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Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association
Open accessAbstract
Background—: Age-related dementia, most commonly caused by Alzheimer disease or cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial hypertension is a well-established risk factor for both types of dementia, but the link between hypertension and its treatment and cognition remains poorly understood. In this scientific statement, a multidisciplinary team of experts examines the impact of hypertension on cognition to assess the state of the knowledge, to identify gaps, and to provide future directions. Methods—: Authors with relevant expertise were selected to contribute to this statement in accordance with the American Heart Association conflict-of-interest management policy. Panel members were assigned topics relevant to their areas of expertise, reviewed the literature, and summarized the available data. Results—: Hypertension disrupts the structure and function of cerebral blood vessels, leads to ischemic damage of white matter regions critical for cognitive function, and may promote Alzheimer pathology. There is strong evidence of a deleterious influence of midlife hypertension on late-life cognitive function, but the cognitive impact of late-life hypertension is less clear. Observational studies demonstrated a cumulative effect of hypertension on cerebrovascular damage, but evidence from clinical trials that antihypertensive treatment improves cognition is not conclusive. Conclusions—: After carefully reviewing the literature, the group concluded that there were insufficient data to make evidence-based recommendations. However, judicious treatment of hypertension, taking into account goals of care and individual characteristics (eg, age and comorbidities), seems justified to safeguard vascular health and, as a consequence, brain health.
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“Vascular risk factors including hypertension (169, 272), diabetes (43, 110), hyperlipidemia (74), and cardiovascular disease (594), as well as environment (e.g., pollution) (87-89, 207) and lifestyle (e.g., obesity, sedentary lifestyle) (281, 643) all affect cerebrovascular and BBB dysfunction (429, 571), and may influence onset and progression of AD.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [272]
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“The evidence suggests that midlife may represent a critical period when exposure to high blood pressure is likely to increase risk of poorer cognition in late-life (8).”
From Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research (2018) · cites this paper as [8]
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“Few trials of antihypertensive agents have included cognitive outcomes and each trial has, almost inevitably, focused on a differing population group and used differing treatment regimens, inclusion criteria, blood pressure targets and in general relatively short follow up (8).”
From Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research (2018) · cites this paper as [8]
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“There is now also emerging evidence for taking a life-course approach to exposure not least as the latter may take account of varying exposure levels over time (8, 9, 10).”
From Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research (2018) · cites this paper as [8]
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“Few trials of antihypertensive agents have included cognitive outcomes and each trial has, almost inevitably, focused on a differing population group and used differing treatment regimens, inclusion criteria, blood pressure targets and in general relatively short follow up (8).”
From Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research (2018) · cites this paper as [8]
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“Advances in our understanding of the role of cardiovascular risks have shown them to be closely associated with cognitive impairment and dementia.”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [5]
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“A more contemporary scientific statement found inconclusive evidence that BP control preserves cognition in the population at-large.5”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [5]
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Items 201–332 of 332
Obisesan, T. O., Obisesan, O. A., Martins, S., Alamgir, L., Bond, V., Maxwell, C., & Gillum, R. F. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01592.x · Cited by 163
Variability in Midlife Systolic Blood Pressure Is Related to Late-Life Brain White Matter Lesions
