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Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy
Open accessAbstract
Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, nicotinamide adenine dinucleotide (NAD + ) is emerging as a metabolic target in a number of diseases including heart failure. Little is known on the mechanisms regulating homeostasis of NAD + in the failing heart. Methods: To explore possible alterations of NAD + homeostasis in the failing heart, we quantified the expression of NAD + biosynthetic enzymes in the human failing heart and in the heart of a mouse model of dilated cardiomyopathy (DCM) triggered by Serum Response Factor transcription factor depletion in the heart (SRF HKO ) or of cardiac hypertrophy triggered by transverse aorta constriction. We studied the impact of NAD + precursor supplementation on cardiac function in both mouse models. Results: We observed a 30% loss in levels of NAD + in the murine failing heart of both DCM and transverse aorta constriction mice that was accompanied by a decrease in expression of the nicotinamide phosphoribosyltransferase enzyme that recycles the nicotinamide precursor, whereas the nicotinamide riboside kinase 2 (NMRK2) that phosphorylates the nicotinamide riboside precursor is increased, to a higher level in the DCM (40-fold) than in transverse aorta constriction (4-fold). This shift was also observed in human failing heart biopsies in comparison with nonfailing controls. We show that the Nmrk2 gene is an AMP-activated protein kinase and peroxisome proliferator-activated receptor α responsive gene that is activated by energy stress and NAD + depletion in isolated rat cardiomyocytes. Nicotinamide riboside efficiently rescues NAD + synthesis in response to FK866-mediated inhibition of nicotinamide phosphoribosyltransferase and stimulates glycolysis in cardiomyocytes. Accordingly, we show that nicotinamide riboside supplementation in food attenuates the development of heart failure in mice, more robustly in DCM, and partially after transverse aorta constriction, by stabilizing myocardial NAD + levels in the failing heart. Nicotinamide riboside treatment also robustly increases the myocardial levels of 3 metabolites, nicotinic acid adenine dinucleotide, methylnicotinamide, and N1-methyl-4-pyridone-5-carboxamide, that can be used as validation biomarkers for the treatment. Conclusions: The data show that nicotinamide riboside, the most energy-efficient among NAD precursors, could be useful for treatment of heart failure, notably in the context of DCM, a disease with few therapeutic options.
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“In addition, they have demonstrated beneficial pharmacological activities in acute renal failure [28], anti-inflammatory [29–31], cardio and vasoprotective actions [32–35], telomere lengthening [36, 37•], extend lifespan and promote health in various organisms, from yeasts to mammals [10, 14, 15, 38].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [35]
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“NR (450 mg/kg body weight for 45 days) stabilized myocardial NAD+ levels, increased glycolysis, and citrate and acetyl-coenzyme A metabolism, attenuating the development of heart failure in a mouse model with dilated cardiomyopathy [35].”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [35]
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Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238
Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210
NAD+ metabolism in health and disease
Belenky, P. A., Bogan, K. L., & Brenner, C. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.006 · Cited by 1,006
Self-citationBieganowski, P., & Brenner, C. (2004) · Cell · doi:10.1016/s0092-8674(04)00416-7 · Cited by 750
Self-citationBogan, K. L., & Brenner, C. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155443 · Cited by 707
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Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications · doi:10.1038/ncomms12948 · Cited by 697
Self-citationLund, L. H., Edwards, L. B., Kucheryavaya, A. Y., Benden, C., Dipchand, A. I., Goldfarb, S., Levvey, B. J., Meiser, B., Rossano, J. W., Yusen, R. D., et al. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.08.003 · Cited by 534
Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics
Ho, C. Y., Jaalouk, D. E., Vartiainen, M. K., & Lammerding, J. (2013) · Nature · doi:10.1038/nature12105 · Cited by 456
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Cantó, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00017-1 · Cited by 1
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Katare, P. B., Nizami, H. L., & Banerjee, S. K. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_25 · Cited by 1
Chen, H., Wu, M., Jiang, W., Liu, X., Zhang, J., & Yu, C. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4472 · Cited by 1
Nicotinamide Adenine Dinucleotide (NAD+) in Aging
Braidy, N., Poljak, A., & Sachdev, P. S. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_1035-1 · Cited by 1
PncA from bacteria improves diet-induced NAFLD by enabling the transition from NAM to NA in micePreprint
