Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy
Chelko, Stephen P., Asimaki, Angeliki, Lowenthal, Justin, Bueno-Beti, Carlos, Bedja, Djahida, Scalco, Arianna, Amat-Alarcon, Nuria, Andersen, Peter, Judge, Daniel P., Tung, Leslie, Saffitz, Jeffrey E.·2019·Circulation
Cited by (197)
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- Desmosome-Dyad CrosstalkMario Delmar, Francisco J. Alvarado, Héctor H. Valdivia · 2020 · Circulation
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- Desmoplakin Haploinsu/iciency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional ActivationEric D. Smith, Karen Jin, Brianna Ferguson, Yao-Chang Tsan, Samuel J. DePalma, Joshua K. Meisner, Aaron Renberg, Kenneth C Bedi, Sabrina Friedline, Kenneth B. Margulies et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Hot phase episodes in arrhythmogenic cardiomyopathy: More than just a desmoplakin issue?Marika Martini, Alessandro Parodi, Maria Bueno Marinas, Ilaria Rigato, Rudy Celeghin, Luigi Filippo Brizzi, Annagrazia Cecere, Kalliopi Pilichou, Barbara Bauce · 2025 · Trends in Cardiovascular Medicine
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- Apremilast improves cardiomyocyte cohesion and arrhythmia in different models for arrhythmogenic cardiomyopathyKonstanze Stangner, Orsela Dervishi, Janina Kuhnert, Carl Wendt, Soumyata Pathak, Maria Shoykhet, Silvana Olivares‐Florez, Sina Moztarzadeh, Jens Opsteen, Ni Luh Cathrin Suniasih Wohlfarth et al. · 2025 · Stem Cell Research & Therapy
- Acute binge alcohol increases risk of arrhythmias and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathyEmily A. Shiel, Waleed Farra, Steven Lee Medarev, Gallage H. D. Nipun Ariyaratne, Elisa Nicole Cannon, Jennifer L. Steiner, Stephen P. Chelko · 2025 · American Journal of Physiology-Heart and Circulatory Physiology
- Cardiomyocyte cohesion is increased after ADAM17 inhibitionMaria Shoykhet, Jens Waschke, Sunil Yeruva · 2023 · Frontiers in Cell and Developmental Biology
- Circadian and Seasonal Pattern of Arrhythmic Events in Arrhythmogenic Cardiomyopathy PatientsSilvia Castelletti, Michele Orini, Annina Salome Vischer, William John McKenna, Pier David Lambiase, Antonios A. Pantazis, Lia Crotti · 2023 · International Journal of Environmental Research and Public Health
- In Vivo Approaches to Understand Arrhythmogenic Cardiomyopathy: Perspectives on Animal ModelsGiovanni Risato, Raquel Brañas Casas, Marco Cason, Maria Bueno Marinas, Serena Pinci, Monica De Gaspari, Silvia Visentin, Stefania Rizzo, Gaetano Thiene, Cristina Basso et al. · 2024 · Cells
- Cardiomyocyte cytosolic nuclear self-DNA contributes to the pathogenesis of desmoplakin cardiomyopathyWeiyue Wang, Benjamin Cathcart, Quoc D. Nguyen, Loi Q. Lao, Amelia Bryans, Sara E Coleman, Leila Rouhi, Priyatansh Gurha, Ali J. Marian · 2025 · JCI Insight
- Inflammation and Genetics in Myo-Pericardial Diseases: Insights from the Italian Study Group on Cardiomyopathies and Pericardial DiseasesMarco Merlo, Giulia Bassetto, Antonio Nicola Cannata, Alberto Aimo, Camillo Autore, Barbara Bauce, Elena Biagini, Francesco Cappelli, Silvia Castelletti, Flavio D’Ascenzi et al. · 2025 · ESC Heart Failure
- Misdiagnosed myocarditis in arrhythmogenic cardiomyopathy induced by a homozygous variant of DSG2: a case reportXuwei Liu, Yue Zhang, Wenjuan Li, Qian Zhang, Letao Zhou, Yimin Hua, Hongyu Duan, Yifei Li · 2023 · Frontiers in Cardiovascular Medicine
- Cardiomyocyte and stromal cell cross-talk influences the pathogenesis of arrhythmogenic cardiomyopathy: a multi-level analysis uncovers DLK1-NOTCH pathway role in fibro-adipose remodellingMaione, Angela Serena, Iengo, Lara, Sala, Luca, Massaiu, Ilaria, Chiesa, Mattia, Lippi, Melania, Ghilardi, Stefania, Florindi, Chiara, Lodola, Francesco, Zaza, Antonio et al. · 2024 · Cell Death Discovery
- The application of autopsy and explanted heart samples in scientific researchXiaorui Liu, Jiangping Song · 2022 · Cardiovascular Pathology
- Episodic Myocarditis in Arrhythmogenic CardiomyopathyEric D. Smith, Adam S. Helms · 2022 · JACC Case Reports