Havlik, R. J., Foley, D. J., Sayer, B., Masaki, K., White, L. R., & Launer, L. J. (2002) · Stroke · doi:10.1161/hs0102.101890 · Cited by 162
Self-citationFaraco, G., Park, L., Zhou, P., Luo, W., Paul, S. M., Anrather, J., & Iadecola, C. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.79 · Cited by 158
Self-citationSabayan, B., Oleksik, A. M., Maier, A. B., van Buchem, M. A., Poortvliet, R. K. E., de Ruijter, W., Gussekloo, J., de Craen, A. J. M., & Westendorp, R. G. J. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04203.x · Cited by 157
Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons
Hoffman, L. B., Schmeidler, J., Lesser, G. T., Beeri, M. S., Purohit, D. P., Grossman, H. T., & Haroutunian, V. (2009) · Neurology · doi:10.1212/01.wnl.0000345881.82856.d5 · Cited by 157
Impaired Cerebrovascular Hemodynamics are Associated with Cerebral White Matter Damage
Purkayastha, S., Fadar, O., Mehregan, A., Salat, D. H., Moscufo, N., Meier, D., Guttmann, C. R. G., Fisher, N. D. L., Lipsitz, L. A., & Sorond, F. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.180 · Cited by 150
Decline in Blood Pressure Over Time and Risk of Dementia
Qiu, C., Strauss, E. I. V., Winblad, B. G., & Fratiglioni, L. (2004) · Stroke · doi:10.1161/01.str.0000133128.42462.ef · Cited by 150
Endothelial Function and White Matter Hyperintensities in Older Adults With Cardiovascular Disease
Hoth, K. F., Tate, D. F., Poppas, A., Forman, D. E., Gunstad, J., Moser, D. J., Paul, R. H., Jefferson, A. L., Haley, A. P., & Cohen, R. A. (2007) · Stroke · doi:10.1161/01.str.0000254517.04275.3f · Cited by 149
White matter hyperintensities predict amyloid increase in Alzheimer's disease
Grimmer, T., Faust, M., Auer, F., Alexopoulos, P., Förstl, H., Henriksen, G., Perneczky, R., Sorg, C., Yousefi, B. H., Drzezga, A. E., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.01.016 · Cited by 146
Midlife cardiovascular risk factors, ApoE, and cognitive decline in elderly male twins
Carmelli, D., Swan, G. E., Reed, T., Miller, B. L., Wolf, P. A., Jarvik, G. P., & Schellenberg, G. D. (1998) · Neurology · doi:10.1212/wnl.50.6.1580 · Cited by 143
Blood pressure and late-life cognitive function change
Hebert, L. E., Scherr, P. A., Bennett, D. A., Bienias, J. L., Wilson, R. S., Morris, M. C., & Evans, D. A. (2004) · Neurology · doi:10.1212/01.wnl.0000129258.93137.4b · Cited by 139
Hypertension and Cognitive Functioning
Elias, M. F., Goodell, A. L., & Dore, G. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.186429 · Cited by 139
Langbaum, J. B. S., Chen, K., Launer, L. J., Fleisher, A., Lee, W., Liu, X., Protas, H. D., Reeder, S., Bandy, D. J., Yu, M., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.020 · Cited by 138
Self-citationCerebral Autoregulation and Acute Ischemic Stroke
Jordan, J. D., & Powers, W. J. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.53 · Cited by 137
Incidence of cerebral microbleeds
Goos, J. D. C., Henneman, W. J. P., Sluimer, J. D., Vrenken, H., Sluimer, I. C., Barkhof, F., Blankenstein, M. A., Scheltens, P., & van der Flier, W. M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e396ea · Cited by 136
Effects of vascular risk factors and APOE ε4 on white matter integrity and cognitive decline
Wang, R., Fratiglioni, L., Laukka, E. J., Lövdén, M., Kalpouzos, G., Keller, L., Graff, C., Salami, A., Bäckman, L., & Qiu, C. (2015) · Neurology · doi:10.1212/wnl.0000000000001379 · Cited by 136
Long-Term Blood–Brain Barrier Permeability Changes in Binswanger Disease
Huisa, B. N., Caprihan, A., Thompson, J., Prestopnik, J., Qualls, C., & Rosenberg, G. A. (2015) · Stroke · doi:10.1161/strokeaha.115.009589 · Cited by 135
Brain Atrophy and Cerebral Small Vessel Disease: A Prospective Follow-Up Study
Nitkunan, A., Lanfranconi, S., Charlton, R. A., Barrick, T. R., & Markus, H. S. (2011) · Stroke · doi:10.1161/strokeaha.110.594267 · Cited by 135
Pearce, L. A., McClure, L. A., Anderson, D. C., Jacova, C., Sharma, M., Hart, R. G., & Benavente, O. R. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70224-8 · Cited by 135
The vascular supply of the functional compartments of the human striatum
Feekes, J. A. (2006) · Brain · doi:10.1093/brain/awl158 · Cited by 134
Nation, D. A., Edmonds, E. C., Bangen, K. J., Delano‐Wood, L., Scanlon, B. K., Han, S. D., Edland, S. D., Salmon, D. P., Galasko, D. R., & Bondi, M. W. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.4477 · Cited by 133
Shams, S., Martola, J., Granberg, T., Li, X., Shams, M., Fereshtehnejad, S. M., Cavallin, L., Aspelin, P., Kristoffersen-Wiberg, M., & Wahlund, L. O. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4176 · Cited by 132
