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Cited by 738Alcohol Consumption and Health EffectsBlood Pressure and Hypertension StudiesSodium Intake and Health

The DOI matches its Crossref record, with a small difference in title or year; 41 of the 43 references it cites were found in a registry or an index.

Effects of Alcohol Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials

Xin, Xue, He, Jiang, Frontini, Maria G., Ogden, Lorraine G., Motsamai, Oaitse I., Whelton, Paul K.·2001·Hypertension
DOI 10.1161/hy1101.093424
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Abstract

Alcohol drinking has been associated with increased blood pressure in epidemiological studies. We conducted a meta-analysis of randomized controlled trials to assess the effects of alcohol reduction on blood pressure. We included 15 randomized control trials (total of 2234 participants) published before June 1999 in which alcohol reduction was the only intervention difference between active and control treatment groups. Using a standard protocol, information on sample size, participant characteristics, study design, intervention methods, duration, and treatment results was abstracted independently by 3 investigators. By means of a fixed-effects model, findings from individual trials were pooled after results for each trial were weighted by the inverse of its variance. Overall, alcohol reduction was associated with a significant reduction in mean (95% confidence interval) systolic and diastolic blood pressures of −3.31 mm Hg (−2.52 to −4.10 mm Hg) and −2.04 mm Hg (−1.49 to −2.58 mm Hg), respectively. A dose-response relationship was observed between mean percentage of alcohol reduction and mean blood pressure reduction. Effects of intervention were enhanced in those with higher baseline blood pressure. Our study suggests that alcohol reduction should be recommended as an important component of lifestyle modification for the prevention and treatment of hypertension among heavy drinkers.

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Research works printed but not linked: 2

  1. Ueshima H, Ogihara T, Baba S, Tabuchi Y, Mikawa K, Hashizume K, Mandai T, Ozawa H, Kumahara Y, Asakura S. The effect of reduced alcohol consumption on blood pressure: a randomized controlled single blind study. J Hum Hypertens. 1987; 1: 113–119.
  2. 10.1161/hyp.27.4.968 · DOI

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Metadata

Authors
Xin, X., He, J., Frontini, M. G., Ogden, L. G., Motsamai, O. I., & Whelton, P. K.
Affiliations
  • Tulane University (US)
  • From the Departments of Epidemiology (X.X., J.H., O.I.M., P.K.W.) and Biostatistics, School of Public Health and Tropical Medicine, and Department of Medicine (J.H., P.K.W.), School of Medicine, Tulane University, New Orleans, La; and Louisiana State Office of Public Health (M.G.F.), New Orleans.
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-11
Volume
38
Issue
5
Pages
1112-1117
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hy1101.093424
OpenAlex
W2106224378
Cited by
738
References
43
Citations by year
2026: 12 · 2025: 16 · 2024: 13 · 2023: 15 · 2022: 23 · 2021: 20 · 2020: 26 · 2019: 38 · 2018: 25 · 2017: 40 · 2016: 35 · 2015: 38 · 2014: 31 · 2013: 37 · 2012: 53
FWCI
2.71
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl060300-05)
  • National Heart, Lung, and Blood Institute (R01HL60300)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
alcohol consumption reduction, blood pressure, heavy drinking, systolic blood pressure, diastolic blood pressure, dose-response relationship, lifestyle modification, hypertension prevention, antihypertensive therapy
MeSH terms
Adult, Alcohol Drinking, Blood Pressure, Female, Humans, Hypertension, Male, Middle Aged, Regression Analysis, Randomized Controlled Trials as Topic, Publication Bias

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