The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy
Open accessAbstract
Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, nicotinamide adenine dinucleotide (NAD + ) is emerging as a metabolic target in a number of diseases including heart failure. Little is known on the mechanisms regulating homeostasis of NAD + in the failing heart. Methods: To explore possible alterations of NAD + homeostasis in the failing heart, we quantified the expression of NAD + biosynthetic enzymes in the human failing heart and in the heart of a mouse model of dilated cardiomyopathy (DCM) triggered by Serum Response Factor transcription factor depletion in the heart (SRF HKO ) or of cardiac hypertrophy triggered by transverse aorta constriction. We studied the impact of NAD + precursor supplementation on cardiac function in both mouse models. Results: We observed a 30% loss in levels of NAD + in the murine failing heart of both DCM and transverse aorta constriction mice that was accompanied by a decrease in expression of the nicotinamide phosphoribosyltransferase enzyme that recycles the nicotinamide precursor, whereas the nicotinamide riboside kinase 2 (NMRK2) that phosphorylates the nicotinamide riboside precursor is increased, to a higher level in the DCM (40-fold) than in transverse aorta constriction (4-fold). This shift was also observed in human failing heart biopsies in comparison with nonfailing controls. We show that the Nmrk2 gene is an AMP-activated protein kinase and peroxisome proliferator-activated receptor α responsive gene that is activated by energy stress and NAD + depletion in isolated rat cardiomyocytes. Nicotinamide riboside efficiently rescues NAD + synthesis in response to FK866-mediated inhibition of nicotinamide phosphoribosyltransferase and stimulates glycolysis in cardiomyocytes. Accordingly, we show that nicotinamide riboside supplementation in food attenuates the development of heart failure in mice, more robustly in DCM, and partially after transverse aorta constriction, by stabilizing myocardial NAD + levels in the failing heart. Nicotinamide riboside treatment also robustly increases the myocardial levels of 3 metabolites, nicotinic acid adenine dinucleotide, methylnicotinamide, and N1-methyl-4-pyridone-5-carboxamide, that can be used as validation biomarkers for the treatment. Conclusions: The data show that nicotinamide riboside, the most energy-efficient among NAD precursors, could be useful for treatment of heart failure, notably in the context of DCM, a disease with few therapeutic options.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In addition, they have demonstrated beneficial pharmacological activities in acute renal failure [28], anti-inflammatory [29–31], cardio and vasoprotective actions [32–35], telomere lengthening [36, 37•], extend lifespan and promote health in various organisms, from yeasts to mammals [10, 14, 15, 38].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [35]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“NR (450 mg/kg body weight for 45 days) stabilized myocardial NAD+ levels, increased glycolysis, and citrate and acetyl-coenzyme A metabolism, attenuating the development of heart failure in a mouse model with dilated cardiomyopathy [35].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [35]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238
Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210
NAD+ metabolism in health and disease
Belenky, P. A., Bogan, K. L., & Brenner, C. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.006 · Cited by 1,006
Self-citationBieganowski, P., & Brenner, C. (2004) · Cell · doi:10.1016/s0092-8674(04)00416-7 · Cited by 750
Self-citationBogan, K. L., & Brenner, C. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155443 · Cited by 707
Self-citationNicotinamide riboside is uniquely and orally bioavailable in mice and humans
Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications · doi:10.1038/ncomms12948 · Cited by 697
Self-citationLund, L. H., Edwards, L. B., Kucheryavaya, A. Y., Benden, C., Dipchand, A. I., Goldfarb, S., Levvey, B. J., Meiser, B., Rossano, J. W., Yusen, R. D., et al. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.08.003 · Cited by 534
Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics
Ho, C. Y., Jaalouk, D. E., Vartiainen, M. K., & Lammerding, J. (2013) · Nature · doi:10.1038/nature12105 · Cited by 456
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 370
Podyacheva, E., N.Yu., N., Vsevolod, V. A., Mukhametdinova, D. V., Goncharova, I., Александровна, З. И., Sviridov, E. E., Martynov, M. O., Osipova, S. A., & Toropova, Y. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113096 · Cited by 13
Hove, J. L. K. V., Friederich, M. W., Hock, D. H., Stroud, D. A., Caruana, N. J., Christians, U., Schniedewind, B., Michel, C. R., Reisdorph, R. M., Gonzalez, E. D. J. L., et al. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101905 · Cited by 13
Self-citationDu, Z., Zhou, Y., Li, Q., Xie, Y., Zhu, T., Qiao, J., Zhang, R., Bao, Y., Wang, L., Xie, Y., et al. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.05.011 · Cited by 11
Du, J., Sudlow, L. C., Shahverdi, K., Zhou, H., Michie, M. S., Schindler, T. H., Mitchell, J. D., Mollah, S. A., & Berezin, M. Y. (2026) · Cardio-Oncology · doi:10.1186/s40959-026-00453-7 · Cited by 12
Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging
Carpenter, B. J., & Dierickx, P. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00239.2022 · Cited by 11
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
Zhang, H., Muhetarijiang, M., Chen, R. J., Hu, X., Han, J., Zheng, L., & Chen, T. (2024) · Aging and Disease · doi:10.14336/ad.2024.0058 · Cited by 12
BubR1 and SIRT2: Insights into aneuploidy, aging, and cancer
Pun, R., Kumari, N., Monieb, R. H., Wagh, S., & North, B. J. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.10.005 · Cited by 10
The interplay between lipid droplets and Parkinson's disease
Zhao, X., Gu, Y., Wang, J., Yi, Y., Zhang, Y.-Q., Shao, Q.-H., Liu, M., & Zhang, X. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167953 · Cited by 10
Cytoskeletal Protein Variants Driving Atrial Fibrillation: Potential Mechanisms of Action
van Wijk, S. W., Su, W., Wijdeveld, L. F. J. M., Ramos, K. S., & Brundel, B. J. J. M. (2022) · Cells · doi:10.3390/cells11030416 · Cited by 13
Kong, Q., Gu, J., Lu, R., Huang, C., Chen, L., Wu, W., & Lin, D. (2022) · Molecules · doi:10.3390/molecules27186115 · Cited by 10
The emerging importance of NAD+ metabolome for nutrition and food sciences: A bibliometric analysis
Alegre, G. F. S., & Pastore, G. M. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103126 · Cited by 10
Doig, C. L., Zielinska, A. E., Fletcher, R. S., Oakey, L. A., Elhassan, Y., Garten, A., Cartwright, D., Heising, S., Alsheri, A., Watson, D. G., et al. (2020) · Skeletal Muscle · doi:10.1186/s13395-019-0216-z · Cited by 13
Self-citationMolecular and functional characteristics of megakaryocytes and platelets in aging
Esparza, O., Higa, K. C., & Davizon‐Castillo, P. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000601 · Cited by 11
N6-methyladenosine modulates long non-coding RNA in the developing mouse heart
Shen, S., Liu, K., Li, S., Rampes, S., Yang, Y., Huang, Y., Tang, J. Y., Xia, Z., Ma, D., & Zhang, L. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01118-x · Cited by 10
NAD in pathological cardiac remodeling: Metabolic regulation and beyond
Norambuena‐Soto, I., Deng, Y., Brenner, C., Lavandero, S., & Wang, Z. V. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167038 · Cited by 9
Self-citationYuan, X., Li, L., Kang, H., Wang, M., Zeng, J., Lei, Y., Li, N., Yu, P., Li, X., & Liu, Z. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02912-2 · Cited by 10
An updated review of YAP: A promising therapeutic target against cardiac aging?