Joint Effect of the APOE Gene and Midlife Systolic Blood Pressure on Late-Life Cognitive Impairment
Peila, R., White, L. R., Petrovitch, H., Masaki, K., Ross, G. W., Havlik, R. J., & Launer, L. J. (2001) · Stroke · doi:10.1161/hs1201.100392 · Cited by 131
Self-citationEffect of Blood Pressure on Cognitive Functions in Elderly Persons
Kuo, H.-K., Sorond, F. A., Iloputaife, I., Gagnon, M., Milberg, W., & Lipsitz, L. A. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.11.1191 · Cited by 131
Toledo, J. B., Toledo, E., Weiner, M. W., Jack, C. R., Jagust, W., Lee, V. M. ‐., Shaw, L. M. J., & Trojanowski, J. Q. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.08.008 · Cited by 130
Blood Pressure and Cognitive Function in Healthy Old People
Starr, J. M., Whalley, L. J., Inch, S., et al. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb07466.x · Cited by 127
Yang, E. Y., Chambless, L. E., Sharrett, A. R., Virani, S. S., Liu, X., Tang, Z.-Z., Boerwinkle, E., Ballantyne, C. M., & Nambi, V. (2011) · Stroke · doi:10.1161/strokeaha.111.626200 · Cited by 126
Kollias, A., Dafni, M., Poulidakis, E., Ntineri, A., & Stergiou, G. S. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000384 · Cited by 125
Clinical and imaging features of mixed Alzheimer and vascular pathologies
Chui, H. C., & Ramirez-Gomez, L. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0104-7 · Cited by 124
White matter lesions and brain gray matter volume in cognitively normal elders
Raji, C. A., López, O. L., Kuller, L. H., Carmichael, O. T., Longstreth, W. T., Jr., Gach, H. M., Boardman, J., Bernick, C. B., Thompson, P. M., & Becker, J. T. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.08.010 · Cited by 123
Angiotensin-II, the Brain, and Hypertension: An Update
Young, C. N., & Davisson, R. L. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.03624 · Cited by 123
The Effect of Age on the Association Between Blood Pressure and Cognitive Function Later in Life
Euser, S. M., van Bemmel, T., Schram, M. T., Gussekloo, J., Albert Hofman, D., Westendorp, R. G. J., & Breteler, M. M. B. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02264.x · Cited by 122
Joutel, A., & Faraci, F. M. (2014) · Stroke · doi:10.1161/strokeaha.113.002878 · Cited by 122
Self-citationWhite matter lesions and hippocampal atrophy in Alzheimer’s disease
de Leeuw, F., Barkhof, F., & Scheltens, P. (2004) · Neurology · doi:10.1212/01.wnl.0000103289.03648.ad · Cited by 122
Bangen, K. J., Nation, D. A., Delano‐Wood, L., Weissberger, G. H., Hansen, L. A., Galasko, D. R., Salmon, D. P., & Bondi, M. W. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.025 · Cited by 118
Temporal Evolution of Cognitive Changes in Incident Hypertension
Köhler, S., Baars, M. A. E., Spauwen, P. J. J., Schievink, S. H. J., Verhey, F. R. J., & van Boxtel, M. P. J. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02096 · Cited by 118
Bangen, K. J., Beiser, A., Delano‐Wood, L., Nation, D. A., Lamar, M., Libon, D. J., Bondi, M. W., Seshadri, S. S., Wolf, P. A., & Au, R. (2013) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.03.013 · Cited by 115
Self-citationWhite matter lesions defined by diffusion tensor imaging in older adults
Back, S. A., Kroenke, C. D., Sherman, L. S., Lawrence, G., Gong, X., Taber, E. N., Sonnen, J. A., Larson, E. B., & Montine, T. J. (2011) · Annals of Neurology · doi:10.1002/ana.22484 · Cited by 109
Pulse Wave Velocity and Cognitive Decline in Elders
Hazzouri, A. Z. A., Newman, A. B., Simonsick, E. M., Sink, K. M., Tyrrell, K. S., Watson, N. L., Satterfield, S., Harris, T. B., Yaffe, K. S., & Study, F. T. H. A. (2013) · Stroke · doi:10.1161/strokeaha.112.673533 · Cited by 109
Self-citationCandesartan and cognitive decline in older patients with hypertension
Saxby, B. K., Harrington, F., Wesnes, K. A., McKeith, I. G., & Ford, G. A. (2008) · Neurology · doi:10.1212/01.wnl.0000311447.85948.78 · Cited by 108
Brain Microbleeds Are Associated With Ambulatory Blood Pressure Levels in a Hypertensive Population
Henskens, L. H. G., van Oostenbrugge, R. J., Kroon, A. A., de Leeuw, P. W., & Lodder, J. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.100610 · Cited by 107
Progression of cerebral white matter hyperintensities on MRI is related to diastolic blood pressure
Veldink, J. H., Scheltens, P., Jonker, C., & Launer, L. J. (1998) · Neurology · doi:10.1212/wnl.51.1.319 · Cited by 106
Self-citationPulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults
Nation, D. A., Edland, S. D., Bondi, M. W., Salmon, D. P., Delano‐Wood, L., Peskind, E. R., Quinn, J. F., & Galasko, D. R. (2013) · Neurology · doi:10.1212/01.wnl.0000436935.47657.78 · Cited by 106
Declining prevalence of dementia in the U.S. elderly population.
