The DOI matches its Crossref record; 332 of the 332 references it cites were found in a registry or an index.
Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association
Open accessAbstract
Background—: Age-related dementia, most commonly caused by Alzheimer disease or cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial hypertension is a well-established risk factor for both types of dementia, but the link between hypertension and its treatment and cognition remains poorly understood. In this scientific statement, a multidisciplinary team of experts examines the impact of hypertension on cognition to assess the state of the knowledge, to identify gaps, and to provide future directions. Methods—: Authors with relevant expertise were selected to contribute to this statement in accordance with the American Heart Association conflict-of-interest management policy. Panel members were assigned topics relevant to their areas of expertise, reviewed the literature, and summarized the available data. Results—: Hypertension disrupts the structure and function of cerebral blood vessels, leads to ischemic damage of white matter regions critical for cognitive function, and may promote Alzheimer pathology. There is strong evidence of a deleterious influence of midlife hypertension on late-life cognitive function, but the cognitive impact of late-life hypertension is less clear. Observational studies demonstrated a cumulative effect of hypertension on cerebrovascular damage, but evidence from clinical trials that antihypertensive treatment improves cognition is not conclusive. Conclusions—: After carefully reviewing the literature, the group concluded that there were insufficient data to make evidence-based recommendations. However, judicious treatment of hypertension, taking into account goals of care and individual characteristics (eg, age and comorbidities), seems justified to safeguard vascular health and, as a consequence, brain health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Vascular risk factors including hypertension (169, 272), diabetes (43, 110), hyperlipidemia (74), and cardiovascular disease (594), as well as environment (e.g., pollution) (87-89, 207) and lifestyle (e.g., obesity, sedentary lifestyle) (281, 643) all affect cerebrovascular and BBB dysfunction (429, 571), and may influence onset and progression of AD.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [272]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The evidence suggests that midlife may represent a critical period when exposure to high blood pressure is likely to increase risk of poorer cognition in late-life (8).”
From Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research (2018) · cites this paper as [8]
The cited source says what the claim attributes to it.
In the citing paper
“Few trials of antihypertensive agents have included cognitive outcomes and each trial has, almost inevitably, focused on a differing population group and used differing treatment regimens, inclusion criteria, blood pressure targets and in general relatively short follow up (8).”
From Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research (2018) · cites this paper as [8]
The cited source says what the claim attributes to it.
In the citing paper
“There is now also emerging evidence for taking a life-course approach to exposure not least as the latter may take account of varying exposure levels over time (8, 9, 10).”
From Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research (2018) · cites this paper as [8]
The cited source says what the claim attributes to it.
In the citing paper
“Few trials of antihypertensive agents have included cognitive outcomes and each trial has, almost inevitably, focused on a differing population group and used differing treatment regimens, inclusion criteria, blood pressure targets and in general relatively short follow up (8).”
From Oversimplification of Dementia Risk Reduction Messaging Is a Threat to Knowledge Translation in Dementia Prevention Research (2018) · cites this paper as [8]
In the citing paper
“Advances in our understanding of the role of cardiovascular risks have shown them to be closely associated with cognitive impairment and dementia.”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [5]
In the citing paper
“A more contemporary scientific statement found inconclusive evidence that BP control preserves cognition in the population at-large.5”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 8,167
A Randomized Trial of Intensive versus Standard Blood-Pressure Control
The SPRINT Research Group (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1511939 · Cited by 6,325
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
Overdependence on degraded gist memory in Alzheimer's disease.
Gallo, D. A., Shahid, K. R., Olson, M. A., Solomon, T. M., Schacter, D. L., & Budson, A. E. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.625 · Cited by 4,757
Structural and functional features of central nervous system lymphatic vessels
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396
Self-citationThe Neuropsychological Assessment
Ogden, J. A. (2005) · Oxford University Press eBooks · doi:10.1093/oso/9780195171358.003.0002 · Cited by 4,382
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130
Berenson, G. S., Srinivasan, S. R., Bao, W., Newman, W. P., Tracy, R. E., & Wattigney, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806043382302 · Cited by 4,032
Hearing loss and cognitive decline in older adults
Lin, F. R., Yaffe, K., Xia, J., Xue, Q.-L., Harris, T. B., Purchase-Helzner, E., Satterfield, S., Ayonayon, H. N., Ferrucci, L., Simonsick, E. M., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1868 · Cited by 4,017
Self-citationGorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Self-citationNgandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689
Wechsler Adult Intelligence Scale-III
Ryan, J. J., & Lopez, S. J. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1185-4_2 · Cited by 3,680
Pantoni, L. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70104-6 · Cited by 3,405
. Cerebral blood flow in dementia.
Hachinski, V. C., Iliff, L. D., Zilhka, E., Du Boulay, G. H., McAllister, V. L., Marshall, J., Russell, R. W. R., & Symon, L. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490510088009 · Cited by 3,186
Law, M. R., Morris, J. K., & Wald, N. J. (2009) · BMJ · doi:10.1136/bmj.b1665 · Cited by 2,775
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K., & Brayne, C. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70136-x · Cited by 2,466
Self-citationSilent Brain Infarcts and the Risk of Dementia and Cognitive Decline
Vermeer, S. E., Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022066 · Cited by 2,313
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
Self-citationDementia: a public health priority
Acosta, D. M., Krishnamoorthy, E. S., Wortmann, M., Prince, M. J., & Saxena, S. (2012) · Cited by 1,955
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857
Self-citationProbability of stroke: a risk profile from the Framingham Study.