Leng, J., Wang, C., Liang, Z., Qiu, F., Zhang, S., & Yuan, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127670 · Cited by 11
Zeng, F., Zhou, P., Wang, M., Xie, L., Huang, X., Wang, Y., Huang, J., Shao, X., Yang, Y., Liu, W., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.111014 · Cited by 10
Dilated cardiomyopathy: from genes and molecules to potential treatments
Wang, X., Lang, Z., Yan, Z., Xu, J., Zhang, J., Jiao, L., & Zhang, H. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05269-0 · Cited by 8
Berven, H., Svensen, M., Eikeland, H., Tvedten, N., Sheard, E., Geijerstam, S. A. A., Søgnen, M., McCann, A., Arnsten, L., Arseth, O., et al. (2026) · iScience · doi:10.1016/j.isci.2026.114764 · Cited by 11
Bortoli, M. D., Meraviglia, V., Macková, K., Frommelt, L. S., König, E., Rainer, J., Volani, C., Benzoni, P., Schlittler, M., Cattelan, G., et al. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.02.029 · Cited by 9
Energy metabolism and redox balance: How phytochemicals influence heart failure treatment
Chen, C., Wang, J., Zhu, X., Hu, J., Liu, C., & Liu, L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116136 · Cited by 9
Intestinal microbiota and metabolome perturbations in ischemic and idiopathic dilated cardiomyopathy
Wang, Y., Xie, Y., Mahara, G., Xiong, Y., Xiong, Y., Zheng, Q., Chen, J., Zhang, W., Zhou, H., & Li, Q. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04605-6 · Cited by 8
Genetic aspects of the oxidative phosphorylation dysfunction in dilated cardiomyopathy
Bayona‐Bafaluy, M. P., Iglesias, E., López‐Gallardo, E., Emperador, S., Pacheu‐Grau, D., Labarta, L., Montoya, J., & Ruiz‐Pesini, E. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108334 · Cited by 8
Dutta, S., Li, D., Wang, A. Y.-Y., Ishak, M., Cook, K. M., Farnham, M. M. J., Dissanayake, H. U., Cistulli, P. A., Hunyor, I., Liu, R., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13631 · Cited by 7
Kargaran, P. K., Mosqueira, D., & Kozicz, T. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.604581 · Cited by 8
Linking NAD metabolism and DNA repair to inflammation in SSc
Avvedimento, E. V., & Gabrielli, A. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00629-8 · Cited by 9
Remodeling of cardiac metabolism in heart failure with preserved ejection fraction
Yoshii, A., & Tian, R. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100559 · Cited by 7
Differences in Extracellular NAD+ and NMN Metabolism on the Surface of Vascular Endothelial Cells
Jabłońska, P., Mierzejewska, P., Tomczyk, M., Koszałka, P., Frańczak, M., Kawecka, A., Kutryb-Zając, B. A., Braczko, A., Smolenski, R. T., & Slominska, E. M. (2022) · Biology · doi:10.3390/biology11050675 · Cited by 7
Zhang, Y., Xie, J., Wu, Y., Zhang, B., Zhou, C., Gao, X., Xie, X., Li, X., Yu, J., Wang, X., et al. (2022) · The Journal of Gene Medicine · doi:10.1002/jgm.3468 · Cited by 7
Hawkins, J., Idoine, R., Kwon, J., Shao, A. E., Dunne, E., Hawkins, E. M., Dawson, K., & Nkrumah-Elie, Y. M. (2024) · medRxiv · doi:10.1101/2024.06.06.24308565 · Cited by 9
Gouchoe, D. A., Vijayakumar, A., Aly, A. H., Cui, E. Y., Essandoh, M. K., Gumina, R. J., Black, S. M., & Whitson, B. A. (2023) · Journal of Thoracic Disease · doi:10.21037/jtd-23-725 · Cited by 7
Cirrhotic cardiomyopathy: pathophysiology, assessment, and implications for liver transplantation
Gill, M. G., Koshy, A. N., Ramachandran, J., McCaughan, G. W., & Majumdar, A. (2026) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848261423358 · Cited by 6
Liu, S., Deshmukh, V., Wang, F., Liang, J., Cusick, J., Li, X., & Martin, J. F. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.02.014 · Cited by 6