Manton, K., Gu, X., & Ukraintseva, S. V. (2005) · PubMed · Cited by 106
Cipolla, M. J. (2016) · Cited by 105
Blood-brain barrier dysfunction in Binswanger’s disease; an immunohistochemical study
Akiguchi, I., Tomimoto, H., Suenaga, T., Wakita, H., & Budka, H. (1998) · Acta Neuropathologica · doi:10.1007/s004010050768 · Cited by 104
Feigin, V. L., Ratnasabapathy, Y., & Anderson, C. S. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.11.020 · Cited by 103
Altered structure of small cerebral arteries in patients with essential hypertension
Rizzoni, D., Ciuceis, C. D., Porteri, E., Paiardi, S., Boari, G. E. M., Mortini, P., Cornali, C., Cenzato, M., Rodella, L. F., Borsani, E., et al. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832401ea · Cited by 102
Elias, M. F., D’Agostino, R. B., Elias, P. K., & Wolf, P. A. (1995) · Experimental Aging Research · doi:10.1080/03610739508253991 · Cited by 102
Birns, J., Morris, R., Donaldson, N., & Kalra, L. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000244934.81180.16 · Cited by 96
Tertiary microvascular territories define lacunar infarcts in the basal ganglia
Feekes, J. A., Hsu, S., Chaloupka, J. C., & Cassell, M. D. (2005) · Annals of Neurology · doi:10.1002/ana.20505 · Cited by 96
Blood Pressure and Cognition Among Older Adults: A Meta-Analysis
Gifford, K. A., Badaracco, M. E., Liu, D., Tripodis, Y., Gentile, A. M., Lu, K., Palmisano, J. N., & Jefferson, A. L. (2013) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/act046 · Cited by 96
Joint effect of mid- and late-life blood pressure on the brain
Muller, M., Sigurdsson, S. O., Kjartansson, Ó., Aspelund, T., López, O. L., Jónsson, P. V., Harris, T. B., van Buchem, M. A., Gudnason, V. G., Launer, L. J., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000517 · Cited by 94
Self-citationCerebral small-vessel disease and progression of brain atrophy
Kloppenborg, R. P., Nederkoorn, P. J., Grool, A. M., Vincken, K. L., Mali, W. P. T. M., Vermeulen, M., van der Graaf, Y., Geerlings, M. I., & On behalf of the SMART Study Group (2012) · Neurology · doi:10.1212/wnl.0b013e3182749f02 · Cited by 89
Hypertension and Cerebral Diffusion Tensor Imaging in Small Vessel Disease
Gons, R. A. R., de Laat, K. F., van Norden, A. G. W., van Oudheusden, L. J. B., van Uden, I. W. M., Norris, D. G., Zwiers, M. P., & de Leeuw, F. (2010) · Stroke · doi:10.1161/strokeaha.110.597237 · Cited by 88
Relationship of Race/Ethnicity and Blood Pressure to Change in Cognitive Function
Bohannon, A., Fillenbaum, G. G., Pieper, C. F., Hanlon, J. T., & Blazer, D. G. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50104.x · Cited by 87
Hypertension, Executive Dysfunction, and Progression to Dementia
Oveisgharan, S., & Hachinski, V. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.312 · Cited by 84
Learning and Attention Problems Among Children With Pediatric Primary Hypertension
Adams, H., Szilagyi, P. G., Gebhardt, L., & Lande, M. B. (2010) · PEDIATRICS · doi:10.1542/peds.2010-1899 · Cited by 84
Weber, R., Weimar, C., Blatchford, J., Hermansson, K., Wanke, I., Möller-Hartmann, C., Gizewski, E. R., Forsting, M., Demchuk, A. M., Sacco, R. L., et al. (2012) · Stroke · doi:10.1161/strokeaha.111.648576 · Cited by 82
Placebo-Controlled Trials of Blood Pressure–Lowering Therapies for Primary Prevention of Dementia
Staessen, J. A., Thijs, L., Richart, T., Odili, A. N., & Birkenhäger, W. H. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.165142 · Cited by 80
Marcus, J., Gardener, H., Rundek, T., Elkind, M. S. V., Sacco, R. L., DeCarli, C., & Wright, C. B. (2011) · Stroke · doi:10.1161/strokeaha.111.617571 · Cited by 79
Microbleeds do not affect rate of cognitive decline in Alzheimer disease
van der Vlies, A. E., Goos, J. D. C., Barkhof, F., Scheltens, P., & van der Flier, W. M. (2012) · Neurology · doi:10.1212/wnl.0b013e3182661f91 · Cited by 79