Wolf, P. A., D'Agostino, R. B., Belanger, A. J., & Kannel, W. B. (1991) · Stroke · doi:10.1161/01.str.22.3.312 · Cited by 1,782
15-year longitudinal study of blood pressure and dementia
Skoog, I., Nilsson, L., Persson, G., Lernfelt, B., Landahl, S., Palmertz, B., Andreasson, L.-A., Odén, A., & Svanborg, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90608-x · Cited by 1,726
Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., et al. (2006) · Stroke · doi:10.1161/01.str.0000237236.88823.47 · Cited by 1,722
Self-citationClearance systems in the brain—implications for Alzheimer disease
Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.119 · Cited by 1,678
Establishment and Dysfunction of the Blood-Brain Barrier
Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging
Wardlaw, J. M., Smith, C., & Dichgans, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70060-7 · Cited by 1,657
Kivipelto, M., Helkala, E.-L., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., Soininen, H., Tuomilehto, J., & Nissinen, A. (2001) · BMJ · doi:10.1136/bmj.322.7300.1447 · Cited by 1,618
Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>
Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590
Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women
Mitchell, G. F., Parise, H., Benjamin, E. J., Larson, M. G., Keyes, M. J., Vita, J. A., Vasan, R. S., & Levy, D. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000128420.01881.aa · Cited by 1,507
Forette, F., Seux, M.-L., Staessen, J. A., Thijs, L., Birkenhäger, W. H., Babarskiene, M.-R., Babeanu, S., Bossini, A., Gil-Extremera, B., Girerd, X., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03086-4 · Cited by 1,441
The Study on Cognition and Prognosis in the Elderly (SCOPE)
Lithell, H., Hansson, L., Skoog, I. G., Elmfeldt, D., Albert Hofman, D., Olofsson, B., Trenkwalder, P., & Zanchetti, A. (2003) · Journal of Hypertension · doi:10.1097/00004872-200305000-00011 · Cited by 1,419
Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360
Midlife cardiovascular risk factors and risk of dementia in late life
Whitmer, R. A., Sidney, S., Selby, J., Johnston, S. C., & Yaffe, K. (2005) · Neurology · doi:10.1212/01.wnl.0000149519.47454.f2 · Cited by 1,238
Self-citationMatthews, F. E., Arthur, A., Barnes, L. E., Bond, J., Jagger, C., Robinson, L., & Brayne, C. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61570-6 · Cited by 1,155
Fugate, J. E., & Rabinstein, A. A. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00111-8 · Cited by 1,145
Midlife blood pressure and dementia: the Honolulu–Asia aging study☆
Launer, L. J., Ross, G. W., Petrovitch, H., Masaki, K., Foley, D., White, L. R., & Havlik, R. J. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00096-8 · Cited by 1,008
Self-citation(2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.9.1069 · Cited by 988
The Association Between Midlife Blood Pressure Levels and Late-Life Cognitive Function
Launer, L. J. (1995) · JAMA · doi:10.1001/jama.1995.03530230032026 · Cited by 944
Self-citationThe neuropathology of probable Alzheimer disease and mild cognitive impairment
Schneider, J. A., Arvanitakis, Z., Leurgans, S. E., & Bennett, D. A. (2009) · Annals of Neurology · doi:10.1002/ana.21706 · Cited by 935
Long-Term Calorie Restriction Is Highly Effective in Reducing the Risk for Atherosclerosis in Humans
Fontana, L., Meyer, T. E., Klein, S., & Holloszy, J. O. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308291101 · Cited by 902
Forette, F. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.18.2046 · Cited by 898
Cardiovascular risk factors and cognitive decline in middle-aged adults
Knopman, D., Boland, L. L., Mosley, T., Howard, G., Liao, D., Szklo, M., McGovern, P., & Folsom, A. R. (2001) · Neurology · doi:10.1212/wnl.56.1.42 · Cited by 883
Self-citationToledo, J. B., Arnold, S. E., Raible, K., Brettschneider, J., Xie, S. X., Grossman, M., Monsell, S. E., Kukull, W. A., & Trojanowski, J. Q. (2013) · Brain · doi:10.1093/brain/awt188 · Cited by 849
Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.
Snowdon, D. A., Greiner, L. H., Mortimer, J. A., et al. (1997) · PubMed · Cited by 846
Avolio, A. P., Deng, F. Q., Li, W. Q., Luo, Y., Huang, Z., Xing, L. F., & O’Rourke, M. F. (1985) · Circulation · doi:10.1161/01.cir.71.2.202 · Cited by 838
Yoshitake, T., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., Nomiyama, K., Kawano, H., Ueda, K., et al. (1995) · Neurology · doi:10.1212/wnl.45.6.1161 · Cited by 829
Lackland, D. T., Roccella, E. J., Deutsch, A. F., Fornage, M., George, M. G., Howard, G., Kissela, B. M., Kittner, S. J., Lichtman, J. H., Lisabeth, L. D., et al. (2014) · Stroke · doi:10.1161/01.str.0000437068.30550.cf · Cited by 815
Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
Debette, S., Seshadri, S., Beiser, A., Au, R., Himali, J. J., Palumbo, C., Wolf, P. A., & DeCarli, C. (2011) · Neurology · doi:10.1212/wnl.0b013e318227b227 · Cited by 772
Self-citationPeters, R., Beckett, N., Forette, F., Tuomilehto, J., Clarke, R., Ritchie, C., Waldman, A., Walton, I., Poulter, R., Ma, S., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70143-1 · Cited by 770
