The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Pathological Analysis of Local Delivery of Paclitaxel Via a Polymer-Coated Stent
Abstract
Background— Paclitaxel can inhibit vascular smooth muscle proliferation in vitro, and early studies suggest that paclitaxel may be useful in preventing restenosis. Early and late intimal growth and local vascular pathological changes associated with paclitaxel delivered via stents have not been fully explored. Methods and Results— Localized drug delivery was accomplished with balloon-expandable stainless steel stents coated with a cross-linked biodegradable polymer, chondroitin sulfate and gelatin (CSG), containing various doses of paclitaxel. CSG-coated stents with paclitaxel (42.0, 20.2, 8.6, or 1.5 μg of paclitaxel per stent), CSG-coated stents without paclitaxel, and uncoated stents (without paclitaxel or CSG) were deployed in the iliac arteries of New Zealand White rabbits, which were killed 28 days after implant. Mean neointimal thickness at stent strut sites was reduced 49% ( P <0.0003) and 36% ( P <0.007) with stents containing 42.0 and 20.2 μg of paclitaxel per stent, respectively, versus CSG-coated stents without paclitaxel. However, histological findings suggested incomplete healing in the higher-dose (42.0 and 20.2 μg) paclitaxel-containing stents consisting of persistent intimal fibrin deposition, intraintimal hemorrhage, and increased intimal and adventitial inflammation. Stents coated with CSG alone (without paclitaxel) had similar neointimal growth as uncoated stents. In a separate group of rabbits killed at 90 days, neointimal growth was no longer suppressed by CSG-coated stents containing 42.0 or 21.0 μg of paclitaxel Conclusions— CSG coating appears to be a promising medium for localized drug delivery. Paclitaxel polymer–coated stents reduce neointima formation but are associated with evidence of incomplete healing at 28 days. However, neointimal suppression was not maintained at 90 days.
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A Polymer-Based, Paclitaxel-Eluting Stent in Patients with Coronary Artery Disease
Stone, G. W., Ellis, S. G., Cox, D. A., Hermiller, J., O'Shaughnessy, C., Mann, J. T., Turco, M., Caputo, R., Bergin, P., Greenberg, J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032441 · Cited by 2,749
Pathology of Drug-Eluting Stents in Humans
Joner, M., Finn, A. V., Farb, A., Mont, E. K., Kolodgie, F. D., Ladich, E., Kutys, R., Skorija, K., Gold, H. K., & Virmani, R. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.042 · Cited by 2,744
Self-citationBiodegradable nanoparticles for drug and gene delivery to cells and tissue
Panyam, J., & Labhasetwar, V. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.023 · Cited by 270
The Foreign Body Response Demystified
Chandorkar, Y., K, R., & Basu, B. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00252 · Cited by 201
Metadata
- Authors
- Farb, A., Heller, P. F., Shroff, S., Cheng, L., Kolodgie, F. D., Carter, A. J., Scott, D. S., Froehlich, J., & Virmani, R.
- Venue
- Circulation
- Published
- 2001-07-24
- Volume
- 104
- Issue
- 4
- Pages
- 473-479
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2133090725
- Cited by
- 423
- References
- 15
- FWCI
- 31.98
- Type
- journal article
- Language
- en
- Open access
- closed
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