Guzman, V. A., Carmichael, O. T., Schwarz, C. G., Tosto, G., Zimmerman, M. E., Brickman, A. M., & Initiative, A. D. N. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.11.009 · Cited by 77
Jennings, J. R., Mendelson, D. N., Muldoon, M. F., Ryan, C. M., Gianaros, P. J., Raz, N., Aizenstein, H. J., & Initiative, T. A. D. N. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.31 · Cited by 76
Association of White-Matter Lesions with Brain Atrophy Markers: The Three-City Dijon MRI Study
Godin, O., Maillard, P., Crivello, F., Alpérovitch, A., Mazoyer, B. M., Tzourio, C., & Dufouil, C. (2009) · Cerebrovascular Diseases · doi:10.1159/000226117 · Cited by 75
Low Diastolic Pressure and Risk of Dementia in Very Old People: A Longitudinal Study
Qiu, C., Winblad, B. G., & Fratiglioni, L. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000236913 · Cited by 74
High Blood Pressure in Children and Adolescents.
Riley, M., Hernandez, A. K., & Kuznia, A. L. (2012) · PubMed · Cited by 74
Kilander, L. (2000) · Age and Ageing · doi:10.1093/ageing/29.3.243 · Cited by 71
Dynamics of cerebral blood flow autoregulation in hypertensive patients
Traon, A. P., Costes-Salon, M.-C., Galinier, M., Fourcade, J., & Larrue, V. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00010-2 · Cited by 70
Pharmacological interventions for hypertension in children
Chaturvedi, S., Lipszyc, D., Licht, C. P. B., Craig, J. C., & Parekh, R. S. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008117.pub2 · Cited by 68
Blood Pressure and Brain Injury in Older Adults: Findings from a Community‐Based Autopsy Study
Wang, L. Y., Larson, E. B., Sonnen, J. A., Shofer, J. B., McCormick, W. C., Bowen, J. D., Montine, T. J., & Li, G. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02493.x · Cited by 67
Moore, S. M., Zhang, H., Maeda, N., Doerschuk, C. M., & Faber, J. E. (2015) · Angiogenesis · doi:10.1007/s10456-015-9465-6 · Cited by 65
MacLullich, A. M. J., Ferguson, K. J., Reid, L. M., Deary, I. J., Starr, J. M., Seckl, J. R., Bastin, M. E., & Wardlaw, J. M. (2009) · Stroke · doi:10.1161/strokeaha.109.547877 · Cited by 63
Some general population norms for the short form Beck Depression Inventory
Knight, R. G. (1984) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198405)40:3 · Cited by 63
Role of the vascular endothelium and plaque in acute ischemic stroke
Madden, J. A. (2012) · Neurology · doi:10.1212/wnl.0b013e3182695836 · Cited by 62
RICHMOND, R. L., Law, J., & KAY‐LAMBKIN, F. J. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.236 · Cited by 62
Johnson, K., Margolis, K. L., Espeland, M. A., Colenda, C. C., Fillit, H. M., Manson, J. E., Masaki, K., Mouton, C. P., Prineas, R. J., Robinson, J. G., et al. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01806.x · Cited by 62
Association Between Hypertension, Menopause, and Cognition in Women
Zilberman, J. M., Cerezo, G. H., Sueldo, M. D., Fernández, C., Martell‐Claros, N., & Vicario, A. (2015) · Journal of Clinical Hypertension · doi:10.1111/jch.12643 · Cited by 59
Henskens, L. H. G., Kroon, A. A., van Oostenbrugge, R. J., Gronenschild, E. H. B. M., Hofman, P. A. M., Lodder, J., & de Leeuw, P. W. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832b5204 · Cited by 58
McGuinness, B., Todd, S., Passmore, A. P., & Bullock, R. (2008) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.118505 · Cited by 57
Suhr, J. A., Stewart, J. C., & France, C. R. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000127870.64234.9f · Cited by 57
Blood Pressure and Progression of Brain Atrophy
Jochemsen, H. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.217 · Cited by 56
Nakagawa, T., Hasegawa, Y., Uekawa, K., Ma, M., Katayama, T., Sueta, D., Toyama, K., Kataoka, K., Koibuchi, N., Maeda, M., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000375 · Cited by 55
The relationship of childhood to adult blood pressure
Klumbienė, J., Šileikienė, L., Milašauskienė, Ž., Zaborskis, A., & Shatchkute, A. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018050-00004 · Cited by 55