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations
Gouw, A. A., Seewann, A., van der Flier, W. M., Barkhof, F., Rozemuller, A. M., Scheltens, P., & Geurts, J. J. G. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.204685 · Cited by 766
High Blood Pressure Trends in Children and Adolescents in National Surveys, 1963 to 2002
Din‐Dzietham, R., Liu, Y., Bielo, M.-V., & Shamsa, F. H. (2007) · Circulation · doi:10.1161/circulationaha.106.683243 · Cited by 746
Blood Pressure Lowering Treatment Trialists’ Collaboration (2008) · BMJ · doi:10.1136/bmj.39548.738368.be · Cited by 739
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology
Attems, J., & Jellinger, K. A. (2014) · BMC Medicine · doi:10.1186/s12916-014-0206-2 · Cited by 739 · cited 1×
“Although dementia caused by AD and vascular dementia have traditionally been considered distinct nosological entities, increasing evidence indicates that these conditions often coexist.(8,9) Thus, the neuropathological hallmarks of AD, amyloid plaques and neurofibrillary tangles (NFTs), are frequently associated with…”
Webb, A. J., Fischer, U., Mehta, Z., & Rothwell, P. M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60235-8 · Cited by 729
Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study
Kivipelto, M., Helkala, E.-L., Hänninen, T., Laakso, M. P., Hallikainen, M., Alhainen, K., Soininen, H., Tuomilehto, J., & Nissinen, A. (2001) · Neurology · doi:10.1212/wnl.56.12.1683 · Cited by 717
Hypertension: Renin–Angiotensin–Aldosterone System Alterations
te Riet, L., van Esch, J. H. M., Roks, A. J. M., van den Meiracker, A. H., & Danser, A. H. J. (2015) · Circulation Research · doi:10.1161/circresaha.116.303587 · Cited by 706
Predominance of Isolated Systolic Hypertension Among Middle-Aged and Elderly US Hypertensives
Franklin, S. S., Jacobs, M. J., Wong, N. D., L'Italien, G. J., & Lapuerta, P. (2001) · Hypertension · doi:10.1161/01.hyp.37.3.869 · Cited by 705
Multilingual Aphasia Examination
Patterson, J. P. (2010) · Springer eBooks · doi:10.1007/978-0-387-79948-3_900 · Cited by 686
Effects of clopidogrel added to aspirin in patients with recent lacunar stroke
The SPS3 Investigators (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1204133 · Cited by 679
Coupling Mechanism and Significance of the BOLD Signal: A Status Report
Hillman, E. M. C. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014111 · Cited by 667
Untreated Blood Pressure Level Is Inversely Related to Cognitive Functioning: The Framingham Study
Elias, M. F., Wolf, P. A., D’Agostino, R. B., Cobb, J. L., & White, L. R. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116868 · Cited by 652
Hypertension Is Related to Cognitive Impairment: A 20-Year Follow-up of 999 Men
Kilander, L., Nyman, H., Boberg, M., Hansson, L., & Lithell, H. (1998) · Hypertension · doi:10.1161/01.hyp.31.3.780 · Cited by 630
Update: Ambulatory Blood Pressure Monitoring in Children and Adolescents
Flynn, J. T., Daniels, S. R., Hayman, L. L., Maahs, D. M., McCrindle, B. W., Mitsnefes, M. M., Zachariah, J. P. V., & Urbina, E. M. (2014) · Hypertension · doi:10.1161/hyp.0000000000000007 · Cited by 608
Fernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000221308.94473.14 · Cited by 587
Morrison, J. A., Friedman, L. A., & Gray‐McGuire, C. (2007) · PEDIATRICS · doi:10.1542/peds.2006-1699 · Cited by 584
van Dijk, E. J., Prins, N. D., Vrooman, H. A., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2008) · Stroke · doi:10.1161/strokeaha.107.513176 · Cited by 580
Meta-analysis of modifiable risk factors for Alzheimer's disease
Xu, W., Tan, L., Wang, H.-F., Jiang, T., Tan, M.-S., Tan, L., Zhao, Q.-F., Li, J.-Q., Wang, J., & Yu, J.-T. (2015) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-310548 · Cited by 573
Prevalence and Risk Factors of Cerebral Microbleeds: An Update of the Rotterdam Scan Study
Poels, M. M. F., Vernooij, M. W., Ikram, M. A., Hofman, A., Krestin, G. P., van der Lugt, A., & Breteler, M. M. B. (2010) · Stroke · doi:10.1161/strokeaha.110.595181 · Cited by 563
Hypertension and Cerebrovascular Dysfunction
Iadecola, C., & Davisson, R. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.010 · Cited by 557
Self-citationBrain barriers: Crosstalk between complex tight junctions and adherens junctions
Tietz, S., & Engelhardt, B. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412147 · Cited by 551
Ambrosius, W. T., Sink, K. M., Foy, C. G., Berlowitz, D. R., Cheung, A. K., Cushman, W. C., Fine, L. J., Goff, D. C., Johnson, K., Killeen, A. A., et al. (2014) · Clinical Trials · doi:10.1177/1740774514537404 · Cited by 550
Vascular risk factors, incidence of MCI, and rates of progression to dementia
Solfrizzi, V., Panza, F., Colacicco, A. M., D’Introno, A., Capurso, C., Torres, F., Grigoletto, F., Maggi, S., Del Parigi, A., Reiman, E. M., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000144281.38555.e3 · Cited by 530
The Structural Factor of Hypertension
Laurent, S., & Boutouyrie, P. (2015) · Circulation Research · doi:10.1161/circresaha.116.303596 · Cited by 517
Remodeling of cerebral arterioles in chronic hypertension.