Feng, S., Guo, L., & Liu, H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.04.471202 · Cited by 1
Activated fibroblasts drive cellular interactions in end-stage pediatric hypertrophic cardiomyopathyPreprint
Tadros, H. J. J., Turaga, D., Zhao, Y., Tsai, C.-R., Adachi, I. A., Li, X., & Martin, J. F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.25.577226 · Cited by 1
Ganoderma lucidum alleviates kidney aging by modulating gut microbiotaPreprint
Liu, X., Zhao, J., Liu, J., Huang, Y., Deng, W., Yan, L., Zhang, L., Liu, Z., Cui, M., Xiao, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.30.605752 · Cited by 1
Doig, C. L., Zielinska, A. E., Fletcher, R. S., Oakey, L. A., Elhassan, Y., Garten, A., Cartwright, D., Heising, S., Alsheri, A., Watson, D. G., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/567297
Self-citationThe Evolving Concept of Mitochondrial Dynamics in Heart: Interventional Opportunities
Ashok, S., Ganjoo, M., Panicker, V. T., Pillai, V. V., & Gopala, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_25
Liver substrate metabolism in non-alcoholic fatty liver
Roumans, K. H. M. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20210915kr
子宮内膜癌細胞株における抗癌剤感受性の検討(子宮体部悪性腫瘍VI, 第57回日本産科婦人科学会学術講演会)
茂木, 真., 新美, 茂., 高倉, 聡., 柳田, 聡., 岡本, 愛., 落合, 和., & 田中, 忠. (2005) · 日本産科婦人科學會雜誌
Nicotinamide Adenine Dinucleotide (NAD+) in Aging
Braidy, N., Poljak, A., & Sachdev, P. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_1035
Period 3 regulates mitochondrial function via the NAD+-SIRT3 axis in micePreprint
Xie, X., Shu, R., Zhang, M., Cui, D., Sun, L., Li, Z., & Han, Q. (2022) · Research Square · doi:10.21203/rs.3.rs-1767038/v1
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Metabolic precursors of nicotinamide adenine dinucleotide and the potential for their clinical use
Sutsko, I. P., Shlyahtun, A. H., & Semenenya, I. N. (2022) · Medical academic journal · doi:10.17816/maj89964
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Meng, X., Li, Y., Weng, S., Guo, Y., Pei, Z., Dong, M., Wang, X., Xia, C., & Wang, F. (2023) · Research Square · doi:10.21203/rs.3.rs-3675580/v1
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Noyan, S., Islakoğlu, Y. Ö., & Akpinar, A. E. (2024) · Medical Records · doi:10.37990/medr.1394921
Habeichi, N. J., Amin, G., Boitard, S. E., Tannous, C., Ghali, R., Momken, I., Diab, R., Booz, G. W., Mericskay, M., & Zouein, F. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.05.611567
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Boitard, S. E., Delouche, M., Karoui, A., Gressette, M., Momken, I., Bouchard, B., Mercier‐Nomé, F., Imbard, A., Lemaire, C., Garnier, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.18.638803
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Feng, Z.-Y., She, J., Qin, Z., & Sheng, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_47
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Zhao, K., Zhu, J., & Sheng, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_23
Advances in the Study of Nicotinamide Mononucleotides in the Treatment of Metabolic Diseases
时, 漪. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1561781
Ghazal, N., Huang, B. X., Shoemaker, L. J., Faúndez, V., & Kwong, J. Q. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.03.674000
Vanni, E., & Montessuit, C. (2025) · Metabolites · doi:10.3390/metabo15100636
Khan, N. A., Ahlqvist, K. J., Pradhan, S., Landoni, J. C., Jackson, C. B., Zhaivoron, A., Kivelä, R., Euro, L., & Suomalainen, A. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117849
Boitard, S. E., Delouche, M., Karoui, A., Gressette, M., Momken, I., Bouchard, B., Mercier‐Nomé, F., Imbard, A., Lemaire, C., Garnier, A., et al. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00764-x
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Liao, B., Zhao, Y., Wang, D., Zhang, X., Hao, X., & Hu, M. (2021) · Figshare · doi:10.6084/m9.figshare.14936274
Wang, Y., Xie, Y., Mahara, G., Xiong, Y., Xiong, Y., Zheng, Q., Chen, J., Zhang, W., Zhou, H., & Li, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26670999
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693005
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693035
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693032
Wang, Y., Xie, Y., Mahara, G., Xiong, Y., Xiong, Y., Zheng, Q., Chen, J., Zhang, W., Zhou, H., & Li, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26671005
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693002
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693029
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693023
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693011
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693017
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693020
Yuan, X., Li, L., Kang, H., Wang, M., Zeng, J., Lei, Y., Nana, L. I., Yu, P., Li, X., & Liu, Z. (2022) · Figshare · doi:10.6084/m9.figshare.21602242
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693008
Wang, Y., Xie, Y., Mahara, G., Xiong, Y., Xiong, Y., Zheng, Q., Chen, J., Zhang, W., Zhou, H., & Li, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26670996
