The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events
Open accessAbstract
Background: High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP genetic profile and its effect on CVD risk. Methods: We constructed a genetic risk score for high BP by using 314 published BP loci in 277 005 individuals without previous CVD from the UK Biobank study, a prospective cohort of individuals aged 40 to 69 years, with a median of 6.11 years of follow-up. We scored participants according to their lifestyle factors including body mass index, healthy diet, sedentary lifestyle, alcohol consumption, smoking, and urinary sodium excretion levels measured at recruitment. We examined the association between tertiles of genetic risk and tertiles of lifestyle score with BP levels and incident CVD by using linear regression and Cox regression models, respectively. Results: Healthy lifestyle score was strongly associated with BP (P<10–320) for systolic and diastolic BP and CVD events regardless of the underlying BP genetic risk. Participants with a favorable in comparison with an unfavorable lifestyle (bottom versus top tertile lifestyle score) had 4.9, 4.3, and 4.1 mm Hg lower systolic BP in low, middle, and high genetic risk groups, respectively (P for interaction=0.0006). Similarly, favorable in comparison with unfavorable lifestyle showed 30%, 33%, and 31% lower risk of CVD among participants in low, middle, and high genetic risk groups, respectively (P for interaction=0.99). Conclusions: Our data further support population-wide efforts to lower BP in the population via lifestyle modification. The advantages and disadvantages of disclosing genetic predisposition to high BP for risk stratification needs careful evaluation.
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AGE STANDARDIZATION OF RATES: A NEW WHO STANDARD
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Self-citationClinical risk factors, DNA variants, and the development of type 2 diabetes
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Research works printed but not linked: 1
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Cited by
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473
Program, T. M. V., Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0205-x · Cited by 1,381
Self-citationCardiovascular disease: The rise of the genetic risk score
Knowles, J. W., & Ashley, E. A. (2018) · PLOS Medicine · doi:10.1371/journal.pmed.1002546 · Cited by 182
Association of Ultraprocessed Food Consumption With Risk of Dementia: A Prospective Cohort Study
Li, H., Li, S., Yang, H., Zhang, Y., Zhang, S., Ma, Y., Hou, Y., Zhang, X., Niu, K., Borné, Y., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200871 · Cited by 107
Liu, J., Bu, X., Wei, L., Wang, X., Lai, L., Dong, C., Ma, A., & Wang, T. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002958 · Cited by 100
Metadata
- Authors
- Pazoki, R., Dehghan, A., Evangelou, E., Warren, H., Gao, H., Caulfield, M., Elliott, P., & Tzoulaki, I.
- Venue
- Circulation
- Published
- 2018-02-13
- Volume
- 137
- Issue
- 7
- Pages
- 653-661
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2777641772
- Cited by
- 283
- References
- 32
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-01-07)
- Open access
- hybrid
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- Pazoki, R., Dehghan, A., Evangelou, E., Warren, H., Gao, H., Caulfield, M., Elliott, P., & Tzoulaki, I. (2018). Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events. Circulation. https://doi.org/10.1161/circulationaha.117.030898
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