Baumbach, G. L., & Heistad, D. D. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.968 · Cited by 496
van Beek, A. H., Claassen, J. A., Rikkert, M. G. O., & Jansen, R. W. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.13 · Cited by 485
Gottesman, R. F., Schneider, A. L. C., Albert, M., Alonso, A., Bandeen-Roche, K., Coker, L., Coresh, J., Knopman, D., Power, M. C., Rawlings, A., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1646 · Cited by 474
Self-citationLongstreth, W. T., Arnold, A. M., Beauchamp, N. J., Manolio, T. A., Lefkowitz, D., Jungreis, C., Hirsch, C. H., O’Leary, D. H., & Furberg, C. D. (2005) · Stroke · doi:10.1161/01.str.0000149625.99732.69 · Cited by 474
Petrovitch, H., White, L. R., Izmirilian, G., Ross, G. W., Havlik, R. J., Markesbery, W., Nelson, J., Davis, D. G., Hardman, J., Foley, D. J., et al. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00106-8 · Cited by 468
Self-citationLongitudinal study of blood pressure and white matter hyperintensities: The EVA MRI Cohort
Dufouil, C., de Kersaint–Gilly, A., Besançon, V., Levy, C., Auffray, E., Brunnereau, L., Alpérovitch, A., & Tzourio, C. (2001) · Neurology · doi:10.1212/wnl.56.7.921 · Cited by 465
Waldstein, S. R., Rice, S. C., Thayer, J. F., Najjar, S. S., Scuteri, A., & Zonderman, A. B. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.093674 · Cited by 462
Dufouil, C., Chalmers, J., Coskun, O., Besançon, V., Bousser, M.-G., Guillon, P., MacMahon, S., Mazoyer, B., Neal, B., Woodward, M., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.501163 · Cited by 461
Chronic Care: Making the Case for Ongoing Care
Anderson, G. F. (2010) · Cited by 457
Haan, M. N. (1999) · JAMA · doi:10.1001/jama.282.1.40 · Cited by 457
Neurological Diseases in Relation to the Blood–Brain Barrier
Rosenberg, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.197 · Cited by 454
Liao, D., Cooper, L. S., Cai, J., Toole, J. F., Bryan, R. N., Burke, G. L., Shahar, E., Nieto, F. J., Mosley, T. H., & HEISS, G. M. (2014) · Neuroepidemiology · doi:10.1159/000368814 · Cited by 428
The effects of hypertension on the cerebral circulation
Pires, P. W., Dams, C. M., Matin, N., & Dorrance, A. M. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00490.2012 · Cited by 417
Microinfarct Pathology, Dementia, and Cognitive Systems
Arvanitakis, Z., Leurgans, S. E., Barnes, L. L., Bennett, D. A., & Schneider, J. A. (2011) · Stroke · doi:10.1161/strokeaha.110.595082 · Cited by 404
Langa, K. M., Larson, E. B., Karlawish, J. H., Cutler, D., Kabeto, M. U., Kim, S. Y. H., & Rosen, A. B. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.01.001 · Cited by 388
Association of midlife blood pressure to late-life cognitive decline and brain morphology
Swan, G. E., DeCarli, C. S., Miller, B. L., Reed, T., Wolf, P. A., Jack, L. M., & Carmelli, D. (1998) · Neurology · doi:10.1212/wnl.51.4.986 · Cited by 388
Gouw, A. A., van der Flier, W. M., Fazekas, F., van Straaten, E. C. W., Pantoni, L., Poggesi, A., Inzitari, D., Erkinjuntti, T., Wahlund, L. O., Waldemar, G., et al. (2008) · Stroke · doi:10.1161/strokeaha.107.498535 · Cited by 384
Long-term caloric restriction ameliorates the decline in diastolic function in humans
Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.069 · Cited by 383
Christensen, K., Thinggaard, M., Oksuzyan, A., Steenstrup, T., Andersen‐Ranberg, K., Jeune, B., McGue, M. K., & Vaupel, J. W. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60777-1 · Cited by 383
Cerebral microbleeds are associated with worse cognitive function: The Rotterdam Scan Study
Poels, M. M. F., Ikram, M. A., van der Lugt, A., Hofman, A., Niessen, W. J., Krestin, G. P., Breteler, M. M. B., & Vernooij, M. W. (2012) · Neurology · doi:10.1212/wnl.0b013e3182452928 · Cited by 378
Li, J., Tan, L., Wang, H.-F., Tan, M., Tan, L., Xu, W., Zhao, Q., Wang, J., Jiang, T., & Yu, J. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-310095 · Cited by 373
A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain
Chen, B. R., Kozberg, M. G., Bouchard, M. B., Shaik, M. A., & Hillman, E. M. C. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000787 · Cited by 370
Dementia After Stroke: The Framingham Study
Ivan, C. S., Seshadri, S., Beiser, A., Au, R., Kase, C. S., Kelly-Hayes, M., & Wolf, P. A. (2004) · Stroke · doi:10.1161/01.str.0000127810.92616.78 · Cited by 369
Self-citationNIDDM and Blood Pressure as Risk Factors for Poor Cognitive Performance: The Framingham Study
Elias, P. K., Elias, M. F., D'Agostino, R. B., Cupples, L. A., Wilson, P. W., Silbershatz, H., & Wolf, P. A. (1997) · Diabetes Care · doi:10.2337/diacare.20.9.1388 · Cited by 368 · cited 1×
“However, studies that have looked for an interaction of diabetes mellitus with hypertension and an adverse impact on cognition have typically found independent, additive effects rather than a synergistic interaction of these 2 risk factors.(134) Among the various metabolic dysfunctions noted in diabetes mellitus, insu…”
Hypertension: A Harbinger of Stroke and Dementia
Faraco, G., & Iadecola, C. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01063 · Cited by 367