- Use of Sirolimus, an mTOR Inhibitor, to Treat Sarcoidosis in Multiple SystemsLiam McGuire, Roxxy Brown, Angeliki Asimaki · 2025 · Journal of Cardiovascular Translational Research
- Adipocyte-Mediated Electrophysiological Remodeling of PKP-2 Mutant Human Pluripotent Stem Cell-Derived CardiomyocytesJustin B.F. Morrissette-McAlmon, Christianne J. Chua, Alexander Arking, Stanley Chun Ming Wu, Roald Teuben, Elaine Zhelan Chen, Leslie Tung, Kenneth R. Boheler · 2024 · Biomedicines
- Advances in arrhythmogenic cardiomyopathy modeling using human-induced pluripotent stem cell-based modelsDylan Mostert, Sabina Ferron, Claudia Vittoria Olmeda, Alessandra Rampazzo, Martina Calore · 2025 · Heart Rhythm
- Circulation and Contacts in Sixteenth Century New Cartography: Spain, Portugal and ItalyJosé María Moreno Madrid · 2021 · Culture & History Digital Journal
- Elucidating arrhythmogenic right ventricular cardiomyopathy with stem cellsKenneth R. Laurita, Sunil K. Vasireddi, Judith A. Mackall · 2022 · Birth Defects Research
- Plasma CCL3 predicts adverse heart failure outcomes in patients with arrhythmogenic cardiomyopathyHao Cui, Songren Shu, Ningning Zhang, Mangyuan Wang, Tianshuo Yang, Zhen Wang, Xiao Chen, Mengxia Fu, Mengda Xu, Yicheng Yang et al. · 2025 · BMC Medicine
- Human iPSC models of cardiac electrophysiology and arrhythmiaBrenda Yang, Justin Lowenthal, Gordon F. Tomaselli, Leslie Tung · 2022 · Elsevier eBooks
- Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathyBertoli, Giorgia, Phadke, Kavya, Cospito, Alessandro, Rizk, Joanna Abi, Zhang, Mingliang, Miliotou, Eleni, Cammer, Michael, Deng, Yan, Mezzano, Valeria, Alu, Mark et al. · 2025
- Cardiomyocyte‐Specific Plakophilin‐2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy2026
- Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome FunctionsJ. Alex Aycinena, Anley E. Tefera, Isaac Perea‐Gil, Duncan Holbrook‐Smith, Kevin Williams, Reva Shenwai, Farshad Farshidfar, Brendan M Ryback, Katelyn S. Foppe, Iris Wu et al. · 2025 · JACC Basic to Translational Science
- Response by Gasperetti et al to Letter Regarding Article, “Prognostic Role of Myocarditis-Like Episodes and Their Treatment in Patients With Pathogenic Desmoplakin Variants”Alessio Gasperetti, Giovanni Peretto, Cynthia A. James, Maurizio Pieroni, Adam S. Helms, Hugh G Calkins, Nisha Aggarwal Gilotra · 2026 · Circulation
- Bioinformatics analysis of JUP in patients with acute myocardial infarction and its potential application in clinical prognostic evaluationXinyue Deng, Ailing Shen, Leiying Jiang · 2025 · Frontiers in Cardiovascular Medicine
- Management Strategies in Arrhythmogenic Cardiomyopathy across the Spectrum of Ventricular InvolvementYash M. Maniar, Nisha Aggarwal Gilotra, Paul J. Scheel · 2023 · Biomedicines
- A Novel DSP Truncating Variant in a Family with Episodic Myocardial Injury in the Course of Arrhythmogenic Cardiomyopathy—A Possible Role of a Low Penetrance NLRP3 VariantPrzemysław Chmielewski, Grażyna T. Truszkowska, Piotr Kukla, Joanna Zakrzewska‐Koperska, Mateusz Śpiewak, Małgorzata Stępień‐Wojno, Maria Bilińska, Anna Lutyńska, Rafał Płoski, Zofia T. Bilińska · 2020 · Diagnostics
- Editorial commentary: Arrhythmogenic cardiomyopathy: An in-depth look at molecular mechanisms and clinical correlatesAngeliki Asimaki · 2020 · Trends in Cardiovascular Medicine
- A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory DiseaseAriyaratne, Gallage H. D. N., Villatore, Andrea, Peretto, Giovanni, Chelko, Stephen P. · 2026 · Cells
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- Integrative genomic and literature assessment of desmoglein 2-related arrhythmogenic cardiomyopathy with Italian cohort validation2026
- Machine learning models enhance detection of arrhythmogenic right ventricular cardiomyopathyKwaku K. Quansah, Sean A. Murphy, Esther Kwon, Emma Anderson, Crystal Tichnell, Brittney A. Murray, Sean Paul Gaine, Alessio Gasperetti, Cynthia A. James, Hugh G Calkins et al. · 2026 · Machine Learning Health
