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Cited by 458

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Myocarditis in the Setting of Cancer Therapeutics: Proposed Case Definitions for Emerging Clinical Syndromes in Cardio-Oncology

Open access
Bonaca, Marc P., Olenchock, Benjamin A., Salem, Joe-Elie, Wiviott, Stephen D., Ederhy, Stephane, Cohen, Ariel, Stewart, Garrick C., Choueiri, Toni K., Di Carli, Marcelo, Allenbach, Yves, Kumbhani, Dharam J., Heinzerling, Lucie, Amiri-Kordestani, Laleh, Lyon, Alexander R., Thavendiranathan, Paaladinesh, Padera, Robert, Lichtman, Andrew, Liu, Peter P., Johnson, Douglas B., Moslehi, Javid·2019·Circulation
DOI 10.1161/circulationaha.118.034497
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Abstract

Recent developments in cancer therapeutics have improved outcomes but have also been associated with cardiovascular complications. Therapies harnessing the immune system have been associated with an immune-mediated myocardial injury described as myocarditis. Immune checkpoint inhibitors are one such therapy with an increasing number of case and cohort reports describing a clinical syndrome of immune checkpoint inhibitor–associated myocarditis. Although the full spectrum of immune checkpoint inhibitor–associated cardiovascular disease still needs to be fully defined, described cases of myocarditis range from syndromes with mild signs and symptoms to fatal events. These observations in the clinical setting stand in contrast to outcomes from randomized clinical trials in which myocarditis is a rare event that is investigator reported and lacking in a specific case definition. The complexities associated with diagnosis, as well as the heterogeneous clinical presentation of immune checkpoint inhibitor–associated myocarditis, have made ascertainment and identification of myocarditis with high specificity challenging in clinical trials and other data sets, limiting the ability to better understand the incidence, outcomes, and predictors of these rare events. Therefore, establishing a uniform definition of myocarditis for application in clinical trials of cancer immunotherapies will enable greater understanding of these events. We propose an operational definition of cancer therapy-associated myocarditis that may facilitate case ascertainment and report and therefore may enhance the understanding of the incidence, outcomes, and risk factors of this novel clinical syndrome.

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Metadata

Authors
Bonaca, M. P., Olenchock, B. A., Salem, J.-E., Wiviott, S. D., Ederhy, S., Cohen, A., Stewart, G. C., Choueiri, T. K., Di Carli, M., Allenbach, Y., Kumbhani, D. J., Heinzerling, L., Amiri-Kordestani, L., Lyon, A. R., Thavendiranathan, P., Padera, R., Lichtman, A., Liu, P. P., Johnson, D. B., & Moslehi, J.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-07-02
Volume
140
Issue
1
Pages
80-91
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.118.034497
OpenAlex
W2955729565
Cited by
458
References
12
FWCI
19.32
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Myocarditis in the Setting of Cancer Therapeutics: Proposed Case Definitions for Emerging Clinical Syndromes in Cardio-Oncology. https://app.cochat.ai/papers/10.1161/circulationaha.118.034497
The paper
Bonaca, M. P., Olenchock, B. A., Salem, J.-E., Wiviott, S. D., Ederhy, S., Cohen, A., Stewart, G. C., Choueiri, T. K., Di Carli, M., Allenbach, Y., Kumbhani, D. J., Heinzerling, L., Amiri-Kordestani, L., Lyon, A. R., Thavendiranathan, P., Padera, R., Lichtman, A., Liu, P. P., Johnson, D. B., & Moslehi, J. (2019). Myocarditis in the Setting of Cancer Therapeutics: Proposed Case Definitions for Emerging Clinical Syndromes in Cardio-Oncology. Circulation. https://doi.org/10.1161/circulationaha.118.034497

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.