Self-citationDiener, H.-C., Sacco, R. L., Yusuf, S., Cotton, D., Ôunpuu, S., Lawton, W. A., Palesch, Y., Martin, R. H., Albers, G. W., Bath, P., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70198-4 · Cited by 359
Self-citationRole of Angiotensin and Oxidative Stress in Essential Hypertension
Romero, J. C., & Reckelhoff, J. F. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.943 · Cited by 358
van Dijk, E. J., Breteler, M. M. B., Schmidt, R., Berger, K., Nilsson, L.-G., Oudkerk, M., Pajak, A., Sans, S., de Ridder, M., Dufouil, C., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000145857.98904.20 · Cited by 345
Self-citationNeuropathologic correlates of white matter hyperintensities
Young, V. G., Halliday, G. M., & Kril, J. J. (2008) · Neurology · doi:10.1212/01.wnl.0000319691.50117.54 · Cited by 336
The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function
Posner, H. B., Tang, M. X., Luchsinger, J. A., Lantigua, R., Stern, Y., & Mayeux, R. P. (2002) · Neurology · doi:10.1212/wnl.58.8.1175 · Cited by 330
Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden
Qiu, C., Strauss, E. I. V., Bäckman, L., Winblad, B. G., & Fratiglioni, L. (2013) · Neurology · doi:10.1212/wnl.0b013e318292a2f9 · Cited by 322
A Verbal Memory Test With High Predictive Accuracy for Dementia of the Alzheimer Type
Knopman, D. S., & Ryberg, S. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520380041011 · Cited by 317
Self-citationLow blood pressure and the risk of dementia in very old individuals
Verghese, J., Lipton, R. B., Hall, C. B., Kuslansky, G., & Katz, M. (2003) · Neurology · doi:10.1212/01.wnl.0000098934.18300.be · Cited by 316
McGuinness, B., Todd, S., Passmore, P., & Bullock, R. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004034.pub3 · Cited by 315
Maillard, P., Seshadri, S. S., Beiser, A., Himali, J. J., Au, R., Fletcher, E., Carmichael, O. T., Wolf, P. A., & DeCarli, C. S. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70241-7 · Cited by 312
Self-citationEarly Adult to Midlife Cardiovascular Risk Factors and Cognitive Function
Yaffe, K., Vittinghoff, E., Pletcher, M. J., Hoang, T. D., Launer, L. J., Whitmer, R. A., Coker, L. H., & Sidney, S. (2014) · Circulation · doi:10.1161/circulationaha.113.004798 · Cited by 308
Self-citationHenskens, L. H. G., Kroon, A. A., van Oostenbrugge, R. J., Gronenschild, E. H. B. M., Fuss-Lejeune, M. M. J. J., Hofman, P. A. M., Lodder, J., & de Leeuw, P. W. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.119024 · Cited by 293
The Pericyte: A Forgotten Cell Type with Important Implications for A lzheimer's Disease?
Winkler, E. A., Sagare, A. P., & Zloković, B. V. (2014) · Brain Pathology · doi:10.1111/bpa.12152 · Cited by 284
Predictors of New-Onset Diastolic and Systolic Hypertension
Franklin, S. S., Pio, J. R., Wong, N. D., Larson, M. G., Leip, E. P., Vasan, R. S., & Levy, D. A. (2005) · Circulation · doi:10.1161/01.cir.0000157159.39889.ec · Cited by 279
Nonlinear Relations of Blood Pressure to Cognitive Function
Waldstein, S. R., Giggey, P. P., Thayer, J. F., & Zonderman, A. B. (2005) · Hypertension · doi:10.1161/01.hyp.0000156744.44218.74 · Cited by 278
Correlates of Cognitive Function in Middle-Aged Adults
Cerhan, J. R., Folsom, A. R., Mortimer, J. A., Shahar, E., Knopman, D. S., McGovern, P. G., Hays, M. A., Crum, L. D., & HEISS, G. M. (1998) · Gerontology · doi:10.1159/000021991 · Cited by 272
Self-citationCurrent and Remote Blood Pressure and Cognitive Decline
Glynn, R. J. (1999) · JAMA · doi:10.1001/jama.281.5.438 · Cited by 270
Makin, S., Turpin, S., Dennis, M. S., & Wardlaw, J. M. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303645 · Cited by 268
Blood Pressure and Risk of Dementia: Results from the Rotterdam Study and the Gothenburg H-70 Study
Ruitenberg, A., Skoog, I. G., Ott, A., Aevarsson, Ó., Witteman, J. C. M., Lernfelt, B., van Harskamp, F., Albert Hofman, D., & Breteler, M. M. B. (2000) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051233 · Cited by 267
Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons
Schneider, J. A., Boyle, P. A., Arvanitakis, Z., Bienias, J. L., & Bennett, D. A. (2007) · Annals of Neurology · doi:10.1002/ana.21142 · Cited by 264
Effects of Blood Pressure Reduction in Mild Hypertension
Sundström, J., Arima, H., Jackson, R., Turnbull, F., Rahimi, K., Chalmers, J. P., Woodward, M., & Neal, B. C. (2014) · Annals of Internal Medicine · doi:10.7326/m14-0773 · Cited by 261
Marco, L. Y. D., Venneri, A., Farkas, E., Evans, P. C., Marzo, A., & Frangi, A. F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.014 · Cited by 260
Daugherty, A., Rateri, D. L., Lu, H. S., Inagami, T., & Cassis, L. A. (2004) · Circulation · doi:10.1161/01.cir.0000150540.54220.c4 · Cited by 258
Midlife Blood Pressure and the Risk of Hippocampal Atrophy
Korf, E. S. C., White, L. R., Scheltens, P., & Launer, L. J. (2004) · Hypertension · doi:10.1161/01.hyp.0000132475.32317.bb · Cited by 258
Self-citationCirculating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review
Poggesi, A., Pasi, M., Pescini, F., Pantoni, L., & Inzitari, D. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.116 · Cited by 257
Amyloid‐β efflux from the central nervous system into the plasma