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- Premature ventricular contractions as a target for arrhythmogenic right ventricular cardiomyopathy trialsAlessio Gasperetti, Norman Stockbridge, Jason D. Roberts, Pyotr G. Platonov, Hugh G Calkins, Wojciech Zaręba, Andrew David Krahn, William John McKenna · 2026 · Heart Rhythm
- Inhibition of Programmed Cell Death-1 in Cytotoxic CD8 + T Cells Exacerbates Pressure Overload–Induced Cardiac InjuryMing‐Ming Wu, Yu Sun, Yue Zhang, Yan-Chao Yang, Zhi-Xi He, Shuang Zhou, Xia Wang, Han Xiao, Miao Yu, Chang Miao et al. · 2026 · Circulation
- Pathogenesis, Diagnosis and Risk Stratification in Arrhythmogenic CardiomyopathyMaria Teresa Florio, Filomena Boccia, Erica Vetrano, Marco Borrelli, Thomas D Gossios, Giuseppe Palmiero · 2021 · Cardiogenetics
- Characteristics and pharmacological responsiveness in hiPSC models of inherited cardiomyopathyMerel Gerritse, Willem B. van Ham, Chris N. Denning, Toon A.B. van Veen, Renée G. C. Maas · 2025 · Pharmacology & Therapeutics
- Early cardiac inflammation as a driver of murine model of Arrhythmogenic CardiomyopathyKeat‐Eng Ng, Paul J. Delaney, Delphine Thenet, Stephen Murtough, C.M. Webb, Elena Tsisanova, Sophie L. M. Walker, Joseph David Westaby, Daniel J. Pennington, Ryan Charles Pink et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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- Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond DesmosomesJ. Alex Aycinena, Anley E. Tefera, Isaac Perea‐Gil, Duncan Holbrook‐Smith, Kevin J. Williams, Reva Shenwai, Farshad Farshidfar, Brendan M Ryback, Katelyn S. Foppe, Iris Wu et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Cytokine Status in Game Sports Athletes with Cardiomyopathy of OverstrainEvgeniy D. Kopylov · 2019 · Biomedical Journal of Scientific & Technical Research
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- Machine Learning Models Enhance Prediction of Arrhythmogenic Right Ventricular CardiomyopathyKwaku K. Quansah, Sean A. Murphy, Esther Kwon, Emma Anderson, Crystal Tichnell, Brittney Murray, Sean Gaines, Alessio Gasperetti, Cynthia A James, Hugh Calkins et al. · 2025 · medRxiv
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- Additional file 3 of Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathyFu, Mengxia, Xiumeng Hua, Songren Shu, Xu, Xinjie, Zhang, Hang, Zhiming Peng, Mo, Han, Liu, Yanyun, Xiao Chen, Yang, Yicheng et al. · 2024 · Figshare
- Additional file 1 of Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathyFu, Mengxia, Xiumeng Hua, Songren Shu, Xu, Xinjie, Zhang, Hang, Zhiming Peng, Mo, Han, Liu, Yanyun, Chen, Xiao, Yicheng Yang et al. · 2024 · Figshare
- Additional file 4 of Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathyFu, Mengxia, Xiumeng Hua, Songren Shu, Xu, Xinjie, Zhang, Hang, Zhiming Peng, Mo, Han, Liu, Yanyun, Chen, Xiao, Yang, Yicheng et al. · 2024 · Figshare
- Additional file 6 of Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathyFu, Mengxia, Xiumeng Hua, Songren Shu, Xu, Xinjie, Zhang, Hang, Zhiming Peng, Mo, Han, Liu, Yanyun, Xiao Chen, Yang, Yicheng et al. · 2024 · Figshare
- Additional file 7 of Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathyFu, Mengxia, Xiumeng Hua, Songren Shu, Xu, Xinjie, Zhang, Hang, Zhiming Peng, Mo, Han, Liu, Yanyun, Xiao Chen, Yang, Yicheng et al. · 2024 · Figshare
- Additional file 2 of Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathyFu, Mengxia, Xiumeng Hua, Songren Shu, Xu, Xinjie, Zhang, Hang, Zhiming Peng, Mo, Han, Liu, Yanyun, Chen, Xiao, Yang, Yicheng et al. · 2024 · Figshare
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- Single nucleus RNA sequencing identifies PLXNA4 upregulation in end-stage arrhythmogenic right ventricular cardiomyopathyBridget Simonson, Mark D. Chaffin, Yasmine Guedira, Talita Zahin Choudhury, Ling Xiao, Richard Ruan, Kirsten Schneider, Jessica Morris, Vera V. Koledova, Kenneth C. Bedi et al. · 2026 · iScience
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