cited by 20
Marelli, A. J. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.09.015 · Cited by 20
Self-citationSood, E., Jacobs, J. P., & Marino, B. S. (2020) · Cardiology in the Young · doi:10.1017/s1047951120003509 · Cited by 20
Self-citationThe Neurodevelopmental Outcomes of Patients With Single Ventricles Across the Lifespan
du Plessis, K., & d’Udekem, Y. (2019) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2019.05.043 · Cited by 20
Growth, Development, and Quality of Life in Children with Congenital Heart Disease Children
Maya, S., Gunawijaya, E., Yantie, N. P. V. K., & Windiani, I. G. A. T. (2020) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2020.4047 · Cited by 19
Cromb, D., Bonthrone, A. F., Maggioni, A., Cawley, P., Dimitrova, R., Kelly, C. J., Cordero‐Grande, L., Carney, O., Egloff, A. M., Hughes, E., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.028565 · Cited by 19
Impact of Cardiopulmonary Bypass on Neurogenesis and Cortical Maturation
Dhari, Z., Leonetti, C., Lin, S., Prince, A., Howick, J. F., Zurakowski, D., Wang, P. C., Jonas, R. A., & Ishibashi, N. (2021) · Annals of Neurology · doi:10.1002/ana.26235 · Cited by 19
HAND1 Loss-of-Function Mutation Causes Tetralogy of Fallot
Wang, J., Hu, X.-Q., Guo, Y., Gu, J.-Y., Xu, J., Li, Y., Li, N., Yang, X., & Yang, Y. (2016) · Pediatric Cardiology · doi:10.1007/s00246-016-1547-8 · Cited by 19
Metadata
- Authors
- Marelli, A., Miller, S. P., Marino, B. S., Jefferson, A. L., & Newburger, J. W.
- Affiliations
- Northwestern University (US)
- Venue
- Circulation
- Published
- 2016-05-17
- Volume
- 133
- Issue
- 20
- Pages
- 1951-1962
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC5519142
- OpenAlex
- W2408520533
- Cited by
- 359
- References
- 109
- Citations by year
- 2026: 26 · 2025: 37 · 2024: 42 · 2023: 40 · 2022: 44 · 2021: 33 · 2020: 48 · 2019: 31 · 2018: 27 · 2017: 26 · 2016: 3
- FWCI
- 27.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Funders
- National Institute on Aging (K24AG046373)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD083211, U54HD090255)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- congenital heart disease, brain, neurodevelopmental outcomes, cerebral dysgenesis, cerebral perfusion, brain immaturity, neonates, heart failure, atrial fibrillation, hypertension, dementia, cognitive decline, executive function, quality of life, cardiovascular comorbidity, lifespan
- MeSH terms
- Brain, Brain Injuries, Child, Child Development, Heart Defects, Congenital, Humans, Longevity, Risk Factors, Cost of Illness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