NAD+ enhancers as therapeutic agents in the cardiorenal axis
Marin-Blazquez, M., Rovira, J., Ramírez-Bajo, M. J., Perez, R. Z., & Rabadán-Ros, R. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01903-4 · Cited by 7
Fluharty, N. T., & Brenner, C. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa109 · Cited by 6
Self-citationKATP channel dependent heart multiome atlas
Arrell, D. K., Park, S., Yamada, S., Alekseev, A. E., Garmany, A., Jeon, R., Vučković, I., Lindor, J. Z., & Terzic, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-11323-4 · Cited by 6
Advances in Metabolic Remodeling and Intervention Strategies in Heart Failure
Meng, S., Yu, Y., Yu, S., Zhu, S., Shi, M., Xiang, M., & Ma, H. (2023) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-023-10443-0 · Cited by 7
Yuan, C., Yang, H., Lan, W., Yang, J., & Tang, Y. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12475 · Cited by 6
Zhou, Q., Liu, L., Lin, X., Shen, B., Huang, W., Zhang, Y., Li, Y., Yang, Y., Liu, H., Zhang, W., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07012-1 · Cited by 8
Li, D., Zhang, Y., Kuang, Y., Lin, Z., Wang, P., Jiang, J., Pi, W., & Ma, Q. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103957 · Cited by 6
Pei, Z., Liang, F., Wang, X., & Li, H. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112174 · Cited by 7
Zhong, Y., Shen, C., Peng, Y., Li, K., Li, Q., Song, Y., Zhou, B., & Rao, L. (2021) · Biomarkers in Medicine · doi:10.2217/bmm-2021-0363 · Cited by 5
Thompson, L. P., Song, H., & Hartnett, J. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01387-6 · Cited by 5
Wang, H., Cai, P., Yu, X., Li, S., Zhu, W., Liu, Y., & Wang, D. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1367848 · Cited by 5
Nicotinamide riboside Induced Energy Stress and Metabolic Reprogramming in BEAS-2B Cells
Cordeiro, E. W. F., Marzola, E. L., Maekawa, R. S., dos Santos, M. R., Assunção, L. G., Massafera, M. P., de Oliveira, J., Batista, T. G. C., de Sales, M. C. O. P., Maria–Engler, S. S., et al. (2024) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.3c00312 · Cited by 5
Habeichi, N. J., Amin, G., Boitard, S. E., Tannous, C., Ghali, R., Momken, I., Diab, R., Booz, G. W., Mericskay, M., & Zouein, F. A. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.038603 · Cited by 5
Self-citationTang, Y., Zhu, Y., Lu, Y., Yang, H., Yang, H., Li, L., Liu, C., Du, Y., & Yuan, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.741920 · Cited by 5
Lee, J. Y., Lee, J., Lee, S. H., Hwang, J. H., & Suh, H. N. (2023) · Toxicological Research · doi:10.1007/s43188-023-00186-0 · Cited by 5
Harnessing NAD+ Metabolism as Therapy for Cardiometabolic Diseases
Chakraborty, A. D., Minor, K., Nizami, H. L., Chiao, Y. A., & Lee, C. F. (2022) · Current Heart Failure Reports · doi:10.1007/s11897-022-00550-5 · Cited by 6
Neopetroside-B alleviates doxorubicin-induced cardiotoxicity via mitochondrial protection
Yoon, C. S., Nifantiev, N. E., Yashunsky, D. V., Kim, H. K., & Han, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115232 · Cited by 5
Enhancing NAD+ Metabolome in Cardiovascular Diseases: Promises and Considerations
Jahan, F., & Bagchi, R. A. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.716989 · Cited by 5
Alterations in Cardiac Metabolism in Heart Failure
Bugger, H., Wende, A. R., & Abel, E. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-60987-6.00017-x · Cited by 5
Heart Failure in Diabetes Mellitus: An Updated Review
Sohrabi, C., Saberwal, B., Lim, W. Y., Tousoulis, D., Ahsan, S., & Παπαγεωργίου, Ν. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201118091659 · Cited by 5
