The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair
Abstract
Background: The impact of gut microbiota on the regulation of host physiology has recently garnered considerable attention, particularly in key areas such as the immune system and metabolism. These areas are also crucial for the pathophysiology of and repair after myocardial infarction (MI). However, the role of the gut microbiota in the context of MI remains to be fully elucidated. Methods: To investigate the effects of gut microbiota on cardiac repair after MI, C57BL/6J mice were treated with antibiotics 7 days before MI to deplete mouse gut microbiota. Flow cytometry was applied to examine the changes in immune cell composition in the heart. 16S rDNA sequencing was conducted as a readout for changes in gut microbial composition. Short-chain fatty acid (SCFA) species altered after antibiotic treatment were identified by high-performance liquid chromatography. Fecal reconstitution, transplantation of monocytes, or dietary SCFA or Lactobacillus probiotic supplementation was conducted to evaluate the cardioprotective effects of microbiota on the mice after MI. Results: Antibiotic-treated mice displayed drastic, dose-dependent mortality after MI. We observed an association between the gut microbiota depletion and significant reductions in the proportion of myeloid cells and SCFAs, more specifically acetate, butyrate, and propionate. Infiltration of CX3CR1+ monocytes to the peri-infarct zone after MI was also reduced, suggesting impairment of repair after MI. Accordingly, the physiological status and survival of mice were significantly improved after fecal reconstitution, transplantation of monocytes, or dietary SCFA supplementation. MI was associated with a reorganization of the gut microbial community such as a reduction in Lactobacillus. Supplementing antibiotic-treated mice with a Lactobacillus probiotic before MI restored myeloid cell proportions, yielded cardioprotective effects, and shifted the balance of SCFAs toward propionate. Conclusions: Gut microbiota–derived SCFAs play an important role in maintaining host immune composition and repair capacity after MI. This suggests that manipulation of these elements may provide opportunities to modulate pathological outcome after MI and indeed human health and disease as a whole.
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“This is indirectly supported by the fact that absence of microbiota alters cardiovascular homeostasis, such as blood pressure regulation150, myocardial repair following post-infarction cardiac repair66, or thrombosis growth127 – functions that all involve ADRs.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [66]
Citations
Cites
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis
Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3444 · Cited by 2,862
Transient Regenerative Potential of the Neonatal Mouse Heart
Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A. (2011) · Science · doi:10.1126/science.1200708 · Cited by 2,545
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Cited by
Sorted by citations
Items 301–354 of 354
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Chen, Y., Chen, R., Wang, X., Zhou, Y., Hong, L., Xiong, N., Zhu, J., Ye, S., & Tan, X. (2024) · Figshare · doi:10.6084/m9.figshare.26599456
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Self-citationBANNING, A. P., Crea, F., & Lüscher, T. F. (2020) · Srce i krvni sudovi · doi:10.5937/siks2002061b
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Zhang, Q.-L., Ou, Q.-X., Wang, Y., Liu, Y.-N., Zeng, Y.-T., Chen, Q., & Wang, Z.-C. (2026) · Scientific Reports · doi:10.1038/s41598-026-46524-8
Ren, B., Wang, H., Cao, Y., Zhang, Z., Wu, X., Ji, S., & Zhao, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1726262
Gut microbiota alters cardiac metabolism and immune system composition in viral myocarditis mice
Chen, L., 伍伟锋, & Kong, Q. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1828423
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Takahashi, K., Yoshikawa, Y., Chaki, T., & Yamakage, M. (2026) · Shock · doi:10.1097/shk.0000000000002882
Diabetic cardiomyopathy: Target immune cell from mechanism to treatment
Lv, J., Bao, X., Jiao, X., Jiang, Y., Lin, M., Zhang, W., & Wang, M. C. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117116
Li, F., Zhao, H., Yilu, L., Luo, J., Chen, B., Chenglin, L. I., Zhao, X., & Jiang, H. (2026) · Journal of Natural Medicines · doi:10.1007/s11418-026-02065-y
Cardiometabolic Aging Driven by Multi-Organ Crosstalk: Mechanisms and Therapeutic Strategies
Zhang, S., Xu, C., Song, Y., & Zhang, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156881
Li, S., Zhang, Y., Li, Y., Lei, Y., Wu, H., Liu, P., Xi, W., Zhuo, X., Huang, P., Yang, T., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3334-4
The crosstalk between gut microbiota and hypertension: Mechanisms and therapeutic prospects
Li, Z., Wang, M., Yao, Y., Yan, K., Wang, S., Li, B., & Li, J. (2026) · Microbiological Research · doi:10.1016/j.micres.2026.128684
Gut microbiota, immune cell traits, and major adverse cardiac events
Liu, J., Liao, J., Liu, C., Zhou, Q., Lu, T., Xu, K., & Zeng, L. (2026) · Medicine · doi:10.1097/md.0000000000050188
Lyu, Y., Hou, J., Ma, I., Mostoufi, T., Jiang, Y., Yang, X., & Gao, W. D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177736
Mamic, P., Shi, H., Zhou, W., Bararpour, N., Contrepois, K., Park, H., Avina, M., Rose, S. M. S., Brooks, A., Kotaka, M., et al. (2026) · Nature Cardiovascular Research · doi:10.1038/s44161-026-00854-y
Liu, X., Jing, D., Liu, X., Hu, S., & Wang, X. (2026) · Metabolites · doi:10.3390/metabo16100766
Research Progress and Translation of Gut-Heart Axis Metabolites in Heart Failure
郑, 冉. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.16103353
Metadata
- Authors
- Tang, T. W. H., Chen, H.-C., Chen, C.-Y., Yen, C. Y. T., Lin, C.-J., Prajnamitra, R. P., Chen, L.-L., Ruan, S.-C., Lin, J.-H., Lin, P.-J., Lu, H.-H., Kuo, C.-W., Chang, C. M., Hall, A. D., Vivas, E. I., Shui, J.-W., Chen, P., Hacker, T. A., Rey, F. E., Kamp, T. J., & Hsieh, P. C. H.
- Affiliations
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Research Center for Applied Science, Academia Sinica (TW)
- University of Wisconsin–Madison (US)
- ORCID
- Venue
- Circulation
- Published
- 2019-01-29
- Volume
- 139
- Issue
- 5
- Pages
- 647-659
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2896600834
- Cited by
- 348
- References
- 43
- Citations by year
- 2026: 29 · 2025: 56 · 2024: 67 · 2023: 51 · 2022: 46 · 2021: 57 · 2020: 32 · 2019: 10
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- gut microbiota, myocardial infarction, cardiac repair, short-chain fatty acids, myeloid cells, Lactobacillus, probiotics, antibiotic depletion, fecal microbiota transplantation, cardioprotection
- MeSH terms
- RAW 264.7 Cells, Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Anti-Bacterial Agents, Bacteria, Disease Models, Animal, Fatty Acids, Female, Lactobacillus, Male, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Myocardial Infarction, Myocardium, Probiotics, Mice, Host-Pathogen Interactions, Dysbiosis
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