Roberts, K. F., Elbert, D. L., Kasten, T. P., Patterson, B. W., Sigurdson, W. C., Connors, R. E., Ovod, V., Munsell, L. Y., Mawuenyega, K. G., Miller‐Thomas, M. M., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24270 · Cited by 254
Wolf, P., Beiser, A., Elias, M., Au, R., Vasan, R., & Seshadri, S. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362263 · Cited by 254
Self-citationRelations of arterial stiffness and endothelial function to brain aging in the community
Tsao, C. W., Seshadri, S. S., Beiser, A., Westwood, A. J., DeCarli, C. S., Au, R., Himali, J. J., Hamburg, N. M., Vita, J. A., Levy, D. A., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a43e1c · Cited by 253
Self-citationRomero, J. R., Preis, S. R., Beiser, A., DeCarli, C. S., Viswanathan, A., Martínez‐Ramírez, S., Kase, C. S., Wolf, P. A., & Seshadri, S. S. (2014) · Stroke · doi:10.1161/strokeaha.114.004130 · Cited by 252
Self-citationAging Causes Collateral Rarefaction and Increased Severity of Ischemic Injury in Multiple Tissues
Faber, J. E., Zhang, H., Lassance‐Soares, R. M., Prabhakar, P., Najafi, A. H., Burnett, M. S., & Epstein, S. E. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.227314 · Cited by 250
Risk Factors for β-Amyloid Deposition in Healthy Aging: Vascular and Genetic Effects
Rodrigue, K. M., Rieck, J. R., Kennedy, K. M., Devous, M. D., Diaz-Arrastia, R., & Park, D. C. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1342 · Cited by 249
Cognitive impact of subcortical vascular and Alzheimer’s disease pathology
Chui, H. C., Zarow, C., Mack, W. J., Ellis, W. G., Zheng, L., Jagust, W. J., Mungas, D., Reed, B. R., Kramer, J. H., DeCarli, C. C., et al. (2006) · Annals of Neurology · doi:10.1002/ana.21009 · Cited by 247
Ishii, M., & Iadecola, C. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.016 · Cited by 245
Self-citationWu, J., Thabet, S., Kirabo, A., Trott, D. W., Saleh, M. A., Xiao, L., Madhur, M. S., Chen, W., & Harrison, D. G. (2013) · Circulation Research · doi:10.1161/circresaha.114.302157 · Cited by 244
Cause and Mechanisms of Intracranial Atherosclerosis
Ritz, K., Denswil, N. P., Stam, O. C. G., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.011147 · Cited by 242
Knopman, D. S., Mosley, T. H., Catellier, D., Coker, L. H., & Study, A. R. I. C. S. B. M. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.01.027 · Cited by 238
Self-citationAssociation between blood pressure, white matter lesions, and atrophy of the medial temporal lobe
den Heijer, T., Launer, L. J., Prins, N. D., van Dijk, E. J., Vermeer, S. E., Albert Hofman, D., Koudstaal, P. J., & Breteler, M. M. B. (2005) · Neurology · doi:10.1212/01.wnl.0000149641.55751.2e · Cited by 237
Self-citationCerebral microbleeds, retinopathy, and dementia: The AGES-Reykjavik Study
Qiu, C., Cotch, M. F., Sigurdsson, S., Jonsson, P. V., Jonsdottir, M. K., Sveinbjrnsdottir, S., Eiriksdottir, G., Klein, R., Harris, T. B., van Buchem, M. A., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3182020349 · Cited by 237
Self-citationEndothelial influences on cerebrovascular tone
Andresen, J., Shafi, N. I., & Bryan, R. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00937.2005 · Cited by 235
Tóth, P., Tucsek, Z., Sosnowska, D., Gautam, T., Mitschelen, M. C., Tarantini, S., Deák, F., Koller, Á., Sonntag, W. E., Csiszár, A., et al. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.143 · Cited by 234
Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle–Aged Adults
Willette, A. A., Xu, G., Johnson, S. C., Birdsill, A. C., Jonaitis, E. M., Sager, M. A., Hermann, B. P., Rue, A. L., Asthana, S., & Bendlin, B. B. (2012) · Diabetes Care · doi:10.2337/dc12-0922 · Cited by 233
Endothelial nitric oxide: protector of a healthy mind
Katušić, Z. S., & Austin, S. A. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht544 · Cited by 230
Consensus statement for diagnosis of subcortical small vessel disease
Rosenberg, G. A., Wallin, A., Wardlaw, J. M., Markus, H. S., Montaner, J., WOLFSON, L. I., Iadecola, C., Zloković, B. V., Joutel, A., Dichgans, M., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.172 · Cited by 228
Self-citationHypertension, Brain Damage and Cognitive Decline
Gąsecki, D., Kwarciany, M., Nyka, W. M., & Narkiewicz, K. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0398-4 · Cited by 228
Neuropathologic basis of white matter hyperintensity accumulation with advanced age
Erten‐Lyons, D., Woltjer, R. L., Kaye, J. A., Mattek, N., Dodge, H. H., Green, S., Tran, H. T. D., Howieson, D. B., Wild, K. V., & Silbert, L. C. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a43e45 · Cited by 227
Chen, W., Bao, W., Begum, S., Elkasabany, A., Srinivasan, S. R., & Berenson, G. S. (2000) · Diabetes · doi:10.2337/diabetes.49.6.1042 · Cited by 226
Pharmacotherapy for hypertension in the elderly
Musini, V. M., Tejani, A. M., Bassett, K. L., & Wright, J. M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000028.pub2 · Cited by 220
Prognosis of Diastolic and Systolic Orthostatic Hypotension in Older Persons
Luukinen, H., Koski, K., Laippala, P. J., & Kivelä, S. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.3.273 · Cited by 218