Wang, Y., Xie, Y., Mahara, G., Xiong, Y., Xiong, Y., Zheng, Q., Chen, J., Zhang, W., Zhou, H., & Li, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26670993
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693026
Wang, Y., Xie, Y., Mahara, G., Xiong, Y., Xiong, Y., Zheng, Q., Chen, J., Zhang, W., Zhou, H., & Li, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26671002
Wang, Y., Xie, Y., Mahara, G., Xiong, Y., Xiong, Y., Zheng, Q., Chen, J., Zhang, W., Zhou, H., & Li, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26671008
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693038
Song, M., Armenian, S. H., Bhandari, R., Lee, K., Ness, K. P. V., Putt, M., Lindenfeld, L., Manoukian, S., Wade, K., Dedio, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20342385
Zhao, L., Yang, H., Li, M., Xiao, M., Li, X., Cheng, L., Cheng, W., Chen, M., & Zhao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26693014
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Zhang, C., Wang, J., Chi, J., Liu, S.-T., Meng, X.-W., Li, L.-G., Dong, S., Cao, H., Zhou, X.-G., Zhang, Y., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104100
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Deloux, R. (2018) · theses.fr (ABES) · doi:10.70675/187a7874z7c88z4ab7z9392zc08078be5b17
Self-citationCardoso, D. (2022) · theses.fr (ABES) · doi:10.70675/e5ce6d96z7253z4119zb119zc07f3977425d
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Zhang, F., Deng, X., Zou, X., Ou, Y., Tang, R., Tang, L., Li, Y., Li, Y., Tang, Q., Liu, R., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103137
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Prasanna, J., Manickam, R., & Tipparaju, S. M. (2026) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001292
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Li, Y., Zheng, K., Liu, Y., Li, R., Wang, S., Ye, W., Luo, Z., Li, X., Tao, Z., Xia, J., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00504-6
Qi, X., Hu, L., van Rinsum, A., Koopman, W. J. H., Keijer, J., & Zhang, D. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00253.2026
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Cheng, C., Tang, M., 张兆波, Qu, R., Pei, J., Liu, T., Qu, S., You, S., Cui, S., Wang, W., et al. (2026) · Advanced Science · doi:10.1002/advs.77260
Wang, X., Liu, C., Wang, J., Chen, F., Han, Z., Chen, X., Zheng, F., & Tian, X. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124684
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Gu, J., Xu, J., Yang, S., Qiu, Y., Yin, L., & Xu, N. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119934
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Chen, X. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1958014
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BindingDB (2023) · UC San Diego · doi:10.7270/q2gb2848
Metadata
- Authors
- Diguet, N., Trammell, S. A. J., Tannous, C., Deloux, R., Piquereau, J., Mougenot, N., Gouge, A., Gressette, M., Manoury, B., Blanc, J., Breton, M., Decaux, J.-F., Lavery, G. G., Baczkó, I., Zoll, J., Garnier, A., Li, Z., Brenner, C., & Mericskay, M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Iowa (US)
- Université Paris-Sud (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- University of Birmingham (GB)
- University of Szeged (HU)
- Hôpital Lariboisière (FR)
- Corresponding author
- Tannous, Cynthia
- Deloux, Robin
- ORCID
- Venue
- Circulation
- Published
- 2018-05-22
- Volume
- 137
- Issue
- 21
- Pages
- 2256-2273
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC6954688
- OpenAlex
- W2775095764
- Cited by
- 358
- References
- 50
- Citations by year
- 2026: 28 · 2025: 42 · 2024: 49 · 2023: 47 · 2022: 57 · 2021: 47 · 2020: 49 · 2019: 24 · 2018: 12
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-05-22)
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Wellcome Trust (104612/Z/14/Z)
- Agence Nationale de la Recherche (ANR-08-GENO-0038, ANR-17-CE17-0015)
- Institut National de la Santé et de la Recherche Médicale
- Université de Strasbourg
- Centre National de la Recherche Scientifique
- Université Pierre et Marie Curie
- Université Paris-Saclay
- Szegedi Tudományegyetem
- Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- National Institute of General Medical Sciences (T32GM008629)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- nicotinamide riboside, NAD+ homeostasis, dilated cardiomyopathy, heart failure, NAD biosynthesis, visfatin, AMPK, PPARα, myocardial energy metabolism, glycolysis, transverse aortic constriction, cardiac hypertrophy, cardiomyocytes, NAD+ precursor supplementation, chronic heart failure
- MeSH terms
- Acrylamides, Animals, Cardiomyopathy, Dilated, Disease Models, Animal, Heart Failure, Mice, Transgenic, NAD, Niacinamide, Piperidines, Pyridinium Compounds, Cytokines, Phosphotransferases (Alcohol Group Acceptor), Citric Acid, Dietary Supplements, Gene Expression Profiling, Serum Response Factor, Myocytes, Cardiac, PPAR alpha, Mice, Rats, Nicotinamide Phosphoribosyltransferase, AMP-Activated Protein Kinases, Metabolome
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