Brenner, C. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519869679 · Cited by 5
Self-citationGong, M., Li, H., Jiao, L., Liu, T., Zhang, Y., Liu, J., Wang, S., Wang, H., Liu, D., Li, Z., et al. (2025) · Engineering · doi:10.1016/j.eng.2025.06.006 · Cited by 4
Self-citationDriving force of deteriorated cellular environment in heart failure: Metabolic remodeling
Fan, L., Meng, C., Wang, X., Wang, Y., Li, Y., Lv, S., & Zhang, J. (2023) · Clinics · doi:10.1016/j.clinsp.2023.100263 · Cited by 4
New COST Action ‘EUropean network to tackle METAbolic alterations in HEART failure’ (EU-METAHEART)
Maack, C., Vilahur, G., Ruiz‐Meana, M., & Hausenloy, D. J. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae457 · Cited by 4
The Role of NAD+ Metabolism in Cardiovascular Diseases: Mechanisms and Prospects
Li, H., Hu, Q., Zhu, D., & Wu, D. (2024) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-024-00711-y · Cited by 5
Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells
Walvekar, A. S., Warmoes, M. O., Cheung, D., Sikora, T., Seyedkatouli, N., Gomez‐Giro, G., Perrone, S., Dengler, L., Unger, F., Santos, B. F. R., et al. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00681-8 · Cited by 4
Need for NAD+: Focus on Striated Muscle Laminopathies
Cardoso, D., & Muchir, A. (2020) · Cells · doi:10.3390/cells9102248 · Cited by 5
Mitochondrial cardiomyopathy and emerging therapeutics
Yang, J., Zhang, X., Kou, M., Lian, B. X., Chiang, Z., Chen, J., Zhou, X., Li, Z., Zhang, J., Su, X., et al. (2023) · Translational Medicine of Aging · doi:10.1016/j.tma.2023.10.002 · Cited by 4
Self-citationNicotinamide Mononucleotide in the Context of Myocardiocyte Longevity
Marzoog, B. A. (2023) · Current Aging Science · doi:10.2174/0118746098266041231212105020 · Cited by 4
Nicotinamide riboside kinase 2: A unique target for skeletal muscle and cardiometabolic diseases
Ahmad, F., & Qaisar, R. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167487 · Cited by 4
Azam, T., Zhang, H., Zhou, F., & Wang, X. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.888190 · Cited by 4
Mierzejewska, P., Denslow, A., Papiernik, D., Zabrocka, A., Kutryb-Zając, B. A., Charkiewicz, K., Braczko, A., Smolenski, R. T., Wietrzyk, J., & Slominska, E. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010035 · Cited by 3
Lejonberg, C., Czuba, T., Egerstedt, A., Ghosh, N., Celik, S., Ljungman, C. E. A., Lundgren, J., Rådegran, G., Gidlöf, O., & Smith, J. G. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039248 · Cited by 4
Yan, T., Li, R., Wang, S., Song, X., Hu, B., Wang, Z., Wang, X., Ding, X., Guan, R., Yu, H., et al. (2026) · Environmental Research · doi:10.1016/j.envres.2026.123735 · Cited by 3
Alegre, G. F. S., & Pastore, G. M. (2025) · CyTA - Journal of Food · doi:10.1080/19476337.2025.2458753 · Cited by 4
Pham, H. D. M., Daher, M., Agbulut, O., Li, Z., & Parlakian, A. (2025) · Physiological Reports · doi:10.14814/phy2.70425 · Cited by 3
Self-citationShi, S., Zhang, X., Lv, J., Fu, Z., Wang, Y., Du, Y., Duan, C., Wang, H., Du, B., Song, Q., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01154-6 · Cited by 3
Letting off electrons to cope with metabolic stress
Heer, C. D., & Brenner, C. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0207-8 · Cited by 3
Self-citationHeart Failure Pathogenesis Elucidation and New Treatment Method Development
Katagiri, M., Yamada, S., Katoh, M., Ko, T., Ito, M., & Komuro, I. (2022) · JMA Journal · doi:10.31662/jmaj.2022-0106 · Cited by 3
Li, Y., Zhang, C., Li, Z., Bai, F., Jing, Y., Ke, H., Zhang, S., Yan, Y., & Yu, Y. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46020082 · Cited by 3
