The DOI matches its Crossref record.
Natural History of Brugada Syndrome: Insights for Risk Stratification and Management
Abstract
Background — Treatment of patients with Brugada syndrome is complicated by the incomplete information on the natural history of the disease related to the small number of cases reported. Furthermore, the value of programmed electrical stimulation (PES) for risk stratification is highly debated. The objective of this study was to search for novel parameters to identify patients at risk of sudden death. Methods and Results — Clinical data were collected for 200 patients (152 men, 48 women; age, 41±18 years) and stored in a dedicated database. Genetic analysis was performed, and mutations on the SCN5A gene were identified in 28 of 130 probands and in 56 of 121 family members. The life-table method of Kaplan-Meier used to define the cardiac arrest-free interval in patients undergoing PES failed to demonstrate an association between PES inducibility and spontaneous occurrence of ventricular fibrillation. Multivariate Cox regression analysis showed that after adjusting for sex, family history of sudden death, and SCN5A mutations, the combined presence of a spontaneous ST-segment elevation in leads V 1 through V 3 and the history of syncope identifies subjects at risk of cardiac arrest (HR, 6.4; 95% CI, 1.9 to 21; P <0.002). Conclusions — The information on the natural history of patients obtained in this study allowed elaboration of a risk-stratification scheme to quantify the risk for sudden cardiac death and to target the use of the implantable cardioverter-defibrillator.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893
Self-citationPriori, S. G., Wilde, A. A., Horie, M., Cho, Y., Behr, E. R., Berul, C., Blom, N., Brugada, J., Chiang, C.-E., Huikuri, H., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.05.014 · Cited by 1,942
Self-citationProbst, V., Veltmann, C., Eckardt, L., Meregalli, P. G., Gaita, F., Tan, H. L., Babuty, D., Sacher, F., Giustetto, C., Schulze-Bahr, E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.887026 · Cited by 847
Self-citationRisk Stratification in Brugada Syndrome
Priori, S. G., Gasparini, M., Napolitano, C., Della Bella, P., Ottonelli, A. G., Sassone, B., Giordano, U., Pappone, C., Mascioli, G., Rossetti, G., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.064 · Cited by 581
Self-citationMorita, H., Kusano, K. F., Miura, D., Nagase, S., Nakamura, K., Morita, S. T., Ohe, T., Zipes, D. P., & Wu, J. (2008) · Circulation · doi:10.1161/circulationaha.108.770917 · Cited by 470
Sroubek, J., Probst, V., Mazzanti, A., Delise, P., Hevia, J. C., Ohkubo, K., Zorzi, A., Champagne, J., Kostopoulou, A., Yin, X., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.017885 · Cited by 242
Self-citationDelise, P., Allocca, G., Marras, E., Giustetto, C., Gaita, F., Sciarra, L., Calo, L., Proclemer, A., Marziali, M., Rebellato, L., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq381 · Cited by 221
Self-citationImplantable Cardioverter-Defibrillator Therapy in Brugada Syndrome
Conte, G., Sieira, J., Ciconte, G., de Asmundis, C., Chierchia, G.-B., Baltogiannis, G., Di Giovanni, G., La Meir, M., Wellens, F., Czapla, J., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.12.031 · Cited by 199
Atrial Fibrillation in Patients With Brugada Syndrome
Kusano, K. F., Taniyama, M., Nakamura, K., Miura, D., Banba, K., Nagase, S., Morita, H., Nishii, N., Watanabe, A., Tada, T., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.060 · Cited by 190
Kaufman, E. S. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.02.009 · Cited by 104
Olde Nordkamp, L. R. A., Vink, A. S., Wilde, A. A. M., de Lange, F. J., de Jong, J. S. S. G., Wieling, W., van Dijk, N., & Tan, H. L. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2014.10.014 · Cited by 80
CUNHA, S., & MOHLER, P. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.03.018 · Cited by 65
SHIMENO, K., TAKAGI, M., MAEDA, K., TATSUMI, H., DOI, A., & YOSHIYAMA, M. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2009.01490.x · Cited by 54
Cerrato, N., Giustetto, C., Gribaudo, E., Richiardi, E., Barbonaglia, L., Scrocco, C., Zema, D., & Gaita, F. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.10.007 · Cited by 48
Self-citationGiustetto, C., Cerrato, N., Ruffino, E., Gribaudo, E., Scrocco, C., Barbonaglia, L., Bianchi, F., Bortnik, M., Rossetti, G., Carvalho, P., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.03.019 · Cited by 36
Self-citationSudden Cardiac Death in Athletes
Link, M. S., & Mark Estes, N. A. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.10.002 · Cited by 26
Characteristics of Syncope in Japan and the Pacific Rim
Abe, H., Kohno, R., & Oginosawa, Y. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.11.008 · Cited by 9
Brisinda, D., Bottelli, G., Napolitano, C., Priori, S. G., & Fenici, R. (2007) · International Congress Series · doi:10.1016/j.ics.2006.12.079 · Cited by 6
Self-citation
Metadata
- Authors
- Priori, S. G., Napolitano, C., Gasparini, M., Pappone, C., Bella, P. D., Giordano, U., Bloise, R., Giustetto, C., De Nardis, R., Grillo, M., Ronchetti, E., Faggiano, G., & Nastoli, J.
- Venue
- Circulation
- Published
- 2002-03-19
- Volume
- 105
- Issue
- 11
- Pages
- 1342-1347
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2111936199
- Cited by
- 1,034
- References
- 0
- FWCI
- 42.56
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