Morris, M. C., Scherr, P. A., Hebert, L. E., Glynn, R. J., Bennett, D. A., & Evans, D. A. (2001) · Archives of Neurology · doi:10.1001/archneur.58.10.1640 · Cited by 217
Anderson, C., Teo, K., Gao, P., Arima, H., Dans, A., Unger, T., Commerford, P., Dyal, L., Schumacher, H., Pogue, J., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70250-7 · Cited by 216
Power, M. C., Weuve, J., Gagne, J. J., McQueen, M. B., Viswanathan, A., & Blacker, D. (2011) · Epidemiology · doi:10.1097/ede.0b013e31822708b5 · Cited by 213
Yaffe, K. S., Haan, M. N., BLACKWELL, T. L., Cherkasova, E., Whitmer, R. A., & West, N. A. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01139.x · Cited by 210
Self-citationConverging Pathogenic Mechanisms in Vascular and Neurodegenerative Dementia
Iadecola, C., & Gorelick, P. B. (2003) · Stroke · doi:10.1161/01.str.0000054050.51530.76 · Cited by 208
Self-citationChange in Blood Pressure and Incident Dementia
Stewart, R. J., Xue, Q., Masaki, K., Petrovitch, H., Ross, G. W., White, L. R., & Launer, L. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.128744 · Cited by 206
Self-citationKennedy, K. M., & Raz, N. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.058 · Cited by 205
Østergaard, S. D., Mukherjee, S., Sharp, S. J., Proitsi, P., Lotta, L. A., Day, F., Perry, J. R. B., Boehme, K. L., Walter, S., Kauwe, J. S., et al. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001841 · Cited by 203
BLOOD PRESSURE AND COGNITIVE PERFORMANCE
Farmer, M. E., White, L. R., Abbott, R. D., Kittner, S. J., Kaplan, E., WOLZ, M. M., Brody, J. A., & Wolf, P. A. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114749 · Cited by 202
Skoog, I. G., LITHELL, H., Hansson, L., Elmfeldt, D., Albert Hofman, D., OLOFSSON, B., Trenkwalder, P., & Zanchetti, A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.02.013 · Cited by 198
Reduced cerebral blood flow response and compensation among patients with untreated hypertension
Jennings, J. R., Muldoon, M. F., Ryan, C., Price, J. C., Greer, P., Sutton-Tyrrell, K., van der Veen, F. M., & Meltzer, C. C. (2005) · Neurology · doi:10.1212/01.wnl.0000158283.28251.3c · Cited by 198 · cited 1×
“hypertension attenuates the increase in CBF induced by neural activity.(16,58) The resulting mismatch between energy”
Lande, M. B., Kaczorowski, J. M., Auinger, P., Schwartz, G. J., & Weitzman, M. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00412-8 · Cited by 197
Protecting against vascular disease in brain
Faraci, F. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01310.2010 · Cited by 196
Self-citationLongitudinal Changes in Cerebral Blood Flow in the Older Hypertensive Brain
Beason‐Held, L. L., Moghekar, A., Zonderman, A. B., Kraut, M. A., & Resnick, S. M. (2007) · Stroke · doi:10.1161/strokeaha.106.477109 · Cited by 195
Dregan, A., Stewart, R., & Gulliford, M. C. (2013) · Age and Ageing · doi:10.1093/ageing/afs166 · Cited by 195
Relationship Between White Matter Hyperintensities, Cortical Thickness, and Cognition
Tuladhar, A. M., Reid, A. T., Shumskaya, E., de Laat, K. F., van Norden, A. G. W., van Dijk, E. J., Norris, D. G., & de Leeuw, F.-E. (2015) · Stroke · doi:10.1161/strokeaha.114.007146 · Cited by 195
White, L. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1178 · Cited by 193
Vascular risk factors and longitudinal changes on brain MRI
Knopman, D. S., Penman, A. D., Catellier, D., Coker, L. H., Shibata, D. K., Sharrett, A. R., & Mosley, T. H. (2011) · Neurology · doi:10.1212/wnl.0b013e31821d753f · Cited by 193
Self-citationDi Bari, M., Pahor, M., Franse, L. V., Shorr, R. I., Wan, J. Y., Ferrucci, L., Somes, G. W., & Applegate, W. B. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.1.72 · Cited by 193
Applegate, W. B. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420190047006 · Cited by 193
Guo, Z., Fratiglioni, L., Winblad, B. G., & Viitanen, M. H. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009073 · Cited by 192
Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults
Hughes, T. M., Kuller, L. H., Barinas-Mitchell, E. J. M., Mackey, R. H., McDade, E. M., Klunk, W. E., Aizenstein, H. J., Cohen, A. D., Snitz, B. E., Mathis, C. A., et al. (2013) · Neurology · doi:10.1212/01.wnl.0000435301.64776.37 · Cited by 190
Firbank, M., Wiseman, R., Burton, E. J., Saxby, B. K., O'Brien, J. T., & Ford, G. A. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0238-4 · Cited by 189
Seals, D. R., Tanaka, H., Clevenger, C. M., Monahan, K. D., Reiling, M. J., Hiatt, W. R., Davy, K. P., & DeSouza, C. A. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01348-1 · Cited by 187
Hypertension and longitudinal changes in cerebral blood flow: The SMART‐MR study
Muller, M., van der Graaf, Y., Visseren, F. L. J., Mali, W. P. T. M., Geerlings, M. I., & for the SMART Study Group (2012) · Annals of Neurology · doi:10.1002/ana.23554 · Cited by 187
Williamson, J. D., Launer, L. J., Bryan, R. N., Coker, L. H., Lazar, R. M., Gerstein, H. C., Murray, A. M., Sullivan, M. D., Horowitz, K. R., Ding, J., et al. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13656 · Cited by 187
Self-citationSystolic Blood Pressure Tracking Over 25 to 30 Years and Cognitive Performance in Older Adults