Self-citationMitochondria for Cardiovascular Therapy: A Deep Dive into Drug Targets and Therapeutic Approaches
Semenzato, M., & Naón, D. (2025) · Current Pharmacology Reports · doi:10.1007/s40495-025-00405-2 · Cited by 3
David, C., Deschênes, S., Ichkhan, G., Daneault, C., Frayne, I. R., Bouchard, B., Forest, A., Shi, Y. F., Higgins, M., Sirois, M. G., et al. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00841.2024 · Cited by 3
Self-citationMetabolic targets in cardiac aging and rejuvenation
Liu, C., Zhang, X., Hu, M., Lu, Y., Gokulnath, P., Vulugundam, G., & Xiao, J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.31 · Cited by 3
Preventing the Fatty Acid-Transporter CD36 From Taking its Toll on the Heart
Mericskay, M. (2024) · Circulation Research · doi:10.1161/circresaha.123.323945 · Cited by 3
Self-citationQualia NAD+® Increases NAD+ Levels In Human Participants: A Double-Blind, Placebo-Controlled StudyPreprint
Blomquist, S. A., Kelly, G., Adães, S., D’Adamo, C. R., Ardagh, A., Ramer, S., & Scuba, W. (2025) · medRxiv · doi:10.1101/2025.03.19.25324259 · Cited by 4
Wang, R. Y., Zhang, H., Yi, Q., Wang, Y., Xu, H., Tan, B., & Zhu, J. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123685 · Cited by 2
Nicotinamide Riboside Alleviates Heat Stress–induced Intestinal Barrier Dysfunction in Mice
Chen, Y., & Yu, T. (2025) · Shock · doi:10.1097/shk.0000000000002628 · Cited by 2
Zou, H. B., Gong, L., Huang, C., Lin, D., & Zhang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188902 · Cited by 2
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis
Shi, L. P., Sun, Z., Cao, Y., Li, Y., Qing, W., Zhou, L., Xu, M., Mai, X., Ou, L., 杨小平, et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2527247123 · Cited by 3
Swaminathan, K., Astan, B., Kaczmarek, S., Lehnert, K., Hannemann, A., Koc, A., Friedrich, N., Budde, K., Henning, A., Domańska, G., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1732461 · Cited by 2
Mechanisms of NAD+ Homeostasis in Aging and Disease
McReynolds, M. R. (2026) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-112525-013335 · Cited by 2
The Role of NAD+ in Myocardial Ischemia-induced Heart Failure in Sprague-dawley Rats and Beagles
Pei, Z., Yang, C., Guo, Y., Dong, M., & Wang, F. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010275059240103054554 · Cited by 2
Roboon, J., Hattori, T., Ishii, H., Takarada‐Iemata, M., Nguyen, D. T., Heer, C. D., O'Mealley, D., Brenner, C., Yamamoto, Y., Okamoto, H., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-135107/v1 · Cited by 2
Self-citationBraczko, A., Stawarska, K., Kawecka, A., Walczak, I., Slominska, E. M., Kutryb-Zając, B. A., & Smolenski, R. T. (2025) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2025.2453105 · Cited by 2
Huang, Q., Wang, Y., Farias, K., Zeng, X., Chen, Q., Cheng, H., Baki, V. B., Gross, S., Geri, J., Sauve, A. A., et al. (2026) · Cardiovascular Research · doi:10.1101/2025.07.15.664959 · Cited by 2
The NARly side of whole-body NAD homeostasis
Brenner, C. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.06.003 · Cited by 1
Self-citationConnexin 43 suppression enhances contractile force in human iPSC-derived cardiac tissues
Takada, T., Matsuura, K., Iida, T., Koike, T., Sekine, H., Higashi, Y., Hara, T., Sasaki, D., Fujita, K., Hinata, Y., et al. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1615953 · Cited by 1
Omics-based integrative analysis of sepsis-induced myocardial dysfunction
Zhao, J., Dong, Z.-X., Wang, W., Sheng, S., & Yu, K.-J. (2025) · Journal of International Medical Research · doi:10.1177/03000605251377660 · Cited by 2
