The DOI matches its Crossref record; 99 of the 100 references it cites were found in a registry or an index.
Adaptation and Maladaptation of the Heart in Obesity
Open accessAbstract
O besity appears to be a major cause of hypertension and associated cardiovascular pathophysiology, including cardiac dysfunction.However, obesity may lead to abnormal cardiac function through mechanisms that are independent of, or that act in concert with, hypertension.One hypothesis of obesity-induced cardiac dysfunction is that an oversupply of substrates leads first to adaptive changes and eventually to contractile dysfunction of the heart.We reason that increased supply of nonesterified fatty acids, together with metabolic dysregulation in obesity, including an inadequate activation of fat oxidation, results in the accumulation of toxic lipid byproducts and subsequent contractile dysfunction.Although the phenomenon may have already been known to Virchow 1 when he described "fatty metamorphosis" of the heart, the concept of cardiac "lipotoxicity" re-emerged only recently with its description in the heart of the obese Zucker diabetic fatty rat. 2 The concept is, however, still a hypothesis rather than an established physiological principle.In spite of the many investigations performed in rodent models, the mechanism(s) responsible for impaired contractile function of the heart is still obscure, and it is uncertain whether lipid metabolites contribute to "obesity cardiomyopathy" in humans.Our brief review is an attempt to understand the chronic regulatory effects of changes in systemic metabolism on cardiac function.In other words, we discuss current concepts of cardiac adaptation and maladaptation to a deranged metabolic environment.
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“Obesity is closely associated with cardiac disorders, which is assumed to be a consequence of the adaption to an oversupply of high-fat substrates [262,263].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [262]
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1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedFridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390
Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects
Graham, T. E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T. P., Henry, R. R., Wason, C. J., Oberbach, A., Jansson, P.-A., Smith, U., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054862 · Cited by 1,319
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285
Lipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265
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Items 101–121 of 121
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Bernstein, D. P. (2012) · Springer eBooks · doi:10.1007/978-88-470-2634-6_6
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Andersson, D. C. (2009)
Nduhirabandi, F. (2010) · SUNScholar (Stellenbosch University)
Regulation and Functions of Cardiac Lipins
Kok, B. P. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r30b09
Study on the role of PGC-1 on the obesity by inflammation
WONCHUNG, L. (2018) · Asian Journal of Physical Education and Sport Science · doi:10.24007/ajpess.2018.6.2.002
Magnetic resonance imaging and spectroscopy
van Ewijk, P. A. (2014) · Research Publications (Maastricht University) · doi:10.26481/dis.20140701pe
A Physiological Approach to Inflammatory Markers in Obesity
Polat, S. H. B., & Darıyerli, N. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815040463122010028
Editorial: Cardiac fat in metabolic and endocrine diseases
Soghomonian, A., Gaborit, B., Carbone, F., Castinetti, F., & Dutour, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1271565
Partington, C., Hodgkiss‐Geere, H., Woods, G. R. T., Dukes‐McEwan, J., Flanagan, J., Biourge, V. C., & German, A. J. (2024) · Figshare · doi:10.6084/m9.figshare.25687583
Partington, C., Hodgkiss‐Geere, H., Woods, G. R. T., Dukes‐McEwan, J., Flanagan, J., Biourge, V. C., & German, A. J. (2024) · Figshare · doi:10.6084/m9.figshare.26711222
Partington, C., Hodgkiss‐Geere, H., Woods, G. R. T., Dukes‐McEwan, J., Flanagan, J., Biourge, V. C., & German, A. J. (2024) · Figshare · doi:10.6084/m9.figshare.25687516
Partington, C., Hodgkiss‐Geere, H., Woods, G. R. T., Dukes‐McEwan, J., Flanagan, J., Biourge, V., & German, A. J. (2022) · Figshare · doi:10.6084/m9.figshare.21175679
Partington, C., Hodgkiss‐Geere, H., Woods, G. R. T., Dukes‐McEwan, J., Flanagan, J., Biourge, V., & German, A. J. (2022) · Figshare · doi:10.6084/m9.figshare.21175673
Partington, C., Hodgkiss‐Geere, H., Woods, G. R. T., Dukes‐McEwan, J., Flanagan, J., Biourge, V., & German, A. J. (2022) · Figshare · doi:10.6084/m9.figshare.21175676
Tissu adipeux ectopique et pathologie cardiaque
Gaborit, B. (2013) · theses.fr (ABES) · doi:10.70675/950549dfzb0e2z4faaz9e53z9e9fd1812f11
Etude de la perméabilité intestinale au cours de l'obésité humaine
Genser, L. (2017) · theses.fr (ABES) · doi:10.70675/b31dde1bz1941z4398zaa56z406e97d709fa
Señales aterogénicas tempranas en un área de salud del municipio Consolación del Sur
Domínguez, A. A. N., González, A. A. P., Aportela, R. A., Cabinda, A., & Alessandrini, G. E. A. (2014) · CorSalud
Alvarez, A., Brodsky, J. B., Lemmens, H. J. M., & Morton, J. M. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511676307.003
Metadata
- Authors
- Harmancey, R., Wilson, C. R., & Taegtmeyer, H.
- Affiliations
- Texas Medical Center (US)
- Venue
- Hypertension
- Published
- 2008-08
- Volume
- 52
- Issue
- 2
- Pages
- 181-187
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3660087
- OpenAlex
- W2137438717
- Cited by
- 121
- References
- 100
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 4 · 2012: 10
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL061483, R01HL073162)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- obesity, obesity cardiomyopathy, cardiac dysfunction, lipotoxicity, free fatty acids, fat oxidation, lipid accumulation, contractile dysfunction, cardiac adaptation, metabolic dysfunction, Zucker diabetic fatty rats
- MeSH terms
- Adaptation, Physiological, Animals, Disease Models, Animal, Fatty Acids, Nonesterified, Female, Heart Failure, Humans, Male, Myocardial Contraction, Myocardium, Obesity, Morbid, Prognosis, Severity of Illness Index, Cohort Studies, Body Mass Index, Reactive Oxygen Species, Risk Assessment, Mice
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