Allan, C. L., Zsoldos, E., Filippini, N., Sexton, C. E., Topiwala, A., Valkanova, V., Singh‐Manoux, A., Tabák, Á. G., Shipley, M. J., Mackay, C. E., et al. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.153536 · Cited by 55
Yaşar, S., Ko, J. Y., Nothelle, S. K., Mielke, M. M., & Carlson, M. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027976 · Cited by 52
Leritz, E. C., Salat, D. H., Milberg, W., Williams, V. J., Chapman, C. E., Grande, L. J., Rudolph, J. L., Schnyer, D. M., Barber, C. E., Lipsitz, L. A., et al. (2010) · Neuropsychology · doi:10.1037/a0018108 · Cited by 51
Nation, D. A., Delano‐Wood, L., Bangen, K. J., Wierenga, C. E., Jak, A. J., Hansen, L. A., Galasko, D. R., Salmon, D. P., & Bondi, M. W. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111697 · Cited by 49
Harrison, S. L., Stephan, B. C. M., Siervo, M., Granic, A., Davies, K., Wesnes, K. A., Kirkwood, T. B. L., Robinson, L. A., & Jagger, C. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13358 · Cited by 48
A brief neuropsychological battery for use in the chronic heart failure population
Bauer, L., Pozehl, B., Hertzog, M., Johnson, J. K., Zimmerman, L., & Filipi, M. (2012) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2011.03.007 · Cited by 48
Hypertension and hypertensive encephalopathy
Price, R. S., & Kasner, S. E. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-7020-4086-3.00012-6 · Cited by 48
Arterial stiffness and progression of structural brain changes
Jochemsen, H. M., Muller, M., Bots, M. L., Scheltens, P., Vincken, K. L., Mali, W. P. T. M., van der Graaf, Y., Geerlings, M. I., Algra, A., Doevendans, P. A., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001201 · Cited by 47
Pathologic evidence of microvascular rarefaction in the brain of renal hypertensive rats
Suzuki, K., Masawa, N., Sakata, N., & Takatama, M. (2003) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1053/jscd.2003.1 · Cited by 47
Peltz, C. B., Corrada, M. M., Berlau, D. J., & Kawas, C. H. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.02.008 · Cited by 47
Hypertension moderates the effect of APOE on 21-year cognitive trajectories.
de Frias, C. M., Schaie, K. W., & Willis, S. L. (2014) · Psychology and Aging · doi:10.1037/a0036828 · Cited by 46
Cognitive decline precedes late-life longitudinal changes in vascular risk factors
van Vliet, P., Westendorp, R. G. J., van Heemst, D., de Craen, A. J. M., & Oleksik, A. M. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.182519 · Cited by 45
Endothelial Activation Is Associated With Cognitive Performance in Patients With Hypertension
Uiterwijk, R., Huijts, M., Staals, J., Rouhl, R. P. W., de Leeuw, P. W., Kroon, A. A., & van Oostenbrugge, R. J. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv122 · Cited by 43
Taylor, C. L., Tillin, T., Chaturvedi, N., Dewey, M. E., Ferri, C. P., Hughes, A. D., Prince, M. J., Richards, M., Shah, A. K., & Stewart, R. J. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12416 · Cited by 43
Pharmacological interventions for hypertension in children
Chaturvedi, S., Lipszyc, D., Licht, C. P. B., Craig, J. C., & Parekh, R. S. (2014) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.1974 · Cited by 41
Cooccurrence of vascular risk factors and late-life white-matter integrity changes
Maillard, P., Carmichael, O. T., Reed, B., Mungas, D., & DeCarli, C. S. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.01.007 · Cited by 41
Cerebral angiography, blood flow and vascular reactivity in progressive hypertension
Li, Y., Shen, Q., Huang, S., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.053 · Cited by 40
García‐Ortiz, L., Recio-Rodriguez, J. I., Schmidt‐Trucksäss, A., Puigdomènech, E., Martínez‐Vizcaíno, V., Fernández-Alonso, C., Rubio-Galán, J., Agudo‐Conde, C., Patino-Alonso, M. C., Rodríguez‐Sánchez, E., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.01.021 · Cited by 39
Impact of Common KIBRA Allele on Human Cognitive Functions