Bloomer, R. J., Timmcke, J. Q., & Ramanathan, C. (2025) · Clinical bioenergetics · doi:10.3390/clinbioenerg1020009 · Cited by 1
Nicotinamide prevents anti-PD1 immune checkpoint inhibitor-associated early stages of cardiotoxicity
Bai, L., Zhao, J., Dong, K., Zhao, M., Zhao, Y., Cong, Q., Wang, Y., Niu, X., Tang, J., & Bai, M. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3116-0 · Cited by 1
Fan, J., & Song, Y. (2026) · PeerJ · doi:10.7717/peerj.20842 · Cited by 1
Kondrachuk, O., Nakhungu, E., Ogundipe, G., Tailor, N., Ciccone, P., Hong, K., Gadiraju, A., Kimura, Y., Zi, A., Yusuf, S., et al. (2026) · Cells · doi:10.3390/cells15050444 · Cited by 1
Pan, Y., Li, W.-H., Zhang, W., Ma, W., & Sun, H. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00599-x · Cited by 1
Metabolic Flexibility and Mitochondrial Bioenergetics in the Failing Heart. Therapeutic Approaches
Rosca, M. G. (2021) · Romanian Journal of Cardiology · doi:10.47803/rjc.2021.31.2.269 · Cited by 1
The Research Progress of Vascular Aging Related Diseases
Wang, S., Liu, J., Cui, Z., Yu, W., Hu, S., & Mao, Y. (2023) · Journal of Innovations in Medical Research · doi:10.56397/jimr/2023.06.06 · Cited by 1
NAD+ controls circadian rhythmicity during cardiac aging
Carpenter, B. J., Lecacheur, M., Mangold, Y. N., Cui, K., Günther, S., Vermunt, M. W., & Dierickx, P. (2026) · Communications Biology · doi:10.1038/s42003-026-09818-1 · Cited by 2
Metadata
- Authors
- Diguet, N., Trammell, S. A. J., Tannous, C., Deloux, R., Piquereau, J., Mougenot, N., Gouge, A., Gressette, M., Manoury, B., Blanc, J., Breton, M., Decaux, J.-F., Lavery, G. G., Baczkó, I., Zoll, J., Garnier, A., Li, Z., Brenner, C., & Mericskay, M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Iowa (US)
- Université Paris-Sud (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- University of Birmingham (GB)
- University of Szeged (HU)
- Hôpital Lariboisière (FR)
- Corresponding author
- Tannous, Cynthia
- Deloux, Robin
- ORCID
- Venue
- Circulation
- Published
- 2018-05-22
- Volume
- 137
- Issue
- 21
- Pages
- 2256-2273
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC6954688
- OpenAlex
- W2775095764
- Cited by
- 358
- References
- 50
- Citations by year
- 2026: 28 · 2025: 42 · 2024: 49 · 2023: 47 · 2022: 57 · 2021: 47 · 2020: 49 · 2019: 24 · 2018: 12
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-05-22)
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Wellcome Trust (104612/Z/14/Z)
- Agence Nationale de la Recherche (ANR-08-GENO-0038, ANR-17-CE17-0015)
- Institut National de la Santé et de la Recherche Médicale
- Université de Strasbourg
- Centre National de la Recherche Scientifique
- Université Pierre et Marie Curie
- Université Paris-Saclay
- Szegedi Tudományegyetem
- Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- National Institute of General Medical Sciences (T32GM008629)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- nicotinamide riboside, NAD+ homeostasis, dilated cardiomyopathy, heart failure, NAD biosynthesis, visfatin, AMPK, PPARα, myocardial energy metabolism, glycolysis, transverse aortic constriction, cardiac hypertrophy, cardiomyocytes, NAD+ precursor supplementation, chronic heart failure
- MeSH terms
- Acrylamides, Animals, Cardiomyopathy, Dilated, Disease Models, Animal, Heart Failure, Mice, Transgenic, NAD, Niacinamide, Piperidines, Pyridinium Compounds, Cytokines, Phosphotransferases (Alcohol Group Acceptor), Citric Acid, Dietary Supplements, Gene Expression Profiling, Serum Response Factor, Myocytes, Cardiac, PPAR alpha, Mice, Rats, Nicotinamide Phosphoribosyltransferase, AMP-Activated Protein Kinases, Metabolome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