Swan, G. E., Carmelli, D., & LaRue, A. A. (1998) · Stroke · doi:10.1161/01.str.29.11.2334 · Cited by 184
Interaction Between Hypertension, apoE, and Cerebral White Matter Lesions
de Leeuw, F., Richard, F., de Groot, J. C., van Duijn, C. M., Albert Hofman, D., van Gijn, J., & Breteler, M. M. B. (2004) · Stroke · doi:10.1161/01.str.0000125859.71051.83 · Cited by 184
Blood pressure levels and brain volume reduction
Beauchet, O., Celle, S., Roche, F., Bartha, R., Montero‐Odasso, M., Allali, G., & Annweiler, C. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32836184b5 · Cited by 182
Blood Pressure-Related Cognitive Decline
Elias, P. K., Elias, M. F., Robbins, M. A., & Budge, M. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000145858.07252.99 · Cited by 181
Reducing the Risk of Dementia: Efficacy of Long-Term Treatment of Hypertension
Peila, R., White, L. R., Masaki, K., Petrovitch, H., & Launer, L. J. (2006) · Stroke · doi:10.1161/01.str.0000217653.01615.93 · Cited by 181
Self-citationShear, C. L., Burke, G. L., Freedman, D. S., & Berenson, G. S. (1986) · PEDIATRICS · doi:10.1542/peds.77.6.862 · Cited by 180
APOE genotype and MRI markers of cerebrovascular disease
Schilling, S., DeStefano, A. L., Sachdev, P. S., Choi, S. H., Mather, K. A., DeCarli, C. S., Wen, W. X., Høgh, P., Raz, N., Au, R., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31829bfda4 · Cited by 180
Self-citationClinical review: the management of hypertensive crises.
Varón, J., & Marik, P. E. (2003) · Critical Care · doi:10.1186/cc2351 · Cited by 180
McGuinness, B., Todd, S., Passmore, P., & Bullock, R. A. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004034.pub2 · Cited by 177
Ecology of the Aging Human Brain
Sonnen, J. A. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.157 · Cited by 174
Gottesman, R. F., Coresh, J., Catellier, D. J., Sharrett, A. R., Rose, K. M., Coker, L. H., Shibata, D. K., Knopman, D. S., Jack, C. R., & Mosley, T. H. (2010) · Stroke · doi:10.1161/strokeaha.109.566992 · Cited by 173
Self-citationClinical risk factors for Alzheimer's disease
Kokmen, E., Beard, C. M., Chandra, V., OFFORD, K. P., Schoenberg, B. S., & Ballard, D. (1991) · Neurology · doi:10.1212/wnl.41.9.1393 · Cited by 171
High Blood Pressure in Children and Adolescents
Harris, J. (1987) · Health Education · doi:10.1080/00970050.1987.10614501 · Cited by 171
Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease
Gupta, A. K., & Iadecola, C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00115 · Cited by 164
Self-citationPark, J., Seo, S. W., Kim, C., Kim, G. H., Noh, H. J., Kim, S. T., Kwak, K., Yoon, U., Lee, J. M., Lee, J. W., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23845 · Cited by 164
Research works printed but not linked: 5
- Schmidt M. Rey Auditory Verbal Learning Test: A Handbook. Los Angeles, CA: Western Psychological Services; 1996.
- Lezak M. Neuropsychological Assessment. New York, NY: Oxford University Press; 2004.
- Army Individual Test Battery: Manual of Directions and Scoring. Washington, DC: War Department, Adjutant General’s Office; 1944.
- 10.1097/00006842-200405000-00002 · DOI
- 10.1097/01.hjh.0000059028.82022.89 · DOI
Cited by
Sorted by citations
2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Hypertension-induced cognitive impairment: From pathophysiology to public health
Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., & Csiszar, A. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00430-6 · Cited by 544
Gorelick, P. B., Furie, K. L., Iadecola, C., Smith, E. E., Waddy, S. P., Lloyd-Jones, D. M., Bae, H.-J., Bauman, M. A., Dichgans, M., Duncan, P. W., et al. (2017) · Stroke · doi:10.1161/str.0000000000000148 · Cited by 411
Self-citation
Metadata
- Authors
- Iadecola, C., Yaffe, K., Biller, J., Bratzke, L. C., Faraci, F. M., Gorelick, P. B., Gulati, M., Kamel, H., Knopman, D. S., Launer, L. J., Saczynski, J. S., Seshadri, S., & Zeki Al Hazzouri, A.
- ORCID
- Venue
- Hypertension
- Published
- 2016-12
- Volume
- 68
- Issue
- 6
- Pages
- e67-e94
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC5361411
- OpenAlex
- W2530115453
- Semantic Scholar
- 1f0aaa0710148c9974472c023c1134b92f24307f
- Cited by
- 746
- References
- 332
- Citations by year
- 2026: 61 · 2025: 68 · 2024: 78 · 2023: 79 · 2022: 77 · 2021: 85 · 2020: 93 · 2019: 95 · 2018: 64 · 2017: 42 · 2016: 1
- FWCI
- 59.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (P30AG010129, K01AG047273)
- National Institute of Neurological Disorders and Stroke (R37NS089323, R01NS017950)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- cognitive function, dementia, Alzheimer's disease, vascular dementia, white matter ischemia, cerebral vasculature, antihypertensive therapy, midlife hypertension, cerebrovascular injury, brain health
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, American Heart Association, Antihypertensive Agents, Cognition Disorders, Female, Follow-Up Studies, Humans, Hypertension, Male, Severity of Illness Index, Sex Factors, United States, Dementia, Vascular, Practice Guidelines as Topic, Disease Progression, Risk Assessment, Evidence-Based Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