Wersching, H., Guske, K., Hasenkamp, S., Hagedorn, C., Schiwek, S., Jansen, S., Witte, A. V., Wellmann, J., Lohmann, H., Duning, K., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.16 · Cited by 39
Joint Effect of Hypertension and APOE Genotype on CSF Biomarkers for Alzheimer's Disease
Kester, M. I., van der Flier, W. M., Mandić, G., Blankenstein, M. A., Scheltens, P., & Muller, M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091198 · Cited by 39
The Treatment of Hypertension: A Remarkable Success Story
Moser, M., & Roccella, E. J. (2012) · Journal of Clinical Hypertension · doi:10.1111/jch.12033 · Cited by 38
Chen, K. H. M., Henderson, V. W., Stolwyk, R. J., et al. (2015) · Age and Ageing · doi:10.1093/ageing/afv026 · Cited by 38
Chan, S., Umesalma, S., & Baumbach, G. L. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04794 · Cited by 36
Liu, J., Liu, S., Matsumoto, Y., Murakami, S., Sugakawa, Y., Kami, A., Tanabe, C., Maeda, T., Michikawa, M., Komano, H., et al. (2015) · Scientific Reports · doi:10.1038/srep12059 · Cited by 35
Ventricular and Vascular Stiffening in Aging and Hypertension
Faconti, L., Bruno, R. M., Ghiadoni, L., et al. (2015) · Current Hypertension Reviews · doi:10.2174/1573402111666150529131208 · Cited by 34
Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles
Chan, S., & Baumbach, G. L. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00133 · Cited by 32
Korf, E. S. C., Scheltens, P., Barkhof, F., & de Leeuw, F. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000088464 · Cited by 29
Andrews, S. J., Das, D., Anstey, K. J., & Easteal, S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-140630 · Cited by 29
Gao, Z., Wang, W., Wang, Z., Zhao, X., Shang, Y., Guo, Y., Gong, M., Yang, L., Shi, X.-B., Xu, X., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091637 · Cited by 27
Dankbaar, J. W., Hom, J., Schneider, T., Cheng, S.-C., Lau, B. C., van der Schaaf, I. C., Virmani, S., Pohlman, S. K., & Wintermark, M. (2009) · Journal of Neuroradiology · doi:10.1016/j.neurad.2009.01.001 · Cited by 27
Høgh, P., Garde, E., Mortensen, E. L., Jørgensen, O. S., Krabbe, K. S., & Waldemar, G. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00779.x · Cited by 27
Effects of Candesartan in Acute Stroke on Cognitive Function and Quality of Life
Hornslien, A. G., Sandset, E. C., Bath, P. M., Wyller, T. B., & Berge, E. (2013) · Stroke · doi:10.1161/strokeaha.113.001022 · Cited by 26
He, J., Wong, V. S. S., Fletcher, E. M., Maillard, P., Lee, D. Y., Iosif, A., Singh, B., Martinez, O., Roach, A. E., Lockhart, S. N., et al. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3048 · Cited by 26
Kesse‐Guyot, E., Julia, C., Andreeva, V. A., Fezeu, L., Herçberg, S., & Galan, P. (2015) · Age and Ageing · doi:10.1093/ageing/afv053 · Cited by 25
Changes in behavior as an early symptom of renovascular hypertension in children
Krause, I., Cleper, R., Kovalski, Y., et al. (2009) · Pediatric Nephrology · doi:10.1007/s00467-009-1205-y · Cited by 25
Aono, J., Suzuki, J., Iwai, M., Horiuchi, M., Nagai, T., Nishimura, K., Inoue, K., Ogimoto, A., Okayama, H., & Higaki, J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.249516 · Cited by 25
Blood pressure and cognitive function
Lyngdoh, T., Viswanathan, B., Kobrosly, R. W., van Wijngaarden, E., Huber, B., Davidson, P. W., Cory‐Slechta, D. A., Strain, J., MYERS, G. J., & Bovet, P. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283604176 · Cited by 23
Ciuceis, C. D., Cornali, C., Porteri, E., Mardighian, D., Pinardi, C., Fontanella, M. M., Rodella, L. F., Rezzani, R., Rizzoni, D., Boari, G. E. M., et al. (2014) · Neuroradiology · doi:10.1007/s00234-014-1423-2 · Cited by 22
Histopathological stainings and definitions of vascular disruptions in the elderly brain
Reuck, J. L. D. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.03.012 · Cited by 20
