The DOI matches its Crossref record, with a small difference in title or year; 41 of the 43 references it cites were found in a registry or an index.
Effects of Alcohol Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Abstract
Alcohol drinking has been associated with increased blood pressure in epidemiological studies. We conducted a meta-analysis of randomized controlled trials to assess the effects of alcohol reduction on blood pressure. We included 15 randomized control trials (total of 2234 participants) published before June 1999 in which alcohol reduction was the only intervention difference between active and control treatment groups. Using a standard protocol, information on sample size, participant characteristics, study design, intervention methods, duration, and treatment results was abstracted independently by 3 investigators. By means of a fixed-effects model, findings from individual trials were pooled after results for each trial were weighted by the inverse of its variance. Overall, alcohol reduction was associated with a significant reduction in mean (95% confidence interval) systolic and diastolic blood pressures of −3.31 mm Hg (−2.52 to −4.10 mm Hg) and −2.04 mm Hg (−1.49 to −2.58 mm Hg), respectively. A dose-response relationship was observed between mean percentage of alcohol reduction and mean blood pressure reduction. Effects of intervention were enhanced in those with higher baseline blood pressure. Our study suggests that alcohol reduction should be recommended as an important component of lifestyle modification for the prevention and treatment of hypertension among heavy drinkers.
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“The last review6 of the effects of alcohol reduction on blood pressure was done more than 15 years ago and showed an average systolic blood pressure reduction of −3·31 mm Hg (95% CI −4·10 to −2·52) when alcohol consumption was reduced; results were not presented by sex.”
From The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis (2017) · cites this paper as [6]
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Cites
Meta-analysis in clinical trials
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Follmann, D. A., Elliott, P., Suh, I., & Cutler, J. A. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90054-q · Cited by 1,391
A method for assessing the quality of a randomized control trial
Chalmers, T. C., Smith, H., Blackburn, B., Silverman, B., Schroeder, B., Reitman, D., & Ambroz, A. (1981) · Controlled Clinical Trials · doi:10.1016/0197-2456(81)90056-8 · Cited by 1,349
Alcohol consumption and mortality among middle-aged and elderly U.S. adults
Thun, M. J., Peto, R., Lopez, A. D., Monaco, J. H., Henley, S. J., Heath, C. W., & Doll, R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712113372401 · Cited by 1,313
Effects of Oral Potassium on Blood Pressure
Whelton, P. K. (1997) · JAMA · doi:10.1001/jama.1997.03540440058033 · Cited by 1,096
Self-citationImplications of Small Reductions in Diastolic Blood Pressure for Primary Prevention
Cook, N. R. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430070053006 · Cited by 828
ALCOHOL AND MORTALITY IN BRITISH MEN: EXPLAINING THE U-SHAPED CURVE
Shaper, A. G., Wannamethee, G., & Walker, M. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92890-5 · Cited by 780
Research works printed but not linked: 2
- Ueshima H, Ogihara T, Baba S, Tabuchi Y, Mikawa K, Hashizume K, Mandai T, Ozawa H, Kumahara Y, Asakura S. The effect of reduced alcohol consumption on blood pressure: a randomized controlled single blind study. J Hum Hypertens. 1987; 1: 113–119.
- 10.1161/hyp.27.4.968 · DOI
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Chobanian, A. V. (2003) · JAMA · doi:10.1001/jama.289.19.2560 · Cited by 25,386
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Self-citationNational High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) · PEDIATRICS · doi:10.1542/peds.114.2.s2.555 · Cited by 6,913
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
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Metadata
- Authors
- Xin, X., He, J., Frontini, M. G., Ogden, L. G., Motsamai, O. I., & Whelton, P. K.
- Affiliations
- Tulane University (US)
- From the Departments of Epidemiology (X.X., J.H., O.I.M., P.K.W.) and Biostatistics, School of Public Health and Tropical Medicine, and Department of Medicine (J.H., P.K.W.), School of Medicine, Tulane University, New Orleans, La; and Louisiana State Office of Public Health (M.G.F.), New Orleans.
- Venue
- Hypertension
- Published
- 2001-11
- Volume
- 38
- Issue
- 5
- Pages
- 1112-1117
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2106224378
- Cited by
- 738
- References
- 43
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 13 · 2023: 15 · 2022: 23 · 2021: 20 · 2020: 26 · 2019: 38 · 2018: 25 · 2017: 40 · 2016: 35 · 2015: 38 · 2014: 31 · 2013: 37 · 2012: 53
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl060300-05)
- National Heart, Lung, and Blood Institute (R01HL60300)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- alcohol consumption reduction, blood pressure, heavy drinking, systolic blood pressure, diastolic blood pressure, dose-response relationship, lifestyle modification, hypertension prevention, antihypertensive therapy
- MeSH terms
- Adult, Alcohol Drinking, Blood Pressure, Female, Humans, Hypertension, Male, Middle Aged, Regression Analysis, Randomized Controlled Trials as Topic, Publication Bias
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