The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Sequential Changes in Antiangiogenic Factors in Early Pregnancy and Risk of Developing Preeclampsia
Open accessAbstract
Concentrations of soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng) increase in maternal blood with the approach of clinical preeclampsia. Although alterations in these circulating antiangiogenic factors herald the signs and symptoms of preeclampsia, in vitro studies suggest they may also play a role in regulating early placental cytotrophoblast functions. Early pregnancy changes in sFlt1 and sEng may thus identify women destined to develop preeclampsia. We performed a nested case-control study of 39 women who developed preeclampsia and 147 contemporaneous normotensive controls each with serum collected in the first (11 to 13 weeks of gestation) and second (17 to 20 weeks) trimesters. Whereas levels of sFlt1 and sEng at 11 to 13 weeks were similar between cases and controls (sFlt1: 3.5±0.3 ng/mL versus 3.0±0.1, P =0.14; sEng 6.9±0.3 ng/mL versus 6.6±0.2, P =0.37, respectively), at 17 to 20 weeks both were elevated in the women destined to develop preeclampsia (sFlt1: 4.1±0.5 ng/mL versus 3.1±0.1, P <0.05; sEng, 6.4±0.4 ng/mL versus 5.2±0.1, P <0.01). Women who developed preterm (<37 weeks) preeclampsia demonstrated even greater sequential changes: difference [ delta { d} ] between second and first trimester levels: d sFlt1, 0.63±0.91 ng/mL in preterm PE versus 0.05±0.15 in controls; d sEng, 0.73±0.77 ng/mL versus −1.32±0.18, P <0.01. Similar findings were noted in a cross-sectional analysis of specimens collected from the Calcium for Preeclampsia Prevention Study. In conclusion, sequential changes in antiangiogenic factors during early pregnancy may be useful for predicting preterm preeclampsia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101
Self-citationCirculating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720
Self-citationCirculating angiogenic factors and the risk of preeclampsia*
(2004) · Obstetrics & Gynecology · doi:10.1097/00006250-200405000-00028 · Cited by 2,615
Latest Advances in Understanding Preeclampsia
Redman, C. W., & Sargent, I. L. (2005) · Science · doi:10.1126/science.1111726 · Cited by 2,607
Soluble endoglin contributes to the pathogenesis of preeclampsia
Venkatesha, S., Toporsian, M., Lam, C., Hanai, J.-I., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K.-H., Yuan, H.-T., Libermann, T. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1429 · Cited by 1,855
Self-citationSoluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia
Levine, R. J., Lam, C., Qian, C., Yu, K. F., Maynard, S. E., Sachs, B. P., Sibai, B. M., Epstein, F. H., Romero, R., Thadhani, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055352 · Cited by 1,802
Self-citationSoluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia
(2006) · New England Journal of Medicine · doi:10.1056/nejmx060063 · Cited by 1,235
SIBAI, B., DEKKER, G., & KUPFERMINC, M. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71003-5 · Cited by 1,089
Practice bulletin #33: diagnosis and management of preeclampsia and eclampsia
ACOG Committee on Obstetric Practice (2002) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(01)01747-1 · Cited by 1,058
Zhou, Y., McMaster, M., Woo, K., Janatpour, M., Perry, J., Karpanen, T., Alitalo, K., Damsky, C., & Fisher, S. J. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62567-9 · Cited by 640
Cited by
Hypertension Across a Woman’s Life Cycle
Wenger, N. K., Arnold, A., Bairey Merz, C. N., Cooper-DeHoff, R. M., Ferdinand, K. C., Fleg, J. L., Gulati, M., Isiadinso, I., Itchhaporia, D., Light-McGroary, K., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.02.033 · Cited by 298
Potential markers of preeclampsia – a review
Grill, S., Rusterholz, C., Zanetti-Dällenbach, R., Tercanli, S., Holzgreve, W., Hahn, S., & Lapaire, O. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-70 · Cited by 293
Erez, O., Romero, R., Espinoza, J., Fu, W., Todem, D., Kusanovic, J. P., Gotsch, F., Edwin, S., Nien, J. K., Chaiworapongsa, T., et al. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050802034545 · Cited by 287
Powers, R. W., Jeyabalan, A., Clifton, R. G., Van Dorsten, P., Hauth, J. C., Klebanoff, M. A., Lindheimer, M. D., Sibai, B., Landon, M., Miodovnik, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013263 · Cited by 162
Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia
LaMarca, B. D., Gilbert, J., & Granger, J. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.108837 · Cited by 142
Metadata
- Authors
- Rana, S., Karumanchi, S. A., Levine, R. J., Venkatesha, S., Rauh-Hain, J. A., Tamez, H., & Thadhani, R.
- Venue
- Hypertension
- Published
- 2007-07
- Volume
- 50
- Issue
- 1
- Pages
- 137-142
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2133547019
- Cited by
- 286
- References
- 26
- FWCI
- 29.73
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sequential Changes in Antiangiogenic Factors in Early Pregnancy and Risk of Developing Preeclampsia. https://app.cochat.ai/papers/10.1161/hypertensionaha.107.087700
- The paper
- Rana, S., Karumanchi, S. A., Levine, R. J., Venkatesha, S., Rauh-Hain, J. A., Tamez, H., & Thadhani, R. (2007). Sequential Changes in Antiangiogenic Factors in Early Pregnancy and Risk of Developing Preeclampsia. Hypertension. https://doi.org/10.1161/hypertensionaha.107.087700
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