Kovács, K. R., Bajkó, Z., Szekeres, C. C., Csapó, K., Oláh, L., Magyar, M. T., Molnár, S., Czuriga, D., Kardos, L., Burainé, A. B., et al. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.04.007 · Cited by 20
Mitchell, G. F. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000717 · Cited by 19
de Jong, L. W., Forsberg, L. E., Vidal, J., Sigurdsson, S. O., Zijdenbos, A. P., García, M., Eiríksdóttir, G., Gudnason, V. G., van Buchem, M. A., & Launer, L. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.009 · Cited by 13
Self-citationBlood Pressure and Progression of Cerebral Atrophy in Patients With Vascular Disease
Vlek, A. L. M., Visseren, F. L. J., Kappelle, L. J., Geerlings, M. I., Vincken, K. L., Mali, W. P. T. M., & van der Graaf, Y. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.166 · Cited by 13
Hara, M., Yakushiji, Y., Nannri, H., Sasaki, S., Noguchi, T., Nishiyama, M., Hirotsu, T., Nakajima, J., & Hara, H. (2013) · Hypertension Research · doi:10.1038/hr.2013.26 · Cited by 11
Low Blood Pressure and Risk of Dementia in the Kungsholmen Project
Qiu, C., Strauss, E. I. V., Fastbom, J., Winblad, B. G., & Fratiglioni, L. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.223 · Cited by 9
Seshadri, S. S. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a35296 · Cited by 7
Self-citationAntihypertensive Medication Use and Incident Alzheimer Disease: The Cache County Study
Khachaturian, A. S. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.noc60013 · Cited by 3
Flagged first, then by citations
Research works printed but not linked: 5
- Schmidt M. Rey Auditory Verbal Learning Test: A Handbook. Los Angeles, CA: Western Psychological Services; 1996.
- Lezak M. Neuropsychological Assessment. New York, NY: Oxford University Press; 2004.
- Army Individual Test Battery: Manual of Directions and Scoring. Washington, DC: War Department, Adjutant General’s Office; 1944.
- 10.1097/00006842-200405000-00002 · DOI
- 10.1097/01.hjh.0000059028.82022.89 · DOI
Cited by
Sorted by citations
2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Hypertension-induced cognitive impairment: From pathophysiology to public health
Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., & Csiszar, A. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00430-6 · Cited by 544
Gorelick, P. B., Furie, K. L., Iadecola, C., Smith, E. E., Waddy, S. P., Lloyd-Jones, D. M., Bae, H.-J., Bauman, M. A., Dichgans, M., Duncan, P. W., et al. (2017) · Stroke · doi:10.1161/str.0000000000000148 · Cited by 411
Self-citation
Metadata
- Authors
- Iadecola, C., Yaffe, K., Biller, J., Bratzke, L. C., Faraci, F. M., Gorelick, P. B., Gulati, M., Kamel, H., Knopman, D. S., Launer, L. J., Saczynski, J. S., Seshadri, S., & Zeki Al Hazzouri, A.
- ORCID
- Venue
- Hypertension
- Published
- 2016-12
- Volume
- 68
- Issue
- 6
- Pages
- e67-e94
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC5361411
- OpenAlex
- W2530115453
- Semantic Scholar
- 1f0aaa0710148c9974472c023c1134b92f24307f
- Cited by
- 746
- References
- 332
- Citations by year
- 2026: 61 · 2025: 68 · 2024: 78 · 2023: 79 · 2022: 77 · 2021: 85 · 2020: 93 · 2019: 95 · 2018: 64 · 2017: 42 · 2016: 1
- FWCI
- 59.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (P30AG010129, K01AG047273)
- National Institute of Neurological Disorders and Stroke (R37NS089323, R01NS017950)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- cognitive function, dementia, Alzheimer's disease, vascular dementia, white matter ischemia, cerebral vasculature, antihypertensive therapy, midlife hypertension, cerebrovascular injury, brain health
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, American Heart Association, Antihypertensive Agents, Cognition Disorders, Female, Follow-Up Studies, Humans, Hypertension, Male, Severity of Illness Index, Sex Factors, United States, Dementia, Vascular, Practice Guidelines as Topic, Disease Progression, Risk Assessment, Evidence-Based Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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